Age-related nuclear cataract—oxidation is the key
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Ahmed, 2003, Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins, Invest. Ophthalmol Vis. Sci., 44, 5287, 10.1167/iovs.03-0573
Al-Ghoul, 2001, Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis, Exp. Eye Res., 199, 10.1006/exer.2000.0937
Ames, 1995, Mitochondrial decay in aging, Biochim. Biophys. Acta, 1271, 165, 10.1016/0925-4439(95)00024-X
Ansari, 2004
Aquilina, 1997, Oxidation products of 3-hydroxykynurenine bind to lens proteins: relevance for nuclear cataract, Exp. Eye Res., 64, 727, 10.1006/exer.1996.0258
Aquilina, 2000, Polypeptide modification and cross-linking by oxidized 3-hydroxykynurenine, Biochemistry, 39, 16176, 10.1021/bi001230t
Arnarsson, 2002, Risk factors for nuclear lens opacification: the Reykjavik Eye Study, Dev. Ophthalmol., 35, 12, 10.1159/000060804
Ball, 2003, Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens, Invest. Ophthalmol. Vis. Sci., 44, 4820, 10.1167/iovs.02-1317
Bando, 1976, Changes in blue fluorescence intensity and colouration of human lens protein with normal lens aging and nuclear cataract, Ophthalmic Res., 8, 456, 10.1159/000264854
Barbazetto, 2004, Oxygen tension in the rabbit lens and vitreous before and after vitrectomy, Exp. Eye Res., 78, 917, 10.1016/j.exer.2004.01.003
Barber, 1968, Free amino acids in senile cataractous lenses: possible osmotic etiology, Invest. Ophthalmol., 7, 564
Baruch, 2001, Defining a link between gap junction communication, proteolysis, and cataract formation, J. Biol. Chem., 276, 28999, 10.1074/jbc.M103628200
Baynes, 2001, The role of AGEs in aging: causation or correlation, Exp. Gerontol., 36, 1527, 10.1016/S0531-5565(01)00138-3
Berry, 2001, The presence of a human UV filter within the lens represents an oxidative stress, Exp. Eye Res., 72, 411, 10.1006/exer.2000.0970
Borchman, 2000, Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipids and nuclear light scatter, Invest. Ophthalmol. Vis. Sci., 41, 3061
Bova, 1999, UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-d-glucoside, Invest. Ophthalmol. Vis. Sci., 40, 3237
Bova, 2001, Major changes in human ocular UV protection with age, Invest. Ophthalmol. Vis. Sci., 42, 200
Broekhuyse, 1981
Bucciantini, 2002, Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases.[see comment], Nature, 416, 507, 10.1038/416507a
Buckingham, 1972, The behaviour of reduced proteins from normal and cataractous lenses in highly dissociating media: a cross-linked protein in cataractous lenses, Exp. Eye Res., 14, 123, 10.1016/0014-4835(72)90057-7
Byrdwell, 1997, Liquid chromatography/mass-spectrometric characterization of sphingomyelin and dihydrosphingomyelin of human lens membranes, Ophthalmic Res., 29, 191, 10.1159/000268014
Calvin, 1986, Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice, Science, 233, 553, 10.1126/science.3726547
Chatterjee, 1982, Prevalence and aetiology of cataract in Punjab, Br. J. Ophthalmol., 66, 35, 10.1136/bjo.66.1.35
Chen, 1997, Molecular evidence for the involvement of alpha crystallin in the colouration/crosslinking of crystallins in age-related nuclear cataract, Exp. Eye Res., 65, 835, 10.1006/exer.1997.0393
Cheng, 2001, Similarity of the yellow chromophores isolated from human cataracts with those from ascorbic acid-modified calf lens proteins: evidence for ascorbic acid glycation during cataract formation, Biochim. Biophys. Acta, 1537, 14, 10.1016/S0925-4439(01)00051-5
Cheng, R., Feng, Q., Ortwerth, B.J., 2004. A novel chromophore in human lens. ARVO#1691.
