Aging, immunity and cancer

Linton, 2001, T cell senescence, Front Biosci, 6, D248, 10.2741/Linton Grubeck-Loebenstein, 2002, The aging of the immune system, Adv Immunol, 80, 243, 10.1016/S0065-2776(02)80017-7 Pawelec, 2002, T cells and aging, January 2002 update, Front Biosci, 7, d1056, 10.2741/A831 Ligthart, 2001, The SENIEUR protocol after 16 years: the next step is to study the interaction of ageing and disease, Mech Ageing Dev, 122, 136, 10.1016/S0047-6374(00)00242-6 Pawelec, 2002, Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’, Trends Immunol, 23, 330, 10.1016/S1471-4906(02)02255-X Huppert, 2003, Survival in a population sample is predicted by proportions of lymphocyte subsets, Mech Ageing Dev, 124, 449, 10.1016/S0047-6374(03)00021-6 Lansdorp, 1994, Age-related decline in proliferative potential of purified stem cell candidates, Blood Cells, 20, 376 Nilsson-Ehle, 1995, Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects, Eur J Haematol, 55, 14, 10.1111/j.1600-0609.1995.tb00227.x Ogawa, 2000, Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages, Mech Ageing Dev, 117, 57, 10.1016/S0047-6374(00)00137-8 Anderlini, 1997, Collection of peripheral blood stem cells from normal donors 60 years of age or older, Br J Haematol, 97, 485, 10.1046/j.1365-2141.1997.302677.x Sharp, 1990, In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors, Eur J Immunol, 20, 2541, 10.1002/eji.1830201203 Stephan, 1998, Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age, Blood, 91, 75, 10.1182/blood.V91.1.75 Imai, 2000, Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population, Lancet, 356, 1795, 10.1016/S0140-6736(00)03231-1 Takeuchi, 2001, Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis, Am J Gastroenterol, 96, 574, 10.1111/j.1572-0241.2001.03535.x Borrego, 1999, NK phenotypic markers and IL2 response in NK cells from elderly people, Exp Gerontol, 34, 253, 10.1016/S0531-5565(98)00076-X Miyaji, 2000, Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians, Hum Immunol, 61, 908, 10.1016/S0198-8859(00)00153-1 Bonafe, 2001, The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old, Crit Rev Oncol Hematol, 39, 227, 10.1016/S1040-8428(01)00168-8 Weksler, 2000, The effect of age on the B-cell repertoire, J Clin Immunol, 20, 240, 10.1023/A:1006659401385 Fisman, 2002, The effect of age on immunologic response to recombinant hepatitis B vaccine: a meta-analysis, Clin Infect Dis, 35, 1368, 10.1086/344271 Remarque, 1996, Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy aging, Vaccine, 14, 127, 10.1016/0264-410X(95)00155-T Zheng, 1997, Immunosenescence and germinal center reaction, Immunol Rev, 160, 63, 10.1111/j.1600-065X.1997.tb01028.x Aydar, 2002, Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation, Eur J Immunol, 32, 2817, 10.1002/1521-4141(2002010)32:10<2817::AID-IMMU2817>3.0.CO;2-Z Colonna-Romano, 2003, B cells in the aged: CD27, CD5, and CD40 expression, Mech Ageing Dev, 124, 389, 10.1016/S0047-6374(03)00013-7 Breitbart, 2002, Altered memory B-cell homeostasis in human aging, J Gerontol A Biol Sci Med Sci, 57, B304, 10.1093/gerona/57.8.B304 Motta, 2003, Alterations of the lymphocytic set-up in elderly patients with cancer, Arch Gerontol Geriatr, 36, 7, 10.1016/S0167-4943(02)00053-5 Haynes, 2000, The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection, Annu Rev Immunol, 18, 529, 10.1146/annurev.immunol.18.1.529 De Rosa, 2001, 11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity, Nat Med, 7, 245, 10.1038/84701 Schwab, 1997, Expanded CD4+ and CD8+ T cell clones in elderly humans, J Immunol, 158, 4493 Fry, 2002, Current concepts of thymic aging, Springer Semin Immunopathol, 24, 7, 10.1007/s00281-001-0092-5 Ortman, 