Alterations to vascular endothelium in the optic nerve head in patients with vascular comorbidities

Abraham, 2008, Endothelin – role in vascular disease, Rheumatology, 47, v23, 10.1093/rheumatology/ken282 Aird, 2007, Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms, Circ. Res., 100, 158, 10.1161/01.RES.0000255691.76142.4a Aird, 2008, Endothelium in health and disease, Pharmacol. Rep., 60, 139 Anderson, 1969, Ultrastructure of human and monkey lamina cribrosa and optic nerve head, Arch. Ophthalmol., 82, 800, 10.1001/archopht.1969.00990020792015 Anderson, 1970, Ultrastructure of the optic nerve head, Arch. Ophthalmol., 83, 63, 10.1001/archopht.1970.00990030065013 Andries, 1993, Endocardial endothelium in the rat: cell shape and organization of the cytoskeleton, Cell. Tissue Res., 273, 107, 10.1007/BF00304617 Armulik, 2005, Endothelial/pericyte interactions, Circ. Res., 97, 512, 10.1161/01.RES.0000182903.16652.d7 Balaratnasingam, 2009, Heterogeneous distribution of axonal cytoskeleton proteins in the human optic nerve, Invest. Ophthalmol. Vis. Sci., 50, 2824, 10.1167/iovs.08-3206 Balaratnasingam, 2009, Histomorphometric measurements in human and dog optic nerve and an estimation of optic nerve pressure gradients in human, Exp. Eye Res., 89, 618, 10.1016/j.exer.2009.06.002 Bonetti, 2003, Endothelial dysfunction: a marker of atherosclerotic risk, Arterioscler. Thromb. Vasc. Biol., 23, 168, 10.1161/01.ATV.0000051384.43104.FC Brummel-Ziedins, 2005, Thrombin generation profiles in deep venous thrombosis, J. Thromb. Haemost., 3, 2497, 10.1111/j.1538-7836.2005.01584.x Butler, 2001, Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity, Am. J. Physiol. Cell. Physiol., 280, C962, 10.1152/ajpcell.2001.280.4.C962 Califano, 2010, Exogenous and endogenous force regulation of endothelial cell behavior, J. Biomech., 43, 79, 10.1016/j.jbiomech.2009.09.012 Cheung, 2008, Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multiethnic study of atherosclerosis, Invest. Ophthalmol. Vis. Sci., 49, 4297, 10.1167/iovs.08-1826 Chiu, 2011, Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives, Physiol. Rev., 91, 327, 10.1152/physrev.00047.2009 Cornhill, 1980, Quantitative study of the rabbit aortic endothelium using vascular casts, Atherosclerosis, 35, 321, 10.1016/0021-9150(80)90130-6 Danton, 2002, Endothelium-targeted pharmacotherapeutics for the treatment of stroke, Curr. Opin. Investig. Drugs, 3, 896 Davies, 1995, Flow-mediated endothelial mechanotransduction, Physiol. Rev., 75, 519, 10.1152/physrev.1995.75.3.519 Davignon, 2004, Role of endothelial dysfunction in atherosclerosis, Circulation, 109, III27, 10.1161/01.CIR.0000131515.03336.f8 DeMaio, 2004, A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells, Am. J. Physiol. (Heart Circ. Physiol.), 286, H731, 10.1152/ajpheart.00427.2003 Dewey, 1981, The dynamic response of vascular endothelial cells to fluid shear stress, J. Biomech. Eng., 103, 177, 10.1115/1.3138276 Ehringer, 1999, Quantitative image analysis of F-actin in endothelial cells, Microcirculation, 6, 291, 10.1111/j.1549-8719.1999.tb00112.x Goode, 1977, Aortic endothelial cell morphology observed in situ by scanning electron microscopy during atherogenesis in the rabbit, Atherosclerosis, 27, 235, 10.1016/0021-9150(77)90061-2 Gorelick, 2011, Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American