Alpha-1-Antitrypsin Deficiency
Tài liệu tham khảo
Abrams, 1981, A model of decreased functional alpha-1-antiproteinase inhibitor: Pulmonary pathology of dogs exposed to chloramine-T, J. Clin. Invest., 68, 1132, 10.1172/JCI110357
Abrams, 1980, The effects of the oxidizing agent chloramine-T and cigarette smoke on dog serum proteinase inhibitors, Exp. Lung Res., 1, 211, 10.3109/01902148009065461
Altay, 1973, Additional evidence for a deleted gene for serum A-1-antitrypsin, N. Engl. J. Med., 289, 754, 10.1056/NEJM197310042891424
Arnaud, 1978, Genetric polymorphism of serum alpha-1-protease inhibitor (alpha-1-antitrypsin): PiI, a deficient allele of the Pi system, J. Lab. Clin. Med., 92, 177
Ascoli, 1903, Das Verhalten des antitryptischen Vermogens dens Beautserums bei der Croupsosen, Pneumonie. Berl. Klin. Wochenschr., 40, 391
Aubry, 1977, Kinetics of the inactivation of human and bovine trypsins and chymotrypsins by alpha-1-proteinase inhibitor and of their reactivation by alpha-2-macroglobulin, Clin. Chim. Acta, 78, 371, 10.1016/0009-8981(77)90070-5
Barnett, 1975, Protease inhibitors in chronic obstructive pulmonary disease, Am. Rev. Respir. Dis., 111, 587
Barrett, 1973, The interaction of A-2-macroglobulin with proteinases, Biochem. J., 133, 709, 10.1042/bj1330709
Beatty, 1980, Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin, J. Biol. Chem., 255, 3931, 10.1016/S0021-9258(19)85615-6
Berg, 1972, Liver disease in adult with alpha-1-antitrypsin deficiency, N. Engl. J. Med., 287, 1264, 10.1056/NEJM197212212872502
Bierman, 1955, The hematologic role of the lung in man, Am. J. Surg., 89, 139, 10.1016/0002-9610(55)90515-8
Bierman, 1955, The sequestration and visceral circulation of leukocytes in man, Ann. N.Y. Acad. Sci., 59, 850, 10.1111/j.1749-6632.1955.tb45987.x
Bierman, 1951, The release of leukocytes and platelets from the pulmonary circulation by epinephrine, Blood, 7, 683, 10.1182/blood.V7.7.683.683
Black, 1972, Mechanism of expiratory airflow limitations in chronic obstructive pulmonary disease associated with A-1-antitrypsin deficiency, Q. J. Med., 41, 301
Black, 1978, Alpha-1-antitrypsin deficiency in nonsmokers, Am. Rev. Respir. Dis., 117, 421
Blackwood, 1973, Experimental emphysema in rats elastolytic titer of inducing enzyme as determinant of response, Proc. Soc. Exp. Biol. Med., 144, 450, 10.3181/00379727-144-37610
Blundell, 1974, Alpha-1-antitrypsin null gene (Pi-), Lancet, 2, 404, 10.1016/S0140-6736(74)91782-6
Bruce, R.: Personal communication, 1983.
Buist, 1983, The natural history of air-flow obstruction in PiZ emphysema, Am. Rev. Respir. Dis., 127, S43
Buist, A. S., Allen, R. C., Black, L. F., et al.: The natural history of PiZ emphysema: A report of a Workshop on the Natural History of PiZ Emphysema. Am. Rev. Respir. Dis., in press.
