Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice

Angst, 2001, The cadherin superfamily: diversity in form and function, J. Cell. Sci., 114, 629, 10.1242/jcs.114.4.629 Bellahcène, 2000, Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis, Circ. Res., 86, 885, 10.1161/01.RES.86.8.885 Blaber, 1987, A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland, Biochemistry, 26, 6742, 10.1021/bi00395a025 Black, 2002, Tumor necrosis factor-a converting enzyme, Int. J. Biochem. Cell Biol., 34, 1, 10.1016/S1357-2725(01)00097-8 Blaustein, 1999, Sodium/calcium exchange: its physiological implications, Physiol. Rev., 79, 763, 10.1152/physrev.1999.79.3.763 Borden, 1996, GABA transporter heterogeneity: pharmacology and cellular localization, Neurochem. Int., 29, 335, 10.1016/0197-0186(95)00158-1 Brady, 1997, Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity, J. Biol. Chem., 272, 20198, 10.1074/jbc.272.32.20198 Brewer, 2002, Messenger RNA decay during aging and development, Ageing Res. Rev., 1, 607, 10.1016/S1568-1637(02)00023-5 Broillet, 1999, Cyclic nucleotide-gated channels. Molecular mechanisms of activation, Ann. N.Y. Acad. Sci., 868, 730, 10.1111/j.1749-6632.1999.tb11352.x Butterfield, 2001, Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer’s disease and Huntington’s disease, Curr. Med. Chem., 8, 815, 10.2174/0929867013373048 Calof, 1996, Neurogenesis and cell death in olfactory epithelium, J. Neurobiol., 30, 67, 10.1002/(SICI)1097-4695(199605)30:1<67::AID-NEU7>3.0.CO;2-E Calof, 2002, Progenitor cells of the olfactory receptor neuron lineage, Microsc. Res. Tech., 58, 176, 10.1002/jemt.10147 Cao, 2001, Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice, Proc. Natl. Acad. Sci. U.S.A., 98, 10630, 10.1073/pnas.191313598 Chen, 2001, An inner ear gene expression database, J. Assoc. Res. Otolaryngol., 3, 140, 10.1007/s101620020029 Chen, 1992, Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue, Neuroreport, 3, 749, 10.1097/00001756-199209000-00007 Choi, 2001, Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas, Proc. Natl. Acad. Sci. U.S.A., 98, 13096, 10.1073/pnas.201417498 Clarris, 2000, Dynamic spatiotemporal expression patterns of neurocan and phosphacan indicate diverse roles in the developing and adult mouse olfactory system, J. Comp. Neurol., 423, 99, 10.1002/1096-9861(20000717)423:1<99::AID-CNE8>3.0.CO;2-I Coates, 2001, Olfactory CO2 receptors, Respir. Physiol., 129, 219, 10.1016/S0034-5687(01)00292-4 Cowan, 2001, Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons, J. Neurosci., 21, 7099, 10.1523/JNEUROSCI.21-18-07099.2001 Dickinson, 1988, Importance of noradrenergic mechanisms in the olfactory bulbs for the maternal behaviour of mice, Physiol. Behav., 43, 313, 10.1016/0031-9384(88)90193-X Doty, 1984, Smell identification ability: changes with age, Science, 226, 1441, 10.1126/science.6505700 Doty, R.L. (Ed.), 1995. Handbook of Olfaction and Gustation. Marcel Dekker, New York, 881 pp. Faruki, 2002, Separating centrosomes interact in the absence of associated chromosomes during mitosis in cultured vertebrate cells, Cell Motil. Cytoskeleton, 52, 107, 10.1002/cm.10036 Fattori, 1998, Immunohistochemical localisation of tear lipocalin in human nasal mucosa, Rhinology, 36, 101 Ferhat, 1998, Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development, J. Neurosci., 18, 7822, 10.1523/JNEUROSCI.18-19-07822.1998 Finger, T.E., Silver, W.L. (Eds.), 2000. The Neurobiology