Agonist-like SERM effects on ERα-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus

Angela Scafonas1, Alfred A. Reszka1, Donald B. Kimmel1, Xiaoli Shirley Hou2, Qin Su1, Elizabeth T. Birzin1, Seongkon Kim3, Helen Y. Chen3, Qiang Tan3, Susan P. Roher1, Frank Dininno3, Milton L. Hammond3, Gideon A. Rodan1, Dwight A. Towler4, Azriel Schmidt1
1Molecular Endocrinology, Merck Research Laboratories, West Point, PA 19486, United States
2Biometrics Research, Merck Research Laboratories, West Point, PA 19486, United States
3Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, United States
4Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, United States

Tài liệu tham khảo

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