Buist, 1979, Pulmonary function in heterozygotes for alhpa-1-antitrvpsin deficiency: A case-control study, Am. Rev. Respir. Dis., 120, 759
Burrows, 1983, A clinical trial of antiproteolytic therapy: Can it be done?, Am. Rev. Respir. Dis. [Suppl.], 127, S42
Burrows, 1969, Course and prognosis of chronic obstructive lung disease, N. Engl. J. Med., 280, 397, 10.1056/NEJM196902202800801
Busch, 1974, Das Verhalten des A-1-antitrypsin bei Verbrennungen und Verbruhungen, Kinderaertzl. Prax., 42, 352
Carrell, 1981, Human alpha-1-antitrypsin: Carbohydrate attachment and sequence homology, F.E.B.S. Lett., 135, 301, 10.1016/0014-5793(81)80805-8
Carlson, 1981, Intra- and extracellular alpha-1-antitrypsin in liver disease with special reference to Pi phenotype, J. Clin. Pathol., 34, 1020, 10.1136/jcp.34.9.1020
Carp, 1982, Potential mechanism of emphysema: Alpha-1-proteinase inhibitor recovered from lungs of cigarette smokers contain oxidized methionine and has decreased elastase inhibitory capacity, Proc. Natl. Acad. Sci. (U.S.A.), 779, 2041, 10.1073/pnas.79.6.2041
Chan, 1973, Purification and chemical composition of human a-1-antitrypsin of the MM type, F.E.B.S. Lett., 35, 79, 10.1016/0014-5793(73)80581-2
Chan, 1975, Molecular basis for the A-1-protease inhibitor, Nature, 255, 240, 10.1038/255240a0
Chan, 1976, Linear structure of oligosaccharide chains in A-1-protease inhibitor isolated from human plasma, J. Biol. Chem., 251, 471, 10.1016/S0021-9258(17)33903-0
Cohen, 1975, The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin, and elastase, Biochim. Biophys. Acta, 391, 193, 10.1016/0005-2744(75)90166-7
Cohen, 1973, Interrelationships between human alveolar macrophages and alpha-1-antitrypsin, J. Clin. Invest., 52, 2793, 10.1172/JCI107475
Cohen, 1979, Opportunities for the development of specific therapeutic agents to treat emphysema, Am. Rev. Respir. Dis., 120, 723
Cohen, A. B.: The effects in vivo and in vitro of oxidative damage to purified alpha-1-antitrypsin and to the enzyme-inhibiting activity of plasma. Am. Rev. Respir. Dis., 119:953, 1979. 33a. Cohen, A. B., et al.: Unpublished data, 1979.
Cohen, 1979, The size of the pool of alveolar neutrophils in normal rabbit lungs, J. Appl. Physiol., 47, 440, 10.1152/jappl.1979.47.2.440
Cohen, A. B., Chenoweth, D. E., and Hugli, T. E.: The release of elastase, myeloperoxidase and lysozyme from human neutrophils by an acid stable factor derived from human alveolar macrophages. Am. Rev. Respir. Dis., in press.
Cohen, 1982, Pathogenesis of emphysema
Cohen, 1983, Neutrophils in normal lungs, Am. Rev. Respir. Dis. [Suppl.], 127, S3
Cohen, 1973, Alpha-1-antitrypsin deficiency, emphysema and cirrhosis in an adult, Ann. Intern. Med., 78, 227, 10.7326/0003-4819-78-2-227
Cox, 1976, A new deficiency allele of A-1-antitrypsin: PiM Malton B Protides, Biol. Fluids, 23, 375
Cox, 1976, Protease inhibitors in patients with chronic obstructive pulmonary disease: The alpha-1-antitrypsin heterozygote controversy, Am. Rev. Respir. Dis., 113, 601
Cox, 1976, Rheumatoid arthritis and alpha-1-antitrypsin, Lancet, 1, 1216
Crawford, 1973, Purification and properties of normal A-1-antitrypsin, Arch. Biochem. Biophys., 156, 215, 10.1016/0003-9861(73)90359-7
Damiano, 1983, Electron microscopic localization of elastase and elastin in the human emphysematous lung, [Abstract]. Am. Rev. Respir. Dis., 127, 288
Dunnand, 1976, Severe obstructive lung disease in a 14 year old girl with alpha-1-antitrypsin deficiency, J. Allergy Clin. Immunol., 57, 615, 10.1016/0091-6749(76)90014-2
El-Bardeesy, 1972, Serum proteinase inhibitors in infants with hyaline membrane disease, J. Pediatr., 81, 579, 10.1016/S0022-3476(72)80196-3
Elson, L. A., Betts, T. E., and Darcy, D. A.: A-1-Antitrypsin in cigarette smokers. In Davis, W., and Maltoni, C. (eds.): Proceedings of the Fifth International Symposium on the Biological Characterization of Human Tumors. Excerpta Medica Amsterdam International Congress Series No. 321, 1973.