of Taste and Smell, 2nd ed. Wiley-Liss, New York, 479 pp. Firestein, 2001, How the olfactory system makes sense of scents, Nature, 413, 211, 10.1038/35093026 Fontijn, 2001, The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis, Mol. Cell. Biol., 21, 2944, 10.1128/MCB.21.8.2944-2955.2001 Fujiwara, 1997, Expressions of a calcium-binding protein (spot35/calbindin-D28K) in mouse olfactory cells: possible relationship to neuronal differentiation, Eur. Arch. Otorhinolaryngol., 254, 105, 10.1007/BF01526190 Gandhi, 1998, Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung, J. Biol. Chem., 273, 32096, 10.1074/jbc.273.48.32096 Getchell, M.L., Getchell, T.V., 1994. Differential expression of cell-specific molecules in olfactory receptor neurons of humans of different ages. In: Kurihara, K., Suzuki, N., Ogawa, H. (Eds.), Olfaction and Taste, vol. XI. Springer-Verlag, Tokyo, pp. 602–603. Getchell, M.L., Mellert, T.K., 1991. Olfactory mucus secretion. In: Getchell, T.V., Doty, R.L., Bartoshuk, L.M., Snow Jr., J.B. (Eds.), Smell and Taste in Health and Disease. Raven, New York, pp. 83–95. Getchell, 1984, Perireceptor and receptor events in vertebrate olfaction, Prog. Neurobiol., 23, 317, 10.1016/0301-0082(84)90008-X Getchell, T.V., Doty, R.L., Bartoshuk, L.M., Snow Jr., J.B. (Eds.), 1991. Smell and Taste in Health and Disease. Raven, New York, 912 pp. Getchell, 1993, Immunohistochemical localization of a cytochrome P-450 isozyme in human nasal mucosa: age-related trends, Ann. Otol. Rhinol. Laryngol., 102, 368, 10.1177/000348949310200509 Getchell, 1998, Androgenic regulation of gene expression in primary and second-order chemosensory neurons, Chem. Senses, 23, 634 Getchell, 2002, Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation, J. Neurosci. Res., 67, 246, 10.1002/jnr.10090 Getchell, T.V., Subhedar, N.K., Shah, D.S., Hackley, G., Partin, J.V., Sen, G., Getchell, M.L., 2002b. Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1a and monocyte chemoattractant protein-1. J. Neurosci. Res. 70, 784–793. Göke, 2001, Trefoil peptides promote restitution of wounded corneal epithelial cells, Exp. Cell Res., 264, 337, 10.1006/excr.2000.5116 Goldstein, B.J., Kulaga, H., Reed, R.R., 2002. Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons, J. Assoc. Res. Otolaryngol. DOI: 10.1007/s10162-002-2039-5. Gu, 1999, Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa, Biochem. Biophys. Res. Commun., 266, 262, 10.1006/bbrc.1999.1807 Han, 2001, Array-based gene expression profiling to study aging, Mech. Ageing Dev., 122, 99, 10.1016/S0047-6374(01)00215-9 Henson, 2001, The phosphatidylserine receptor: a crucial molecular switch?, Nat. Rev. Mol. Cell Biol., 2, 627, 10.1038/35085094 Higuchi, 1997, Genetic characterization of senescence-accelerated mouse (SAM), Exp. Gerontol., 32, 129, 10.1016/S0531-5565(96)00060-5 Holness, 1993, Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family, J. Biol. Chem., 268, 9661, 10.1016/S0021-9258(18)98400-0 Hosokawa, 1999, Aging of blood–brain barrier and neuronal cells of eye and ear in SAM mice, Neurobiol. Ageing, 20, 117, 10.1016/S0197-4580(99)00029-9 Hosokawa, 1984, Cataract and other opthalmic lesions in senescence-accelerated mouse (SAM): morphology and incidence of senescence-associated opthalmic changes in mice, Exp. Eye Res., 38, 105, 10.1016/0014-4835(84)90095-2 Hosokawa, 1988, Cataract in senescence-accelerated mouse (SAM). Part 2. Development of a new strain of