Clayton, 1984, Epidemiological and other studies in the assessment of factors contributing to cataractogenesis, Ciba Found. Symp., 106, 25
Cobb, 2002, Alpha-crystallin chaperone-like activity and membrane binding in age-related cataracts, Biochemistry, 41, 483, 10.1021/bi0112457
Coghlan, 1977, Changes in the distribution of proteins in the aging human lens, Exp. Eye Res., 25, 603, 10.1016/0014-4835(77)90139-7
Congdon, 2004, Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors, Invest. Ophthalmol. Vis. Sci., 45, 2182, 10.1167/iovs.03-1163
Crow, 1994, Micromolar levels of intracellular calcium reduce gap junctional permeability in lens cultures, Invest. Ophthalmol. Vis. Sci., 35, 3332
David, 1984, State of sulfhydryl in selenite cataract, Toxicol. Appl. Pharmacol., 74, 109, 10.1016/0041-008X(84)90276-X
David, 1993, Sequence analysis of lens beta-crystallins suggests involvement of calpain in cataract formation, J. Biol. Chem., 268, 1937, 10.1016/S0021-9258(18)53944-2
Dickerson, 1997, Free cysteine levels in normal human lenses, Exp. Eye Res., 65, 451, 10.1006/exer.1997.0343
DiMattio, 1989, Active transport of ascorbic acid into lens epithelium of the rat, Exp. Eye Res., 49, 873, 10.1016/S0014-4835(89)80046-6
Duncan, 1989, Human lens membrane cation permeability increases with age, Invest. Ophthalmol. Vis. Sci., 30, 1855
Evans, 1998, Age-related nuclear lens opacities are associated with reduced growth before 1 year of age. [see comments], Invest. Ophthalmol. Vis. Sci., 39, 1740
Frederikse, 1996, Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid in mammalian lenses, and beta-amyloid has toxic effects on lens epithelial cells, J. Biol. Chem., 271, 10169, 10.1074/jbc.271.17.10169
Freel, 2003, Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model, Exp. Eye Res., 76, 405, 10.1016/S0014-4835(03)00004-6
Fu, 1998, The hydroxyl radical in lens nuclear cataractogenesis, J. Biol. Chem., 273, 28603, 10.1074/jbc.273.44.28603
Garland, 1990, Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis, Exp. Eye Res., 50, 677, 10.1016/0014-4835(90)90113-9
Garland, 1986, Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen, Arch. Biochem. Biophys., 251, 771, 10.1016/0003-9861(86)90389-9
Garner, 1980, Selective oxidation of cysteine and methionine in normal and senile cataractous lenses, Proc. Natl Acad. Sci. USA, 77, 1274, 10.1073/pnas.77.3.1274
Garner, 1999, Redox availability of lens iron and copper: implications for HO* generation in cataract, Redox Rep., 4, 313, 10.1179/135100099101535007
Garner, 2000, Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract, Exp. Eye Res., 70, 81, 10.1006/exer.1999.0754
Giblin, 2000, Glutathione: a vital lens antioxidant, J. Ocul. Pharmacol. Ther., 16, 121, 10.1089/jop.2000.16.121
Giblin, 1988, Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level, Invest. Ophthalmol. Vis. Sci., 29, 1312
Glasser, 1998, Presbyopia and the optical changes in the human crystalline lens with age, Vis. Res., 38, 209, 10.1016/S0042-6989(97)00102-8
Goldstein, 2003, Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease, Lancet, 361, 1258, 10.1016/S0140-6736(03)12981-9
Grami, V., Marrero, Y.G., Tang, D., Yappert, M.C., Borchman, D., 2004. The influence of age and diabetes on the binding capacity of alpha crystallin to human lens lipids. ARVO abstract #3963.
