Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter
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State of global air 2019. . In: Health Effects Institute Boston; 2019: No. 2578-6873.
Jones LL, Hashim A, McKeever T, Cook DG, Britton J, Leonardi-Bee J. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis. Respir Res. 2011;12:5.
Ferrante G, Antona R, Malizia V, Montalbano L, Corsello G, La Grutta S. Smoke exposure as a risk factor for asthma in childhood: a review of current evidence. Allergy Asthma Proc. 2014;35(6):454–61.
Li Z, Tang Y, Song X, Lazar L, Li Z, Zhao J. Impact of ambient PM2.5 on adverse birth outcome and potential molecular mechanism. Ecotoxicol Environ Saf. 2019;169:248–54.
Korten I, Ramsey K, Latzin P. Air pollution during pregnancy and lung development in the child. Paediatr Respir Rev. 2017;21:38–46.
Hehua Z, Qing C, Shanyan G, Qijun W, Yuhong Z. The impact of prenatal exposure to air pollution on childhood wheezing and asthma: a systematic review. Environ Res. 2017;159:519–30.
Clifford A, Lang L, Chen R, Anstey KJ, Seaton A. Exposure to air pollution and cognitive functioning across the life course--a systematic literature review. Environ Res. 2016;147:383–98.
Lim CC, Thurston GD. Air pollution, oxidative stress, and diabetes: a life course epidemiologic perspective. Curr Diab Rep. 2019;19(8):58.
Payne-Sturges DC, Marty MA, Perera F, Miller MD, Swanson M, Ellickson K, et al. Healthy air, healthy brains: advancing air pollution policy to protect children’s health. Am J Public Health. 2019;109(4):550–4.
Stieb DM, Chen L, Eshoul M, Judek S. Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis. Environ Res. 2012;117:100–11.
Zhu X, Liu Y, Chen Y, Yao C, Che Z, Cao J. Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis. Environ Sci Pollut Res Int. 2015;22(5):3383–96.
Lamichhane DK, Leem JH, Lee JY, Kim HC. A meta-analysis of exposure to particulate matter and adverse birth outcomes. Environ Health Toxicol. 2015;30:e2015011.
Sun X, Luo X, Zhao C, Zhang B, Tao J, Yang Z, et al. The associations between birth weight and exposure to fine particulate matter (PM2.5) and its chemical constituents during pregnancy: a meta-analysis. Environ Pollut. 2016;211:38–47.
DeFranco E, Moravec W, Xu F, Hall E, Hossain M, Haynes EN, et al. Exposure to airborne particulate matter during pregnancy is associated with preterm birth: a population-based cohort study. Environ Health. 2016;15:6.
Percy Z, DeFranco E, Xu F, Hall ES, Haynes EN, Jones D, et al. Trimester specific PM2.5 exposure and fetal growth in Ohio, 2007-2010. Environ Res. 2019;171:111–8.
Rich DQ, Liu K, Zhang J, Thurston SW, Stevens TP, Pan Y, et al. Differences in birth weight associated with the 2008 Beijing Olympics air pollution reduction: results from a natural experiment. Environ Health Perspect. 2015;123(9):880–7.
Siddika N, Balogun HA, Amegah AK, Jaakkola JJ. Prenatal ambient air pollution exposure and the risk of stillbirth: systematic review and meta-analysis of the empirical evidence. Occup Environ Med. 2016;73(9):573–81.
DeFranco E, Hall E, Hossain M, Chen A, Haynes EN, Jones D, et al. Air pollution and stillbirth risk: exposure to airborne particulate matter during pregnancy is associated with fetal death. Plos One. 2015;10(3):e0120594.
EA MI, Gehring U, Molter A, Fuertes E, Klumper C, Kramer U, et al. Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project. Environ Health Perspect. 2014;122(1):107–13.
de Planell-Saguer M, Lovinsky-Desir S, Miller RL. Epigenetic regulation: the interface between prenatal and early-life exposure and asthma susceptibility. Environ Mol Mutagen. 2014;55(3):231–43.
Rychlik KA, FCM S. Environmental exposures during pregnancy: mechanistic effects on immunity. Birth Defects Res. 2019;111(4):178–96.
Baiz N, Slama R, Bene MC, Charles MA, Kolopp-Sarda MN, Magnan A, et al. Maternal exposure to air pollution before and during pregnancy related to changes in newborn’s cord blood lymphocyte subpopulations. The EDEN study cohort. BMC Pregnancy Childbirth. 2011;11:87.
Herr CE, Dostal M, Ghosh R, Ashwood P, Lipsett M, Pinkerton KE, et al. Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths. Environ Health. 2010;9:46.
Bobak M, Leon DA. The effect of air pollution on infant mortality appears specific for respiratory causes in the postneonatal period. Epidemiology. 1999;10(6):666–70.
Xu X, Ha SU, Basnet R. A review of epidemiological research on adverse neurological effects of exposure to ambient air pollution. Front Public Health. 2016;4:157.
Lam J, Sutton P, Kalkbrenner A, Windham G, Halladay A, Koustas E, et al. A systematic review and meta-analysis of multiple airborne pollutants and autism spectrum disorder. Plos One. 2016;11(9):e0161851.