Eriksson, 1965, Studies in A-1-antitrypsin deficiency, Acta Med. Scand. [Suppl.], 177, 175
Eriksson, 1964, Pulmonary emphysema and antitrypsin deficiency, Acta Med. Scand., 175, 197, 10.1111/j.0954-6820.1964.tb00567.x
Eriksson, 1974, Cirrhosis and malignant hepatoma in A-1-antitrypsin deficiency, Acta Med. Scand., 195, 451, 10.1111/j.0954-6820.1974.tb08170.x
Erlanger, 1961, The preparation and properties of two new chromogenic substrates of trypsin, Arch. Biochem. Biophys., 95, 271, 10.1016/0003-9861(61)90145-X
Evans, 1970, Serum enzyme inhibitor concentration in the respiratory distress syndrome, Am. Rev. Respir. Dis., 101, 359
Evans, 1972, Serum type inhibitory capacity and the idiopathic respiratory distress syndrome, J. Pediatr., 81, 588, 10.1016/S0022-3476(72)80197-5
Fagerhol, 1967, Serum Pi types in Norwegians, Acta Pathol. Microbiol. Scand., 70, 421, 10.1111/j.1699-0463.1967.tb01310.x
Fagerhol, 1969, Quantitative studies on the inherited variants of serum A-1-antitrypsin, Scand. J. Clin. Lab. Invest., 23, 97, 10.3109/00365516909078092
Fagerhol, 1972, Acid starch gel electrophoresis for detection of alpha-1-antitrypsin variants (Pi types): Outline of techniques employed currently
Fagerhol, 1969, Serum Pi types in some Lappish and Finnish populations, Hum. Hered., 19, 360, 10.1159/000152239
Fagerhol, 1969, Genetics of the Pi serum types: Family studies of the inherited variants of serum alpha-1-antitrypsin, Hum. Hered., 19, 354, 10.1159/000152238
Fagerhol, 1967, The polymorphism of “prealbumins” and alpha-1-antitrypsin in human sera, Clin. Chim. Acta, 16, 199, 10.1016/0009-8981(67)90181-7
Fagerhol, 1970, The Pi system inherited variants of serum A-1-antitrypsin, Progr. Med. Genet., 7, 96
Fagerhol, 1968, Serum Pi types in some European, American, Asian and African populations, Acta Pathol. Microbiol. Scand., 72, 601, 10.1111/j.1699-0463.1968.tb00472.x
Fallat, 1973, 133Xe ventilatory studies in A-1 antitrypsin deficiency, J. Nucl. Med., 14, 5
Fertakis, 1974, Pi phenotypes in Greeks, Hum. Hered., 24, 313, 10.1159/000152667
Fisher, 1974, Alpha-1-antitrypsin deficiency in liver disease: The extent of the problem [Abstract], Gastroenterology, 67, 792
Fritz, 1972, Antitrypsin and C1-Inactivator, Progresswinhibitoren fur Serumkallikreine von Mensch und Schwein Hoppe-Seylers. Z. Physiol. Chem., 353, 906, 10.1515/bchm2.1972.353.1.906
Gadek, E., and Crystal, R. G.: Experience with replacement therapy in the destructive lung diseaseassociated with severe A-1-antitrypsin deficiency. Am. Rev. Respir. Dis. [Suppl.], in press.
Gadek, 1979, Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans, Science, 206, 1315, 10.1126/science.316188
Gadek, 1980, Danazol-induced augmentation of serum alpha-1-antitrypsin levels in individuals with marked deficiency of this antiprotease, J. Clin. Invest., 66, 82, 10.1172/JCI109838
Gadek, 1980, Replacement therapy in hereditary angioedema with partially purified C1 inhibitor, N. Engl. J. Med., 302, 542, 10.1056/NEJM198003063021002
Gadek, 1981, Replacement therapy of alpha-1-antitrypsin deficiency, J. Clin. Invest., 68, 1158, 10.1172/JCI110360
Galdston, 1977, Interrelations of neutrophil elastase, serum trypsin inhibitory activity and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ and ZZ phenotypes for alpha-1-antitrypsin, Am. Rev. Respir. Dis., 116, 837
Ganrot, 1967, A-1-Antitrypsin and A-2-macroglobulin concentration during pregnancy, Acta Obstet. Gynecol. Scand., 46, 126, 10.3109/00016346709158192
Ganrot, 1967, Obstructive lung disease and trypsin inhibitors in A-1-antitrypsin deficiency, Scand. J. Clin. Lab. Invest., 19, 205, 10.3109/00365516709090627
Gedde-Dahl, 1972, Autosomal linkage between the GM and Pi loci in man, Ann. Human Genet., 35, 393
Gee, 1976, Oxygen metabolism in the alveolar macrophage: Friend and foe, J. Reticuloendothel. Soc., 19, 229
Gee, 1970, Catalase dependent peroxidative metabolism in the alveolar macrophage during phagocytosis, J. Clin. Invest., 49, 1280, 10.1172/JCI106340
Gelb, 1977, Pulmonary function in nonsmoking subjects with alpha-1-antitrypsin deficiency (MZ phenotype), Am. J. Med., 62, 93, 10.1016/0002-9343(77)90354-0
Gherardi, 1971, Alpha-1-antitrypsin deficiency and its effect on the liver, Hum. Pathol., 2, 173, 10.1016/S0046-8177(71)80026-6
Gishen, 1982, Alpha-1-antitrypsin deficiency: The radiologic features of pulmonary emphysema in subjects of Pi type Z and Pi Type SZ: A survey by the British Thoracic Association, Clin. Radiol., 33, 371, 10.1016/S0009-9260(82)80297-3
Glaser, G.: Can A-1-protease inhibitor be used in replacement therapy? Am. Rev. Respir. Dis. [Suppl.], in press.
