Ageing of the human metaorganism: the microbial counterpart

Springer Science and Business Media LLC - Tập 34 Số 1 - Trang 247-267 - 2012
Elena Biagi1, Marco Candela1, Susan J. Fairweather‐Tait2, Claudio Franceschi3, Patrizia Brigidi1
1University of Bologna,
2#N#University of East Anglia
3Department of Experimental Pathology and CIG - Interdipartimental Center L. Galvani, University of Bologna, Bologna, Italy

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Aldoori WH, Giovannucci EL, Rockett HR, Sampson L, Rimm EB, Willett WC (1998) A prospective study of dietary fiber type and symptomatic diverticular disease in men. J Nutr 128:714–719

Allen LH (2008) Causes of vitamin B12 and folate deficiency. Food Nutr Bull 29:S20–S34

Amhed M, Prased J, Gill H, Stevenson L, Gopal P (2007) Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging 11:26–31

An HM, Baek EH, Jang S, Lee DK, Kim MJ, Kim JR, Lee KO, Park JG, Ha NJ (2010) Efficacy of lactic acid bacteria (LAB) supplement in management of constipation among nursing home residents. Nutr J 9:5

Andersson AF, Lindberg M, Jakobsson H, Backhed F, Nyrén P, Engstrand L (2008) Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS ONE 3:e2836

Antoine JM (2010) Probiotics: beneficial factors of the defence system. Proc Nutr Soc 69:429–433

Armougom F, Raoult D (2008) Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans. BMC Genomics 9:576

Arunachalam K, Gills HS, Chandra RK (2000) Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 54:263–267

Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307:1915–1920

Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF (2010) An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am J Clin Nutr 91:1044–1059

Barbut F, Petit JC (2001) Epidemiology of Clostridium difficile-associated infections. Clin Microbiol Infect 7:405–410

Bartosch S, Fite A, Macfarlane GT, McMurdo MET (2004) Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real time PCR and effects of antibiotic treatment on the fecal microbiota. Appl Environ Microbiol 70:3575–3581

Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo MET, Macfarlane GT (2005) Microbiological effects of consuming a symbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis and oligofructose in elderly persons, determined by real time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis 40:28–37

Biagi E, Nylund L, Candela M, Bucci L, Ostan R, Nikkila J, Monti D, Satokari R, Franceschi C, Brigidi P, de Vos WM (2010) Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE 5:e10667

Blum S, Haller D, Pfeifer A, Schiffrin EJ (2002) Probiotics and immune response. Clin Rev Allergy Immunol 22:287–309

Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S (2009) A probiotic fermented diary drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine 27:5677–5684

Bouhnik Y, Achour L, Paineau D, Riottot M, Attar A, Bornet F (2007) Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutr J 6:42

Candela M, Maccaferri S, Turroni S, Carnevali P, Brigidi P (2010) Functional intestinal microbiome, new frontiers in prebiotic design. Int J Food Microbiol 140:93–101

Candela M, Guidotti M, Fabbri A, Brigidi P, Franceschi C, Fiorentini C (2011) Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Crit Rev Microbiol 37:1–14

Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listì F, Scola L, Vasto S, Caruso C (2008) Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuv Res 11:425–432

Carlsson M, Gustafson Y, Haglin L, Eriksson S (2009) The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB21 and Lactococcus lactis L1A—a pilot study among old people with dementia in a residential care facility. J Nutr Health Aging 13:813–819

Chang JY, Antonopoulos DA, Kalra A, Tonelli A, Khalife WT, Schmidt TM, Young WB (2008) Decreased diversity of fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis 197:435–438

Chermesh I, Eliakim R (2006) Probiotics and the gastrointestinal tract: where are we in 2005? World J Gastroenterol 12:853–857

Chiang BL, Sheih YH, Wang LH, Lial CH, Gills HS (2000) Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr 54:849–855

Chmielewska A, Szajewska H (2010) Systematic review of randomised controlled trials: probiotics for functional constipation. World J Gastroenterol 16:69–75

Christensen K, Doblhammer G, Rau R, Vaupel JW (2009) Ageing populations: the challenges ahead. Lancet 374:1196–1208

Claesson MJ, O'Sullivan O, Wang Q, Nikkila J, Marchesi JR, Smidt H, de Vos WM, Paul Ross R, O'Toole PW (2009) Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE 4:e6669

Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, de Weerd H, Flannery E et al. (2010) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1000097107

Cober ED, Malani PN (2009) Clostridium difficile infections in the “oldest” old: clinical outcomes in patients aged 80 and older. J Am Geriatr Soc 57:659–662

Cohen JE (2003) Human population: the next half century. Science 302:1172–1175

Comparato G, Pilotto A, Franzè A, Franceschi M, Di Mario F (2007) Diverticular disease in the elderly. Dig Dis 25:151–159

Cummings JH (1995) Short chain fatty acids. In: Gibson GR, Macfarlane GT (eds) Human colonic bacteria: role in nutrition, physiology and health. CRC, Boca Raton

Cust AE, Skilton MR, van Bakel MM, Halkjaer J, Olsen A, Agnoli C, Psaltopoulou T, Buurma E, Sonestedt E, Chirlaque MD, Rinaldi S, Tjønneland A, Jensen MK, Clavel-Chapelon F, Boutron-Ruault MC, Kaaks R, Nöthlings U, Chloptsios Y, Zylis D, Mattiello A, Caini S, Ocké MC, van der Schouw YT, Skeie G, Parr CL, Molina-Montes E, Manjer J, Johansson I, McTaggart A, Key TJ, Bingham S, Riboli E, Slimani N (2009) Total dietary carbohydrate, sugar, starch and fibre intakes in the European Prospective Investigation into Cancer and Nutrition. Eur J Clin Nutr 63:S37–S60

Dahl WJ, Whiting SJ, Healey A, Zello GA, Hilderbrandt SL (2003) Increased stool frequency occurs when finely processed pea hull fiber is added to usual foods consumed by elderly residents in long-term care. J Am Diet Assoc 103:1199–1202

Dali-Youcef N, Andrès E (2009) An update on cobalamin deficiency in adults. QJ Med 102:17–28

De Benedictis G, Franceschi C (2006) The unusual genetics of human longevity. Sci Aging Knowledge Environ 10:pe20

de Groot LC, Verheijden MW, de Henauw S, Schroll M, van Staveren WA, SENECA Investigators (2004) Lifestyle, nutritional status, health, and mortality in elderly people across Europe: a review of the longitudinal results of the SENECA study. J Gerontol A Biol Sci Med Sci 59:1277–1284

Dean M, Raats MM, Grunert KG, Lumbers M, Food in Later Life Team (2009) Factors influencing eating a varied diet in old age. Public Health Nutr 12:2421–2427

den Elzen WP, Groeneveld Y, de Ruijter W, Souverijn JH, le Cessie S, Assendelft WJ, Gussekloo J (2008) Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther 27:491–497

Dethlefsen L, Huse S, Sogin ML, Reiman D (2008) The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6:e280

Dixon T, Mitchell P, Beringer T, Gallacher S, Moniz C, Patel S, Pearson G, Ryan P (2006) An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 22:405–415

Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L (1984) Smell identification ability: changes with age. Science 226:1441–1443

Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA (2005) Diversity of the human intestinal flora. Science 308:1635–1638

Ervin RB (2008) Healthy Eating Index scores among adults, 60 years of age and over, by sociodemographic and health characteristics: United States, 1999–(2002). Adv Data 395:1–16

FAO/WHO (2001) Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. ftp://ftp.fao.org/es/esn/food/probio_report_en.pdf

Fernández-Bañares F, Monzón H, Forné M (2009) A short review of malabsorption and anemia. World J Gastroenterol 15:4644–4652

Finch S, Doyle W, Lowe C, Bates CJ, Prentice A, Smithers G, Clarke PC (1998) National Diet and Nutrition Survey: people aged 65 years and over. The Stationery Office, London

Flint HJ, Duncan SH, Scott KP, Louis P (2007) Interactions and competition within the microbial community of the human colon: links between diet and health. Environ Microbiol 9:1101–1111

Franceschi C (2007) Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev 65:S173–S176

Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128:92–105

Frank DN, St. Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 104:13780–13785

Fukoshima Y, Miyaguchi S, Yamano T, Kaburagi T, Iino H, Ushida K, Sato K (2007) Improvement of nutritional status and incidence of infections in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533). Br J Nutr 98:969–977