Guxens M, Lubczynska MJ, Muetzel RL, Dalmau-Bueno A, VWV J, Hoek G, et al. Air pollution exposure during fetal life, brain morphology, and cognitive function in school-age children. Biol Psychiatry. 2018;84(4):295–303.
Mortamais M, Pujol J, Martinez-Vilavella G, Fenoll R, Reynes C, Sabatier R, et al. Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children. Environ Res. 2019;178:108734.
Rivas I, Basagana X, Cirach M, Lopez-Vicente M, Suades-Gonzalez E, Garcia-Esteban R, et al. Association between early life exposure to air pollution and working memory and attention. Environ Health Perspect. 2019;127(5):57002.
Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity among adults and youth: United States, 2015-2016. NCHS Data Brief. 2017;(288):1–8.
Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med. 2017;376(15):1419–29.
Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes Metab Syndr Obes. 2014;7:587–91.
Gingras V, Hivert MF, Oken E. Early-life exposures and risk of diabetes mellitus and obesity. Curr Diab Rep. 2018;18(10):89.
Alderete TL, Song AY, Bastain T, Habre R, Toledo-Corral CM, Salam MT, et al. Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatr Obes. 2018;13(6):348–56.
Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, et al. Longitudinal associations between ambient air pollution with insulin sensitivity, beta-cell function, and adiposity in Los Angeles Latino children. Diabetes. 2017;66(7):1789–96.
Fleisch AF, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, et al. Prenatal exposure to traffic pollution: associations with reduced fetal growth and rapid infant weight gain. Epidemiology. 2015;26(1):43–50.
Fleisch AF, Luttmann-Gibson H, Perng W, Rifas-Shiman SL, Coull BA, Kloog I, et al. Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood. Pediatr Obes. 2017;12(1):48–57.
Fleisch AF, Aris IM, Rifas-Shiman SL, Coull BA, Luttmann-Gibson H, Koutrakis P, et al. Prenatal exposure to traffic pollution and childhood body mass index trajectory. Front Endocrinol (Lausanne). 2018;9:771.
Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, et al. Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia. 2013;56(8):1696–704.
Thiering E, Markevych I, Bruske I, Fuertes E, Kratzsch J, Sugiri D, et al. Associations of residential long-term air pollution exposures and satellite-derived greenness with insulin resistance in German adolescents. Environ Health Perspect. 2016;124(8):1291–8.
Moody EC, Cantoral A, Tamayo-Ortiz M, Pizano-Zarate ML, Schnaas L, Kloog I, et al. Association of prenatal and perinatal exposures to particulate matter with changes in hemoglobin A1c levels in children aged 4 to 6 years. JAMA Netw Open. 2019;2(12):e1917643.
Zhang M, Mueller NT, Wang H, Hong X, Appel LJ, Wang X. Maternal exposure to ambient particulate matter </=2.5 microm during pregnancy and the risk for high blood pressure in childhood. Hypertension. 2018;72(1):194–201.
Sears CG, Braun JM, Ryan PH, Xu Y, Werner EF, Lanphear BP, et al. The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int. 2018;121(Pt 1):574–81.
Pereira G, Haggar F, Shand AW, Bower C, Cook A, Nassar N. Association between pre-eclampsia and locally derived traffic-related air pollution: a retrospective cohort study. J Epidemiol Community Health. 2013;67(2):147–52.
Wu M, Ries JJ, Proietti E, Vogt D, Hahn S, Hoesli I. Development of late-onset preeclampsia in association with road densities as a proxy for traffic-related air pollution. Fetal Diagn Ther. 2016;39(1):21–7.
Ohlwein S, Kappeler R, Kutlar Joss M, Kunzli N, Hoffmann B. Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence. Int J Public Health. 2019;64(4):547–59.
Wright RJ, Coull BA. Small but mighty: prenatal ultrafine particle exposure linked to childhood asthma incidence. Am J Respir Crit Care Med. 2019;199(12):1448–50.
Lavigne E, Donelle J, Hatzopoulou M, Van Ryswyk K, van Donkelaar A, Martin RV, et al. Spatiotemporal variations in ambient ultrafine particles and the incidence of childhood asthma. Am J Respir Crit Care Med. 2019;199(12):1487–95.
Wright RJ, Hsu HL, Chiu YM, Coull BA, Simon MC, Hudda N, Schwartz J, Kloog I, Durant JL: Prenatal ambient ultrafine particle exposure and childhood asthma in the northeastern United States. Am J Respir Crit Care Med. 2021. https://doi.org/10.1164/rccm.202010-3743OC. Online ahead of print.
Pan H, Deutsch GH, Wert SE, Ontology S, Consortium NMAoLDP. Comprehensive anatomic ontologies for lung development: a comparison of alveolar formation and maturation within mouse and human lung. J Biomed Semantics. 2019;10(1):18.
Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(Suppl 3):511–33.
Chen LC, Lippmann M. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures. Curr Protoc Toxicol. 2015;63:24 24 21–3.
Mauad T, Rivero DH, de Oliveira RC, Lichtenfels AJ, Guimaraes ET, de Andre PA, et al. Chronic exposure to ambient levels of urban particles affects mouse lung development. Am J Respir Crit Care Med. 2008;178(7):721–8.
Wei Y, Zhang JJ, Li Z, Gow A, Chung KF, Hu M, et al. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing. FASEB J. 2016;30(6):2115–22.