Goedde, 1970, Gene frequencies of red cell adenosine deaminase, adenylfate kinase phosphoglutamase, acid phosphatase and serum A-1-antitrypsin (Pi) in a German population, Humangenetik, 10, 235
Gordon, 1972, Alpha-1-antitrypsin (A-1-AT) accumulation in livers of emphysematous patients with A-1 AT deficiency, Hum. Pathol., 3, 361, 10.1016/S0046-8177(72)80037-6
Gross, 1965, Experimental emphysema, its production with papain in normal and silicotic rats, Arch, Environ. Health, 11, 50, 10.1080/00039896.1965.10664169
Hall, 1976, Pulmonary abnormalities in intermediate alpha-1-antitrypsin deficiency, J. Clin. Invest., 58, 1069, 10.1172/JCI108558
Harada, 1970, Electrophoretic variants of human serum alpha-1-antitrypsin in Japan, J. Anthropol. Soc. Nippon, 78, 22, 10.1537/ase1911.78.22
Harris, 1974, Elevated A-1-antitrypsin serum levels in lung cancer patients, Cancer, 34, 280, 10.1002/1097-0142(197408)34:2<280::AID-CNCR2820340210>3.0.CO;2-4
Harris, 1969, Collagenase in human synovial fluid, J. Clin. Invest., 48, 2104, 10.1172/JCI106177
Hepper, 1978, Roentgenographic study of chronic obstructive pulmonary disease by alpha-1-antitrypsin phenotype, Mayo Clin. Proc, 53, 166
Hinman, 1980, Elastase and lysozyme activity in human alveolar macrophages, Am. Rev. Respir. Dis., 121, 263
Hiti-Harper, 1978, Inhibition of neutrophil collagenase by platelet factor 4, Science, 199, 991, 10.1126/science.203038
Hodges, 1981, Heterozygous MZ alpha-1-antitrypsin deficiency in adults with chronic active hepatitis and cryptogenic cirrhosis, N. Engl. J. Med., 304, 357, 10.1056/NEJM198103053041001
Homer, 1963, A spectrophotometric method for measuring serum trypsin inhibitor capacity, Clin. Chem., 9, 428, 10.1093/clinchem/9.4.428
Horng, 1975, The reaction of human plasma A-1-antitrypsin with cyanogen bromide, Int. J. Biochem., 6, 555, 10.1016/0020-711X(75)90072-5
Hunninghake, 1979, Inflammatory and immune processes in the human lung in health and disease: Evaluation by bronchoalveolar lavage, Am. J. Pathol., 97, 149
Hyde, 1979, Protease inhibitor variants in children and young adults with chronic asthma, Ann. Allergy, 43, 8
Ishak, 1972, Cirrhosis of the liver associated with A-1-antitrypsin deficiency, Arch. Pathol., 94, 445
James, 1978, Mechanism of inhibition of porcine elastase by human alpha-1-antitrypsin, J. Clin. Invest., 62, 1344, 10.1172/JCI109255
Janeway, 1966, The gamma globulins, IV. Therapeutic uses of gamma globulin. N. Engl. J. Med., 275, 826
Janoff, A., Carp, H., Laurent, P., et al.: The role of oxidative processes in emphysema. Am. Rev. Respir. Dis. [Suppl.], in press.
