Age-related changes in skeletal muscle: changes to life-style as a therapy
Tóm tắt
As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting.
Tài liệu tham khảo
citation_journal_title=J Nutr Health Aging; citation_title=Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity; citation_author=O Addison, MJ Drummond, PC LaStayo, LE Dibble, AR Wende, DA McClain; citation_volume=18; citation_publication_date=2014; citation_pages=532-538; citation_id=CR1
citation_journal_title=Med Sci Sports Exerc; citation_title=Muscle function in 164 men and women aged 20–84 yr; citation_author=H Akima, Y Kano, Y Enomoto, M Ishizu, M Okada, Y Oishi; citation_volume=33; citation_publication_date=2001; citation_pages=220-226; citation_id=CR2
citation_journal_title=Age Ageing; citation_title=Longitudinal evidence on the association between interleukin-6 and C-reactive protein with the loss of total appendicular skeletal muscle in free-living older men and women; citation_author=H Aleman, J Esparza, FA Ramirez, H Astiazaran, H Payette; citation_volume=40; citation_publication_date=2011; citation_pages=469-475; citation_id=CR3
citation_journal_title=Am J Clin Nutr; citation_title=Protein-induced hypercalciuria: a longer term study; citation_author=LH Allen, EA Oddoye, S Margen; citation_volume=32; citation_publication_date=1979; citation_pages=741-749; citation_id=CR4
citation_journal_title=J Anat; citation_title=Connective tissue changes and physical properties of developing and ageing skeletal muscle; citation_author=MA Alnaqeeb, NS Al Zaid, G Goldspink; citation_volume=139; citation_publication_date=1984; citation_pages=677-689; citation_id=CR5
citation_journal_title=J Biol Chem; citation_title=Muscle wasting in aged, sarcopenic rats Is associated with enhanced activity of the ubiquitin proteasome pathway; citation_author=M Altun, H Besche, H Overkleeft, R Piccirillo, MJ Edelmann, BM Kessler; citation_volume=285; citation_publication_date=2010; citation_pages=39597-39608; citation_id=CR6
citation_journal_title=Med Sci Sports; citation_title=Muscle fibre type adaptation in the elderly human muscle; citation_author=J Andersen; citation_volume=13; citation_publication_date=2003; citation_pages=40-47; citation_id=CR7
citation_journal_title=J Neurol Sci; citation_title=Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats. Relation to the number of soleus muscle fibers; citation_author=T Ansved, L Larsson; citation_volume=96; citation_publication_date=1990; citation_pages=269-282; citation_id=CR8
citation_journal_title=Am J Pathol; citation_title=Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-κB activation; citation_author=E Ardite, J Albert Barbera, J Roca, JC Fernández-Checa; citation_volume=165; citation_publication_date=2004; citation_pages=719-728; citation_id=CR9
citation_journal_title=J Nutr; citation_title=Chronic maternal protein deprivation in mice is associated with overexpression of the cohesin-mediator complex in liver of their offspring; citation_author=A Balasa, A Sanchez-Valle, B Sadikovic, H Sangi-Haghpeykar, J Bravo, L Chen; citation_volume=141; citation_publication_date=2011; citation_pages=2106-2112; citation_id=CR10
citation_journal_title=Exp Gerontol; citation_title=Blunted hypertrophic response in old mouse muscle is associated with a lower satellite cell density and is not alleviated by resveratrol; citation_author=SB Ballak, RT Jaspers, L Deldicque, S Chalil, EL Peters, A Haan; citation_volume=62; citation_publication_date=2015; citation_pages=23-31; citation_id=CR11
citation_journal_title=J Appl Physiol; citation_title=Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution; citation_author=MM Bamman, MSF Clarke, DL Feeback, RJ Talmadge, BR Stevens, SA Lieberman; citation_volume=84; citation_publication_date=1998; citation_pages=157-163; citation_id=CR12
citation_journal_title=J Nutr Health Aging; citation_title=Grip work estimation during sustained maximal contraction: validity and relationship with dependency and inflammation in elderly persons; citation_author=I Bautmans, O Onyema, K Puyvelde, S Pleck, T Mets; citation_volume=15; citation_publication_date=2011; citation_pages=731-736; citation_id=CR13
citation_journal_title=Obes Res Clin Pract; citation_title=Exercise, strict physical inactivity (experimental bed-rest) and their effects on visceral adipose tissue and fat distribution; citation_author=D Belavy, M Möhlig, A Pfeiffer, D Felsenberg, G Armbrecht; citation_volume=8; citation_publication_date=2014; citation_pages=6-7; citation_id=CR14