mouse with late-appearing cataract, Exp. Eye Res., 47, 629, 10.1016/0014-4835(88)90100-5 Hunter, 2002, Expression microarray analysis of brain tumors: what we have learned so far, Front. Biosci., 7, 74, 10.2741/hunter Jain, 2002, Three SIBLINGs (Small Intergrin-binding LIgand, N-linked glycoproteins) enhance factor H’s cofactor activity enabling MCP-like cellular evasion of complement-mediated attack, J. Biol. Chem., 277, 13700, 10.1074/jbc.M110757200 Jiang, 2001, The effects of aging on gene expression in the hypothalamus and cortex of mice, Proc. Natl. Acad. Sci. U.S.A., 98, 1930, 10.1073/pnas.98.4.1930 Johnson, 2002, Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death, J. Biol. Chem., 277, 23000, 10.1074/jbc.M201907200 Jones, 2002, Clusterin, Int. Arch. Allergy Appl. Immunol., 34, 427 Jones, 2002, NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors, J. Neurosci., 22, 2792, 10.1523/JNEUROSCI.22-07-02792.2002 Kanzaki, 2002, From gene identification to gene therapy, Audiol. Neurootol., 7, 161, 10.1159/000058303 Kawajiri, 2002, Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity, Arch. Biochem. Biophys., 398, 51, 10.1006/abbi.2001.2685 Kern, 1997, Localization of 11 β-hydroxysteroid dehydrogenase: specific protector of the mineralocorticoid receptor in mammalian olfactory mucosa, Acta Otolaryngol., 117, 738, 10.3109/00016489709113470 Kobayakawa, 2002, Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons, J. Neurosci., 22, 5931, 10.1523/JNEUROSCI.22-14-05931.2002 Krautwurst, 1998, Identification of ligands for olfactory receptors by functional expression of a receptor library, Cell, 95, 917, 10.1016/S0092-8674(00)81716-X Kumar, 2000, Identification of age-dependent changes in expression of senescence-accelerated mouse (SAMP8) hippocampal proteins by expression array analysis, Biochem. Biophys. Res. Commun., 272, 657, 10.1006/bbrc.2000.2719 Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction, Science, 285, 1390, 10.1126/science.285.5432.1390 Lee, 2000, Gene-expression profile of the ageing brain in mice, Nat. Genet., 25, 294, 10.1038/77046 Lefebvre, 1998, Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest, Nat. Genet., 20, 163, 10.1038/2464 Lefebvre, 2002, Mechanisms of cell death in the injured auditory system: otoprotective strategies, Audiol. Neurootol., 7, 165, 10.1159/000058304 Li, 1998, Control of apoptosis and mitotic spindle checkpoint by survivin, Nature, 396, 580, 10.1038/25141 Liu, 1999, The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription, EMBO J., 18, 2845, 10.1093/emboj/18.10.2845 Mackay-Sim, 2000, Neurotrophic factors in the primary olfactory pathway, Prog. Neurobiol., 62, 527, 10.1016/S0301-0082(00)00009-5 Majji, 2000, Age-related retinal pigment epithelium and Bruch’s membrane degeneration in senescence-accelerated mouse, Invest. Ophthalmol. Vis. Sci., 41, 3936 Margolis, 1991, Regulation of gene expression in the olfactory neuroepithelium: a neurogenetic matrix, Prog. Brain Res., 89, 97, 10.1016/S0079-6123(08)61718-5 Markowska, 1998, Behaviorial assesment of the senescence-accelerated mouse (SAM P8 and R1), Physiol. Behav., 64, 15, 10.1016/S0031-9384(98)00011-0 Matsunami, 1997, A multigene family encoding a diverse array of putative pheromone receptors in mammals, Cell, 90, 775, 10.1016/S0092-8674(00)80537-1 Michel, 1997, Clusterin/ApoJ expression is associated with neuronal apoptosis in the olfactory mucosa of the adult mouse, J. Cell