Allen JL, Conrad K, Oberdorster G, Johnston CJ, Sleezer B, Cory-Slechta DA. Developmental exposure to concentrated ambient particles and preference for immediate reward in mice. Environ Health Perspect. 2013;121(1):32–8.
Allen JL, Liu X, Weston D, Prince L, Oberdorster G, Finkelstein JN, et al. Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation. Toxicol Sci. 2014;140(1):160–78.
Allen JL, Liu X, Pelkowski S, Palmer B, Conrad K, Oberdorster G, et al. Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice. Environ Health Perspect. 2014;122(9):939–45.
Allen JL, Oberdorster G, Morris-Schaffer K, Wong C, Klocke C, Sobolewski M, et al. Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders. Neurotoxicology. 2017;59:140–54.
Cory-Slechta DA, Allen JL, Conrad K, Marvin E, Sobolewski M. Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction. Neurotoxicology. 2018;69:217–31.
Sobolewski M, Anderson T, Conrad K, Marvin E, Klocke C, Morris-Schaffer K, et al. Developmental exposures to ultrafine particle air pollution reduces early testosterone levels and adult male social novelty preference: risk for children’s sex-biased neurobehavioral disorders. Neurotoxicology. 2018;68:203–11.
Klocke C, Allen JL, Sobolewski M, Mayer-Proschel M, Blum JL, Lauterstein D, et al. Neuropathological consequences of gestational exposure to concentrated ambient fine and ultrafine particles in the mouse. Toxicol Sci. 2017;156(2):492–508.
Klocke C, Sherina V, Graham UM, Gunderson J, Allen JL, Sobolewski M, et al. Enhanced cerebellar myelination with concomitant iron elevation and ultrastructural irregularities following prenatal exposure to ambient particulate matter in the mouse. Inhal Toxicol. 2018;30(9-10):381–96.
Church JS, Tijerina PB, Emerson FJ, Coburn MA, Blum JL, Zelikoff JT, et al. Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice. Neurotoxicology. 2018;65:231–40.
Gorr MW, Velten M, Nelin TD, Youtz DJ, Sun Q, Wold LE. Early life exposure to air pollution induces adult cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2014;307(9):H1353–60.
Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long VP, 3rd, Bonilla IM, Shettigar V, Ziolo MT, Davis JP, Baine SH et al: In utero particulate matter exposure produces heart failure, electrical remodeling, and epigenetic changes at adulthood. J Am Heart Assoc. 2017;6(4):e005796. https://doi.org/10.1161/JAHA.117.005796.
Chen M, Wang X, Hu Z, Zhou H, Xu Y, Qiu L, et al. Programming of mouse obesity by maternal exposure to concentrated ambient fine particles. Part Fibre Toxicol. 2017;14(1):20.
Zhang R, Wang G, Guo S, Zamora ML, Ying Q, Lin Y, et al. Formation of urban fine particulate matter. Chem Rev. 2015;115(10):3803–55.
Rychlik KA, Secrest JR, Lau C, Pulczinski J, Zamora ML, Leal J, et al. In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. Proc Natl Acad Sci U S A. 2019;116(9):3443–8.
Wu G, Brown J, Zamora ML, Miller A, Satterfield MC, Meininger CJ, et al. Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter. Proc Natl Acad Sci U S A. 2019;116(24):11590–5.
Guo S, Hu M, Zamora ML, Peng J, Shang D, Zheng J, et al. Elucidating severe urban haze formation in China. Proc Natl Acad Sci U S A. 2014;111(49):17373–8.
Vejerano EP, Rao G, Khachatryan L, Cormier SA, Lomnicki S. Environmentally persistent free radicals: insights on a new class of pollutants. Environ Sci Technol. 2018;52(5):2468–81.
Thevenot PT, Saravia J, Jin N, Giaimo JD, Chustz RE, Mahne S, et al. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. Am J Respir Cell Mol Biol. 2013;48(2):188–97.
Saravia J, You D, Thevenot P, Lee GI, Shrestha B, Lomnicki S, et al. Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression. Mucosal Immunol. 2014;7(3):694–704.
Lee GI, Saravia J, You D, Shrestha B, Jaligama S, Hebert VY, et al. Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection. Part Fibre Toxicol. 2014;11:57.
Stephenson EJ, Ragauskas A, Jaligama S, Redd JR, Parvathareddy J, Peloquin MJ, et al. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in adult mice. Am J Physiol Endocrinol Metab. 2016;310(11):E1003–15.
Jaligama S, Saravia J, You D, Yadav N, Lee GI, Shrestha B, et al. Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Respir Res. 2017;18(1):15.
dela Cruz AL, Gehling W, Lomnicki S, Cook R, Dellinger B. Detection of environmentally persistent free radicals at a superfund wood treating site. Environ Sci Technol. 2011;45(15):6356–65.
Hamada K, Suzaki Y, Leme A, Ito T, Miyamoto K, Kobzik L, et al. Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A. 2007;70(8):688–95.
Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, et al. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. Plos One. 2013;8(5):e64128.
Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, et al. Exposure to nanoscale particulate matter from gestation to adulthood impairs metabolic homeostasis in mice. Sci Rep. 2019;9(1):1816.
Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, et al. Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice. Part Fibre Toxicol. 2008;5:3.
Corson L, Zhu H, Quan C, Grunig G, Ballaney M, Jin X, et al. Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice. Allergy Asthma Clin Immunol. 2010;6(1):7.
Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, et al. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2008;38(1):57–67.
Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014;134(1):63–72.
Hong X, Liu C, Chen X, Song Y, Wang Q, Wang P, et al. Maternal exposure to airborne particulate matter causes postnatal immunological dysfunction in mice offspring. Toxicology. 2013;306:59–67.
Chen M, Liang S, Qin X, Zhang L, Qiu L, Chen S, et al. Prenatal exposure to diesel exhaust PM2.5 causes offspring beta cell dysfunction in adulthood. Am J Physiol Endocrinol Metab. 2018;315(1):E72–80.
Chen M, Liang S, Zhou H, Xu Y, Qin X, Hu Z, et al. Prenatal and postnatal mothering by diesel exhaust PM2.5-exposed dams differentially program mouse energy metabolism. Part Fibre Toxicol. 2017;14(1):3.
Costa DL, Lehmann JR, Winsett D, Richards J, Ledbetter AD, Dreher KL. Comparative pulmonary toxicological assessment of oil combustion particles following inhalation or instillation exposure. Toxicol Sci. 2006;91(1):237–46.
Liu Y, Wang L, Wang F, Li C. Effect of fine particulate matter (PM2.5) on rat placenta pathology and perinatal outcomes. Med Sci Monit. 2016;22:3274–80.
Xie P, Zhao C, Huang W, Yong T, ACK C, He K, et al. Prenatal exposure to ambient fine particulate matter induces dysregulations of lipid metabolism in adipose tissue in male offspring. Sci Total Environ. 2019;657:1389–97.
Yoshida S, Takano H, Nishikawa M, Miao H, Ichinose T. Effects of fetal exposure to urban particulate matter on the immune system of male mouse offspring. Biol Pharm Bull. 2012;35(8):1238–43.
Morales-Rubio RA, Alvarado-Cruz I, Manzano-Leon N, Andrade-Oliva MD, Uribe-Ramirez M, Quintanilla-Vega B, et al. In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice. Part Fibre Toxicol. 2019;16(1):7.
Miranda RA, da Silva Franco CC, Previate C, Alves VS, Francisco FA, Moreira VM, de Moraes AMP, Gomes RM, Picinato MC, Natali MRM et al: Particulate matter exposure during perinatal life results in impaired glucose metabolism in adult male rat offspring. Cell Physiol Biochem 2018, 49(1):395-405.
Tang W, Huang S, Du L, Sun W, Yu Z, Zhou Y, et al. Expression of HMGB1 in maternal exposure to fine particulate air pollution induces lung injury in rat offspring assessed with micro-CT. Chem Biol Interact. 2018;280:64–9.
Shang Y, Sun Q. Particulate air pollution: major research methods and applications in animal models. Environ Dis. 2018;3(3):57–62.
Ema M, Naya M, Horimoto M, Kato H. Developmental toxicity of diesel exhaust: a review of studies in experimental animals. Reprod Toxicol. 2013;42:1–17.
Yokota S, Oshio S, Moriya N, Takeda K. Social isolation-induced territorial aggression in male offspring is enhanced by exposure to diesel exhaust during pregnancy. Plos One. 2016;11(2):e0149737.
Chang YC, Cole TB, Costa LG. Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Part Fibre Toxicol. 2018;15(1):18.
Weldy CS, Liu Y, Chang YC, Medvedev IO, Fox JR, Larson TV, et al. In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice. Part Fibre Toxicol. 2013;10(1):59.
Harrigan J, Ravi D, Ricks J, Rosenfeld ME. In utero exposure of hyperlipidemic mice to diesel exhaust: lack of effects on atherosclerosis in adult offspring fed a regular chow diet. Cardiovasc Toxicol. 2017;17(4):417–25.
Tsukue N, Tsubone H, Suzuki AK. Diesel exhaust affects the abnormal delivery in pregnant mice and the growth of their young. Inhal Toxicol. 2002;14(6):635–51.
Sharkhuu T, Doerfler DL, Krantz QT, Luebke RW, Linak WP, Gilmour MI. Effects of prenatal diesel exhaust inhalation on pulmonary inflammation and development of specific immune responses. Toxicol Lett. 2010;196(1):12–20.
Reiprich M, Rudzok S, Schutze N, Simon JC, Lehmann I, Trump S, et al. Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. Allergy. 2013;68(4):481–9.
Wang P, You D, Saravia J, Shen H, Cormier SA. Maternal exposure to combustion generated PM inhibits pulmonary Th1 maturation and concomitantly enhances postnatal asthma development in offspring. Part Fibre Toxicol. 2013;10:29.
El-Sayed YS, Shimizu R, Onoda A, Takeda K, Umezawa M. Carbon black nanoparticle exposure during middle and late fetal development induces immune activation in male offspring mice. Toxicology. 2015;327:53–61.
Paul E, Franco-Montoya ML, Paineau E, Angeletti B, Vibhushan S, Ridoux A, et al. Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring. Nanotoxicology. 2017;11(4):484–95.
de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Junior G, et al. Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ Pollut. 2018;241:511–20.
Meyer-Martin H, Reuter S, Taube C. Mouse models of allergic airway disease. Methods Mol Biol. 2014;1193:127–41.