citation_journal_title=Eur J Med Res; citation_title=A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α; citation_author=A-L Bian, H-Y Hu, Y-D Rong, J Wang, J-X Wang, X-Z Zhou; citation_volume=22; citation_publication_date=2017; citation_pages=25; citation_id=CR15
citation_journal_title=Science; citation_title=Identification of ubiquitin ligases required for skeletal muscle atrophy; citation_author=S Bodine, E Latres, S Baumhueter, V Lai, L Nunez, B Clarke; citation_volume=294; citation_publication_date=2001; citation_pages=1704-1708; citation_id=CR16
citation_journal_title=Anat Rec; citation_title=Cell death in denervated skeletal muscle is distinct from classical apoptosis; citation_author=AB Borisov, BM Carlson; citation_volume=258; citation_publication_date=2000; citation_pages=305-318; citation_id=CR17
citation_journal_title=Anat Rec; citation_title=Interrelations of myogenic response, progressive atrophy of muscle fibers, and cell death in denervated skeletal muscle; citation_author=AB Borisov, EI Dedkov, BM Carlson; citation_volume=264; citation_publication_date=2001; citation_pages=203-218; citation_id=CR18
citation_journal_title=Science; citation_title=Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis; citation_author=A Brack, M Conboy, S Roy, M Lee, C Kuo, C Keller; citation_volume=317; citation_publication_date=2007; citation_pages=807-810; citation_id=CR19
citation_journal_title=J Clin Endocrinol Metab; citation_title=Two weeks of reduced activity decreases leg lean mass and induces “anabolic resistance” of myofibrillar protein synthesis in healthy elderly; citation_author=L Breen, KA Stokes, TA Churchward-Venne, DR Moore, SK Baker, K Smith; citation_volume=98; citation_publication_date=2013; citation_pages=2604-2612; citation_id=CR20
citation_journal_title=FASEB J; citation_title=Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity; citation_author=CS Broome, AC Kayani, J Palomero, WH Dillmann, R Mestril, MJ Jackson; citation_volume=20; citation_publication_date=2006; citation_pages=1549-1551; citation_id=CR21
citation_journal_title=Am J Hum Genet; citation_title=Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers; citation_author=E Bua, J Johnson, A Herbst, B Delong, D McKenzie, S Salamat; citation_volume=79; citation_publication_date=2006; citation_pages=469-480; citation_id=CR22
citation_journal_title=J Appl Physiol; citation_title=Artificial gravity as a countermeasure to microgravity: a pilot study examining the effects on knee extensor and plantar flexor muscle groups; citation_author=VJ Caiozzo, F Haddad, S Lee, M Baker, W Paloski, KM Baldwin; citation_volume=1985; citation_issue=107; citation_publication_date=2009; citation_pages=39-46; citation_id=CR23
citation_journal_title=J Gerontol Ser A; citation_title=Impaired expression of notch signaling genes in aged human skeletal muscle; citation_author=KA Carey, MM Farnfield, SD Tarquinio, D Cameron-Smith; citation_volume=62; citation_publication_date=2007; citation_pages=9-17; citation_id=CR24
citation_journal_title=Am J Physiol; citation_title=Muscle transplantation between young and old rats: age of host determines recovery; citation_author=B Carlson, J Faulkner; citation_volume=256; citation_publication_date=1989; citation_pages=1262-1266; citation_id=CR25
citation_journal_title=J Gerontol Ser A; citation_title=Skeletal muscle regeneration in very old rats; citation_author=BM Carlson, EI Dedkov, AB Borisov, JA Faulkner; citation_volume=56; citation_publication_date=2001; citation_pages=B224-B233; citation_id=CR26
citation_journal_title=Public Health Rep; citation_title=Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research; citation_author=CJ Caspersen, KE Powell, GM Christenson; citation_volume=100; citation_publication_date=1985; citation_pages=126-131; citation_id=CR27
citation_journal_title=Nature; citation_title=The aged niche disrupts muscle stem cell quiescence; citation_author=J Chakkalakal, K Jones, A Basson, A Brack; citation_volume=490; citation_publication_date=2012; citation_pages=355-360; citation_id=CR28
citation_journal_title=Biol Ageing; citation_title=Fibroblast cultures from healthy centenarians have an active proteasome; citation_author=N Chondrogianni, I Petropoulos, C Franceschi, B Friguet, E Gonos; citation_volume=35; citation_publication_date=2000; citation_pages=721-728; citation_id=CR29
citation_journal_title=Ageing Res Rev; citation_title=Molecular inflammation: underpinnings of aging and age-related diseases; citation_author=HY Chung, M Cesari, S Anton, E Marzetti, S Giovannini, AY Seo; citation_volume=8; citation_publication_date=2009; citation_pages=18-30; citation_id=CR30
