All three human scavenger receptor class B proteins can bind and transport all three macular xanthophyll carotenoids

Bone, 1997, Distribution of lutein and zeaxanthin stereoisomers in the human retina, Exp. Eye Res., 64, 211, 10.1006/exer.1996.0210 Bernstein, 2016, Lutein, zeaxanthin, and meso-zeaxanthin: the basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease, Prog. Retin. Eye Res., 50, 34, 10.1016/j.preteyeres.2015.10.003 During, 2002, Carotenoid uptake and secretion by CaCo-2 cells: beta-carotene isomer selectivity and carotenoid interactions, J. Lipid Res., 43, 1086, 10.1194/jlr.M200068-JLR200 Kiefer, 2002, A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila, Proc. Natl. Acad. Sci., 99, 10581, 10.1073/pnas.162182899 Borel, 2013, CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK-293T cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans, J. Nutr., 143, 448, 10.3945/jn.112.172734 During, 2008, Xanthophylls are preferentially taken up compared with β-carotene by retinal cells via a SRBI-dependent mechanism, J. Lipid Res., 49, 1715, 10.1194/jlr.M700580-JLR200 Thomas, 2016, Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins, J. Lipid Res., 57, 1865, 10.1194/jlr.M070193 Snodderly, 1984, The macular pigment. II. Spatial distribution in primate retinas, Invest. Ophthalmol. Vis. Sci., 25, 674 Junghans, 2001, Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes, Arch. Biochem. Biophys., 391, 160, 10.1006/abbi.2001.2411 Li, 2010, Studies on the singlet oxygen scavenging mechanism of human macular pigment, Arch. Biochem. Biophys., 504, 56, 10.1016/j.abb.2010.07.024 Chew, 2014, Secondary analyses of the effects of lutein/zeaxanthin on Age-related macular degeneration progression, JAMA Ophthalmol., 132, 142, 10.1001/jamaophthalmol.2013.7376 Connolly, 2011, Supplementation with all three macular carotenoids: response, stability, and safety, Invest. opthalmol. Vis. Sci., 52, 9207, 10.1167/iovs.11-8025 Tserentsoodol, 2006, Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors, Mol. Vis., 12, 1319 Sun, 2011, Sudan black B reduces autofluorescence in murine renal tissue, Arch. Pathol. Lab. Med., 135, 1335, 10.5858/arpa.2010-0549-OA Gorusupudi, 2016, Developmentally regulated production of meso- Zeaxanthin in chicken retinal pigment epithelium/choroid and retina, Invest. Opthalmol.Vis. Sci., 57, 1853, 10.1167/iovs.16-19111 Vachali, 2016, Protein-flavonoid interaction studies by a taylor dispersion Surface Plasmon Resonance (SPR) technique: a novel method to assess biomolecular interactions, Biosensors, 6, 6, 10.3390/bios6010006 Vachali, 2013, Carotenoids as possible interphotoreceptor retinoid-binding protein (IRBP) ligands: a surface plasmon resonance (SPR) based study, Arch. Biochem. Biophys., 539, 181, 10.1016/j.abb.2013.07.008 Li, 2010, Human ocular carotenoid-binding proteins, Photochem. Photobiol. Sci., 9, 1418, 10.1039/c0pp00126k Bhosale, 2004, Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye, J. Biol. Chem., 279, 49447, 10.1074/jbc.M405334200 Sakudoh, 2013, CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori, J. Lipid Res., 54, 482, 10.1194/jlr.M032771 Sakudoh, 2010, A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon coloration, J. Biol. Chem., 285, 7739, 10.1074/jbc.M109.074435 Li, 2011, Identification of StARD3 as a lutein-binding protein in the macula of the primate retina, Biochemistry, 50, 2541, 10.1021/bi101906y Vachali, 2012, Surface plasmon resonance (SPR) studies on the interactions of carotenoids and their binding proteins, Arch. Biochem. Biophys., 519, 32, 10.1016/j.abb.2012.01.006 El-Sohemy, 2002, Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake, Am. J. Clin. Nutr., 76, 172, 10.1093/ajcn/76.1.172 Borel, 1996, Carotenoids in biological emulsions: solubility, surface-to-core distribution, and release from lipid droplets, J. Lipid Res., 37, 250, 10.1016/S0022-2275(20)37613-6 Tyssandier, 2001, Main factors governing the transfer of carotenoids from emulsion lipid droplets to micelles, Biochim. Biophys. Acta, 1533, 285, 10.1016/S1388-1981(01)00163-9 Nolan, 2013, What is meso-zeaxanthin, and where does it come from?, Eye (Lond), 27, 899, 10.1038/eye.2013.98 Shyam, 2017, RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye, Proc. Nat. Acad. Sci. U.S.A., 10.1073/pnas.1706332114