Gutierrez-Vazquez C, Quintana FJ. Regulation of the immune response by the aryl hydrocarbon receptor. Immunity. 2018;48(1):19–33.
Ege MJ, Bieli C, Frei R, van Strien RT, Riedler J, Ublagger E, et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol. 2006;117(4):817–23.
Dysart MM, Galvis BR, Russell AG, Barker TH. Environmental particulate (PM2.5) augments stiffness-induced alveolar epithelial cell mechanoactivation of transforming growth factor beta. Plos One. 2014;9(9):e106821.
Suzuki T, Oshio S, Iwata M, Saburi H, Odagiri T, Udagawa T, et al. utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. Part Fibre Toxicol. 2010;7:7.
Onoda A, Takeda K, Umezawa M. Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle. Part Fibre Toxicol. 2017;14(1):4.
Kulas JA, Hettwer JV, Sohrabi M, Melvin JE, Manocha GD, Puig KL, et al. In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice. Environ Pollut. 2018;241:279–88.
Klocke C, Allen JL, Sobolewski M, Blum JL, Zelikoff JT, Cory-Slechta DA. Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology. 2018;65:196–206.
Woodward NC, Haghani A, Johnson RG, Hsu TM, Saffari A, Sioutas C, et al. Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits. Transl Psychiatry. 2018;8(1):261.
Cui J, Fu Y, Lu R, Bi Y, Zhang L, Zhang C, et al. Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice. Ecotoxicol Environ Saf. 2019;169:687–95.
Morris-Schaffer K, Merrill A, Jew K, Wong C, Conrad K, Harvey K, et al. Effects of neonatal inhalation exposure to ultrafine carbon particles on pathology and behavioral outcomes in C57BL/6J mice. Part Fibre Toxicol. 2019;16(1):10.
Loomes R, Hull L, WPL M. What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017;56(6):466–74.
DJ DS, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem. 2016;139(Suppl 2):136–53.
Bresgen N, Eckl PM. Oxidative stress and the homeodynamics of iron metabolism. Biomolecules. 2015;5(2):808–47.
Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, et al. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci. 2012;125(1):233–47.
Hamanaka RB, Mutlu GM. Particulate matter air pollution: effects on the cardiovascular system. Front Endocrinol (Lausanne). 2018;9:680.
Goodson JM, Weldy CS, JW MD, Liu Y, Bammler TK, Chien WM, et al. In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation. FASEB J. 2017;31(11):4935–45.
Ye Z, Lu X, Deng Y, Wang X, Zheng S, Ren H, et al. In utero exposure to fine particulate matter causes hypertension due to impaired renal dopamine D1 receptor in offspring. Cell Physiol Biochem. 2018;46(1):148–59.
Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol. 2002;53(4 Pt 1):503–14.
Yang W, Omaye ST. Air pollutants, oxidative stress and human health. Mutat Res. 2009;674(1-2):45–54.
Lo Sasso G, Schlage WK, Boue S, Veljkovic E, Peitsch MC, Hoeng J. The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction. J Transl Med. 2016;14(1):146.
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661–71.
Saenen ND, Martens DS, Neven KY, Alfano R, Bove H, Janssen BG, et al. Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype? Clin Epigenetics. 2019;11(1):124.
Yan Q, Liew Z, Uppal K, Cui X, Ling C, Heck JE, et al. Maternal serum metabolome and traffic-related air pollution exposure in pregnancy. Environ Int. 2019;130:104872.
Muoth C, Aengenheister L, Kucki M, Wick P, Buerki-Thurnherr T. Nanoparticle transport across the placental barrier: pushing the field forward! Nanomedicine (Lond). 2016;11(8):941–57.
Bove H, Bongaerts E, Slenders E, Bijnens EM, Saenen ND, Gyselaers W, et al. Ambient black carbon particles reach the fetal side of human placenta. Nat Commun. 2019;10(1):3866.
Valentino SA, Tarrade A, Aioun J, Mourier E, Richard C, Dahirel M, et al. Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits. Part Fibre Toxicol. 2016;13(1):39.
Veras MM, Damaceno-Rodrigues NR, Caldini EG, Maciel Ribeiro AA, Mayhew TM, Saldiva PH, et al. Particulate urban air pollution affects the functional morphology of mouse placenta. Biol Reprod. 2008;79(3):578–84.
Erickson AC, Arbour L. The shared pathoetiological effects of particulate air pollution and the social environment on fetal-placental development. J Environ Public Health. 2014;2014:901017.
Kannan S, Misra DP, Dvonch JT, Krishnakumar A. Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect. 2006;114(11):1636–42.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003;111(4):455–60.
Pardo M, Xu F, Shemesh M, Qiu X, Barak Y, Zhu T, et al. Nrf2 protects against diverse PM2.5 components-induced mitochondrial oxidative damage in lung cells. Sci Total Environ. 2019;669:303–13.
Stejskalova L, Pavek P. The function of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the placenta. Curr Pharm Biotechnol. 2011;12(5):715–30.
Yang SI, Kim BJ, Lee SY, Kim HB, Lee CM, Yu J, et al. Prenatal particulate matter/tobacco smoke increases infants’ respiratory infections: COCOA study. Allergy Asthma Immunol Res. 2015;7(6):573–82.
Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, et al. Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol. 2008;128(3):366–73.
Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, et al. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002;168(5):2560–7.
Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, et al. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol. 2007;27(20):7188–97.
Li N, Nel AE. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. Antioxid Redox Signal. 2006;8(1-2):88–98.
Gilmour MI, Jaakkola MS, London SJ, Nel AE, Rogers CA. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect. 2006;114(4):627–33.
Kabe Y, Ando K, Hirao S, Yoshida M, Handa H. Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal. 2005;7(3-4):395–403.
Wardyn JD, Ponsford AH, Sanderson CM. Dissecting molecular cross-talk between Nrf2 and NF-kappaB response pathways. Biochem Soc Trans. 2015;43(4):621–6.
Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW. When NRF2 talks, who’s listening? Antioxid Redox Signal. 2010;13(11):1649–63.
Nagiah S, Phulukdaree A, Naidoo D, Ramcharan K, Naidoo RN, Moodley D, et al. Oxidative stress and air pollution exposure during pregnancy: a molecular assessment. Hum Exp Toxicol. 2015;34(8):838–47.
Ambroz A, Vlkova V, Rossner P Jr, Rossnerova A, Svecova V, Milcova A, et al. Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. Int J Hyg Environ Health. 2016;219(6):545–56.
Ren C, Baccarelli A, Wilker E, Suh H, Sparrow D, Vokonas P, et al. Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study. J Epidemiol Community Health. 2010;64(1):49–56.
JGF H, Madhloum N, Saenen ND, Janssen BG, Penders J, Vanpoucke C, et al. Prenatal particulate air pollution exposure and cord blood homocysteine in newborns: results from the ENVIRONAGE birth cohort. Environ Res. 2019;168:507–13.
Saenen ND, Vrijens K, Janssen BG, Madhloum N, Peusens M, Gyselaers W, et al. Placental nitrosative stress and exposure to ambient air pollution during gestation: a population study. Am J Epidemiol. 2016;184(6):442–9.
Rosa MJ, Just AC, Guerra MS, Kloog I, Hsu HL, Brennan KJ, et al. Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood. Environ Int. 2017;98:198–203.
Brunst KJ, Sanchez-Guerra M, Chiu YM, Wilson A, Coull BA, Kloog I, et al. Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: effect modification by maternal lifetime trauma and child sex. Environ Int. 2018;112:49–58.
Grevendonk L, Janssen BG, Vanpoucke C, Lefebvre W, Hoxha M, Bollati V, et al. Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs. Environ Health. 2016;15:10.
Martens DS, Cox B, Janssen BG, DBP C, Gasparrini A, Vanpoucke C, et al. Prenatal air pollution and newborns’ predisposition to accelerated biological aging. JAMA Pediatr. 2017;171(12):1160–7.
Rosa MJ, Hsu HL, Just AC, Brennan KJ, Bloomquist T, Kloog I, et al. Association between prenatal particulate air pollution exposure and telomere length in cord blood: effect modification by fetal sex. Environ Res. 2019;172:495–501.
Vadillo-Ortega F, Osornio-Vargas A, Buxton MA, Sanchez BN, Rojas-Bracho L, Viveros-Alcaraz M, et al. Air pollution, inflammation and preterm birth: a potential mechanistic link. Med Hypotheses. 2014;82(2):219–24.
Lee PC, Talbott EO, Roberts JM, Catov JM, Sharma RK, Ritz B. Particulate air pollution exposure and C-reactive protein during early pregnancy. Epidemiology. 2011;22(4):524–31.
Mihu D, Costin N, Mihu CM, Blaga LD, Pop RB. C-reactive protein, marker for evaluation of systemic inflammatory response in preeclampsia. Rev Med Chir Soc Med Nat Iasi. 2008;112(4):1019–25.
Nachman RM, Mao G, Zhang X, Hong X, Chen Z, Soria CS, et al. Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston birth cohort. Environ Health Perspect. 2016;124(10):1608–15.
Fujimoto A, Tsukue N, Watanabe M, Sugawara I, Yanagisawa R, Takano H, et al. Diesel exhaust affects immunological action in the placentas of mice. Environ Toxicol. 2005;20(4):431–40.
de Melo JO, Soto SF, Katayama IA, Wenceslau CF, Pires AG, Veras MM, et al. Inhalation of fine particulate matter during pregnancy increased IL-4 cytokine levels in the fetal portion of the placenta. Toxicol Lett. 2015;232(2):475–80.
Liu W, Zhang M, Feng J, Fan A, Zhou Y, Xu Y: The influence of quercetin on maternal immunity, oxidative stress, and inflammation in mice with exposure of fine particulate matter during gestation. Int J Environ Res Public Health. 2017;14(6):592. https://doi.org/10.3390/ijerph14060592.
Veras MM, Guimaraes-Silva RM, Caldini EG, Saldiva PH, Dolhnikoff M, Mayhew TM. The effects of particulate ambient air pollution on the murine umbilical cord and its vessels: a quantitative morphological and immunohistochemical study. Reprod Toxicol. 2012;34(4):598–606.
Song P, Li Z, Li X, Yang L, Zhang L, Li N, Guo C, Lu S, Wei Y: Transcriptome profiling of the lungs reveals molecular clock genes expression changes after chronic exposure to ambient air particles. Int J Environ Res Public Health. 2017;14(1):90. Published online 2017 Jan 18. https://doi.org/10.3390/ijerph14010090.