Janoff, 1979, Cigarette smoke inhalation decreases alpha-1-antitrypsin activity in rat lung, Science, 206, 1313, 10.1126/science.316187
Janoff, 1977, Experimental emphysema induced with purified human neutrophil elastase, tissue localization of the instilled protease, Am. Rev. Respir. Dis., 115, 461
Janus, 1975, Alpha-1-antitrypsin variants in New Zealand, N. Z. Med. J., 82, 289
Jeppsson, 1975, Characterization of A-1-antitrypsin in the inclusion bodies from the liver in A-1-antitrypsin deficiency, N. Engl. J. Med., 293, 576, 10.1056/NEJM197509182931203
Johnson, 1969, Preparation of and clinical experience with antihemophilic factor concentrates, Thromb. Diath. Haemorrh., 35, 49
Johnson, 1976, Genetic typing of A-1-antitrypsin by immunofixation electrophoresis: Identification of subtypes of PiM, J. Lab. Clin. Med., 87, 152
Johnson, 1976, Human alpha-1-proteinase inhibitor mechanisms of action: Evidence for activation by limited proteolysis, Biochem. Biophys. Res. Commun., 72, 33, 10.1016/0006-291X(76)90956-6
Johnson, 1978, Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor, J. Biol. Chem., 253, 71427144, 10.1016/S0021-9258(17)34475-7
Johnson, 1978, Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor, J. Biol. Chem., 253, 71427144, 10.1016/S0021-9258(17)34475-7
Johnson, 1979, The oxidative inactivation of human alpha-1-proteinase inhibitor: Further evidence for methionine at the reactive center, J. Biol. Chem., 254, 4022, 10.1016/S0021-9258(18)50689-X
Kanner, 1973, Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha-1-antitrypsin, Am. J. Med., 54, 706, 10.1016/0002-9343(73)90056-9
Karsh, 1979, Alpha-1-antitrypsin phenotypes in rheumatoid arthritis and systemic lupus erythematosus, Arthritis Rheum., 22, 111, 10.1002/art.1780220202
Katz, 1976, Alpha-1-antitrypsin levels and prevalence of pi variant phenotypes in asthmatic children, J. Allergy Clin. Immunol., 57, 41, 10.1016/0091-6749(76)90077-4
Kellermann, 1970, Investigation on the population genetics of A-1-antitrypsin polymorphism, Humangenetik, 10, 145
Klayton, 1975, Determinants of chronic obstructive pulmonary disease in patients with intermediate levels of alpha-1-antitrypsin, Am. Rev. Respir. Dis., 112, 71
Kramps, 1980, A matched pair study of the leukocyte elastase-like activity in normal persons and unemphysema four patients with and without alpha-1-antitrypsin deficiency, Am. Rev. Respir. Dis., 121, 253
Kress, 1973, Large scale purification of A-1-antitrypsin inhibitor from human plasma, Prep. Biochem., 3, 541
. Kueppers, F.: Personal communication, 1983.
Kueppers, 1967, Immunologic assay of alpha-1-antitrypsin in deficient subjects and their families, Humangenetik, 5, 54
Kueppers, 1968, Genetically determined differences in the response of alpha-1-antitrypsin levels in human serum to typhoid vaccine, Humangenetik, 6, 207
Kueppers, 1968, Serum alpha-1-antitrypsin levels, N. Engl. J. Med., 279, 164, 10.1056/NEJM196807182790320
Kueppers, 1969, Identification of the heterozygous state for the A-1-antitrypsin deficiency gene in man, Biochem. Genet., 3, 283, 10.1007/BF00521143
Kueppers, 1971, Alpha-1-antitrypsin: Physiology genetics and pathology, Humangenetik, 11, 177
Kueppers, 1978, Inherited differences in alpha-a-antitrypsin
Kueppers, 1966, A possible experimental approach to the association of hereditary A-1-antitrypsin deficiency and pulmonary emphysema, Proc. Soc. Exp. Biol. Med., 121, 1207, 10.3181/00379727-121-31006
Kueppers, 1974, Alpha-1-antitrypsin and its deficiency, Am. Rev. Respir. Dis., 110, 176