Groenen, 1993, Age dependent deamidation of alpha b crystallin, FEBS Lett., 322, 69, 10.1016/0014-5793(93)81113-E
Guptasarma, 1992, Hydroxyl radical mediated damage to proteins, with special reference to the crystallins, Biochemistry, 31, 4296, 10.1021/bi00132a021
Halliwell, 1989
Hanson, 2000, The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage, Exp. Eye Res., 71, 195, 10.1006/exer.2000.0868
Harding, 1991
Harocopos, 2004, Importance of vitreous liquefaction in age-related cataract, Invest. Ophthalmol. Vis. Sci., 45, 77, 10.1167/iovs.03-0820
Hejtmancik, J.F., Kantorow, M., 2004. Molecular genetics of age-related cataract. Exp. Eye Res. 79, 3–9.
Heys, K.R., Cram, S.L., Truscott, R.J.W., 2004. Massive increase in the stiffness of the human lens nucleus with age: the basis for presbyopia? Mol. Vis. 10, 956–963.
Hidasi, 1995, Transglutaminase activity in normal human lenses and in senile cataracts, Ann. Clin. Lab. Sci., 25, 236
Holleschau, 1994, The effects of age on glutathione peroxidase and glutathione reductase activities in lenses of Old World simians and prosimians, Curr. Eye Res., 13, 331, 10.3109/02713689409167296
Hood, 1999, Human lens colouration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxykynurenine glucoside, J. Biol. Chem., 274, 32547, 10.1074/jbc.274.46.32547
Horwitz, 1992, Alpha-crystallin can function as a molecular chaperone, Proc. Natl Acad. Sci. USA, 89, 10449, 10.1073/pnas.89.21.10449
Jimenez, 2002, The protofilament structure of insulin amyloid fibrils, Proc. Natl Acad. Sci. USA, 99, 9196, 10.1073/pnas.142459399
Kanayama, 1987, Detection of the crosslinking amino acid histidinoalanine in human brown cataractous protein, Exp. Eye Res., 44, 165, 10.1016/S0014-4835(87)80001-5
Kistler, 1987, Protein processing in lens intercellular junctions: cleavage of MP70 to MP38, Invest. Ophthalmol. Vis. Sci., 28, 1687
Kistler, 1995, Ocular lens gap junctions: protein expression, assembly, and structure-function analysis, Microsc. Res. Tech., 31, 347, 10.1002/jemt.1070310504
Kodama, 1988, Characterization of disulfide-linked crystallins associated with human cataractous lens membranes, Invest. Ophthalmol. Vis. Sci., 29, 145
Kuck, 1983, The Emory mouse cataract: loss of soluble protein, glutathione, protein sulfhydryl and other changes, Exp. Eye Res., 36, 351, 10.1016/0014-4835(83)90117-3
Kuck, 1982, Total sulfhydryl by Raman spectroscopy in the intact lens of several species: variations in the nucleus and along the optical axis during aging, Exp. Eye Res., 34, 23, 10.1016/0014-4835(82)90005-7
Lampi, 1998, Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry, Exp. Eye Res., 67, 31, 10.1006/exer.1998.0481
Lampi, 2001, Deamidation of human B1 alters the elongated structure of the dimer, Exp. Eye Res., 72, 279, 10.1006/exer.2000.0950
Lapko, 2001, In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92, Protein Sci., 10, 1130, 10.1110/ps.40901
Lapko, 2002, Deamidation in human gamma S-crystallin from cataractous lenses is influenced by surface exposure, Biochemistry, 41, 8638, 10.1021/bi015924t
Lapko, 2002, S-methylated cysteines in human lens gamma S-crystallins, Biochemistry, 41, 14645, 10.1021/bi0267700
Lee, 1998, The relative ability of glucose and ascorbate to glycate and crosslink lens proteins in vitro. off, Exp. Eye Res., 67, 95, 10.1006/exer.1998.0500