Ferrari L, Carugno M, Bollati V. Particulate matter exposure shapes DNA methylation through the lifespan. Clin Epigenet. 2019;11(1):129.
Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Na Rev Genet. 2007;8(4):253.
Waddington CH: Organisers and genes. Organisers and genes 1940. https://www.amazon.com/Organisers-Genes-C-H-Waddington/dp/B000GU4IUM.
Vaiserman A. Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility? Clin Epigenet. 2015;7(1):96.
Janssen BG, Godderis L, Pieters N, Poels K, Kiciński M, Cuypers A, et al. Placental DNA hypomethylation in association with particulate air pollution in early life. Part Fibre Toxicol. 2013;10(1):22.
Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet. 2007;23(8):413–8.
Wilson AS, Power BE, Molloy PL. DNA hypomethylation and human diseases. Biochim Biophys Acta (BBA)-Rev Cancer. 2007;1775(1):138–62.
Reichetzeder C, Putra SD, Pfab T, Slowinski T, Neuber C, Kleuser B, et al. Increased global placental DNA methylation levels are associated with gestational diabetes. Clin Epigenet. 2016;8(1):82.
Jin S, Lee YK, Lim YC, Zheng Z, Lin XM, Ng DP, et al. Global DNA hypermethylation in down syndrome placenta. Plos Genet. 2013;9(6):e1003515.
Kingsley SL, Eliot MN, Whitsel EA, Huang YT, Kelsey KT, Marsit CJ, et al. Maternal residential proximity to major roadways, birth weight, and placental DNA methylation. Environ Int. 2016;92-93:43–9.
Maghbooli Z, Hossein-nezhad A, Adabi E, Asadollah-pour E, Sadeghi M, Mohammad-nabi S, Rad LZ, Hosseini A-aM, Radmehr M, Faghihi F: Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation. Plos One 2018, 13(7):e0199772.
Saenen ND, Vrijens K, Janssen BG, Roels HA, Neven KY, Vanden Berghe W, et al. Lower placental leptin promoter methylation in association with fine particulate matter air pollution during pregnancy and placental nitrosative stress at birth in the ENVIR ON AGE cohort. Environ Health Perspect. 2016;125(2):262–8.
Zhou G, He T, Huang H, Feng F, Liu X, Li Z, et al. Prenatal ambient air pollution exposure and SOD2 promoter methylation in maternal and cord blood. Ecotoxicol Environ Saf. 2019;181:428–34.
Breton CV, Gao L, Yao J, Siegmund KD, Lurmann F, Gilliland F. Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood. Environ Epigenet. 2016;2(2):dvw005.
Yang AS, Estécio MR, Doshi K, Kondo Y, Tajara EH, JPJ I. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 2004;32(3):e38.
Neven KY, Saenen ND, Tarantini L, Janssen BG, Lefebvre W, Vanpoucke C, et al. Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIRONAGE cohort study. Lancet Planet Health. 2018;2(4):e174–83.
Alvarado-Cruz I, Sánchez-Guerra M, Hernández-Cadena L, De Vizcaya-Ruiz A, Mugica V, Pelallo-Martínez NA, et al. Increased methylation of repetitive elements and DNA repair genes is associated with higher DNA oxidation in children in an urbanized, industrial environment. Mut Res. 2017;813:27–36.
Wallace DC. Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagenesis. 2010;51(5):440–50.
Janssen BG, Byun H-M, Gyselaers W, Lefebvre W, Baccarelli AA, Nawrot TS. Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: an ENVIR ON AGE birth cohort study. Epigenetics. 2015;10(6):536–44.
Nana-Sinkam SP, Hunter MG, Nuovo GJ, Schmittgen TD, Gelinas R, Galas D, et al. Integrating the MicroRNome into the study of lung disease. Am J Respir Crit Care Med. 2009;179(1):4–10.
Alvarez-Garcia I, Miska EA. MicroRNA functions in animal development and human disease. Development. 2005;132(21):4653–62.
Tsamou M, Vrijens K, Madhloum N, Lefebvre W, Vanpoucke C, Nawrot TS. Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. Epigenetics. 2018;13(2):135–46.
Bollati V, Marinelli B, Apostoli P, Bonzini M, Nordio F, Hoxha M, et al. Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes. Environ Health Perspect. 2010;118(6):763–8.
Bourdon JA, Saber AT, Halappanavar S, Jackson PA, Wu D, Hougaard KS, et al. Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung. Environ Mol Mutagenesis. 2012;53(6):462–8.
Janssen BG, Saenen ND, Roels HA, Madhloum N, Gyselaers W, Lefebvre W, et al. Fetal thyroid function, birth weight, and in utero exposure to fine particle air pollution: a birth cohort study. Environ Health Perspect. 2017;125(4):699–705.
Niu Y, Chen R, Xia Y, Cai J, Ying Z, Lin Z, et al. Fine particulate matter constituents and stress hormones in the hypothalamus-pituitary-adrenal axis. Environ Int. 2018;119:186–92.
Khamirchi R, Moslem A, Agah J, Pozo OJ, Miri M, Dadvand P. Maternal exposure to air pollution during pregnancy and cortisol level in cord blood. Sci Total Environ. 2020;713:136622.