citation_journal_title=Mech Ageing Dev; citation_title=Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle; citation_author=S Clavel, AS Coldefy, E Kurkdjian, J Salles, I Margaritis, B Derijard; citation_volume=127; citation_publication_date=2006; citation_pages=794-801; citation_id=CR31
citation_journal_title=J Appl Physiol; citation_title=Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women; citation_author=AR Coggan, RJ Spina, DS King, MA Rogers, M Brown, PM Nemeth; citation_volume=72; citation_publication_date=1992; citation_pages=1780-1786; citation_id=CR32
citation_journal_title=Science; citation_title=Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase; citation_author=HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler; citation_volume=305; citation_publication_date=2004; citation_pages=390-392; citation_id=CR33
citation_journal_title=J Am Med Dir Assoc; citation_title=Prevalence of sarcopenia based on different diagnostic criteria using DEXA and appendicular skeletal muscle mass reference values in an italian population aged 20 to 80; citation_author=A Coin, S Sarti, E Ruggiero, S Giannini, M Pedrazzoni, S Minisola; citation_volume=14; citation_publication_date=2013; citation_pages=507-512; citation_id=CR34
citation_journal_title=J Gerontol Ser A; citation_title=Attenuation of sarcopenia by dietary restriction in rhesus monkeys; citation_author=RJ Colman, TM Beasley, DB Allison, R Weindruch; citation_volume=63; citation_publication_date=2008; citation_pages=556-559; citation_id=CR35
citation_journal_title=Nat Commun; citation_title=Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys; citation_author=RJ Colman, TM Beasley, JW Kemnitz, SC Johnson, R Weindruch, RM Anderson; citation_volume=5; citation_publication_date=2014; citation_pages=3557; citation_id=CR36
citation_journal_title=Nature; citation_title=Rejuvenation of aged progenitor cells by exposure to a young systemic environment; citation_author=IM Conboy, MJ Conboy, AJ Wagers, ER Girma, IL Weissman, TA Rando; citation_volume=433; citation_publication_date=2005; citation_pages=760-764; citation_id=CR37
citation_journal_title=J Biol Chem; citation_title=Age-related decline in chaperone-mediated autophagy; citation_author=A Cuervo, J Dice; citation_volume=275; citation_publication_date=2000; citation_pages=31505-31513; citation_id=CR38
citation_journal_title=FASEB J; citation_title=Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle; citation_author=D Cuthbertson, K Smith, J Babraj, G Leese, T Waddell, P Atherton; citation_volume=19; citation_publication_date=2005; citation_pages=422-424; citation_id=CR39
citation_journal_title=Dev Biol; citation_title=The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progenitors to produce reserve progeny; citation_author=K Day, G Shefer, A Shearer, Z Yablonka-Reuveni; citation_volume=340; citation_publication_date=2010; citation_pages=330-343; citation_id=CR40
citation_journal_title=Scand J Med Sci Sports; citation_title=The role of systemic inflammation in age-related muscle weakness and wasting; citation_author=H Degens; citation_volume=20; citation_publication_date=2010; citation_pages=28-38; citation_id=CR41
citation_journal_title=Cell; citation_title=FOXO/4E-BP signaling in drosophila muscles regulates organism-wide proteostasis during aging; citation_author=F Demontis, N Perrimon; citation_volume=143; citation_publication_date=2010; citation_pages=813-825; citation_id=CR42
citation_journal_title=Exp Gerontol; citation_title=Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers; citation_author=MR Deschenes, MA Roby, MK Eason, MB Harris; citation_volume=45; citation_publication_date=2010; citation_pages=389-393; citation_id=CR43
citation_journal_title=Free Rad Biol Med; citation_title=Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12; citation_author=AJ Dirks, C Leeuwenburgh; citation_volume=36; citation_publication_date=2004; citation_pages=27-39; citation_id=CR44
citation_journal_title=J Nutr; citation_title=Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men; citation_author=ML Dirks, BT Wall, R Nilwik, DH Weerts, LB Verdijk, LJ Loon; citation_volume=144; citation_publication_date=2014; citation_pages=1196-1203; citation_id=CR45
citation_journal_title=Physiol Genom; citation_title=Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis; citation_author=MJ Drummond, JJ McCarthy, M Sinha, HM Spratt, E Volpi, KA Esser; citation_volume=43; citation_publication_date=2011; citation_pages=595-603; citation_id=CR46
citation_journal_title=J Gerontolol Ser A; citation_title=Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison; citation_author=MJ Drummond, O Addison, L Brunker, PN Hopkins, DA McClain, PC LaStayo; citation_volume=69; citation_publication_date=2014; citation_pages=1040-1048; citation_id=CR47