Lerman, 1991, NMR and fluorescence studies on human and animal lenses, Lens Eye Toxicol. Res., 8, 121
Lin, 1997, Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain, Eur. J. Cell Biol., 73, 141
Lin, 1998, Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage, Eur. J. Cell Biol., 76, 246, 10.1016/S0171-9335(98)80002-2
Lin, 1998, In vivo acetylation identified at lysine 70 of human lens alphaA- crystallin, Protein Sci., 7, 1451, 10.1002/pro.5560070622
Lindner, 2001, The molecular chaperone alpha-crystallin is in kinetic competition with aggregation to stabilize a monomeric molten-globule form of alpha-lactalbumin, Biochem. J., 354, 79, 10.1042/0264-6021:3540079
Linetsky, 1995, The generation of hydrogen peroxide by the UV-A irradiation of human lens proteins, Photochem. Photobiol., 62, 87, 10.1111/j.1751-1097.1995.tb05243.x
Linetsky, 1996, The generation of superoxide anion by the UVA irradiation of human lens proteins, Exp. Eye Res., 63, 67, 10.1006/exer.1996.0092
Linetsky, 2004, Dehydroalanine crosslinks in human lens, Exp. Eye Res., 79, 499, 10.1016/j.exer.2004.06.026
Lou, 2000, Thiol regulation in the lens, J. Ocul. Pharmacol. Ther., 16, 137, 10.1089/jop.2000.16.137
Lou, 1999, Correlation of nuclear color and opalescence with protein S-thiolation in human lenses, Exp. Eye Res., 68, 547, 10.1006/exer.1998.0638
MacCoss, 2002, Shotgun identification of protein modifications from protein complexes and lens tissue, Proc. Natl Acad. Sci. USA, 99, 7900, 10.1073/pnas.122231399
Marcantonio, 1987, Amino acid transport and protein synthesis in human normal and cataractous lenses, Curr. Eye Res., 6, 1299, 10.3109/02713688708997555
Masters, 1977, Aspartic acid racemisation in the human lens during ageing and in cataract formation, Nature, 268, 71, 10.1038/268071a0
McFall-Ngai, 1985, Spatial and temporal mapping of the age-related changes in human lens crystallins, Exp. Eye Res., 41, 745, 10.1016/0014-4835(85)90183-6
McNulty, 2004, Regulation of tissue oxygen levels in the mammalian lens, J. Physiol., 559, 883, 10.1113/jphysiol.2004.068619
Meehan, 2004, Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation, J. Biol. Chem., 279, 3413, 10.1074/jbc.M308203200
Michels, 1984, Vitrectomy for Macular Pucker, Ophthalmology, 91, 1384, 10.1016/S0161-6420(84)34136-7
Moffat, 1999, Age-related changes in the kinetics of water transport in normal human lenses, Exp. Eye Res., 69, 663, 10.1006/exer.1999.0747
Moffat, 2002, Explanation of the lens paradox, Optom. Vis. Sci., 79, 148, 10.1097/00006324-200203000-00008
Nagaraj, 1994, Modifications of lens proteins by the oxidation products of ascorbate: isolation and characterization of a marker for the maillard reaction by L-threose, Invest. Ophthalmol. Vis. Sci., 35, 1930
Ortwerth, 1988, Glutathione inhibits the glycation and crosslinking of lens proteins by ascorbic acid, Exp. Eye Res., 47, 737, 10.1016/0014-4835(88)90041-3
Ortwerth, 1998, Singlet oxygen production correlates with His and Trp destruction in brunescent cataract water-insoluble proteins, Exp. Eye Res., 67, 377, 10.1006/exer.1998.0550
Padgaonkar, 1989, Disulfide cross-linking of urea-insoluble proteins in rabbit lenses treated with hyperbaric oxygen, Exp. Eye Res., 49, 887, 10.1016/S0014-4835(89)80047-8
Palmquist, 1984, Nuclear cataract and myopia during hyperbaric oxygen therapy, Br. J. Ophthalmol., 68, 113, 10.1136/bjo.68.2.113