Kueppers, 1964, Hereditary deficiency of A-1-antitrypsin, Science, 146, 1678, 10.1126/science.146.3652.1678
Kueppers, 1976, Alpha-1-antitrypsin phenotypes in chronic liver disease and primary biliary cirrhosis, Mayo Clin. Proc., 51, 286
Kueppers, 1974, Obstructive lung disease in heterozygotes for alpha-1-antitrypsin deficiency, Ann. Intern. Med., 80, 209, 10.7326/0003-4819-80-2-209
Kurachi, 1981, Cloning and sequence of cDNA coding for alpha-1-antitrypsin, Proc. Natl. Acad. Sci. U.S.A., 78, 6826, 10.1073/pnas.78.11.6826
Lam, 1979, Neutrophil elastase and pulmonary function in subjects with intermediate alpha-1-antitrypsin deficiency, Am. Rev. Respir. Dis., 119, 941
Larsson, 1978, Natural history and life expectancy in severe alpha-1-antitrypsin deficiency, PiZ. Acta Med. Scand., 204, 345, 10.1111/j.0954-6820.1978.tb08452.x
Larsson, 1976, Lung function studies in asymptomatic individuals with moderately (PiSZ) and severely (PiZ) reducted levels of alpha-1-antitrypsin, Scand. J. Respir. Dis., 57, 267
Larsson, 1977, Smoking and intermediate alpha-1-antitrypsin deficiency and lung function in middle aged men, Br. Med. J., 2, 922, 10.1136/bmj.2.6092.922
Latimer, 1980, Alpha-1-antitrypsin deficiency in childhood, Curr. Probl. Pediatr., 11, 1, 10.1016/S0045-9380(80)80006-5
Laurell, 1965, Electrophoretic microheterogeneity of serum A-1-antitrypsin, Scand. J. Clin. Lab. Invest., 17, 271, 10.1080/00365516509075347
Laurell, 1965, Antigen antibody crossed electrophoresis, Anal. Biochem., 10, 358, 10.1016/0003-2697(65)90278-2
Laurell, 1963, The electrophoretic A-1-globulin pattern of serum in A-1-antitrypsin deficiency, Scand. J. Clin. Lab. Invest., 15, 131, 10.1080/00365516309051324
Laurell, 1975, Protease inhibitors in plasma
Laurell, 1973, Analysis of plasma A-1-antitrypsin variants and their microheterogeneity, Biochem. Biophys. Acta, 310, 500
Laurell, 1975, Purification of A-1-antitrypsin from plasma through thioldisulfide interchange, Eur. J. Biochem., 57, 107, 10.1111/j.1432-1033.1975.tb02281.x
Laurell, 1974, A-1-antitrypsin deficiency Pi genotype ZO, SO, MO, Acta Paediatr. Scand., 63, 855, 10.1111/j.1651-2227.1974.tb04876.x
Laurent, 1982, In vitro-synthesis of desmosine cross-links is suppressed by extracts of cigarette smoke [Abstract], Fed. Proc., 41, 450
Lieberman, 1972, Identification and characteristics of the common A-1-antitrypsin phenotypes, Chest, 62, 557, 10.1378/chest.62.5.557
Lieberman, 1976, A new deficient variant of A-1-antitrypsin (M, Duarte). Am. Rev. Respir. Dis., 113, 31
Lieberman, 1976, Intermediate A-1-antitrypsin deficiency resulting from a null gene (M-phenotype), Chest, 70, 532, 10.1378/chest.70.4.532
Lieberman, 1972, Alpha-1-antitrypsin in the livers of patients with emphysema, Science, 175, 63, 10.1126/science.175.4017.63
Lieberman, 1975, Hepatocellular carcinoma and intermediate A-1-antitrypsin deficiency (MZ Phenotype), Am. J. Clin. Pathol., 64, 304, 10.1093/ajcp/64.3.304
Lonky, 1980, Protease and antiprotease response in lung and peripheral blood experimental canine pneumococcal pneumonia, Am. Rev. Respir. Dis., 121, 685
Lonky, 1983, Neutrophils and their enzymes in the lung, Am. Rev. Respir. Dis. [Suppl.], 127, S9
Lonky, 1981, Stimulation of human leukocyte elastase by platelet factor 4: Physiologic, morphologic and biochemical effects on hamster lungs in vitro, J. Clin. Invest., 67, 817, 10.1172/JCI110099
Mancini, 1965, Immunochemical quantitation of antigens by single radial immunodiffusion, Immunochemistry, 2, 235, 10.1016/0019-2791(65)90004-2
Martin, 1975, Further examples confirming the existence of Pi null (Pi-), Pathol. Biol., 23, 521