Gallagher P, O'Mahony D (2009) Constipation in old age. Best Pract Res Clin Gastroenterol 23:875–887

Gavazzi G, Krause KH (2002) Ageing and infections. Lancet Infect Dis 2:659–666

Gavini F, Cayuela C, Antoine JM, Lecoq C, Le Fabure B, Membré JM, Neut C (2001) Differences in distribution of bifidobacterial and enterobacterial species in human fecal microflora of three different (children, adults, elderly) age groups. Microb Ecol Health Dis 13:40–45

Genser D (2008) Food and drug interaction: consequences for the nutrition/health status. Ann Nutr Metab 52:29–32

Gibson GR, Roberfoid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412

Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259–275

Gill SR, Pop M, DeBoy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE (2006) Metagenomic analysis of the human distal gut microbiome. Science 312:1355–1359

Gills HS, Rutherfurd KJ, Cross ML (2001a) Dietary probiotic supplementation enhances natural killer cells activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol 21:264–271

Gills HS, Rutherfurd KJ, Cross ML, Gopal PK (2001b) Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr 74:833–839

Goodwin K, Viboud C, Simonsen L (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24:1159–1169

Guigoz Y, Rochat F, Perruisseau-Carrier G, Rochat I, Schiffrin J (2002) Effects of oligosaccharide on the fecal flora and non-specific immune system in elderly people. Nutr Res 22:13–25

Guigoz Y, Doré J, Schiffrin J (2008) The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care 11:13–20

Guillermard E, Tondu F, Lacoin F, Schrezenmeir J (2010) Consumption of a fermented diary product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr 103:58–68

Harris DG, Davies C, Ward H, Haboubi NY (2008) An observational study of screening for malnutrition in elderly people living in sheltered accommodation. J Hum Nutr Diet 21:3–9

Hattori M, Taylor TD (2009) The human intestinal microbiome: a new frontier of human biology. DNA Res 16:1–12

Hayashi H, Sakamoto M, Kitahara M, Benno Y (2003) Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP. Microbiol Immunol 47:557–570

Henry HL, Bouillon R, Norman AW, Gallagher JC, Lips P, Heaney RP, Vieth R, Pettifor JM, Dawson-Hughes B, Lamberg-Allardt CJ, Ebeling PR (2010) 14th Vitamin D Workshop consensus on vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 121:4–6

Heuvelin E, Lebreton C, Grangette C, Pot B, Cerf-Bensussan N, Heyman M (2009) Mechanisms involved in alleviation of intestinal inflammation by Bifidobacterium breve soluble factors. PLoS ONE 4:e5184

Hickson M, D’Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ (2007) Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 335:80–83

Hooper LV, Midtvedt T, Gordon JI (2002) How host microbial interactions shape the nutrient environment of the mammalian intestine. Ann Rev Nutr 22:283–307

Hooper LV, Macpherson AJ (2010) Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 10:159–169

Hopkins MJ, Sharp R, Macfarlane GT (2001) Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48:198–205

Hopkins MJ, Macfarlane GT (2002) Changes in predominant bacterial populations in human feces with age and with Clostridium difficile infection. J Med Microbiol 51:448–454

Ibrahim F, Ruvio S, Granlund L, Salminen S, Viitanen M, Ouwehand AC (2010) Probiotics and immunosenescence: cheese as a carrier. FEMS Immunol Med Microbiol 59:53–59

Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG, Pettersson S, Conway S (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma. Nat Immunol 5:104–112

Kelly CP (2009) A 76-years old man with recurrent Clostridium difficile associated diarrhea: review of C difficile infection. JAMA 3010:954–962

Kharicha K, Iliffe S, Harari D, Swift C, Gillmann G, Stuck AE (2007) Health risk appraisal in older people 1: are older people living alone an “at-risk” group? Br J Gen Pract 57:271–276

Kleessen B, Sycura B, Zunft HJ, Blaut M (1997) Affects of inulin and lactose on fecal microflora, microbial activity and bowel habits in elderly constipated persons. Am J Clin Nutr 65:1397–1402

Koehler J, Leonhaeuser I-U (2008) Changes in food preferences during aging. Ann Nutr Metab 52:15–19