citation_journal_title=Diabetes; citation_title=Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study; citation_author=BB Duncan, MI Schmidt, JS Pankow, CM Ballantyne, D Couper, A Vigo; citation_volume=52; citation_publication_date=2003; citation_pages=1799-1805; citation_id=CR48
citation_journal_title=J Gerontol Ser A; citation_title=From muscle properties to human performance, using magnetic resonance; citation_author=WJ Evans, KE Conley, ME Cress, SA Jubrias, PC Esselman, IR Odderson; citation_volume=50A; citation_publication_date=1995; citation_pages=35-40; citation_id=CR49
citation_journal_title=Increased cytokine production in mononuclear cells of healthy elderly people European journal of Immunology; citation_author=U Fagiolo, A Cossarizza, E Scala, E Fanales-Belasio, C Ortolani, E Cozzi; citation_volume=23; citation_publication_date=1993; citation_pages=2375-2378; citation_id=CR50
citation_journal_title=N Engl J Med; citation_title=Exercise training and nutritional supplementation for physical frailty in very elderly people; citation_author=MA Fiatarone, EF O’Neill, ND Ryan, KM Clements, GR Solares, ME Nelson; citation_volume=330; citation_publication_date=1994; citation_pages=1769-1775; citation_id=CR51
citation_journal_title=J Am Geriatr Soc; citation_title=High-velocity resistance training increases skeletal muscle peak power in older women; citation_author=RA Fielding, NK LeBrasseur, A Cuoco, J Bean, K Mizer, MAF Singh; citation_volume=50; citation_publication_date=2002; citation_pages=655-662; citation_id=CR52
citation_journal_title=Nature; citation_title=A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing; citation_author=MC Florian, KJ Nattamai, K Dorr, G Marka, B Uberle, V Vas; citation_volume=503; citation_publication_date=2013; citation_pages=392-396; citation_id=CR53
citation_journal_title=Proc Natl Acad Sci USA; citation_title=Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans; citation_author=L Fontana, TE Meyer, S Klein, JO Holloszy; citation_volume=101; citation_publication_date=2004; citation_pages=6659-6663; citation_id=CR54
citation_journal_title=Nutrients; citation_title=Aging reduces the activation of the mTORC1 pathway after resistance exercise and protein intake in human skeletal muscle: potential role of REDD1 and impaired anabolic sensitivity; citation_author=M Francaux, B Demeulder, D Naslain, R Fortin, O Lutz, G Caty; citation_volume=8; citation_publication_date=2016; citation_pages=47; citation_id=CR55
citation_journal_title=Ann N Y Acad Sci; citation_title=Inflamm-aging. An evolutionary perspective on immunosenescence; citation_author=C Franceschi, M Bonafè, S Valensin, F Olivieri, M Luca, E Ottaviani; citation_volume=908; citation_publication_date=2000; citation_pages=244-254; citation_id=CR56
citation_journal_title=Brain; citation_title=The relation between inflammation and neurodegeneration in multiple sclerosis brains; citation_author=JM Frischer, S Bramow, A Dal-Bianco, CF Lucchinetti, H Rauschka, M Schmidbauer; citation_volume=132; citation_publication_date=2009; citation_pages=1175-1189; citation_id=CR57
citation_journal_title=Skelet Muscle; citation_title=Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis; citation_author=CS Fry, MJ Drummond, EL Glynn, JM Dickinson, DM Gundermann, KL Timmerman; citation_volume=1; citation_publication_date=2011; citation_pages=11; citation_id=CR58
citation_journal_title=Nature; citation_title=Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia; citation_author=CS Fry, JD Lee, J Mula, TJ Kirby, JR Jackson, F Liu; citation_volume=21; citation_publication_date=2015; citation_pages=76-80; citation_id=CR59
citation_journal_title=Diabetes; citation_title=Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling; citation_author=S Fujita, B Rasmussen, J Cadenas, M Drummond, E Glynn, F Sattler; citation_volume=56; citation_publication_date=2007; citation_pages=1615-1622; citation_id=CR60
citation_journal_title=Neuromuscul Disord; citation_title=Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome; citation_author=S Fulle, S Belia, J Vecchiet, C Morabito, L Vecchiet, G Fano; citation_volume=13; citation_publication_date=2003; citation_pages=479-484; citation_id=CR61
citation_journal_title=J Appl Physiol; citation_title=PKB signaling and atrogene expression in skeletal muscle of aged mice; citation_author=M Gaugler, A Brown, E Merrell, M DiSanto-Rose, JA Rathmacher, TH Reynolds; citation_volume=111; citation_publication_date=2011; citation_pages=192-199; citation_id=CR62