2002, Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments, Int Immunol, 14, 813, 10.1093/intimm/dxf042 Yehuda, 1998, Checkpoints in thymocytopoiesis in aging: expression of the recombination activating genes RAG-1 and RAG-2, Mech Ageing Dev, 102, 239, 10.1016/S0047-6374(98)00021-9 Andrew, 2002, Age-associated thymic atrophy is linked to a decline in IL-7 production, Exp Gerontol, 37, 455, 10.1016/S0531-5565(01)00213-3 Andrew, 2001, Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice, J Immunol, 166, 1524, 10.4049/jimmunol.166.3.1524 Sempowski, 2000, Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy, J Immunol, 164, 2180, 10.4049/jimmunol.164.4.2180 Sempowski, 2002, Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy, Eur J Immunol, 32, 3066, 10.1002/1521-4141(200211)32:11<3066::AID-IMMU3066>3.0.CO;2-J Forsey, 2003, Plasma cytokine profiles in elderly humans, Mech Ageing Dev, 124, 487, 10.1016/S0047-6374(03)00025-3 Fagnoni, 2000, Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging, Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868 Zanni, 2003, Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8(+) T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence, Exp Gerontol, 38, 981, 10.1016/S0531-5565(03)00160-8 Ouyang, 2003, Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old, J Clin Immunol, 23, 247, 10.1023/A:1024580531705 Wikby, 2002, Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study, Exp Gerontol, 37, 445, 10.1016/S0531-5565(01)00212-1 Valenzuela, 2002, Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus, Clin Immunol, 105, 117, 10.1006/clim.2002.5271 Brenchley, 2003, Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells, Blood, 101, 2711, 10.1182/blood-2002-07-2103 Ouyang, 2003, An age-related increase in the number of CD8(+) T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness, Mech Ageing Dev, 124, 477, 10.1016/S0047-6374(03)00026-5 Hakim, 1997, Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells, Blood, 90, 3789, 10.1182/blood.V90.9.3789 Mackall, 1995, Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy, N Engl J Med, 332, 143, 10.1056/NEJM199501193320303 Mackall, 1997, Thymic aging and T-cell regeneration, Immunol Rev, 160, 91, 10.1111/j.1600-065X.1997.tb01030.x Klein, 2001, T-cell recovery in adults and children following umbilical cord blood transplantation, Biol Blood Marrow Transplant, 7, 454, 10.1016/S1083-8791(01)80013-6 Douek, 2000, Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution, Lancet, 355, 1875, 10.1016/S0140-6736(00)02293-5 Mackall, 1998, Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution, Eur J Immunol, 28, 1886, 10.1002/(SICI)1521-4141(199806)28:06<1886::AID-IMMU1886>3.0.CO;2-M Mackall, 1997, Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy, Blood, 89, 3700, 10.1182/blood.V89.10.3700 Dumont-Girard, 1998, Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants, Blood, 92, 4464, 10.1182/blood.V92.11.4464 Street, 2002, Suppression of lymphoma and epithelial malignancies effected by interferon gamma, J Exp Med, 196, 129, 10.1084/jem.20020063 Smyth, 2000, Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma, J Exp Med, 192, 755, 10.1084/jem.192.5.755 DePinho, 2000, The age of cancer, Nature, 408, 248, 10.1038/35041694 Stanta, 1997, Cancer of the oldest old. What we have learned from autopsy studies, Clin Geriatr Med, 13, 55, 10.1016/S0749-0690(18)30182-4 Ershler, 1997, Aging and cancer: issues of basic and clinical science, J Natl Cancer Inst, 89, 1489, 10.1093/jnci/89.20.1489 French, 2002, Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution, Endocrinology, 143, 690, 10.1210/en.143.2.690 Min, 2002, Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation, Blood, 99, 4592, 10.1182/blood.V99.12.4592