Lahtinen SJ, Tammela L, Korpela J, Parhiala R, Ahokoski H, Mykkanen H, Salminen S (2009) Probiotics modulate the Bifidobacterium microbiota of elderly nursing home residents. Age 31:59–66

Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G (2008) Aging of the immune system as a prognostic factor of human longevity. Physiology 23:64–74

Lay C, Rigottier-Gois L, Holmstrøm K, Rajilic M, Vaughan EE, de Vos WM, Collins MD, Thiel R, Namsolleck P, Blaut M, Doré J (2005) Colonic microbiota signatures across five northern European countries. Appl Environ Microbiol 71:4153–4155

Leffler DA, Lamont JT (2009) Treatment of Clostridium difficile-associated disease. Gastroenterology 136:1899–1912

Leser TD, Molbak L (2009) Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host. Environ Microbiol 11:2194–2206

Ley RE, Peterson DA, Gordon JI (2006a) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124:837–848

Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006b) Human gut microbes associated with obesity. Nature 444:1022–1023

Lomax AR, Calder PC (2009) Prebiotics, immune function, infection and inflammation: a review of the evidence. Br J Nutr 101:633–658

Macfarlane GT, Steed H, Macfarlane S (2007) Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. J Appl Microbiol 104:305–344

Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, Cantarel BL, Coutinho PM, Henrissat B, Crock LW, Russell A, Verberkmoes NC, Hettich RL, Gordon JI (2009) Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci USA 106:5859–5864

Mäkivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N (2010) The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr 103:227–234

Maloy KJ (2008) The interleukin-23/interleukin-17 axis in intestinal inflammation. J Intern Med 263:584–590

Mariat D, Firmesse O, Levenez F, Guimaraes VD, Sokol H, Doré J, Corthier G, Furet JP (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9:123

Matsumoto M, Benno Y (2006) Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512. Biosci Biotechnol Biochem 70:1287–1292

Matsumoto M, Sakamoto M, Benno Y (2009) Dynamics of fecal microbiota in hospitalized elderly fed prebiotic LKM512 yogurt. Microbiol Immunol 53:421–432

McFarland LV, Elmer GW, Surawicz CM (2002) Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 97:1769–1775

McFarland LV (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101:812–822

Meydani SN, Ha W-K (2000) Immunologic effects of yogurt. Am J Clin Nutr 71:861–872

Mitsuoka T (1992) Intestinal flora and ageing. Nutr Rev 50:438–446

Monaghan T, Boswell T, Mahida YR (2008) Recent advances in Clostridium difficile-associated disease. Gut 57:850–860

Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T, Cresci A, Silvi S, Orpianesi C, Verdenelli MC, Clavel T, Koebnick C, Zunft HJF, Doré J, Blaut M (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72:1027–1033

Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136:65–80

Newton JP, Yemm R, Abel RW, Menhinick S (1993) Changes in human jaw muscles with age and dental state. Gerodontology 10:16–22

Nova E, Warnberg J, Gòmez-Martìnez S, Diaz LE, Romeo J, Marcos A (2007) Immunomodulatory effects of probiotics in different stages of life. Br J Nutr 98:S90–S95

Orr WC, Chen CL (2002) Aging and neural control of the GI tract: IV. Clinical and physiological aspects of gastrointestinal motility and aging. Am J Physiol Gastrointest Liver Physiol 283:G1226–G1231

Ostan R, Bucci L, Capri M, Salvioli S, Scurti M, Pini E, Monti D, Franceschi F (2008) Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation 15:224–240

Ouwehand AC, Bergsma N, Parhiala R, Lahtinen S, Gueimonde M, Finne-Soveri H, Strandberg T, Pitkala K, Salminen S (2008) Bifidobacterium microbiota and parameters of immune function in elderly subjects. FEMS Immunol Med Microbiol 53:18–25

Ouwehand AC, Tiihonen K, Saarinen M, Putaala H, Rautonen N (2009) Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal immune parameters. Br J Nutr 101:367–375

Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO (2007) Development of the human infant intestinal microbiota. PLoS Biol 5:e177

Park J, Floch MH (2007) Prebiotics, probiotics, and dietary fiber in gastrointestinal disease. Gastroenterol Clin North Am 36:47–63