Sci., 110, 1635, 10.1242/jcs.110.14.1635 Miyawaki, 1994, Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ, EMBO J., 13, 5835, 10.1002/j.1460-2075.1994.tb06927.x Mombaerts, 1999, Seven-transmembrane proteins as odorant and chemosensory receptors, Science, 286, 707, 10.1126/science.286.5440.707 Murphy, 1993, Nutrition and chemosensory perception in the elderly, Crit. Rev. Food Sci. Nutr., 33, 3, 10.1080/10408399309527607 Nadon, 2002, Statistical issues with microarrays: processing and analysis, Trends Genet., 18, 265, 10.1016/S0168-9525(02)02665-3 Nagawa, 2002, Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map, Gene, 292, 73, 10.1016/S0378-1119(02)00670-4 Nakamura, 2000, Cellular and molecular constituents of olfactory sensation in vertebrates, Comp. Biochem. Physiol. A: Mol. Integr. Physiol., 126, 17, 10.1016/S1095-6433(00)00191-4 Nakayasu, 2000, Sensitivity of the olfactory sense declines with aging in senescence-accelerated mouse (SAM-P1), Physiol. Behav., 70, 135, 10.1016/S0031-9384(00)00234-1 Nan, 2001, Leukemia inhibitory factor and interleukin-6 and their receptors are transiently expressed in the olfactory mucosa following target ablation, J. Comp. Neurol., 435, 60, 10.1002/cne.1193 Nef, 1992, Spatial pattern of receptor expression in the olfactory epithelium, Proc. Natl. Acad. Sci. U.S.A., 89, 8948, 10.1073/pnas.89.19.8948 Nesic, 2002, DNA microarray analysis of the contused spinal cord: effect of NMDA receptor inhibition, J. Neurosci. Res., 68, 406, 10.1002/jnr.10171 Nielsen, 2002, Complement’s participation in acquired immunity, J. Leukoc. Biol., 72, 249, 10.1189/jlb.72.2.249 Null, 2002, Both alpha and beta isoforms of mammalian DNA topoisomerase II associate with chromosomes in mitosis, Cell Growth Diff., 13, 325 Oppermann, 1995, Cloning and primary structure of murine 11 β-hydroxysteroid dehydrogenase/microsomal carbonyl reductase, Eur. J. Biochem., 227, 202, 10.1111/j.1432-1033.1995.tb20377.x Orsida, 2002, Clinical relevance of airway 11 β-hydroxysteroid dehydrogenase type II enzyme in asthma, Am. J. Respir. Crit. Care Med., 165, 1010, 10.1164/ajrccm.165.7.2105003 Pes, 1998, Cloning and expression of odorant-binding proteins Ia and Ib from mouse nasal tissue, Gene, 212, 49, 10.1016/S0378-1119(98)00131-0 Pitari, 2000, Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice, FEBS Lett., 483, 149, 10.1016/S0014-5793(00)02110-4 Pixley, 1998, Effects of insulin-like growth factor 1 on olfactory neurogenesis in vivo and in vitro, Ann. N.Y. Acad. Sci., 855, 244, 10.1111/j.1749-6632.1998.tb10575.x Pletcher, 2002, Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster, Curr. Biol., 12, 712, 10.1016/S0960-9822(02)00808-4 Prolla, 2002, DNA microarray analysis of the aging brain, Chem. Senses, 27, 299, 10.1093/chemse/27.3.299 Prolla, 2001, Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction, Trends Neurosci., 24, S21, 10.1016/S0166-2236(00)01957-3 Prussak, 1989, Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions, J. Biol. Chem., 25, 4957, 10.1016/S0021-9258(18)83684-5 Pyrski, 2002, Expression of Na+/Ca2+/(K+) exchangers in olfactory receptor neurons (ORNs), Chem. Senses, 27, 11 Rabinowitz, 1991, Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli, J. Exp. Med., 174, 827, 10.1084/jem.174.4.827 Rama Krishna, 1995, Age- and gender-related trends in the expression of glutathione S-transferases in human nasal mucosa, Ann. Otol. Rhinol. Laryngol., 104, 812, 10.1177/000348949510401012 