Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma

Michael Ronellenfitsch1, Pia S. Zeiner1, Michel Mittelbronn2, H. Urban1, Torsten Pietsch3, Dirk Reuter4, Christian Senft5, Joachim P. Steinbach6, Manfred Westphal7, Patrick N. Harter6
1Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany
2Institute of Neurology (Edinger-Institute), University Hospital Frankfurt, Goethe University, Heinrich-Hoffmann-Str. 7, 60528, Frankfurt am Main, Germany
3Department of Neuropathology, University of Bonn, Bonn, Germany
4Oncoscience GmbH, Schenefeld, Germany
5Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
6German Cancer Consortium (DKTK) Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany
7Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

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