Parkes GC, Sanderson JD, Whelan K (2009) The mechanism of efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea. Lancet Infect Dis 9:237–244

Pédron T, Sansonetti P (2008) Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois. Cell Host Microbes 3:344–347

Persky SE, Brandt LJ (2000) Treatment of recurrent Clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope. Am J Gastroenterol 95:3283–3285

Pillai A, Nelson R (2008) Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev CD004611

Pilotto A, Di Mario F, Malfertheiner P, Valerio G, Naccarato R (1999) Upper gastrointestinal diseases in the elderly: report of a meeting held in Vicenza, Italy, on 20 March 1998. Eur J Gastroenterol Hepatol 11:801–808

Pitkala KH, Strandberg TE, Finne Soveri UH, Ouwehand AC, Poussa T, Salminen S (2007) Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized controlled trial. J Nutr Health Aging 11:305–311

Poutanen SM, Simor AE (2004) Clostridium difficile-associated diarrhea in adults. CMAJ 171:51–58

Pultz NJ, Donskey CJ (2005) Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice. Antimicrob Agents Chemother 49:3529–3532

Rajilic-Stojanovic M, Smidt H, de Vos WM (2007) Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol 9:2125–2136

Rajilic-Stojanovic M, Heilig HGHJ, Molenaar D, Kajander K, Surakka A, Smidt H, de Vos WM (2009) Development and application of the Human Intestinal Tract Chip, a phylogenetic microarray: analysis of the universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol 11:1736–1751

Raskin MJ (2008) History, incidence, and epidemiology of diverticulosis. J Clin Gastroenterol 42:1125–1127

Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313–323

Roush W (1996) Live long and prosper? Science 273:42–46

Rubin TA, Gessert CE, Aas J (2009) Stool transplantation for older patients with Clostridium difficile infection. JAGS 57:2386–2387

Russell RM (1992) Changes in gastrointestinal function attributed to aging. Am J Clin Nutr 55:1203S–1207S

Salles N, Ménard A, Georges A, Salzmann M, de Ledinghen V, de Mascarel A, Emeriau JP, Lamoiulieatte H, Mégraud F (2006) Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly patients. J Gerontol A Biol Sci Med Sci 61:1144–1150

Sansonetti PJ (2011) To be or not to be a pathogen: that is the mucosally relevant question. Mucosal Immunol 4:8–14

Sansonetti PJ, Medzhitov R (2009) Learning tolerance while fighting ignorance. Cell 138:416–420

Saulnier DMA, Spinler JK, Gibson GR, Versalovic J (2009) Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol 20:135–141

Schiffrin EJ, Thomas DR, Kumar VB, Brown C, Hager C, Van’t Hof MA, Morlev JE, Guigoz Y (2007) Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics. J Nutr Health Aging 11:475–479

Schiffrin EJ, Morley JE, Donnet-Hughes A, Guigoz Y (2009a) The inflammatory status of the elderly: the intestinal contribution. Mutat Res 690:50–56

Schiffrin EJ, Parlesak A, Bode C, Bode JC, Van’t Hof MA, Grathwohl D, Guigoz Y (2009b) Probiotic yogurt in the elderly with intestinal bacterial overgrowth: endotoxaemia and innate immune functions. Br J Nutr 101:961–966

Shanley DP, Aw D, Manley NR, Palmer DB (2009) An evolutionary perspective on the mechanisms of immunosenescence. Trends Immunol 30:374–381

Sheih YH, Chiang BL, Wang LH, Liao CK, Gills HS (2001) Systemic immunity enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr 20:149–156

Slavin JL (2008) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 108:1716–1731

Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 105:16731–16736

Spinzi G, Amato A, Imperiali G, Lenoci N, Mandelli G, Paggi S, Radaelli F, Terreni N, Terruzzi V (2009) Constipation in the elderly: management strategies. Drugs Aging 26:469–474

Sturtzel B, Dietrich A, Wagner KH, Gisinger C, Elmadfa I (2010) The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber. J Nutr Health Aging 14:219–223

Takeda K, Okumura K (2007) Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity. J Nutr 137:791S–793S

Tap J, Mondot S, Levenez F, Pelletier E, Caron C, Furet JP, Ugarte E, Munoz-Tamayo R, Paslier DLE, Nalin R, Doré J, Leclerc M (2009) Towards the human intestinal microbiota phylogenetic core. Environ Microbiol 11:2574–2584

Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppée JY, Bourdet-Sicard R, Sansonetti PJ, Pédron T (2006) Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 176:1228–1237

Tiihonen K, Tynkkynen S, Ouwehand AC, Ahlroos T, Rautonen N (2008) The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology. Br J Nutr 100:130–137

Tiihonen K, Ouwehand AC, Rautonen N (2010) Human intestinal microbiota and healthy ageing. Ageing Res Rev 9:107–116

Topping DL, Clifton PM (2001) Short chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81:1031–1064

Triantafyllou K, Vlachogiannakos J, Ladas SD (2010) Gastrointestinal and liver side effects of drugs in elderly patients. Best Pract Res Clin Gastroenterol 24:203–215

Troen BR (2003) The biology of aging. Mt Sinai J Med 70:3–22

Tschop MH, Hugenholtz P, Karp CL (2009) Getting to the core microbiome. Nat Biotechnol 27:344–346

Turchet P, Laurenzano M, Auboiron S, Antoine JM (2003) Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J Nutr Health Aging 7:75–77

Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031

Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI (2007) The human microbiome project. Nature 449:804–810

Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI (2009) A core gut microbiome in obese and lean twins. Nature 457:480–484

Van Baarlen P, Troost FJ, Van Hemert S, Van der Meer C, De Vos WM, De Groot PJ, Hooiveld GJ, Brummer RJ, Kleerebezem M (2009) Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance. Proc Natl Acad Sci USA 106:2371–2376

van Ommen B, Fairweather-Tait S, Freidig A, Kardinaal A, Scalbert A, Wopereis S (2008) A network biology model of micronutrient related health. Br J Nutr 99:S72–S80

Van Tongeren SP, Slaets JPJ, Harmsen HJM, Welling GW (2005) Fecal microbiota composition and frailty. Appl Environ Microbiol 71:6438–6442

Vanhoutte T, Huys G, De Brandt E, Swings J (2004) Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers. FEMS Microbiol Ecol 48:437–446

Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGrath JJ, Norman AW, Scragg R, Whiting SJ, Willett WC, Zittermann A (2007) The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr 85:649–650

Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR (2008) Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr 88:1438–1446

Wald A (1993) Constipation in elderly patients. Pathogenesis and management. Drugs Aging 3:220–231

Weiffenbach JM, Bartoshuk LM (1992) Taste and smell. Clin Geriatr Med 8:543–555

Welch AA, Fransen H, Jenab M, Boutron-Ruault MC, Tumino R, Agnoli C, Ericson U, Johansson I, Ferrari P, Engeset D, Lund E, Lentjes M, Key T, Touvier M, Niravong M, Larrañaga N, Rodríguez L, Ocké MC, Peeters PH, Tjønneland A, Bjerregaard L, Vasilopoulou E, Dilis V, Linseisen J, Nöthlings U, Riboli E, Slimani N, Bingham S (2009) Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study. Eur J Clin Nutr 63:S101–S121

Woodmansey EJ, McMurdo MET, Macfarlane CT, Macfarlane S (2004) Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic treated elderly subjects. Appl Environ Microbiol 70:6113–6122

Xu J, Mahowald MA, Ley RE, Lozupone CA, Hamady M, Martens EC, Henrissat B, Coutinho PM, Minx P, Latreille P, Cordum H, Van Brunt A, Kim K, Fulton RS, Fulton LA, Clifton SW, Wilson RK, Knight RD, Gordon JI (2007) Evolution of symbiotic bacteria in the distal human intestine. PLoS Biol 5:1574–1586

You DM, Franzos MA, Holman RP (2008) Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy. Ann Intern Med 148:632–633

Zoetendal EG, Akkermans AD, de Vos WM (1998) Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 64:3854–3859

Zoetendal EG, Akkermans AD, Akkermans-van Vliet WM, de Visser JAGM, de Vos WM (2001) The host genotype affects the bacterial community in the human gastrointestinal tract. Microb Ecol Health Dis 13:129–134

Zwielehner J, Liszt K, Handschur M, Lassl C, Lapin A, Haslberger AG (2009) Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly. Experimen Gerontol 44:440–446