AlphaB-crystallin and breast cancer: role and possible therapeutic strategies

Cell Stress and Chaperones - Tập 26 Số 1 - Trang 19-28 - 2021
Daniela Caporossi1, Attilio Parisi2, Cristina Fantini1, Elisa Grazioli2, Claudia Cerulli2, Ivan Dimauro1
1Unit of Biology and Genetics of Movement, Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy
2Unit of Sport Medicine, Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy

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Acunzo, 2012, Small heat shock proteins HSP27 (HspB1), alphaB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death, Int J Biochem Cell Biol, 44, 1622, 10.1016/j.biocel.2012.04.002

Adhikari, 2011, AlphaB-crystallin, a small heat shock protein, modulates NF-kappaB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-alpha induced cytotoxicity, Biochim Biophys Acta, 1813, 1532, 10.1016/j.bbamcr.2011.04.009

Antonioni, 2020, αB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: an “in vitro” and “in vivo” study, Free Radic Biol Med, 152, 301, 10.1016/j.freeradbiomed.2020.03.013

Aoyama, 1993, Expression of alpha B-crystallin in human brain tumors, Int J Cancer, 55, 760, 10.1002/ijc.2910550511

Arrigo, 2013, Human small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an update, FEBS Lett, 587, 1959, 10.1016/j.febslet.2013.05.011

Arrigo, 2014, HspB1, HspB5 and HspB4 in human cancers: potent oncogenic role of some of their client proteins, Cancers, 6, 333, 10.3390/cancers6010333

Bagnéris, 2009, Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20, J Mol Biol, 392, 1242, 10.1016/j.jmb.2009.07.069

Bakthisaran, 2015, Small heat shock proteins: role in cellular functions and pathology, Biochim Biophys Acta, 1854, 291, 10.1016/j.bbapap.2014.12.019

Baranova, 2011, Three-dimensional structure of α-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6, J Mol Biol, 411, 110, 10.1016/j.jmb.2011.05.024

Baylot, 2011, OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer, Cell Death Dis, 2, 10.1038/cddis.2011.104

Bellmunt, 2017, Borealis-1: a randomized, first-line, placebo-controlled, phase II study evaluating apatorsen and chemotherapy for patients with advanced urothelial cancer, Ann Oncol, 28, 2481, 10.1093/annonc/mdx400

Benjamin, 2007, CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice, Am J Physiol Heart Circ Physiol, 293, H3201, 10.1152/ajpheart.01363.2006

Bosman, 2010, Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast cancer, Breast Cancer Res Treat, 119, 63, 10.1007/s10549-009-0330-4

Braun, 2011, Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach, Proc Natl Acad Sci U S A, 108, 20491, 10.1073/pnas.1111014108

Calderwood, 2010, Signal transduction pathways leading to heat shock transcription, Sign Transduct Insights, 2, 13

Carey, 2007, The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes, Clin Cancer Res, 13, 2329, 10.1158/1078-0432.CCR-06-1109

Carra, 2017, The growing world of small heat shock proteins: from structure to functions, Cell Stress Chaperones, 22, 601, 10.1007/s12192-017-0787-8

Chalova, 2014, Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1, Cell Stress Chaperones, 19, 963, 10.1007/s12192-014-0520-9

Chatterjee, 2017, Targeting heat shock proteins in cancer: a promising therapeutic approach, Int J Mol Sci, 18, 1978, 10.3390/ijms18091978

Chatterjee, 2016, HSP90 inhibitors in lung cancer: promise still unfulfilled, Clin Adv Hematol Oncol, 14, 346

Chelouche-Lev, 2004, alphaB-crystallin as a marker of lymph node involvement in breast carcinoma, Cancer, 100, 2543, 10.1002/cncr.20304

Chen, 2012, Alpha-crystallins and tumorigenesis, Curr Mol Med, 12, 1164, 10.2174/156652412803306747

Chen, 2014, Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo, Breast Cancer Res Treat, 145, 45, 10.1007/s10549-014-2940-8

Chi, 2017, PACIFIC trial: a randomized phase II study of apatorsen and abiraterone in patients with metastatic castration-resistant prostate cancer who have had PSA progression while receiving abiraterone, J Clin Oncol, 35, 146, 10.1200/JCO.2017.35.6_suppl.146

Choi, 2011, Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance, Int J Radiat Oncol Biol Phys, 79, 1196, 10.1016/j.ijrobp.2010.10.025

Choi, 2019, A nuclear phosphoinositide kinase complex regulates p53, Nat Cell Biol, 21, 462, 10.1038/s41556-019-0297-2

Choueiri, 2014, The Borealis-2 clinical trial: a randomized phase 2 study of OGX-427 (apatorsen) plus docetaxel versus docetaxel alone in relapsed/refractory metastatic urothelial cancer, J Clin Oncol, 32, TP4593A, 10.1200/jco.2014.32.15_suppl.tps4593