Quintana-Belmares RO, Krais AM, Esfahani BK, Rosas-Perez I, Mucs D, Lopez-Marure R, et al. Phthalate esters on urban airborne particles: levels in PM10 and PM2.5 from Mexico City and theoretical assessment of lung exposure. Environ Res. 2018;161:439–45.
Nieuwenhuijsen MJ, Gascon M, Martinez D, Ponjoan A, Blanch J, Garcia-Gil MDM, Ramos R, Foraster M, Mueller N, Espinosa A et al: Air pollution, noise, blue space, and green space and premature mortality in Barcelona: a mega cohort. Int J Environ Res Public Health. 2018;15(11):2405. https://doi.org/10.3390/ijerph15112405.
Bloemsma LD, Gehring U, Klompmaker JO, Hoek G, NAH J, Lebret E, et al. Green space, air pollution, traffic noise and cardiometabolic health in adolescents: the PIAMA birth cohort. Environ Int. 2019;131:104991.
The impact of green space on heat and air pollution in urban communities: a meta-narrative systematic review. https://davidsuzuki.org/wp-content/uploads/2017/09/impact-green-space-heat-air-pollution-urban-communities.pdf. Accessed 10 Feb 2020.
Lovasi GS, Quinn JW, Neckerman KM, Perzanowski MS, Rundle A. Children living in areas with more street trees have lower prevalence of asthma. J Epidemiol Community Health. 2008;62(7):647–9.
Dadvand P, de Nazelle A, Triguero-Mas M, Schembari A, Cirach M, Amoly E, et al. Surrounding greenness and exposure to air pollution during pregnancy: an analysis of personal monitoring data. Environ Health Perspect. 2012;120(9):1286–90.
Nardone A, Rudolph KE, Morello-Frosch R, Casey JA. Redlines and greenspace: the relationship between historical redlining and 2010 greenspace across the United States. Environ Health Perspect. 2021;129(1):17006.
Mikati I, Benson AF, Luben TJ, Sacks JD, Richmond-Bryant J. Disparities in distribution of particulate matter emission sources by race and poverty status. Am J Public Health. 2018;108(4):480–5.
Fahey JW, Talalay P, Kensler TW. Notes from the field: “green” chemoprevention as frugal medicine. Cancer Prev Res (Phila). 2012;5(2):179–88.
Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim Biophys Acta. 2012;1822(5):714–28.
Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Munoz A, et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis. 2012;33(1):101–7.
Jedrychowski W, Perera F, Mrozek-Budzyn D, Flak E, Mroz E, Sochacka-Tatara E, et al. Higher fish consumption in pregnancy may confer protection against the harmful effect of prenatal exposure to fine particulate matter. Ann Nutr Metab. 2010;56(2):119–26.
Jedrychowski W, Perera F, Maugeri U, Mrozek-Budzyn D, Miller RL, Flak E, et al. Effects of prenatal and perinatal exposure to fine air pollutants and maternal fish consumption on the occurrence of infantile eczema. Int Arch Allergy Immunol. 2011;155(3):275–81.
Calderon-Garciduenas L, San Juan Chavez V, Vacaseydel-Aceves NB, Calderon-Sanchez R, Macias-Escobedo E, Frias C, et al. Chocolate, air pollution and children’s neuroprotection: what cognition tools should be at hand to evaluate interventions? Front Pharmacol. 2016;7:232.
Calderon-Garciduenas L, Mora-Tiscareno A, Franco-Lira M, Cross JV, Engle R, Aragon-Flores M, et al. Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children. Front Pharmacol. 2013;4:104.
Grassi D, Desideri G, Mai F, Martella L, De Feo M, Soddu D, et al. Cocoa, glucose tolerance, and insulin signaling: cardiometabolic protection. J Agric Food Chem. 2015;63(45):9919–26.
Li G, Chan YL, Sukjamnong S, Anwer AG, Vindin H, Padula M, Zakarya R, George J, Oliver BG, Saad S et al: A mitochondrial specific antioxidant reverses metabolic dysfunction and fatty liver induced by maternal cigarette smoke in mice. Nutrients. 2019;11(7):1669. Published online 2019 July 21. https://doi.org/10.3390/nu11071669.
Onoda A, Takeda K, Umezawa M. Pretreatment with N-acetyl cysteine suppresses chronic reactive astrogliosis following maternal nanoparticle exposure during gestational period. Nanotoxicology. 2017;11(8):1012–25.
Zhang Y, Darland D, He Y, Yang L, Dong X, Chang Y: Reduction of Pm2.5 toxicity on human alveolar epithelial cells A549 by tea polyphenols. J Food Biochem. 2018;42(3):e12496. https://doi.org/10.1111/jfbc.12496. Epub 2018 Jan 18.
Zielinsky P, Busato S. Prenatal effects of maternal consumption of polyphenol-rich foods in late pregnancy upon fetal ductus arteriosus. Birth Defects Res C Embryo Today. 2013;99(4):256–74.
Folic acid for the prevention of neural tube defects. American Academy of Pediatrics. Committee on Genetics. Pediatrics 1999, 104(2 Pt 1):325-327.
Yue C, Ji C, Zhang H, Zhang LW, Tong J, Jiang Y, et al. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/beta-catenin signal pathways. Environ Toxicol. 2017;32(10):2316–22.
Jiang Y, Li J, Ren F, Ji C, Aniagu S, Chen T. PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Environ Pollut. 2019;255(Pt 3):113331.