citation_journal_title=Nutr Clin Pract; citation_title=Dietary protein intake in elderly women: association with muscle and bone mass; citation_author=P Genaro, M Pinheiro, V Szejnfeld, L Martini; citation_volume=30; citation_publication_date=2015; citation_pages=283-289; citation_id=CR63
citation_journal_title=Diabetes; citation_title=Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance; citation_author=S Ghosh, R Lertwattanarak, N Lefort, M Molina-Carrion, J Joya-Galeana, BP Bowen; citation_volume=60; citation_publication_date=2011; citation_pages=2051-2060; citation_id=CR64
citation_journal_title=Neuromuscul Disord; citation_title=Age-related changes in collagen gene expression in the muscles of mdx dystrophic and normal mice; citation_author=G Goldspink, K Fernandes, PE Williams, DJ Wells; citation_volume=4; citation_publication_date=1994; citation_pages=183-191; citation_id=CR65
citation_journal_title=J Cell Sci; citation_title=Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation; citation_author=K Goljanek-Whysall, H Pais, T Rathjen, D Sweetman, T Dalmay, A Munsterberg; citation_volume=125; citation_publication_date=2012; citation_pages=3590-3600; citation_id=CR66
citation_journal_title=FASEB J; citation_title=Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans; citation_author=G Gouspillou, N Sgarioto, S Kapchinsky, F Purves-Smith, B Norris, CH Pion; citation_volume=28; citation_publication_date=2014; citation_pages=1621-1633; citation_id=CR67
citation_journal_title=Eur J Appl Physiol; citation_title=Peak anaerobic power in master athletes; citation_author=B Grassi, P Cerretelli, MV Narici, C Marconi; citation_volume=62; citation_publication_date=1991; citation_pages=394-399; citation_id=CR68
citation_journal_title=Nat Med; citation_title=Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration; citation_author=P Grumati, L Coletto, P Sabatelli, M Cescon, A Angelin, E Bertaggia; citation_volume=16; citation_publication_date=2010; citation_pages=1313-1320; citation_id=CR69
citation_journal_title=J Physiol; citation_title=Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise; citation_author=M Hameed, RW Orrell, M Cobbold, G Goldspink, SD Harridge; citation_volume=547; citation_publication_date=2003; citation_pages=247-254; citation_id=CR70
citation_journal_title=Am J Physiol Endocrinol Metab; citation_title=Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78–84 and 23–32 yr olds; citation_author=DL Hasten, J Pak-Loduca, KA Obert, KE Yarasheski; citation_volume=278; citation_publication_date=2000; citation_pages=E620-E626; citation_id=CR71
citation_journal_title=J Appl Physiol; citation_title=Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle; citation_author=JM Haus, JA Carrithers, SW Trappe, TA Trappe; citation_volume=103; citation_publication_date=2007; citation_pages=2068-2076; citation_id=CR72
He W, Goodkind D, Kowal P (2016) U.S. Census Bureau, international population reports, P95/16-1, an aging world: 2015. U.S. Government Publishing Office, Washington, DC
citation_journal_title=Gerontology; citation_title=Improved physical performance in older adults undertaking a short-term programme of high-velocity resistance training; citation_author=TR Henwood, DR Taaffe; citation_volume=51; citation_publication_date=2005; citation_pages=108-115; citation_id=CR73
citation_journal_title=Am J Physiol Regul Integr Comp Physiol; citation_title=Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia; citation_author=RT Hepple, M Qin, H Nakamoto, S Goto; citation_volume=295; citation_publication_date=2008; citation_pages=R1231-R1237; citation_id=CR74
citation_journal_title=J Physiol; citation_title=Role of reactive oxygen species in age-related neuromuscular deficits; citation_author=MJ Jackson, A McArdle; citation_volume=594; citation_publication_date=2016; citation_pages=1979-1988; citation_id=CR75
citation_journal_title=Am J Physiol Cell Physiol; citation_title=Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy; citation_author=J Jackson, J Mula, TJ Kirby, CS Fry, JD Lee, MF Ubele; citation_volume=303; citation_publication_date=2012; citation_pages=C854-C861; citation_id=CR76
citation_journal_title=J Am Geriatr Soc; citation_title=The healthcare costs of sarcopenia in the United States; citation_author=I Janssen, DS Shepard, PT Katzmarzyk, R Roubenoff; citation_volume=52; citation_publication_date=2004; citation_pages=80-85; citation_id=CR77
citation_journal_title=FASEB J; citation_title=An intervention resembling caloric restriction prolongs life span and retards aging in yeast; citation_author=JC Jiang, E Jaruga, MV Repnevskaya, SM Jazwinski; citation_volume=14; citation_publication_date=2000; citation_pages=2135-2137; citation_id=CR78
