Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses inPlasmodium falciparum

Molecular Pharmacology - Tập 61 Số 1 - Trang 35-42 - 2002
Roland A. Cooper1,2,3,4, Michael T. Ferdig1,2,3,4, Xin Su1,2,3,4, Lyann M. B. Ursos1,2,3,4, Jianbing Mu1,2,3,4, Takashi Nomura1,2,3,4, Hisashi Fujioka1,2,3,4, David A. Fidock1,2,3,4, Paul D. Roepe1,2,3,4, Thomas E. Wellems1,2,3,4
11National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (R.A.C., M.T.F., X.-Z.S., J.M., T.N., T.E.W)
22Department of Chemistry and Program in Tumor Biology, Lombardi Cancer Center, Georgetown University, Washington DC (L.M.B.U., P.D.R.)
33Institute of Pathology, Case Western Reserve University, Cleveland, Ohio (H.F.)
44Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York (D.A.F.)

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