Allergen Immunotherapy (AIT): a prototype of Precision Medicine

Giorgio Walter Canonica1, Claus Bachert2, Peter W. Hellings3,4, Dermot Ryan5, Erkka Valovirta6, Magnus Wickman7, Olivier Beaumont8, Jean Bousquet9,10,11
1Allergy and Respiratory Diseases -DIMI Department of Internal Medicine, University of Genova, IRCCS AOU San Martino, Genova 16132, Italy
2Upper Airways Research Laboratory, ENT-Department, University of Ghent, 9000 Ghent, Belgium
3Department of Otorhinolaryngology, University of Leuven, Leuven, Belgium
4Department of Otorhinolaryngology, University of Amsterdam, Amsterdam, The Netherlands
5Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK
6Department of Pulmonary and Allergic Diseases and Clinical Allergology, University of Turku, Turku, Finland
7Department of Environmental Medecine, Karolinska Institutet, Sachs’ Children’s Hospital, Stockholm, Sweden
8Stallergenes, Antony, France
9UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles, France
10INSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, U1168, Paris, France
11University hospital, Montpellier, MACVIA-LR, Contre les Maladies Chronique spour un Vieillissement Actif en Languedoc Roussilon, European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Paving the way for personalizdd medicine, FDA’s role in a new era of medical product development. http://www.fdagov/downloads/ScienceResearch/SpecialTopics/PersonalizedMedicine/UCM372421pdf. 2013

Hamburg, 2010, The path to personalized medicine, N Engl J Med, 363, 301, 10.1056/NEJMp1006304

Bousquet, 2014, Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies, Curr Pharm Des, 20, 5928, 10.2174/1381612820666140314115505

Ramsey, 2011, A CFTR potentiator in patients with cystic fibrosis and the G551D mutation, N Engl J Med, 365, 1663, 10.1056/NEJMoa1105185

Collins, 2015, A new initiative on precision medicine, N Engl J Med, 372, 793, 10.1056/NEJMp1500523

Braido, 2012, From "blockbusters" to "biosimilars": an opportunity for patients, medical specialists and health care providers, Pulm Pharmacol Ther, 25, 483, 10.1016/j.pupt.2012.09.005

Vieths, 2013, Personalised medicine for the diagnosis and treatment of allergic diseases, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 56, 1531, 10.1007/s00103-013-1821-3

Bousquet, 2014, Integrated care pathways for airway diseases (AIRWAYS-ICPs), Eur Respir J, 44, 304, 10.1183/09031936.00014614

Bousquet, 2014, MACVIA-LR Reference Site of the European Innovation Partnership on Active and Healthy Ageing, Eur Geriatr Med, 5, 406, 10.1016/j.eurger.2014.07.013

Bousquet, 2009, GA2LEN skin test study III: minimum battery of test inhalent allergens needed in epidemiological studies in patients, Allergy, 64, 1656, 10.1111/j.1398-9995.2009.02169.x

Canonica, 2013, A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnostics, World Allergy Organ J, 6, 17, 10.1186/1939-4551-6-17

Incorvaia C, Mauro M, Ridolo E, Makri E, Montagni M, Ciprandi G. A Pitfall to Avoid When Using an Allergen Microarray: The Incidental Detection of IgE to Unexpected Allergens. J Allergy Clin Immunol Pract. 2014. doi:10.1016/j.jaip.2014.09.020.