citation_journal_title=Exp Gerontol; citation_title=Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals; citation_author=A-M Joseph, AG Malamo, J Silvestre, N Wawrzyniak, S Carey-Love, LMD Nguyen; citation_volume=48; citation_publication_date=2013; citation_pages=858-868; citation_id=CR79
citation_journal_title=PLoS ONE; citation_title=Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging; citation_author=AM Joseph, PJ Adhihetty, NR Wawrzyniak, SE Wohlgemuth, A Picca, GC Kujoth; citation_volume=8; citation_publication_date=2013; citation_pages=e69327; citation_id=CR80
citation_journal_title=J Physiol; citation_title=Properties of single motor units in medial gastrocnemius muscles of adult and old rats; citation_author=VA Kadhiresan, CA Hassett, JA Faulkner; citation_volume=493; citation_publication_date=1996; citation_pages=543-552; citation_id=CR81
citation_journal_title=Endocrinol Metab; citation_title=A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly; citation_author=CS Katsanos, H Kobayashi, M Sheffield-Moore, A Aarsland, RR Wolfe; citation_volume=291; citation_publication_date=2006; citation_pages=E381-E387; citation_id=CR82
citation_journal_title=Am J Physiol Regul Integr Comp Physiol; citation_title=Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits; citation_author=AC Kayani, GL Close, MJ Jackson, A McArdle; citation_volume=294; citation_publication_date=2008; citation_pages=R568-R576; citation_id=CR83
citation_journal_title=J Strength Cond Res; citation_title=Effects of whole-body electromyostimulation on resting metabolic rate, body composition, and maximum strength in postmenopausal women: the training and electrostimulation trial; citation_author=W Kemmler, R Schliffka, JL Mayhew, S Stengel; citation_volume=24; citation_publication_date=2010; citation_pages=1880-1887; citation_id=CR84
citation_journal_title=Age; citation_title=Impact of whole-body electromyostimulation on body composition in elderly women at risk for sarcopenia: the training and electrostimulation trial (TEST-III); citation_author=W Kemmler, M Bebenek, K Engelke, S Stengel; citation_volume=36; citation_publication_date=2014; citation_pages=395-406; citation_id=CR85
citation_journal_title=J Cell Sci; citation_title=Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age; citation_author=R Kiffin, S Kaushik, M Zeng, U Bandyopadhyay, C Zhang, AC Massey; citation_volume=120; citation_publication_date=2007; citation_pages=782-791; citation_id=CR86
citation_journal_title=Brain Behav Immun; citation_title=Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults; citation_author=ML Kohut, DA McCann, DW Russell, DN Konopka, JE Cunnick, WD Franke; citation_volume=20; citation_publication_date=2006; citation_pages=201-209; citation_id=CR87
citation_journal_title=J Biogerontol; citation_title=Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training; citation_author=A Konopka, M Suer, C Wolff, MP Harber; citation_volume=69; citation_publication_date=2013; citation_pages=371-378; citation_id=CR88
citation_journal_title=J Nutr; citation_title=Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men; citation_author=R Koopman, S Walrand, M Beelen, AP Gijsen, AK Kies, Y Boirie; citation_volume=139; citation_publication_date=2009; citation_pages=1707-1713; citation_id=CR89
citation_journal_title=Redox Biol; citation_title=Proteostasis, oxidative stress and aging; citation_author=I Korovila, M Hugo, JP Castro, D Weber, A Hohn, T Grune; citation_volume=13; citation_publication_date=2017; citation_pages=550-567; citation_id=CR90
citation_journal_title=Science; citation_title=Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging; citation_author=GC Kujoth, A Hiona, TD Pugh, S Someya, K Panzer, SE Wohlgemuth; citation_volume=309; citation_publication_date=2005; citation_pages=481-484; citation_id=CR91
citation_journal_title=Cell Prolif; citation_title=Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting; citation_author=M Kurosaka, S Machida; citation_volume=46; citation_publication_date=2013; citation_pages=365-373; citation_id=CR92
citation_journal_title=Circulation; citation_title=C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon?; citation_author=WK Lagrand, CA Visser, WT Hermens, HWM Niessen, FWA Verheugt, G-J Wolbink; citation_volume=100; citation_publication_date=1999; citation_pages=96-102; citation_id=CR93