stroke association, Stroke, 42, 2672, 10.1161/STR.0b013e3182299496 Gottlieb, 1991, Structure and function of the endothelial cytoskeleton, Lab. Invest., 65, 123 Green, 1981, Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases, Trans. Am. Ophthalmol. Soc., 79, 371 Hadi, 2005, Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome, Vasc. Health Risk Manag., 1, 183 Halim, 1994, Endothelin-1 increased immunoreactive von Willebrand factor in endothelial cells and induced micro thrombosis in rats, Thromb. Res., 76, 71, 10.1016/0049-3848(94)90208-9 Hayreh, 2005, Prevalent misconceptions about acute retinal vascular occlusive disorders, Prog. Retin. Eye Res., 24, 493, 10.1016/j.preteyeres.2004.12.001 Hayreh, 2011, Acute retinal arterial occlusive disorders, Prog. Retin. Eye Res., 30, 359, 10.1016/j.preteyeres.2011.05.001 Hazel, 2000, Vascular endothelial cells minimize the total force on their nuclei, Biophys. J., 78, 47, 10.1016/S0006-3495(00)76571-4 Hazin, 2009, Thrombolytic therapy in central retinal artery occlusion: cutting edge therapy, standard of care therapy, or impractical therapy?, Curr. Opin. Ophthalmol., 20, 210, 10.1097/ICU.0b013e328329b5d5 Hiatt, 2001, Medical treatment of peripheral arterial disease and claudication, N. Engl. J. Med., 344, 1608, 10.1056/NEJM200105243442108 Hsiai, 2002, Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt), Ann. Biomed. Eng., 30, 646, 10.1114/1.1484222 Kang, 2011, Morphometric characteristics of central retinal artery and vein endothelium in the normal human optic nerve head, Invest. Ophthalmol. Vis. Sci., 52, 1359, 10.1167/iovs.10-6366 Kawanabe, 2002, Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant endothelin(A) receptor, Mol. Pharmacol., 61, 277, 10.1124/mol.61.2.277 Kim, 1989, Patterns of endothelial microfilament distribution in the rabbit aorta in situ, Circ. Res., 64, 21, 10.1161/01.RES.64.1.21 Levesque, 1985, The elongation and orientation of cultured endothelial cells in response to shear stress, J. Biomech. Eng., 107, 341, 10.1115/1.3138567 Ludman, 2009, Statins and cardioprotection–more than just lipid lowering?, Pharmacol. Ther., 122, 30, 10.1016/j.pharmthera.2009.01.002 Marrie, 2010, Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis, Neurology, 74, 1041, 10.1212/WNL.0b013e3181d6b125 McAllister, 2012, Central retinal vein occlusion: a review, Clin. Experiment. Ophthalmol., 40, 48, 10.1111/j.1442-9071.2011.02713.x McCue, 2004, Shear-induced reorganization of endothelial cell cytoskeleton and adhesion complexes, Trends Cardiovasc. Med., 14, 143, 10.1016/j.tcm.2004.02.003 Metea, 2006, Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling, J. Neurosci., 26, 2862, 10.1523/JNEUROSCI.4048-05.2006 Millan, 2010, Adherens junctions connect stress fibres between adjacent endothelial cells, BMC. Biol., 8, 11, 10.1186/1741-7007-8-11 Mozaffarian, 2008, Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease, Circulation, 117, 3031, 10.1161/CIRCULATIONAHA.107.738732 Nerem, 1981, Vascular endothelial morphology as an indicator of the pattern of blood flow, J. Biomech. Eng., 103, 172, 10.1115/1.3138275 Noria, 2004, Assembly and reorientation of stress fibers drives morphological changes to endothelial cells exposed to shear stress, Am. J. Pathol., 164, 1211, 10.1016/S0002-9440(10)63209-9 Orgul, 1999, Physiology of