Ciocca, 2013, Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update, Arch Toxicol, 87, 19, 10.1007/s00204-012-0918-z

Cortese, 2005, Uncovering the unfoldome: enriching cell extracts for unstructured proteins by acid treatment, J Proteome Res, 4, 1610, 10.1021/pr050119c

de Thonel, 2012, Transcriptional regulation of small HSP-HSF1 and beyond, Int J Biochem Cell Biol, 44, 1593, 10.1016/j.biocel.2012.06.012

Delaye, 1983, Short-range order of crystallin proteins accounts for eye lens transparency, Nature, 302, 415, 10.1038/302415a0

Delbecq, 2013, One size does not fit all: the oligomeric states of αB crystallin, FEBS Lett, 587, 1073, 10.1016/j.febslet.2013.01.021

Delbecq, 2015, A mechanism of subunit recruitment in human small heat shock protein oligomers, Biochemistry, 54, 4276, 10.1021/acs.biochem.5b00490

Diallo-Danebrock, 2007, Protein expression profiling in high-risk breast cancer patients treated with high-dose or conventional dose-dense chemotherapy, Clin Cancer Res, 13, 488, 10.1158/1078-0432.CCR-06-1842

Dimauro, 2018, The role of αB-crystallin in skeletal and cardiac muscle tissues, Cell Stress Chaperones, 23, 491, 10.1007/s12192-017-0866-x

Dimauro, 2019, The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features, Redox Biol, 24, 101183, 10.1016/j.redox.2019.101183

Dubin, 1990, Human alpha B-crystallin gene and preferential promoter function in lens, Genomics., 7, 594, 10.1016/0888-7543(90)90204-8

Fan, 2012, Role of heat shock proteins in stem cell behavior, Prog Mol Biol Transl Sci, 111, 305, 10.1016/B978-0-12-398459-3.00014-9

Fittipaldi, 2015, Alpha B-crystallin induction in skeletal muscle cells under redox imbalance is mediated by a JNK-dependent regulatory mechanism, Free Radic Biol Med, 86, 331, 10.1016/j.freeradbiomed.2015.05.035

Fosu-Mensah, 2019, The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction, Med Chem Res, 28, 182, 10.1007/s00044-018-2275-9

Gleave, 2005, Antisense therapy for cancer, Nat Rev Cancer, 5, 468, 10.1038/nrc1631

Panel members, 2011, Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer, Ann Oncol, 22, 1736, 10.1093/annonc/mdr304

Golenhofen, 1999, Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo, J Mol Cell Cardiol, 31, 569, 10.1006/jmcc.1998.0892

Gopal-Srivastava, 1993, The murine alpha Bcrystallin/small heat-shock protein enhancer: identification of alpha BE-1, alpha BE-2, alpha BE-3, and MRF control elements, Mol Cell Biol, 13, 7144

Gopal-Srivastava, 1995, Regulation of the murine alpha B-crystallin/small heat-shock protein gene in cardiac muscle, Mol Cell Biol, 15, 7081, 10.1128/MCB.15.12.7081

Gupta, 2004, Deamidation affects structural and functional properties of human alphaA-crystallin and its oligomerization with alphaB-crystallin, J Biol Chem, 279, 44258, 10.1074/jbc.M405648200

Haslbeck, 2005, Some like it hot: the structure and function of small heat-shock proteins, Nat Struct Mol Biol, 12, 842, 10.1038/nsmb993

Haslbeck, 2015, Regulation of the chaperone function of small Hsps, 10.1007/978-3-319-16077-1_6

Heinrich, 2011, RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients, J Cancer Res Clin Oncol, 137, 1349, 10.1007/s00432-011-1005-1

Heinrich, 2016, New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells, Oncotarget, 7, 68156, 10.18632/oncotarget.11905

Horwitz, 2000, The function of alpha-crystallin in vision, Sem Cell Dev Biol, 11, 53, 10.1006/scdb.1999.0351

Ischia, 2013, The promise of heat shock protein inhibitors in the treatment of castration resistant prostate cancer, Curr Opin Urol, 23, 194, 10.1097/MOU.0b013e32835e9f1a

Iwaki, 1997, Identification and characterization of the gene encoding a new member of the alpha-crystallin/small HSP family, closely linked to the alphaB-crystallin gene in a head-to-head manner, Genomics, 45, 386, 10.1006/geno.1997.4956

Jehle, 2011, N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity, Proc Natl Acad Sci U S A, 108, 6409, 10.1073/pnas.1014656108