Martin, 1975, Le deficit on alpha-1-antitrypsine et d’allele Pi nul, Rev. Fr. Transfus., 18, 27
Martin, 1970, Genetic variants of serum A-1-antitrypsin (Pi types) in Portuguese, Hum. Hered., 26, 310, 10.1159/000152819
Martin, 1973, Alpha-1-antitrypsin deficiency, PiO., Lancet, 2, 845, 10.1016/S0140-6736(73)90885-4
Martodam, 1981, The interaction of alpha-1-antitrypsin with trypsin, chymotrypsin and human leukocyte elastase as revealed by end group analysis, Biochim. Biophys. Acta, 667, 328, 10.1016/0005-2795(81)90199-9
Matheson, 1980, Enzymatic inactivation of human alpha-1-antiproteinase inhibitory neutrophil myeloperoxidase, Biochem. Biophys. Res. Commun., 88, 402, 10.1016/0006-291X(79)92062-X
Mathis, 1973, Alpha-1-antitrypsin in the respiratory distress syndrome, N. Engl. J. Med., 288, 59, 10.1056/NEJM197301112880201
McDonagh, 1979, Assessment of alpha-1-antitrypsin deficiency heterozygosity as a risk factor in the etiology of emphysema, J. Clin. Invest., 63, 299, 10.1172/JCI109303
McGuire, 1982, Studies on the pathogenesis of the adult respiratory distress syndrome, J. Clin. Invest., 69, 543, 10.1172/JCI110480
Meyer, 1975, On the inhibition of elastase by serum: Some distinguishing properties of alpha-1-antitrypsin and alpha-2-macroglobulin, Clin. Chim. Acta, 62, 43, 10.1016/0009-8981(75)90278-8
Mittman, 1978, The PiMZ phenotype: Is it a significant risk factor for the development of chronic obstructive lung disease [Editorial], Am, Rev. Respir. Dis., 118, 649, 10.1164/arrd.1978.118.4.649
Mittman, 1972, Pulmonary disease in intermediate alpha-1-antitrypsin deficiency
Morin, 1975, Heterozygous A-1-antitrypsin deficiency and cirrhosis in adults, Lancet, 1, 250, 10.1016/S0140-6736(75)91143-5
Moroi, 1974, Mechanism of interaction of bovine trypsin with human alpha-1-antitrypsin, Biochim. Biophys. Acta, 359, 130, 10.1016/0005-2795(74)90138-X
Moroz, 1976, Membranoproliferatus glomerulonephritis in childhood cirrhosis associated with A-1-antitrypsin deficiency, Pediatrics, 57, 232
Moroz, 1976, Liver disease associated with A-1-antitrypsin deficiency in childhood, J. Pediatr., 88, 19, 10.1016/S0022-3476(76)80720-2
Morris, 1971, Spirometric standards for healthy nonsmoking adults, Am. Rev. Respir. Dis., 103, 57
Morse, 1981, A community study of the relation of alpha-1-antitrypsin levels to obstructive lung diseases, N. Engl. J. Med., 292, 278, 10.1056/NEJM197502062920602
Novis, 1975, Chronic pancreatitis and alpha-1-antitrypsin, Lancet, 2, 748, 10.1016/S0140-6736(75)90728-X
Ohlsson, 1971, Neutral leukocyte proteases and elastase inhibited by plasma alpha-1-antitrypsin, Scand. J. Clin. Lab. Invest., 28, 251, 10.3109/00365517109095696
Ohlsson, 1973, The neutral proteases of human granulocytes: Isolation and partial characterization of two granulocyte collagenases, Eur. J. Biochem., 36, 473, 10.1111/j.1432-1033.1973.tb02932.x
Olsen, 1975, Alpha-1-antitrypsin content in the serum alveolar macrophages and alveolar lavage fluid of smoking and nonsmoking normal subjects, J. Clin. Invest., 55, 427, 10.1172/JCI107947
Osman, 1982, Tobacco smoke exposure retards elastin repair in experimental emphysema [Abstract], Am. Rev. Respir. Dis., [Suppl.] Part 2, 125, 213
Pannell, 1974, Isolation and properties of human plasma A-1-proteinase inhibitors, Biochemistry, 13, 5439, 10.1021/bi00723a031
Pierce, 1975, Antitrypsin phenotypes in St, Louis. J.A.M.A., 231, 609, 10.1001/jama.1975.03240180045014
Powers, J. C.: Synthetic elastase inhibitors: Prospects for use in the treatment of emphysema. Am. Rev. Respir. Dis. [Suppl.], in press.
