Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis

Molecular Cell - Tập 77 - Trang 600-617.e4 - 2020
Hai P. Nguyen1,2, Danielle Yi1,2, Frances Lin2, Jose A. Viscarra2, Chihiro Tabuchi2, Katina Ngo2, Gawon Shin2, Angus Yiu-fai Lee3, Yuhui Wang2, Hei Sook Sul1,2
1Endocrinology Program, University of California, Berkeley, Berkeley, CA, USA
2Department of Nutritional Sciences & Toxicology, University of California Berkeley, Berkeley, CA, USA.
3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA

Tài liệu tham khảo

Ahmadian, 2011, Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype, Cell Metab., 13, 739, 10.1016/j.cmet.2011.05.002 Alfadda, 2004, Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender, Am. J. Physiol. Regul. Integr. Comp. Physiol., 287, R147, 10.1152/ajpregu.00103.2004 Barquissau, 2016, White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways, Mol. Metab., 5, 352, 10.1016/j.molmet.2016.03.002 Barron, 1998, Malate-aspartate shuttle, cytoplasmic NADH redox potential, and energetics in vascular smooth muscle, J. Mol. Cell. Cardiol., 30, 1571, 10.1006/jmcc.1998.0722 Bartelt, 2014, Adipose tissue browning and metabolic health, Nat. Rev. Endocrinol., 10, 24, 10.1038/nrendo.2013.204 Betz, 2018, Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease, Nat. Rev. Endocrinol., 14, 77, 10.1038/nrendo.2017.132 Blondin, 2017, Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans, Cell Metab., 25, 438, 10.1016/j.cmet.2016.12.005 Cannon, 1979, The physiological role of pyruvate carboxylation in hamster brown adipose tissue, Eur. J. Biochem., 94, 419, 10.1111/j.1432-1033.1979.tb12909.x Cannon, 2004, Brown adipose tissue: function and physiological significance, Physiol. Rev., 84, 277, 10.1152/physrev.00015.2003 Carpentier, 2018, Brown Adipose Tissue Energy Metabolism in Humans, Front. Endocrinol. (Lausanne), 9, 447, 10.3389/fendo.2018.00447 Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N. Engl. J. Med., 360, 1509, 10.1056/NEJMoa0810780 DosSantos, 2003, Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol-3-phosphate dehydrogenase gene, Endocrinology, 144, 5469, 10.1210/en.2003-0687 Dupuis, 2010, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, Nat. Genet., 42, 105, 10.1038/ng.520 Elguindy, 2015, Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2), J. Biol. Chem., 290, 20815, 10.1074/jbc.M115.641498 Feldmann, 2009, UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality, Cell Metab., 9, 203, 10.1016/j.cmet.2008.12.014 Harris, 2012, A single centrifugation method for isolating fat droplets from cells and tissues, J. Lipid Res., 53, 1021, 10.1194/jlr.D023598 Heid, 2010, Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution, Nat. Genet., 42, 949, 10.1038/ng.685 Hung, 2011, Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor, Cell Metab., 14, 545, 10.1016/j.cmet.2011.08.012 Inokuma, 2005, Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue, Diabetes, 54, 1385, 10.2337/diabetes.54.5.1385 Iwata, 2012, The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates, Proc. Natl. Acad. Sci. USA, 109, 15247, 10.1073/pnas.1210059109 Iwen, 2017, Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men, J. Clin. Endocrinol. Metab., 102, 4226, 10.1210/jc.2017-01250 Jeong, 2018, Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice, Sci. Rep., 8, 6672, 10.1038/s41598-018-25265-3 Jimenez, 2013, In vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice, Diabetes, 62, 4012, 10.2337/db13-0311 Kajimura, 2008, Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex, Genes Dev., 22, 1397, 10.1101/gad.1666108 Kauppinen, 1987, Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates, Biochim. Biophys. Acta, 930, 173, 10.1016/0167-4889(87)90029-2 Kozak, 1994, An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene, Mol. Cell. Biol., 14, 59, 10.1128/MCB.14.1.59 Kriszt, 2017, Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes, Sci. Rep., 7, 1383, 10.1038/s41598-017-00291-9 Luttik, 1998, The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH, J. Biol. Chem., 273, 24529, 10.1074/jbc.273.38.24529 Marshall, 2005, The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity, J. Biol. Chem., 280, 30735, 10.1074/jbc.M414018200 Mei, 2006, The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression, Oncogene, 25, 849, 10.1038/sj.onc.1209121 Melo, 2004, New insights into type II NAD(P)H:quinone oxidoreductases, Microbiol. Mol. Biol. Rev., 68, 603, 10.1128/MMBR.68.4.603-616.2004 Nedergaard, 2010, Three years with adult human brown adipose tissue, Ann. N Y Acad. Sci., 1212, E20, 10.1111/j.1749-6632.2010.05905.x Ohiro, 2002, A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF), FEBS Lett., 524, 163, 10.1016/S0014-5793(02)03049-1 Reers, 1995, Mitochondrial membrane potential monitored by JC-1 dye, Methods Enzymol., 260, 406, 10.1016/0076-6879(95)60154-6 Salvioli, 1997, JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis, FEBS Lett., 411, 77, 10.1016/S0014-5793(97)00669-8 Schmitt, 2000, β 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf, J. Biol. Chem., 275, 25342, 10.1074/jbc.M003213200 Schreiber, 2017, Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue, Cell Metab., 26, 753, 10.1016/j.cmet.2017.09.004 Shin, 2017, Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice, Cell Metab., 26, 764, 10.1016/j.cmet.2017.09.002 Speliotes, 2010, Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, Nat. Genet., 42, 937, 10.1038/ng.686 Suzuki, 2010, Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system, Proteomics, 10, 1780, 10.1002/pmic.200900783 Symonds, 2018, Recent advances in our understanding of brown and beige adipose tissue: the good fat that keeps you healthy, F1000Res., 7, 10.12688/f1000research.14585.1 U Din, 2018, Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis, Cell Metab., 28, 207, 10.1016/j.cmet.2018.05.020 van Marken Lichtenbelt, 2009, Cold-activated brown adipose tissue in healthy men, N. Engl. J. Med., 360, 1500, 10.1056/NEJMoa0808718 Vergnes, 2014, Adaptive thermogenesis in white adipose tissue: is lactate the new brown(ing)?, Diabetes, 63, 3175, 10.2337/db14-0815 Virtanen, 2009, Functional brown adipose tissue in healthy adults, N. Engl. J. Med., 360, 1518, 10.1056/NEJMoa0808949 Winther, 2018, Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption, Am. J. Physiol. Endocrinol. Metab., 314, E214, 10.1152/ajpendo.00218.2017 Wu, 2004, AMID is a p53-inducible gene downregulated in tumors, Oncogene, 23, 6815, 10.1038/sj.onc.1207909 Yamashita, 2018, Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors, Sci. Rep., 8, 2427, 10.1038/s41598-018-20775-6 Yu, 2002, Cold elicits the simultaneous induction of fatty acid synthesis and beta-oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo, FASEB J., 16, 155, 10.1096/fj.01-0568com