Aging and cancer: are telomeres and telomerase the connection?

Wright, 1989, Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts, Mol. Cell. Biol., 9, 3088, 10.1128/MCB.9.7.3088

Shay, 1991, A role for both RB and p53 in the regulation of human cellular senescence, Exp. Cell Res., 196, 33, 10.1016/0014-4827(91)90453-2

Hara, 1991, Cooperative effect of antisense-RB and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1, Biochem. Biophys. Res. Commun., 179, 528, 10.1016/0006-291X(91)91403-Y

Counter, 1992, Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity, EMBO. J., 11, 1921, 10.1002/j.1460-2075.1992.tb05245.x

Shay, 1993, E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts, Oncogene, 8, 1407

Watson, 1972, Origin of concatameric T4 DNA, Nature (London), 239, 197

Muller, 1938, The remaking of chromosomes, The Collecting Net. Woods Hole, 13, 181

McClintock, 1941, The stability of broken ends of chromosomes in Zea mays, Genetics, 41, 234, 10.1093/genetics/26.2.234

Blackburn, 1978, A tandemly repeated sequence at the termini of the extrachromosomal RNA genes in Tetrahymena, J. Mol. Biol., 120, 33, 10.1016/0022-2836(78)90294-2

Greider, 1985, Identification of a specific telomere terminal tranferase activity in Tetrahymena extracts, Cell, 43, 405, 10.1016/0092-8674(85)90170-9

Morin, 1989, The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats, Cell, 59, 521, 10.1016/0092-8674(89)90035-4

Cooke, 1986, Variability at the telomeres of the human X/Y pseudoautosomal region, 6, 213

Allshire, 1988, Telomeric repeat from T. thermophila cross hybridizes the human telomeres, Nature, 332, 656, 10.1038/332656a0

Harley, 1990, Telomeres shorten during aging of human fibroblasts, Nature, 345, 458, 10.1038/345458a0

Hastie, 1990, Telomere reduction in human colorectal carcinoma and with aging, Nature, 346, 866, 10.1038/346866a0

de Lange, 1990, Structure and variability of human chromosome ends, Mol. Cell. Biol., 10, 518, 10.1128/MCB.10.2.518

Greider, 1990, Telomeres, telomerase and senescence, Bioessays, 12, 363, 10.1002/bies.950120803

Harley, 1991, Telomere loss: mitotic clock or genetic time bomb?, Mutat. Res., 256, 271, 10.1016/0921-8734(91)90018-7

Harley, 1995, Telomeres and aging: fact, fancy, and the future, J. NIH Res., 7, 64

Lundblad, 1989, A mutant with a defect in telomere elongation leads to senescence in yeast, Cell, 57, 633, 10.1016/0092-8674(89)90132-3

Sandell, 1993, Loss of a yeast telomere: arrest recovery and chromosome loss, Cell, 75, 729, 10.1016/0092-8674(93)90493-A

Singer, 1994, TLC1: template RNA component of Saccharomyces cerevisiae telomerase, Science, 266, 404, 10.1126/science.7545955

Allsopp, 1992, Telomere length predicts replicative capacity of human fibroblasts, 89, 10114

Vaziri, 1993, Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes, Am. J. Hum. Genet., 52, 661

Goldstein, 1990, Replicative senescence: the human fibroblast comes of age, Science, 249, 1129, 10.1126/science.2204114

Zglinick, 1995, Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?, Exp. Cell. Res., 220, 186, 10.1006/excr.1995.1305

Wright, 1992, Telomere positional effects and the regulation of cellular senescence, Trends Genet., 8, 193, 10.1016/0168-9525(92)90232-S

Wright, 1995, Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?, Trends Cell Biol., 5, 293, 10.1016/S0962-8924(00)89044-3

Kim, 1994, Specific association of human telomerase activity with immortal cells and cancer, Science, 266, 2011, 10.1126/science.7605428

Counter, 1994, 91, 2900

Hiyama, 1995, Correlating telomerase activity levels with human neuroblastoma outcomes, Nat. Med., 1, 249, 10.1038/nm0395-249

Hiyama, 1995, Telomerase activity in gastric cancer, Cancer Res., 455, 3258

Hiyama, 1995, Telomerase activity in small-cell and non-small-cell lung cancers, J. Natl Cancer Inst., 87, 895, 10.1093/jnci/87.12.895

Chadeneau, 1995, Telomerase activity associated with acquisition of malignancy in human colorectal cancer, Cancer Res., 55, 2533

Tahara, 1995, Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas, Cancer Res., 55, 2734

Counter, 1995, Telomerase activity in normal leukocytes and in hematologic malignancies, Blood, 85, 2315, 10.1182/blood.V85.9.2315.bloodjournal8592315

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Piatyszek, 1995, Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP), Methods Cell Sci., 17, 1, 10.1007/BF00981880

Feng, 1995, The RNA component of human telomerase, Science, 269, 1236, 10.1126/science.7544491

Blasco, 1995, Functional characterization and developmental regulation of mouse telomerase RNA, Science, 269, 1267, 10.1126/science.7544492