Altered expression of p53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro

Toxicon - Tập 46 - Trang 171-177 - 2005
Wen-yu Fu1, Jia-ping Chen1, Xiu-min Wang1, Li-hong Xu1
1Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, 310031, China

Tài liệu tham khảo

Blagosklonny, 2001, Unwinding the loop of Bcl-2 phosphorylation, Leukemia, 15, 869, 10.1038/sj.leu.2402134 Bossy-Wetzel, 1999, Apoptosis: checkpoint at the mitochondrial frontier, Mutat. Res., 434, 243, 10.1016/S0921-8777(99)00032-4 Bradford, 1976, A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principal of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Carmichael, 1992, Cyanobacterial secondary metabolites-the cyanotoxins, J. Appl. Bacteriol., 72, 445, 10.1111/j.1365-2672.1992.tb01858.x Carmichael, 1994, The toxins of cyanobacteria, Sci. Am., 270, 78, 10.1038/scientificamerican0194-78 Dawson, 1998, The toxicology of microcystins, Toxicon, 36, 953, 10.1016/S0041-0101(97)00102-5 Deng, 1998, Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A, J. Biol. Chem., 273, 34157, 10.1074/jbc.273.51.34157 Ding, 1998, Microcystic cyanobacteria causes mitochondrial membrane potential alteration and reactive oxygen species formation in primary cultured rat hepatocytes, Environ. Health Perspect., 106, 409 Ding, 1998, Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes, Environ. Res., 78, 12, 10.1006/enrs.1998.3843 Ding, 2000, Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes, Hepatology, 32, 547, 10.1053/jhep.2000.16183 Ding, 2002, Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes, Biochem. Biophys. Res. Commun., 291, 321, 10.1006/bbrc.2002.6453 Fladmark, 1999, Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors, Cell Death Differ., 6, 1099, 10.1038/sj.cdd.4400590 Fu, 2004, Detection of apoptosis of renal cells of rat induced by microcystin-LR, Acta Hydrobiol. Sinica, 28, 101 Guzman, 2003, Inhibition of nuclear protein phosphatase activity in mouse hepatocytes by the cyanobacterial toxin microcystin-LR, Toxicon, 41, 773, 10.1016/S0041-0101(03)00030-8 Herrera, 2001, Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes, FASEB J., 15, 741, 10.1096/fj.00-0267com Humpage, 2000, Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon, J. Toxicol. Environ. Health A., 61, 155, 10.1080/00984100050131305 Ito, 1997, Bcl-2 phosphorylation required for anti-apoptosis function, J. Biol. Chem., 272, 11671, 10.1074/jbc.272.18.11671 Jochimsen, 1998, Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil, N. Engl. J. Med., 338, 873, 10.1056/NEJM199803263381304 Klumpp, 2002, Serine/threonine protein phosphatases in apoptosis, Curr. Opin. Pharmacol., 2, 458, 10.1016/S1471-4892(02)00176-5 McDermott, 1998, The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types, Toxicon, 36, 1981, 10.1016/S0041-0101(98)00128-7 Mihara, 2003, p53 has a direct apoptogenic role at the mitochondria, Mol. Cell, 11, 577, 10.1016/S1097-2765(03)00050-9 Milczarek, 1999, Okadaic acid mediates p53 hyperphosphorylation and growth arrest in cells with wild-type p53 but increases aberrant mitoses in cells with non-functional p53, Carcinogenesis, 20, 1043, 10.1093/carcin/20.6.1043 Miyashita, 1995, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene, Cell, 80, 293, 10.1016/0092-8674(95)90412-3 Nishiwaki-Matsushima, 1992, Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR, J. Cancer Res. Clin. Oncol., 118, 420, 10.1007/BF01629424 Pilotto, 1997, Health effects of exposure to cyanobacteria (blue-green algae) during recreational water-related activities, Aust. NZ J. Public Health, 21, 562, 10.1111/j.1467-842X.1997.tb01755.x Pouria, 1998, Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil Lancet., 352, 21, 10.1016/S0140-6736(97)12285-1 Raha, 2001, Mitochondria, oxygen free radicals, and apoptosis, Am. J. Med. Genet., 106, 62, 10.1002/ajmg.1398 Reed, 1998, Bcl-2 family proteins, Oncogene, 17, 3225, 10.1038/sj.onc.1202591 Reed, 1998, Bcl-2 family proteins and mitochondria, Biochim. Biophys. Acta., 1366, 127, 10.1016/S0005-2728(98)00108-X Ruvolo, 1999, Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A, J. Biol. Chem., 274, 20296, 10.1074/jbc.274.29.20296 Ruvolo, 2001, Phosphorylation of Bcl2 and regulation of apoptosis, Leukemia, 15, 515, 10.1038/sj.leu.2402090 Scheidtmann, 1991, Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen, Mol. Cell. Biol., 11, 1996, 10.1128/MCB.11.4.1996 Symonds, 1994, p53-dependent apoptosis suppresses tumor growth and progression in vivo, Cell, 78, 703, 10.1016/0092-8674(94)90534-7 Tamura, 2004, The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria, FEBS Lett., 569, 249, 10.1016/j.febslet.2004.06.003 Van Hoof, 2003, Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question, Biochim. Biophys. Acta., 1640, 97, 10.1016/S0167-4889(03)00029-6 Yan, 1997, Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation, J. Biol. Chem., 272, 15220, 10.1074/jbc.272.24.15220 Yoshizawa, 1990, Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity, J. Cancer Res. Clin. Oncol., 116, 609, 10.1007/BF01637082