Kampinga, 2012, HSPBs: small proteins with big implications in human disease, Int J Biochem Cell Biol, 44, 1706, 10.1016/j.biocel.2012.06.005

Kamradt, 2001, The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation, J Biol Chem, 276, 16059, 10.1074/jbc.C100107200

Kamradt, 2002, The small heat-shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation, J Biol Chem, 277, 38731, 10.1074/jbc.M201770200

Kappé, 2003, The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10, Cell Stress Chaperones, 8, 53, 10.1379/1466-1268(2003)8<53:THGECS>2.0.CO;2

Kim, 2011, αB-Crystallin is a novel oncoprotein associated with poor prognosis in breast cancer, J Breast Cancer, 14, 14, 10.4048/jbc.2011.14.1.14

Ko, 2017, A randomized, double-blinded, phase II trial of gemcitabine and nab-paclitaxel plus apatorsen or placebo in patients with metastatic pancreatic cancer: the RAINIER trial, Oncologist, 22, 1427, 10.1634/theoncologist.2017-0066

Koh, 2004, Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions, Am J Physiol Cell Physiol, 286, C713, 10.1152/ajpcell.00341.2003

Kriehuber, 2010, Independent evolution of the core domain and its flanking sequences in small heat shock proteins, FASEB J, 24, 3633, 10.1096/fj.10-156992

Lamoureux, 2014, Suppression of heat shock protein 27 using OGX-427 induces endoplasmic reticulum stress and potentiates heat shock protein 90 inhibitors to delay castrate-resistant prostate cancer, Eur Uro, l66, 145, 10.1016/j.eururo.2013.12.019

Launay, 2006, Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton, Exp Cell Res, 312, 3570, 10.1016/j.yexcr.2006.07.025

Lelj-Garolla, 2015, Hsp27 inhibition with OGX-427 sensitizes non-small cell lung cancer cells to erlotinib and chemotherapy, Mol Cancer Ther, 14, 1107, 10.1158/1535-7163.MCT-14-0866

Liu, 2007, Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma, Zhong Nan Da Xue Xue Bao Yi Xue Ban, 32, 660

Liu, 2007, Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide induced apoptosis, Biochem Biophys Res Commun, 354, 109, 10.1016/j.bbrc.2006.12.152

Lu, 2013, The gain of function of p53 cancer mutant in promoting mammary tumorigenesis, Oncogene, 32, 2900, 10.1038/onc.2012.299

Ma, 2019, A novel homozygous initiation codon variant associated with infantile alpha-B crystallinopathy in a Chinese family, Mol Genet Genomic Med, 7, 10.1002/mgg3.825

Magi, 2018, Telomere length is independently associated with age, oxidative biomarkers, and sport training in skeletal muscle of healthy adult males, Free Radic Res, 52, 639, 10.1080/10715762.2018.1459043

Malin, 2015, ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo, Oncogene, 34, 5626, 10.1038/onc.2015.12

Maloyan, 2007, Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy, Proc Natl Acad Sci U S A, 104, 5995, 10.1073/pnas.0609202104

Mao, 2004, Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis, Cell Death Differ, 11, 512, 10.1038/sj.cdd.4401384

Mercatelli, 2010, AlphaB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts, Free Radic Biol Med, 49, 374, 10.1016/j.freeradbiomed.2010.04.027

Milioli, 2017, Basal-like breast cancer: molecular profiles, clinical features and survival outcomes, BMC Med Genet, 10, 19

Mineva, 2005, Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing, Cell Stress Chaperones, 10, 171, 10.1379/CSC-107R.1

Moyano, 2006, AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer, J Clin Invest, 116, 261, 10.1172/JCI25888

Muller, 2014, Mutant p53 in cancer: new functions and therapeutic opportunities, Cancer Cell, 25, 304, 10.1016/j.ccr.2014.01.021

Mymrikov, 2017, The chaperone activity and substrate spectrum of human small heat shock proteins, J Biol Chem, 292, 672, 10.1074/jbc.M116.760413

Neckers, 2012, Hsp90 molecular chaperone inhibitors: are we there yet?, Clin Cancer Res, 18, 64, 10.1158/1078-0432.CCR-11-1000

Ohto-Fujita, 2020, Dynamic localization of αB-crystallin at the microtubule cytoskeleton network in beating heart cells, J Biochem, 168, 125, 10.1093/jb/mvaa025

Oliveira, 2016, αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington’s disease, Hum Mol Genet, 25, 1677, 10.1093/hmg/ddw028

Peschek, 2013, Regulated structural transitions unleash the chaperone activity of αB-crystallin, Proc Natl Acad Sci U S A, 110, E3780, 10.1073/pnas.1308898110

Pinder, 1994, The expression of alpha B-crystallin in epithelial tumours: a useful tumour marker?, J Pathol, 174, 209, 10.1002/path.1711740310