citation_journal_title=PNAS; citation_title=The genetics of caloric restriction in Caenorhabditis elegans; citation_author=B Lakowski, S Hekimi; citation_volume=95; citation_publication_date=1989; citation_pages=13091-13096; citation_id=CR94
citation_journal_title=Am J Physiol Regul Integr Comp Physiol; citation_title=Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation; citation_author=LM Larkin, CS Davis, C Sims-Robinson, TY Kostrominova, HV Remmen, A Richardson; citation_volume=301; citation_publication_date=2011; citation_pages=R1400-R1407; citation_id=CR95
citation_journal_title=J Gerontol Ser A; citation_title=Motor units: remodeling in aged animals; citation_author=L Larsson; citation_volume=50A; citation_publication_date=1995; citation_pages=91-95; citation_id=CR96
citation_journal_title=Acta Physiol Scand; citation_title=Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years; citation_author=L Larsson, B Sjödin, J Karlsson; citation_volume=103; citation_publication_date=1978; citation_pages=31-39; citation_id=CR97
citation_journal_title=Oncotarget; citation_title=Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice; citation_author=JP Leduc-Gaudet, M Picard, F St-Jean Pelletier, N Sgarioto, MJ Auger, J Vallee; citation_volume=6; citation_publication_date=2015; citation_pages=17923-17937; citation_id=CR98
citation_journal_title=PLoS ONE; citation_title=Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways; citation_author=S-J Lee; citation_volume=2; citation_publication_date=2007; citation_pages=e789; citation_id=CR99
citation_journal_title=Free Rad Biol Med; citation_title=Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy; citation_author=CM Lee, ME Lopez, R Weindruch, JM Aiken; citation_volume=25; citation_publication_date=1998; citation_pages=964-972; citation_id=CR100
citation_journal_title=Ann N Y Acad Sci; citation_title=Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and Micea; citation_author=CM Lee, LE Aspnes, SS Chung, R Weindruch, JM Aiken; citation_volume=854; citation_publication_date=1998; citation_pages=182-191; citation_id=CR101
citation_journal_title=Clin Orthop Relat Res; citation_title=Age-associated decrease of type IIA/B human skeletal muscle fibers; citation_author=WS Lee, WH Cheung, L Qin, N Tang, KS Leung; citation_volume=450; citation_publication_date=2006; citation_pages=231-237; citation_id=CR102
citation_journal_title=Gerontology; citation_title=Associated factors and health impact of sarcopenia in older chinese men and women: a cross-sectional study; citation_author=JS Lee, TW Auyeung, T Kwok, EM Lau, PC Leung, J Woo; citation_volume=53; citation_publication_date=2007; citation_pages=404-410; citation_id=CR103
citation_journal_title=Cell Metab; citation_title=Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance; citation_author=HY Lee, CS Choi, AL Birkenfeld, TC Alves, FR Jornayvaz, MJ Jurczak; citation_volume=12; citation_publication_date=2010; citation_pages=668-674; citation_id=CR104
citation_journal_title=BioArchitecture; citation_title=Aged skeletal muscle retains the ability to fully regenerate functional architecture; citation_author=ASJ Lee, JE Anderson, JE Joya, SI Head, N Pather, AJ Kee; citation_volume=3; citation_publication_date=2013; citation_pages=25-37; citation_id=CR105
citation_journal_title=J Gerontol; citation_title=Elderly men and women benefit equally from prolonged resistance-type exercise training; citation_author=M Leenders, LB Verdijk, L Hoeven, J Kranenburg, R Nilwik, LJ Loon; citation_volume=68; citation_publication_date=2013; citation_pages=769-779; citation_id=CR106
citation_journal_title=Exerc Immunol Rev; citation_title=Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women; citation_author=I Levinger, KF Howlett, J Peake, A Garnham, DL Hare, G Jerums; citation_volume=16; citation_publication_date=2010; citation_pages=98-104; citation_id=CR107
citation_journal_title=J Neurol Sci; citation_title=What is the cause of the ageing atrophy?: total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men; citation_author=J Lexell, CC Taylor, M Sjöström; citation_volume=84; citation_publication_date=1988; citation_pages=275-294; citation_id=CR108
citation_journal_title=Am J Cell Physiol; citation_title=TNF-alpha is a mitogen in skeletal muscle; citation_author=YP Li; citation_volume=285; citation_publication_date=2003; citation_pages=C370-C376; citation_id=CR109
citation_journal_title=FASEB J; citation_title=Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha; citation_author=YP Li, RJ Schwartz, ID Waddell, BR Holloway, MB Reid; citation_volume=12; citation_publication_date=1998; citation_pages=871-880; citation_id=CR110