Barber, 2015, Challenges for allergy diagnosis in regions with complex pollen exposures, Curr Allergy Asthma Rep, 15, 496, 10.1007/s11882-014-0496-7

Stringari, 2014, The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever, J Allergy Clin Immunol, 134, 75, 10.1016/j.jaci.2014.01.042

Vallier, 1995, Identification of profilin as an IgE-binding component in latex from Hevea brasiliensis: clinical implications, Clin Exp Allergy, 25, 332, 10.1111/j.1365-2222.1995.tb01051.x

Holzweber, 2013, Inhibition of IgE binding to cross-reactive carbohydrate determinants enhances diagnostic selectivity, Allergy, 68, 1269, 10.1111/all.12229

Lupinek, 2014, Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip, Methods, 66, 106, 10.1016/j.ymeth.2013.10.008

Flicker, 2003, Renaissance of the blocking antibody concept in type I allergy, Int Arch Allergy Immunol, 132, 13, 10.1159/000073260

Matsuoka, 2013, Allergen immunotherapy and tolerance, Allergol Int, 62, 403, 10.2332/allergolint.13-RAI-0650

Akdis, 2014, Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs, J Clin Invest, 124, 4678, 10.1172/JCI78891

Allam, 2014, Immunological mechanisms of sublingual immunotherapy, Curr Opin Allergy Clin Immunol, 14, 564, 10.1097/ACI.0000000000000118

2001, Biomarkers and surrogate endpoints: preferred definitions and conceptual framework, Clin Pharmacol Ther, 69, 89, 10.1067/mcp.2001.113989

Taylor, 2008, Biomarkers in the assessment and management of airways diseases, Postgrad Med J, 84, 628, 10.1136/pgmj.2008.069864

Manolio, 2010, Genomewide association studies and assessment of the risk of disease, N Engl J Med, 363, 166, 10.1056/NEJMra0905980

Fitzpatrick, 2010, The molecular phenotype of severe asthma in children, J Allergy Clin Immunol, 125, 851, 10.1016/j.jaci.2010.01.048

Brasier, 2008, Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines, J Allergy Clin Immunol, 121, 30, 10.1016/j.jaci.2007.10.015

Anto, 2012, Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar, J Allergy Clin Immunol, 129, 943, 10.1016/j.jaci.2012.01.047

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Institutes of Medicines of the National Academies http://www.iomedu/Reports/2010/Evaluation-of-Biomarkers-and-Surrogate-Endpoints-in-Chronic-Diseaseaspx. 2010.

Auffray, 2010, An integrative systems biology approach to understanding pulmonary diseases, Chest, 137, 1410, 10.1378/chest.09-1850

Bousquet, 2011, MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine, Allergy, 66, 596, 10.1111/j.1398-9995.2010.02534.x

Westman, 2015, Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence, J Allergy Clin Immunol, 135, 1199, 10.1016/j.jaci.2014.10.042

Willis, 2015, Immune biomarkers: the promises and pitfalls of personalized medicine, Nat Rev Immunol, 15, 323, 10.1038/nri3820

Campbell, 1998, Integrated care pathways, BMJ, 316, 133, 10.1136/bmj.316.7125.133

Integrated Care Pathways users in Scotland (ICPUS). A workbook for people starting to develop integrated care pathways. http://www.icpus.org.uk2007. Accessed May 2015

Bousquet, 2014, The European Innovation Partnership on Active and Healthy Ageing: the European Geriatric Medicine introduces the EIP on AHA Column, Eur Geriatr Med, 5, 361, 10.1016/j.eurger.2014.09.010

Bousquet, 2012, Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper, Int Arch Allergy Immunol, 158, 216, 10.1159/000332924

Bousquet, 2012, Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs, J Allergy Clin Immunol, 130, 1049, 10.1016/j.jaci.2012.07.053

Morais-Almeida, 2013, Prevalence and classification of rhinitis in the elderly: a nationwide survey in Portugal, Allergy, 68, 1150

Morais-Almeida, 2013, Prevalence and classification of rhinitis in preschool children in Portugal: a nationwide study, Allergy, 68, 1278, 10.1111/all.12221

Klimek, 2015, Effectiveness of MP29-02 for the treatment of allergic rhinitis in real-life: results from a noninterventional study, Allergy Asthma Proc, 36, 40, 10.2500/aap.2015.36.3823

Bousquet, 2009, Unmet needs in severe chronic upper airway disease (SCUAD), J Allergy Clin Immunol, 124, 428, 10.1016/j.jaci.2009.06.027