perfusion as it relates to the optic nerve head, Surv. Ophthalmol., 43, 17, 10.1016/S0039-6257(99)00009-0 Pearson, 1994, Endothelial cell function and thrombosis, Baillieres Clin. Haematol., 7, 441, 10.1016/S0950-3536(05)80092-7 Pober, 2007, Evolving functions of endothelial cells in inflammation, Nat. Rev. Immunol., 7, 803, 10.1038/nri2171 Pollack, 1989, The fellow eye in retinal vein occlusive disease, Ophthalmology, 96, 842, 10.1016/S0161-6420(89)32801-6 Prasain, 2009, The actin cytoskeleton in endothelial cell phenotypes, Microvasc. Res., 77, 53, 10.1016/j.mvr.2008.09.012 Rehak, 2010, Retinal vein thrombosis: pathogenesis and management, J. Thromb. Haemost., 8, 1886, 10.1111/j.1538-7836.2010.03909.x Rocha, 2010, Oxidative stress and endothelial dysfunction in cardiovascular disease: mitochondria-targeted therapeutics, Curr. Med. Chem., 17, 3827, 10.2174/092986710793205444 Rudkin, 2010, Vascular risk factors for central retinal artery occlusion, Eye (Lond.), 24, 678, 10.1038/eye.2009.142 R Development Core Team, 2011 Schiffrin, 2005, Vascular endothelin in hypertension, Vascul. Pharmacol., 43, 19, 10.1016/j.vph.2005.03.004 Sumagin, 2008, Microvascular endothelial cells exhibit optimal aspect ratio for minimizing flow resistance, Ann. Biomed. Eng., 36, 580, 10.1007/s10439-008-9467-2 Sun, 2009, The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse, J. Comp. Neurol., 516, 1, 10.1002/cne.22058 van Nieuw Amerongen, 2008, Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis, Am. J. Physiol. Cell. Physiol., 294, C1234, 10.1152/ajpcell.00551.2007 Vanhoutte, 2009, Endothelial dysfunction and vascular disease, Acta Physiol. (Oxf), 196, 193, 10.1111/j.1748-1716.2009.01964.x Versari, 2009, Endothelial dysfunction as a target for prevention of cardiovascular disease, Diabetes Care, 32, S314, 10.2337/dc09-S330 Vouret-Craviari, 1998, Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function, Mol. Biol. Cell., 9, 2639, 10.1091/mbc.9.9.2639 Williamson, 1997, Central retinal vein occlusion: what's the story?, Br. J. Ophthalmol., 81, 698, 10.1136/bjo.81.8.698 Wong, 2005, Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the atherosclerosis risk in communities & cardiovascular health studies, Ophthalmology, 112, 540, 10.1016/j.ophtha.2004.10.039 Xue, 2007, Effects of HELP therapy on acute ischemic stroke and vascular endothelial cell function, Ther. Apher. Dial., 11, 171, 10.1111/j.1744-9987.2007.00467.x Yong, 2006, Trends in registered blindness and its causes over 19 years in western Australia, Ophthalmic Epidemiol., 13, 35, 10.1080/09286580500473779 Yu, 1997, Heterogeneous endothelial cell structure along the porcine retinal microvasculature, Exp. Eye Res., 65, 379, 10.1006/exer.1997.0340 Yu, 2010, Microstructure and network organization of the microvasculature in the human macula, Invest. Ophthalmol. Vis. Sci., 51, 6735, 10.1167/iovs.10-5415 Yu, 2010, The structural relationship between the microvasculature, neurons, and glia in the human retina, Invest. Ophthalmol. Vis. Sci., 51, 447, 10.1167/iovs.09-3978 Yu, 2012, Age-related changes in venous endothelial phenotype at human retinal artery-vein crossing points, Invest. Ophthalmol. Vis. Sci., 53, 1108, 10.1167/iovs.11-8865 Yusuf, 2004, Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study, Lancet, 364, 937, 10.1016/S0140-6736(04)17018-9