Ray, 2000, Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells, Brain Res., 852, 326, 10.1016/S0006-8993(99)02148-4 Restrepo, 1996, Second messenger signaling in olfactory transduction, J. Neurobiol., 30, 37, 10.1002/(SICI)1097-4695(199605)30:1<37::AID-NEU4>3.0.CO;2-H Robinson, 1998, Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa: physiologic and pathophysiologic implications, Laryngoscope, 108, 1238, 10.1097/00005537-199808000-00026 Roy, 2002, Impacts of transcriptional regulation on aging and senescenece, Ageing Res. Rev., 1, 367, 10.1016/S1568-1637(02)00006-5 Ruiz, 1996, Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart, J. Mol. Cell Cardiol., 28, 1453, 10.1006/jmcc.1996.0136 Sandberg, 2000, Regional and strain-specific gene expression mapping in the adult mouse brain, Proc. Natl. Acad. Sci. U.S.A., 97, 11038, 10.1073/pnas.97.20.11038 Scaloni, 2001, Purification, cloning and characterisation of odorant- and pheromone-binding proteins from pig nasal epithelium, Cell. Mol. Life Sci., 58, 823, 10.1007/PL00000903 Schiffman, 1997, Taste and smell losses in normal aging and disease, JAMA, 278, 1357, 10.1001/jama.278.16.1357 Schmale, 1990, Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins, Nature, 343, 366, 10.1038/343366a0 Schwartz Levey, 1991, Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography, J. Neurosci., 11, 3556, 10.1523/JNEUROSCI.11-11-03556.1991 Schwob, 2002, Neural regeneration and the peripheral olfactory system, Anat. Rec., 269, 33, 10.1002/ar.10047 Shigenaga, 1993, Oxidative damage and mitochondrial decay in aging, Proc. Natl. Acad. Sci. U.S.A., 91, 10771, 10.1073/pnas.91.23.10771 Shin, 2001, An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7, Biochemistry, 40, 1117, 10.1021/bi001603q Shoji, 1998, A morphological and morphometrical study of the retina in aging SAM mice, Ophthal. Res., 30, 172, 10.1159/000055471 Siu, 1989, Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation, J. Immunol., 143, 3813, 10.4049/jimmunol.143.11.3813 Smits, 2001, Checking out the G2/M transition, Biochim. Biophys. Acta, 1519, 1, 10.1016/S0167-4781(01)00204-4 Song, 2002, GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats, Neurosci. Res., 68, 730, 10.1002/jnr.10268 Sprott, R.L., Takeda, T., McClearn, G. (Eds.), 1997. Animal Models for Aging Research. Exp. Gerontol. 32, 1–242. Stewart, 1997, Stomatin, Int. J. Biochem. Cell Biol., 29, 271, 10.1016/S1357-2725(96)00072-6 Stockton, 2001, Modulation of cell-substrate adhesion by arachidonic acid: lipoxygenase regulates cell spreading and ERK1/2-inducible cyclooxygenase regulates cell migration in NIH-3T3 fibroblasts, Mol. Biol. Cell, 12, 1937, 10.1091/mbc.12.7.1937 Strotmann, 1999, Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization, Gene, 236, 281, 10.1016/S0378-1119(99)00275-9 Suzuki, 2000, Tumor necrosis factor-a-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32), Exp. Neurol., 165, 35, 10.1006/exnr.2000.7465 Takada, 1993, Age-related changes in Bruch’s membrane of the senescence-accelerated mouse, J. Jpn. Opthalmol. Soc., 97, 595 Takada, 1994, Proteoglycan in Bruch’s membrane of senescence-accelerated mouse: localization and age-related changes, J. Jpn. Opthalmol. Soc., 98, 469 Takada, 1994, Immunohistochemical study in Bruch’s membrane of the senescence-accelerated mouse, J. Jpn. Opthalmol. Soc., 98, 955 Takeda, T. (Ed.), 1994. The SAM model of senescence. In: Proceedings of the First