Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish

Agarwal, 2000, Antifungal activity of anthraquinone derivatives from Rheum emodi, J. Ethnopharmacol., 72, 43, 10.1016/S0378-8741(00)00195-1 Akhtar, 2006, Neural precursor cells possess multiple p53-dependent apoptotic pathways, Cell Death Differ., 13, 1727, 10.1038/sj.cdd.4401879 Al-Fatlawi, 2014, Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells, Asian Pac. J. Cancer Prev., 15, 3731, 10.7314/APJCP.2014.15.8.3731 Anelli, 2009, Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation, Zebrafish, 6, 417, 10.1089/zeb.2009.0612 Baldwin, 1996, THE NF-κB AND IκB PROTEINS: new discoveries and insights, Annu. Rev. Immunol., 14, 649, 10.1146/annurev.immunol.14.1.649 Beuerle, 2007, Zebrafish: methods for assessing drug safety and toxicity, J. Exp. Nanosci., 2, 147, 10.1080/17458080701502091 Bugel, 2016, Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen’s effects on skin epithelium, Toxicol. Appl. Pharmacol., 296, 31, 10.1016/j.taap.2016.02.013 Carotenuto, 2016, Α-linolenic acid reduces TNF-Induced apoptosis in C2C12 myoblasts by regulating expression of apoptotic proteins, Eur. J. Transl. Myol., 26, 10.4081/ejtm.2016.6033 Catz, 2001, Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer, Oncogene, 20, 7342, 10.1038/sj.onc.1204926 Chen, 2015, Beware of docking!, Trends Pharmacol. Sci., 36, 78, 10.1016/j.tips.2014.12.001 Chen, 2014, Potential antineoplastic effects of aloe-emodin: a comprehensive review, Am. J. Chin. Med. (Gard City N Y), 42, 275, 10.1142/S0192415X14500189 Chen, 2017, Schisandra lignan extract protects against carbon tetrachloride-induced liver injury in mice by inhibiting oxidative stress and regulating the NF-κB and JNK signaling pathways, Evid. Complement. Alternat. Med., 2017, 1 Conner, 1999, HGF-mediated apoptosis via p53/bax-independent pathway activating JNK1, Carcinogenesis, 20, 583, 10.1093/carcin/20.4.583 Dai, 2016, Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells, Food Chem. Toxicol., 95, 52, 10.1016/j.fct.2016.06.025 Dong, 2014, Eighteen cases of liver injury following ingestion of Polygonum multiflorum, Complement. Ther. Med., 22, 70, 10.1016/j.ctim.2013.12.008 Dong, 2017, Induction of apoptosis in HepaRG cell line by aloe-emodin through generation of reactive oxygen species and the mitochondrial pathway, Cell. Physiol. Biochem., 42, 685, 10.1159/000477886 Dong, 2017, Aloe-emodin induces apoptosis in human liver HL-7702 cells through fas death pathway and the mitochondrial pathway by generating reactive oxygen species, Phytother. Res., 31, 927, 10.1002/ptr.5820 Etemadi, 2015, TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1, eLife, 4, 4 Fang, 2013, Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration, Proc. Natl. Acad. Sci. U. S. A., 110, 13416, 10.1073/pnas.1309810110 Francoz, 2006, Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo, Proc. Natl. Acad. Sci. U. S. A., 103, 3232, 10.1073/pnas.0508476103 Gautier, 2011, The gsdf gene locus harbors evolutionary conserved and clustered genes preferentially expressed in fish previtellogenic oocytes, Gene, 472, 7, 10.1016/j.gene.2010.10.014 Gerton, 2015, Ribosomal protein mutations result in constitutive p53 protein degradation through impairment of the AKT pathway, PLoS Genet., 11 Gioacchini, 2017, Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches, Sci. Rep., 7, 10.1038/s41598-017-01322-1 Grivennikov, 2010, Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer, Cytokine Growth Factor Rev., 21, 11, 10.1016/j.cytogfr.2009.11.005 Hamman, 2008, Composition and applications of aloe vera leaf gel, Molecules, 13, 1599, 10.3390/molecules13081599 Han, 2018, Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-κB/TNF-α/IL-6-dependent pathway, Chemosphere, 200, 283, 10.1016/j.chemosphere.2018.02.137 Hanazono, 2006, Distribution of p53 mutations in esophageal and gastric carcinomas and the relationship with p53 expression, Oncol. Rep., 15, 821 Hattori, 2003, Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation, Eur. J. Pharmacol., 481, 153, 10.1016/j.ejphar.2003.09.034 Hayden, 2008, Shared principles in NF-κB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020 