Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

Arango, 1995, Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims, Brain Res, 688, 121, 10.1016/0006-8993(95)00523-S Barchas, 1973 Bengel, 1997, Cellular localization and expression of the serotonin transporter in mouse brain, Brain Res, 778, 338, 10.1016/S0006-8993(97)01080-9 Bengel, 1998, Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice, Mol Pharmacol, 53, 649, 10.1124/mol.53.4.649 Blier, 1994, Current advances and trends in the treatment of depression, Trends Pharmacol Sci, 15, 220, 10.1016/0165-6147(94)90315-8 Bodnoff, 1988, The effects of chronic antidepressant treatment in an animal model of anxiety, Psychopharmacology (Berl), 95, 298, 10.1007/BF00181937 Brown, 1982, Evidence for a serotonergic mechanism of the learned helplessness phenomenon, Pharmacol Biochem Behav, 17, 877, 10.1016/0091-3057(82)90465-8 Caldarone, 2000, Gender differences in learned helplessness behavior are influenced by genetic background, Pharmacol Biochem Behav, 66, 811, 10.1016/S0091-3057(00)00271-9 Caspi, 2003, Influence of life stress on depression, Science, 301, 386, 10.1126/science.1083968 Charnay, 1996, Mapping of serotonin transporter messenger RNA-containing nerve cell populations in the cat brainstem, J Chem Neuroanat, 10, 93, 10.1016/0891-0618(96)00108-1 Collier, 1996, A novel functional polymorphism within the promoter of the serotonin transporter gene, Mol Psychiatry, 1, 453 Fabre, 2000, Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter, Eur J Neurosci, 12, 2299, 10.1046/j.1460-9568.2000.00126.x File, 1983, Neonatal clomipramine treatment in the rat does not affect social, sexual and exploratory behaviors in adulthood, Neurobehav Toxicol Teratol, 5, 3 Fujita, 1993, Cellular localization of serotonin transporter mRNA in the rat brain, Neurosci Lett, 162, 59, 10.1016/0304-3940(93)90559-4 Furlong, 1998, Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders, Am J Med Genet, 81, 58, 10.1002/(SICI)1096-8628(19980207)81:1<58::AID-AJMG11>3.0.CO;2-V Gingrich, 2000, The broken mouse, Curr Opin Neurobiol, 10, 146, 10.1016/S0959-4388(99)00061-6 Gobbi, 2001, Modifications of the serotonergic system in mice lacking serotonin transporters, J Pharmacol Exp Ther, 296, 987 Gorman, 1999, SSRIs and SMRIs, J Clin Psychiatry, 60, 33 Greenberg, 1999, Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets, Am J Med Genet, 88, 83, 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 Gross, 2002, Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult, Nature, 416, 396, 10.1038/416396a Gutierrez, 1998, Variability in the serotonin transporter gene and increased risk for major depression with melancholia, Hum Genet, 103, 319, 10.1007/s004390050823 Hansen, 1997, Neonatal administration of the selective serotonin reuptake inhibitor Lu 10–134-C increases forced swimming-induced immobility in adult rats, J Pharmacol Exp Ther, 283, 1333 Heinz, 2000, A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity, Biol Psychiatry, 47, 643, 10.1016/S0006-3223(99)00171-7 Hof, 2000 Holmes, 2002, Reduced aggression in mice lacking the serotonin transporter, Psychopharmacology (Berl), 161, 160, 10.1007/s00213-002-1024-3 Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL (in press): Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology. Holmes, 2002, Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter, Neuropsychopharmacology, 27, 914, 10.1016/S0893-133X(02)00374-3 Johnston, 1988, Profiles of the antipanic compounds, triazolobenzodiazepines and phenelzine, in two animal tests of anxiety, Psychiatry Res, 25, 81, 10.1016/0165-1781(88)90161-8 Kung, 1999, Characterization of, Eur J Nucl Med, 26, 844, 10.1007/s002590050458 la Cour, 2001, Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity, J Neurosci, 21, 2178, 10.1523/JNEUROSCI.21-06-02178.2001 Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 Leshner, 1979, Desmethylimipramine (DMI) counteracts learned helplessness in rats, Psychopharmacology (Berl), 66, 207, 10.1007/BF00427633 Li, 2000, Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice, J Neurosci, 20, 7888, 10.1523/JNEUROSCI.20-21-07888.2000 Lister, 1987, The use of a plus-maze to measure anxiety in the mouse, Psychopharmacology (Berl), 92, 180, 10.1007/BF00177912 Little, 1998, Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels, Am J Psychiatry, 155, 207, 10.1176/ajp.155.2.207 Lucki, 2001, Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice, Psychopharmacology (Berl), 155, 315, 10.1007/s002130100694 Malison, 1998, Reduced brain serotonin transporter availability in major depression as measured by, Biol Psychiatry, 44, 1090, 10.1016/S0006-3223(98)00272-8 Mangiarini, 1996, Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice, Cell, 87, 493, 10.1016/S0092-8674(00)81369-0 Mann, 2000, A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide, Arch Gen Psychiatry, 57, 729, 10.1001/archpsyc.57.8.729 Mayorga, 2001, Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice, J Pharmacol Exp Ther, 298, 1101 McLaughlin, 1996, Expression of serotonin transporter mRNA in human brainstem raphe nuclei, Neuropsychopharmacology, 15, 523, 10.1016/S0893-133X(96)00093-0 Petty, 1979, Reversal of learned helplessness by imipramine, Commun Psychopharmacol, 3, 371 Porsolt, 1977, Behavioral despair in mice, Arch Int Pharmacodyn Ther, 229, 327 Praschak-Rieder, 2002, Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder, Eur Neuropsychopharmacol, 12, 129, 10.1016/S0924-977X(01)00146-8 Ramboz, 1998, Serotonin receptor 1A knockout, Proc Natl Acad Sci U S A, 95, 14476, 10.1073/pnas.95.24.14476 Ramos, 1997, A multiple-test study of anxiety-related behaviours in six inbred rat strains, Behav Brain Res, 85, 57, 10.1016/S0166-4328(96)00164-7 Rioux, 1999, Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter, Neurosci Lett, 262, 113, 10.1016/S0304-3940(99)00049-X Rodgers, 1995, Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety, Pharmacol Biochem Behav, 52, 297, 10.1016/0091-3057(95)00138-M Santarelli, 2001, Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function, Proc Natl Acad Sci U S A, 98, 1912, 10.1073/pnas.98.4.1912 Seligman, 1972, Learned helplessness, Annu Rev Med, 23, 407, 10.1146/annurev.me.23.020172.002203 Steru, 1985, The tail suspension test, Psychopharmacology (Berl), 85, 367, 10.1007/BF00428203 Telner, 1981, Reversal of learned helplessness by nortriptyline, Prog Neuropsychopharmacol, 5, 587, 10.1016/0364-7722(81)90052-7 Thiebot MH, Martin P, Puech AJ (1992): Animal behavioural studies in the evaluation of antidepressant drugs. Br J Psychiatry Suppl Feb:44–50 Underwood, 1999, Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims, Biol Psychiatry, 46, 473, 10.1016/S0006-3223(99)00043-8 Vaugeois, 1996, A genetic mouse model of helplessness sensitive to imipramine, Eur J Pharmacol, 316, R1, 10.1016/S0014-2999(96)00800-X Velazquez-Moctezuma, 1992, Neonatal treatment with clomipramine increased immobility in the forced swim test, Pharmacol Biochem Behav, 42, 737, 10.1016/0091-3057(92)90022-8 Wall, 2000, Ethological confirmatory factor analysis of anxiety-like behaviour in the murine elevated plus-maze, Behav Brain Res, 114, 199, 10.1016/S0166-4328(00)00229-1 Watase, 2002, A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration, Neuron, 34, 905, 10.1016/S0896-6273(02)00733-X West, 1991, Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator, Anat Rec, 231, 482, 10.1002/ar.1092310411 White, 1997, Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion, Nat Genet, 17, 404, 10.1038/ng1297-404 Willeit, 2000, [123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder, Biol Psychiatry, 47, 482, 10.1016/S0006-3223(99)00293-0