Pfaar, 2014, Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper, Allergy, 69, 854, 10.1111/all.12383

Bousquet, 2010, Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial, J Allergy Clin Immunol, 126, 666, 10.1016/j.jaci.2010.06.034

Demoly, 2013, Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: Asthma and Rhinitis, Clin Exp Immunol, 43, 881

Just, 2014, Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA Study, Pediatri Allergy Immunol, 25, 668, 10.1111/pai.12287

Just, 2014, Childhood allergic asthma is not a single phenotype, J Pediatr, 164, 815, 10.1016/j.jpeds.2013.11.037

Pinart, 2014, Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study, Lancet Respir Med, 2, 131, 10.1016/S2213-2600(13)70277-7

Hellings, 2013, Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today?, Allergy, 68, 1, 10.1111/all.12040

Bousquet, 2013, Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care, Int Arch Allergy Immunol, 160, 393, 10.1159/000342991

Sullivan, 2011, The burden of adult asthma in the United States: evidence from the Medical Expenditure Panel Survey, J Allergy Clin Immunol, 127, 363, 10.1016/j.jaci.2010.10.042

Sullivan, 2014, The relationship between asthma, asthma control and economic outcomes in the United States, J Asthma, 51, 769, 10.3109/02770903.2014.906607

Walker, 2007, Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case–control study, J Allergy Clin Immunol, 120, 381, 10.1016/j.jaci.2007.03.034

Samolinski, 2012, Council of the European Union conclusions on chronic respiratory diseases in children, Lancet, 379, e45, 10.1016/S0140-6736(12)60514-5

Zuberbier, 2014, Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review, Allergy, 69, 1275, 10.1111/all.12470

Masoli, 2004, The global burden of asthma: executive summary of the GINA Dissemination Committee Report, Allergy, 59, 469, 10.1111/j.1398-9995.2004.00526.x

Asher, 2006, Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys, Lancet, 368, 733, 10.1016/S0140-6736(06)69283-0

Pearce, 2007, Worldwide trends in the prevalence of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), Thorax, 62, 758, 10.1136/thx.2006.070169

Bousquet J, Khaltaev N. Global surveillance, prevention and control of Chronic Respiratory Diseases. A comprehensive approach. Global Alliance against Chronic Respiratory Diseases. World Health Organization. 2007:148. ISBN 978 92 4 156346 8.

Gibson G, Loddenkemper R, Lundback B, Sibille Y. The new European Lung White Book: Respiratory health and disease in Europe: Geneve. ERS Publications; 2013.

Gibson, 2013, Respiratory health and disease in Europe: the new European Lung White Book, Eur Respir J, 42, 559, 10.1183/09031936.00105513

Hankin, 2014, Allergy immunotherapy: what is the evidence for cost saving?, Curr Opin Allergy Immunol, 14, 363, 10.1097/ACI.0000000000000084

Creticos, 1996, Ragweed immunotherapy in adult asthma, N Engl J Med, 334, 501, 10.1056/NEJM199602223340804

Bousquet, 2011, How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement, Allergy, 66, 765, 10.1111/j.1398-9995.2011.02590.x

Dranitsaris, 2014, Sublingual or subcutaneous immunotherapy for seasonal allergic rhinitis: an indirect analysis of efficacy, safety and cost, J Eval Clin Pract, 20, 225, 10.1111/jep.12112

Meadows, 2013, A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis, Health Technol Assess, 17, vi, 10.3310/hta17270

Barabasi, 2011, Network medicine: a network-based approach to human disease, Nat Rev Genet, 12, 56, 10.1038/nrg2918

Szepfalusi, 2014, Preventive sublingual immunotherapy in preschool children: First evidence for safety and pro-tolerogenic effects, Pediatr Allergy Immunol, 25, 788, 10.1111/pai.12310

Leynaert, 2000, Quality of life in allergic rhinitis and asthma. A population-based study of young adults, Am J Respir Crit Care Med, 162, 1391, 10.1164/ajrccm.162.4.9912033