He, 2015, Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway, Mol. Med. Rep., 11, 374, 10.3892/mmr.2014.2676 Heissmeyer, 2001, Shared pathways of I B kinase-induced SCF TrCP-Mediated ubiquitination and degradation for the NF- B precursor p105 and I B, Mol. Cell. Biol., 21, 1024, 10.1128/MCB.21.4.1024-1035.2001 Himes, 2006, The JNK are important for development and survival of macrophages, J. Immunol., 176, 2219, 10.4049/jimmunol.176.4.2219 Hoeflich, 1999, Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1), Oncogene, 18, 5814, 10.1038/sj.onc.1202975 Huang, 2007, Anti-cancer properties of anthraquinones from rhubarb, Med. Res. Rev., 27, 609, 10.1002/med.20094 Isogai, 2001, The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development, Dev. Biol. (Basel), 230, 278, 10.1006/dbio.2000.9995 Jeon, 2012, Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells, Cell Biol. Int., 36, 163, 10.1042/CBI20100723 Jiang, 2013, BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2, Hum. Exp. Toxicol., 32, 1245, 10.1177/0960327113488613 Jorgensen, 2004, The many roles of computation in drug discovery, Science, 303, 1813, 10.1126/science.1096361 Joyce, 2011, SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments, Mamm. Genome, 22, 420, 10.1007/s00335-011-9339-1 Jupp, 2001, Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways, Biochem. J., 359, 525, 10.1042/bj3590525 Kao, 2014, The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling, Apoptosis, 20, 174, 10.1007/s10495-014-1062-4 Kavitha, 2012, Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells, Eur. J. Pharmacol., 681, 6, 10.1016/j.ejphar.2012.01.024 Kim, 2014, Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human Colon Cancer hct116 cells, J. Microbiol. Biotechnol., 24, 1654, 10.4014/jmb.1307.07071 Kong, 2015, The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by (TNF-α related apoptosis inducing ligand) TRAIL in hepatoma cells, Virol. J., 12, 10.1186/s12985-015-0416-z Kuo, 2002, The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines, Life Sci., 71, 1879, 10.1016/S0024-3205(02)01900-8 Lei, 2017, Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors, Nucleic Acids Res., 45, 3422, 10.1093/nar/gkw1043 Li, 2014, Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation, Eur. J. Pharmacol., 738, 125, 10.1016/j.ejphar.2014.05.028 Lu, 2007, Anticancer effects of aloe-emodin on HepG2 cells: cellular and proteomic studies, Proteomics Clin. Appl., 1, 410, 10.1002/prca.200600798 Matthews, 2009, TNF-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase, Development, 136, 865, 10.1242/dev.027565 Miccoli, 2015, Beneficial Bacteria Affect <b><i>Danio rerio</i></b> development by the modulation of maternal factors involved in Autophagic, apoptotic and dorsalizing processes, Cell. Physiol. Biochem., 35, 1706, 10.1159/000373983 Moulin, 2004, Islet-brain (IB)/JNK-interacting proteins (JIPs): future targets for the treatment of neurodegenerative diseases?, Curr. Neurovasc. Res., 1, 111, 10.2174/1567202043480161 Muller, 2002, Activation of NF- B is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis, Mol. Cell. Biol., 22, 1060, 10.1128/MCB.22.4.1060-1072.2002 Muller, 2016, Immunotoxicity of β-Diketone antibiotic mixtures to zebrafish (Danio rerio) by transcriptome analysis, PLoS One, 11 Mullins, 2017, Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation, PLoS Genet., 13 Nesslany, 2009, Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay, Mutat. Res.-Gen. Tox. En, 678, 13, 10.1016/j.mrgentox.2009.06.004 Nguyen, 2011, A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish, Dis. Model. Mech., 4, 801, 10.1242/dmm.007831 Olsen, 2012, Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression, Diabetes, 61, 485, 10.2337/db11-0588 Panigrahi, 2015, Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-Exposed patients and experimental rats, Chem. Res. Toxicol., 28, 1120, 10.1021/acs.chemrestox.5b00056 Panigrahi, 2015, Investigation of the interaction of anthraquinones of Cassia occidentalis seeds with bovine serum albumin by molecular docking and spectroscopic analysis: correlation to their in vitro cytotoxic potential, Food Res. Int., 77, 368, 