International Conference on Senescence, the SAM model, Excerpta Medica, Amsterdam, 458 pp. Takeda, 1999, Senescence-accelerated mouse (SAM): a biogerontological resource in aging research, Neurobiol. Ageing, 20, 105, 10.1016/S0197-4580(99)00008-1 Takeda, 1981, A new murine model of accelerated senescence, Mech. Ageing Dev., 17, 183, 10.1016/0047-6374(81)90084-1 Takeda, 2002, Identification of G protein-coupled receptor genes from the human genome sequence, FEBS Lett., 520, 97, 10.1016/S0014-5793(02)02775-8 Tamura, 2002, Regulation of stress-activated protein kinase signaling pathways by protein phosphatases, Eur. J. Biochem., 269, 1060, 10.1046/j.0014-2956.2002.02754.x Taupin, 1999, The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation, J. Clin. Invest., 103, R31, 10.1172/JCI3304 Taylor, 1997, Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage, Cell, 89, 727, 10.1016/S0092-8674(00)80255-X Taylor, 2001, Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells, J. Cell Sci., 114, 4385, 10.1242/jcs.114.24.4385 Terada, 1998, AIM-1: a mammalian midbody-associated protein required for cytokinesis, EMBO J., 17, 667, 10.1093/emboj/17.3.667 Thomaidou, 2001, Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells, J. Neurochem., 78, 767, 10.1046/j.1471-4159.2001.00454.x Tolosano, 2002, Hemopexin: structure, function, and regulation, DNA Cell Biol., 21, 297, 10.1089/104454902753759717 Tsuboi, 1999, Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb, J. Neurosci., 19, 8409, 10.1523/JNEUROSCI.19-19-08409.1999 van Kooyk, 2000, Avidity regulation of integrins: the driving force in leukocyte adhesion, Curr. Opin. Cell Biol., 12, 542, 10.1016/S0955-0674(00)00129-0 van’t Hof, 1997, The salivary lipocalin von Ebner’s gland protein is a cysteine proteinase inhibitor, J. Biol. Chem., 272, 1837, 10.1074/jbc.272.3.1837 Virgintino, 1999, Regional distribution and cell type-specific expression of the mouse F3 axonal glycoprotein: a developmental study, J. Comp. Neurol., 413, 357, 10.1002/(SICI)1096-9861(19991025)413:3<357::AID-CNE1>3.0.CO;2-S Walters, 1996, Proximal regions of the olfactory marker protein gene promoter direct olfactory neuron-specific expression in transgenic mice, J. Neurosci. Res., 43, 146, 10.1002/(SICI)1097-4547(19960115)43:2<146::AID-JNR3>3.0.CO;2-G Wang, 1994, Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gand epidermal growth factor-binding protein, members of the kallikrein family, J. Biol. Chem., 269, 13806, 10.1016/S0021-9258(17)36719-4 Welle, 2001, Senescence-related changes in gene expression in muscle: similarities and differences btween mice and men, Physiol. Genomics, 5, 67, 10.1152/physiolgenomics.2001.5.2.67 White, 2000, The multifunctional properties and characteristics of vitamin D-binding protein, Trends Endocrinol. Metab., 11, 320, 10.1016/S1043-2760(00)00317-9 Wong, 2002, Matrix metalloproteinases in disease and repair processes in the anterior segment, Surv. Ophthalmol., 47, 239, 10.1016/S0039-6257(02)00287-4 Yamagishi, 1996, Ontogenetic expression of spot 35 protein (calbindin-D28K) in human olfactory receptor neurons and its decrease in Alzheimer’s disease patients, Ann. Otol. Rhinol. Laryngol., 105, 132, 10.1177/000348949610500208 Yoshida, 2002, Microarray analysis of gene expression n the aging human retina, Invest. Ophthalmol. Vis. Sci., 43, 2554 Zhang, 2002, The olfactory receptor gene superfamily of the mouse, Nat. Neurosci., 5, 124, 10.1038/nn800