Parker, 2004, Protein-bound kynurenine is a photosensitiser of oxidative damage, Free Radic. Biol. Med., 37, 1479, 10.1016/j.freeradbiomed.2004.07.015
Patrick, 1990, Nonenzymatic glycosylation of protein does not increase with age in normal human lenses, J. Gerontol., 45, B18, 10.1093/geronj/45.1.B18
Pfahnl, 1999, Gating of cx46 gap junction hemichannels by calcium and voltage, Pflugers Arch.—Eur. J. Physiol., 437, 345, 10.1007/s004240050788
Piatigorsky, 1984, Crystallin genes: templates for lens transparency, Ciba Found. Symp., 106, 191
Pirie, 1968, Color and solubility of the proteins of human cataracts, Invest. Ophthalmol., 7, 634
Rathbun, 1986, Activity of glutathione synthesis enzymes in the rhesus monkey lens related to age: a model for the human lens, Curr. Eye Res., 5, 161, 10.3109/02713688609015104
Rathbun, 1986, Activity of glutathione peroxidase and glutathione reductase in the human lens related to age, Curr. Eye Res., 5, 381, 10.3109/02713688609025177
Rathbun, 1986, Species survey of glutathione peroxidase and glutathione reductase: search for an animal model of the human lens, Ophthal. Res., 18, 282, 10.1159/000265449
Reddan, 1992, Tempol and deferoxamine protect cultured rabbit lens epithelial cells from H2O2 insult: insight into the mechanism of H2O2-induced injury, Lens Eye Toxicol. Res., 9, 385
Reddy, 1984, Metabolism and function of glutathione in the lens, Ciba Found. Symp., 106, 65
Rose, 1991, Ocular ascorbate transport and metabolism, Comparitive Biochem. Physiol. A, 100, 273, 10.1016/0300-9629(91)90470-W
Roy, 1976, Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses, Proc. Natl Acad. Sci. USA, 73, 3484, 10.1073/pnas.73.10.3484
Shearer, 1995, Precipitation of crystallins from young rat lens by endogenous calpain, Exp. Eye Res., 61, 141, 10.1016/S0014-4835(05)80033-8
Shearer, 1996, Crystallins from rat lens are especially susceptible to calpain-induced light scattering compared to other species, Curr. Eye Res., 15, 860, 10.3109/02713689609017627
Shiels, 1998, A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant ‘zonular pulverulent’ cataract, on chromosome 1q, Am. J. Hum. Genet., 62, 526, 10.1086/301762
Shih, 1998, Cleavage of beta crystallins during maturation of bovine lens, Mol. Vis., 4, 4
Siik, 1999, Lens autofluorescence and light scatter in relation to the lens opacities classification system, LOCS III, Acta Ophthalmol. Scand., 77, 509, 10.1034/j.1600-0420.1999.770504.x
Simpson, 2000, The non-oxidative degradation of ascorbic acid at physiological conditions, Biochim. Biophys. Acta, 1501, 12, 10.1016/S0925-4439(00)00009-0
Smith, 1995, Glutathione adducts, not carbamylated lysines, are the major modification of lens alpha-crystallins from renal failure patients, J. Prot. Chem., 14, 179, 10.1007/BF01980330
Sochaski, 2001, Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein, Anal. Chem., 73, 4662, 10.1021/ac010228k
Spector, 1984, Oxidation and cataract, Ciba Found. Symp., 106, 48
Spector, 1981, Hydrogen peroxide and human cataract, Exp. Eye Res., 33, 673, 10.1016/S0014-4835(81)80107-8
Spector, 1998, The aqueous humor is capable of generating and degrading H2O2, Invest. Ophthalmol. Vis. Sci., 39, 1188
Streete, 2004, Lenticular levels ofamino acids and free UV filters differ significantly between normals and cataract patients, Invest. Ophthalmol. Vis. Sci., 45, 4091, 10.1167/iovs.04-0178