Rajasekaran, 2007, Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice, Cell, 130, 427, 10.1016/j.cell.2007.06.044

Rosenberg, 2018, Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2), Br J Cancer, 118, 1434, 10.1038/s41416-018-0087-9

Rouzier, 2005, Breast cancer molecular subtypes respond differently to preoperative chemotherapy, Clin Cancer Res, 11, 5678, 10.1158/1078-0432.CCR-04-2421

Ruan, 2011, αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells, Mol Cancer Res, 9, 1632, 10.1158/1541-7786.MCR-11-0327

Satish Kumar, 2004, Enhanced degradation and decreased stability of eye lens alphacrystallin upon methylglyoxal modification, Exp Eye Res, 79, 577, 10.1016/j.exer.2004.07.003

Sato, 2000, Modulation of Akt kinase activity by binding to Hsp90, Proc Natl Acad Sci U S A, 97, 10832, 10.1073/pnas.170276797

Seigneuric, 2011, Targeting cancer with peptide aptamers, Oncotarget, 2, 557, 10.18632/oncotarget.297

So, 1997, Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen, Cancer Lett, 112, 127, 10.1016/S0304-3835(96)04557-0

Somu, 2019, HSP90 and its inhibitors for cancer therapy: use of nano-delivery system to improve its clinical application, 10.1007/978-3-030-23158-3_8

Spigel, 2019, A randomized, double-blinded, phase II trial of carboplatin and pemetrexed with or without apatorsen (OGX-427) in patients with previously untreated stage IV non-squamous-non-small-cell lung cancer: the SPRUCE trial, Oncologist, 24, e1409, 10.1634/theoncologist.2018-0518

Su, 2011, Association of Alpha B-Crystallin (CRYAB) genotypes with breast cancer susceptibility in Taiwan, Cancer Genomics Proteomics, 8, 251

Taha, 2019, Roles of extracellular HSPs as biomarkers in immune surveillance and immune evasion, Int J Mol Sci, 20, 4588, 10.3390/ijms20184588

Tang, 2009, Expression and prognostic significance of the alpha B-crystallin gene in human hepatocellular carcinoma, Hum Pathol, 40, 300, 10.1016/j.humpath.2008.09.002

Thornell, 2015, Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis, Cell Mol Life Sci, 72, 4127, 10.1007/s00018-015-1996-x

Tsang, 2012, αB-crystallin is a useful marker for triple negative and basal breast cancers, Histopathology, 61, 378, 10.1111/j.1365-2559.2012.04234.x

van de Schootbrugge, 2013, αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer, Int J Biol Markers, 28, e365, 10.5301/JBM.5000032

van Montfort, 2001, Crystal structure and assembly of a eukaryotic small heat shock protein, Nat Struct Biol, 8, 1025, 10.1038/nsb722

van Rijk, 2000, Alpha-B-crystallin in neuropathology, Ophthalmologica, 214, 7, 10.1159/000027468

Voduc KD, Nielsen TO, Perou CM, Harrell JC, Fan C, Kennecke H, Minn AJ, Cryns VL, Cheang MCU (2015) αB-crystallin expression in breast cancer is associated with brain metastasis. NPJ Breast Cancer. 21;1. pii: 15014. doi: https://doi.org/10.1038/npjbcancer.2015.14

Webster, 2003, Serine phosphorylation and suppression of apoptosis by the small heat shock protein alphaB-crystallin, Circ Res, 92, 130, 10.1161/01.RES.0000056967.51841.21

Westerheide, 2005, Heat shock response modulators as therapeutic tools for diseases of protein conformation, J Biol Chem, 280, 33097, 10.1074/jbc.R500010200

Wójtowicz, 2015, Drosophila small heat shock protein CryAB ensures structural integrity of developing muscles, and proper muscle and heart performance, Development, 142, 994, 10.1242/dev.115352

Won, 2011, Nano self-assembly of recombinant human gelatin conjugated with α-tocopheryl succinate for Hsp90 inhibitor, 17-AAG, delivery, ACS Nano, 5, 3839, 10.1021/nn200173u

Xia, 2012, Targeting heat shock response pathways to treat pancreatic cancer, Drug Discov Today, 17, 35, 10.1016/j.drudis.2011.09.016

Zhang, 2012, The differences in CXCR4 protein expression are significant for the five molecular subtypes of breast cancer, Ultrastruct Pathol, 36, 381, 10.3109/01913123.2012.728687

Zhang, 2019, Progression of the role of CRYAB in signaling pathways and cancers, Onco Targets Ther, 12, 4129, 10.2147/OTT.S201799

Zoppino, 2018, Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer, BMC Cancer, 18, 700, 10.1186/s12885-018-4621-1