10.1016/j.foodres.2015.08.022 Panis, 2005, Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation, J. Pediatr. Gastroenterol. Nutr., 41, 256, 10.1097/01.MPG.0000164699.41282.67 Park, 2014, Histamine promotes the release of Interleukin-6 via the H1R/p38 and NF-κB pathways in nasal fibroblasts, Allergy Asthma Immunol. Res., 6, 567, 10.4168/aair.2014.6.6.567 Pomerantz, 2002, Two pathways to NF-κB, Mol. Cell, 10, 693, 10.1016/S1097-2765(02)00697-4 Rajaraman, 2007, Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment, Mol. Cell. Biochem., 295, 27, 10.1007/s11010-006-9268-6 Rodrigues, 2015, Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis, Sci. Rep., 5, 10.1038/srep17528 Sandoval, 2017, A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC), eLife, 6, 6 Schow, 1997, N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo, Cell. Immunol., 175, 199, 10.1006/cimm.1996.1061 Seo, 2010, Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation, J. Cell. Biochem., 110, 1022, 10.1002/jcb.22616 Sertori, 2016, Conserved IL-2Rγc signaling mediates lymphopoiesis in zebrafish, J. Immunol., 196, 135, 10.4049/jimmunol.1403060 Shoichet, 2004, Virtual screening of chemical libraries, Nature, 432, 862, 10.1038/nature03197 Speranskii, 2016, Enrichment of extracellular DNA from the cultivation medium of human peripheral blood mononuclears with genomic CpG rich fragments results in increased cell production of IL-6 and TNF-a via activation of the NF-kB signaling pathway, Biomed. Khim., 62, 331, 10.18097/pbmc20166203331 Stitt, 2014, Deciphering combinations of PI3K/AKT/mTOR pathway drugs augmenting anti-angiogenic efficacy in vivo, PLoS One, 9 Suboj, 2012, Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB, Eur. J. Pharm. Sci., 45, 581, 10.1016/j.ejps.2011.12.012 Venkatesan, 2010, EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κB andMKK7/JNK/AP-1 signaling, J. Mol. Cell. Cardiol., 49, 655, 10.1016/j.yjmcc.2010.05.007 Vliegenthart, 2014, Zebrafish as model organisms for studying drug-induced liver injury, Br. J. Clin. Pharmacol., 78, 1217, 10.1111/bcp.12408 Wang, 2015, Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans, Fish. Shellfish Immunol., 44, 109, 10.1016/j.fsi.2015.01.038 Wei, 2014, Tamoxifen reduces infiltration of inflammatory cells, apoptosis and inhibits IKK/NF-kB pathway after spinal cord injury in rats, Neurol. Sci., 35, 1763, 10.1007/s10072-014-1828-z Westerfield, 2000, The zebrafish book. A Guide for the laboratory use of zebrafish (Danio rerio) Williams, 2017, Cyp1b1 regulates ocular fissure closure through a retinoic acid–Independent pathway, Biochem. Mol. Biol., 58, 1084 Xie, 2017, Hepatitis C virus nonstructural 5A protein (HCV-NS5A) inhibits hepatocyte apoptosis through the NF-κb/miR-503/bcl-2 pathway, Mol. Cells, 40, 202 Yang, 2006, A signaling mechanism from g q-protein-coupled metabotropic glutamate receptors to gene expression: role of the c-Jun N-Terminal kinase pathway, J. Neurosci., 26, 971, 10.1523/JNEUROSCI.4423-05.2006 Yang, 2006, Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK, EMBO Rep., 10.1038/sj.embor.7400687 Yang, 2015, Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish, BMC Genomics, 16, 10.1186/s12864-015-1740-9 Yi, 2007, Identification and determination of the major constituents in traditional Chinese medicinal plantPolygonum multiflorum thunb by HPLC coupled with PAD and ESI/MS, Phytochem. Anal., 18, 181, 10.1002/pca.963 Zeldich, 2010, Enamel matrix derivative protects human gingival fibroblasts from TNF‐induced apoptosis by inhibiting caspase activation, J. Cell. Physiol., 213, 750, 10.1002/jcp.21142 Zhan, 2014, Arrestin-dependent activation of JNK family kinases, Handb. Exp. Pharmacol., 219, 259, 10.1007/978-3-642-41199-1_13 Zhang, 2014, Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes, PLoS One, 9 Zhang, 2016, L-FABP-deficiency provoked oxidative stress, inflammation and apoptosis-mediated hepatotoxicity induced by pyrazinamide on zebrafish larvae, Antimicrob. Agents Chemother. AAC, 10.1128/AAC.01693-16 Zhou, 2006, The role of mitogen-activated protein kinase Phosphatase-1 in oxidative damage–induced cell death, Cancer Res., 66, 4888, 10.1158/0008-5472.CAN-05-4229