Powers, 1977, Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G: Inhibition with peptide chlorimethyl ketones, Biochim. Biophys. Acta, 485, 156, 10.1016/0005-2744(77)90203-0
Rimon, 1966, The plasmin inhibitor of human plasma, IV. Its action on plasmin, trypsin, chymotrypsin, and thrombin. J. Biol. Chem., 241, 5102
Rodriguez, 1979, Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease, Am. Rev. Respir. Dis., 119, 409
Rodriguez, 1977, Elastase release from human alveolar macrophages comparison between smokers and nonsmokers, Science, 198, 313, 10.1126/science.910131
Rucinski, 1979, Antiheparin proteins secreted by human platelets: Purification, characterization and radioimmunoassay, Blood, 53, 47, 10.1182/blood.V53.1.47.47
Satch, 1979, The dual nature of the reacton between porcine elastase and human alpha-1-proteinase inhibitor, Biochem. Biophys. Res. Comm., 86, 130, 10.1016/0006-291X(79)90391-7
Schultze, 1962, Alpha-1-antitrypsin aus humanserum, Klin. Wochenschr., 40, 427, 10.1007/BF01732842
Schwick, 1966, Antiproteinasen des Hummanserume Z, Gesamte. Inn. Med., 21, 193
Sharp, 1971, Alpha-1-antitrypsin deficiency, Hosp. Pract., 6, 83, 10.1080/21548331.1971.11706032
Sharp, 1969, Cirrhosis associated with alpha-1-antitrypsin deficiency: A previously unrecognized inherited disorder, J. Lab. Clin. Med., 73, 934
Shigeoka, 1983, The prevalence of alpha-1-antitrypsin heterzygotes (PiMZ) in patients with obstructive pulmonary disease, Am. Rev. Resp. Dis., 114:1077, 1976. 186a. Snider, G. L.: Prospects for chemical treatment of emphysema. Am. Rev. Respir. Dis. [Suppl.], 127, S39
Stone, P., Calore, W. J., McGowen, S., et al.: Failure to detect decreased levels of functional alpha-1-protease inhibitor in the lower respiratory tract of smokers [Abstract], In Proceedings of the Twentyfifth Aspen Lung Conference.
Sveger, 1976, Liver disease in alpha-1-antitrypsin deficiency detected by screening of 200,000 infants, N. Engl. J. Med., 294, 1316, 10.1056/NEJM197606102942404
Talamo, 1966, Familial emphysema and alpha-1-antitrypsin deficiency, N. Engl. J. Med., 275, 1301, 10.1056/NEJM196612082752308
Talamo, 1973, A-1-antitrypsin deficiency: A variant with no detectable A-1-antitrypsin, Science, 181, 70, 10.1126/science.181.4094.70
Tattersall, 1979, Lung distensibility and airway function in intermediate alpha-1-antitrypsin deficiency (PiMZ), Thorax, 34, 637, 10.1136/thx.34.5.637
Tokoro, 1972, Characterization of a collagenase from rat skin, Biochim. Biophys. Acta, 258, 289, 10.1016/0005-2744(72)90986-2
Triger, 1976, Alpha-1-antitrypsin deficiency and liver disease in adults, Q. J. Med., 178, 351
Tuhy, 1975, Inhibition of human leukocyte elastase by peptide chlormethyl ketones, F.E.B.S. Lett., 5, 359, 10.1016/0014-5793(75)80527-8
Tuttle, 1975, Fluorescent antibody studies of alpha-1-antitrypsin in adult human lung, Am. J. Clin. Pathol., 64, 477, 10.1093/ajcp/64.4.477
Vandeville, 1974, A-1-Antitrypsin polymorphism of a Bantu population: Description of a new allele PiL, Humangenetik, 21, 33
Webb, 1973, Serum A-1-antitrypsin variants: Prevalence and clinical spirometry, Am. Rev. Respir. Dis., 108, 918
Werner, 1975, Alterations in lung function in children with chronic asthma and Pi variants [Abstract], J. Allergy Clin. Immunol., 55, 128
. Wu, M.: Unpublished data, 1983.
Yoshida, 1976, Molecular abnormality of human alpha-1-antitrypsin variant (PiZ) associated with plasma activity deficiency, Proc. Natl. Acad. Sci. U.S.A., 73, 1324, 10.1073/pnas.73.4.1324