Allergens TRP a swITCH to Initiate Type 2 Immunity

Belvisi, 2017, The emerging role of transient receptor potential channels in chronic lung disease, Eur. Respir. J., 50, 1601357, 10.1183/13993003.01357-2016 Cohen, 2019, Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity, Cell, 178, 919, 10.1016/j.cell.2019.06.022 Hammad, 2009, House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells, Nat. Med., 15, 410, 10.1038/nm.1946 Kashem, 2015, Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity, Immunity, 43, 515, 10.1016/j.immuni.2015.08.016 Kumamoto, 2013, CD301b+ dermal dendritic cells drive T helper 2 cell-mediated immunity, Immunity, 39, 733, 10.1016/j.immuni.2013.08.029 Perner, 2020, Substance P release by sensory neurons triggers dendritic cell migration and initiates the Type-2 immune response to allergens, Immunity, 53, 1063, 10.1016/j.immuni.2020.10.001 Reed, 2004, The role of protease activation of inflammation in allergic respiratory diseases, J. Allergy Clin. Immunol., 114, 997, 10.1016/j.jaci.2004.07.060 Serhan, 2019, House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation, Nat. Immunol., 20, 1435, 10.1038/s41590-019-0493-z Sokol, 2018, The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response, Immunity, 49, 449, 10.1016/j.immuni.2018.07.012