Sweeney, 1998, An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract, Exp. Eye Res., 67, 587, 10.1006/exer.1998.0549
Takemoto, 1995, Identification of the in vivo truncation sites at the C-terminal region of alpha-a crystallin from aged bovine and human lens, Curr. Eye Res., 14, 837, 10.3109/02713689508995806
Takemoto, 1976, Amino acid composition of normal and cataractous human lens proteins, Exp. Eye Res., 23, 1, 10.1016/0014-4835(76)90022-1
Taylor, 2003, Eye care for the future: the Weisenfeld lecture, Invest. Ophthalmol. Vis. Sci., 44, 1413, 10.1167/iovs.02-0571
Taylor, 2002, UV filter instability: consequences for the human lens, Exp. Eye Res., 75, 165, 10.1006/exer.2002.2012
Taylor, 2002, Glutathione and NADH, but not ascorbate, protect lens proteins from modification by UV filters, Exp. Eye Res., 74, 503, 10.1006/exer.2001.1165
Tessier, 1999, Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis, J. Biol. Chem., 274, 20796, 10.1074/jbc.274.30.20796
Thylefors, 2002, A simplified cataract grading system, Ophthalmic Epidemiol., 9, 83, 10.1076/opep.9.2.83.1523
Truscott, 2000, Age-related nuclear cataract: a lens transport problem, Ophthalmic Res., 32, 185, 10.1159/000055612
Truscott, 1977, Changes in human lens proteins during nuclear cataract formation, Exp. Eye Res., 24, 159, 10.1016/0014-4835(77)90256-1
Truscott, 1977, Oxidative changes in human lens proteins during senile nuclear cataract formation, Biochim. Biophys. Acta, 492, 43, 10.1016/0005-2795(77)90212-4
Truscott, 1977, The state of sulphydryl groups in normal and cataractous human lenses, Exp. Eye Res., 25, 139, 10.1016/0014-4835(77)90126-9
Truscott, 1995, Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients, Clin. Sci., 89, 591, 10.1042/cs0890591
Truscott, 1992, Identification of 3-hydroxykynurenine as the lens pigment in the gourami Trichogaster trichopterus, Exp. Eye Res., 54, 1015, 10.1016/0014-4835(92)90167-Q
Ueda, 2002, Lens proteomics: the accumulation of crystallin modifications in the mouse lens with age, Invest. Ophthalmol. Vis. Sci., 43, 205
van Heyningen, 1972, The human lens III some observations on the post-mortem lens, Exp. Eye Res., 13, 155, 10.1016/0014-4835(72)90028-0
Vazquez, 2002, Novel protein modification by kynurenine in human lenses, J. Biol. Chem., 277, 4867, 10.1074/jbc.M107529200
Wang-Su, 2003, Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line, Invest. Ophthalmol. Vis. Sci., 44, 4829, 10.1167/iovs.03-0556
Wegener, 1994, In vivo studies on the effect of UV-radiation on the eye lens in animals, Doc. Ophthalmol., 88, 221, 10.1007/BF01203676
Wells-Knecht, 1993, Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens, J. Biol. Chem., 268, 12348, 10.1016/S0021-9258(18)31396-6
West, 1995, Epidemiology of risk factors for age-related cataract, Surv. Ophthalmol., 39, 323, 10.1016/S0039-6257(05)80110-9
Wistow, 1987, Recruitment of enzymes as lens structural proteins, Science, 236, 1554, 10.1126/science.3589669
Yim, 2001, Protein glycation: creation of catalytic sites for free radical generation, Ann. NY Acad. Sci., 928, 48, 10.1111/j.1749-6632.2001.tb05634.x
Yu, 1985, Disulfide bond formation in the eye lens, Proc. Natl Acad. Sci. USA, 82, 7965, 10.1073/pnas.82.23.7965
Zigler, 1989, Oxidative modification of lens crystallins by H2O2 and chelated iron, Free Radic. Biol. Med., 7, 499, 10.1016/0891-5849(89)90025-7