citation_journal_title=Redox Biol; citation_title=SS-31 attenuates TNF-alpha induced cytokine release from C2C12 myotubes; citation_author=AP Lightfoot, GK Sakellariou, GA Nye, F McArdle, MJ Jackson, RD Griffiths; citation_volume=6; citation_publication_date=2015; citation_pages=253-259; citation_id=CR111
citation_journal_title=Arch Phys Med Rehabil; citation_title=Age-associated changes in motor unit physiology: observations from the Baltimore longitudinal study of aging; citation_author=SM Ling, RA Conwit, L Ferrucci, EJ Metter; citation_volume=90; citation_publication_date=2009; citation_pages=1237-1240; citation_id=CR112
citation_journal_title=Cochrane Database Syst Rev; citation_title=Progressive resistance strength training for improving physical function in older adults; citation_author=CJ Liu, NK Latham; citation_volume=3; citation_publication_date=2009; citation_pages=CD002759; citation_id=CR113
citation_journal_title=Elife; citation_title=Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration; citation_author=W Liu, A Klose, S Forman, ND Paris, L Wei-LaPierre, M Cortes-Lopez; citation_volume=6; citation_publication_date=2017; citation_pages=e26464; citation_id=CR114
citation_journal_title=Aging Cell; citation_title=In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice; citation_author=A Logan, IG Shabalina, TA Prime, S Rogatti, AV Kalinovich, RC Hartley; citation_volume=13; citation_publication_date=2014; citation_pages=765-768; citation_id=CR115
citation_journal_title=J Strength Cond Res; citation_title=The effect of resistance training and different sources of post-exercise protein supplementation on muscle mass and physical capacity in sarcopenic elderly men; citation_author=ML Maltais, J Perreault-Ladouceur, IJ Dionne; citation_volume=30; citation_publication_date=2015; citation_pages=1680-1687; citation_id=CR116
citation_journal_title=Mech Ageing Dev; citation_title=Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle; citation_author=E Marzetti, SE Wohlgemuth, HA Lees, HY Chung, S Giovannini, C Leeuwenburgh; citation_volume=129; citation_publication_date=2008; citation_pages=542-549; citation_id=CR117
citation_journal_title=Scand J Med Sci Sports; citation_title=Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice; citation_author=CD McMahon, R Chai, HG Radley-Crabb, T Watson, KG Matthews, PW Sheard; citation_volume=24; citation_publication_date=2014; citation_pages=e423-e435; citation_id=CR118
citation_journal_title=Free Rad Biol Med; citation_title=Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle; citation_author=P Mecocci, G Fano, S Fulle, U MacGarvey, L Shinobu, MC Polidori; citation_volume=26; citation_publication_date=1999; citation_pages=303-308; citation_id=CR119
citation_journal_title=Aging Cell; citation_title=Calorie restriction in humans inhibits the PI3 K/AKT pathway and induces a younger transcription profile; citation_author=EM Mercken, SD Crosby, DW Lamming, L JeBailey, S Krzysik-Walker, DT Villareal; citation_volume=12; citation_publication_date=2013; citation_pages=645-651; citation_id=CR120
citation_journal_title=Biogerontology; citation_title=Cultured senescent myoblasts derived from human vastus lateralis exhibit normal mitochondrial ATP synthesis capacities with correlating concomitant ROS production while whole cell ATP production is decreased; citation_author=AD Minet, M Gaster; citation_volume=13; citation_publication_date=2012; citation_pages=277-285; citation_id=CR121
citation_journal_title=Exp Gerontol; citation_title=Mitochondrial role in cell aging; citation_author=J Miquel, AC Economos, J Fleming, JE Johnson; citation_volume=15; citation_publication_date=1980; citation_pages=575-591; citation_id=CR122
citation_journal_title=J Nutr Health Aging; citation_title=Body composition in the elderly: the influence of nutritional factors and physical activity; citation_author=D Mitchell, MN Haan, FM Steinberg, M Visser; citation_volume=7; citation_publication_date=2003; citation_pages=130-139; citation_id=CR123
citation_journal_title=J Gerontol Ser A; citation_title=Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men; citation_author=DR Moore, TA Churchward-Venne, O Witard, L Breen, NA Burd, KD Tipton; citation_volume=70; citation_publication_date=2015; citation_pages=57-62; citation_id=CR124
citation_journal_title=PLoS ONE; citation_title=High whey protein intake delayed the loss of lean body mass in healthy old rats, whereas protein type and polyphenol/antioxidant supplementation had no effects; citation_author=L Mosoni, E Gatineau, P Gatellier, C Migne, I Savary-Auzeloux, D Remond; citation_volume=9; citation_publication_date=2014; citation_pages=e109098; citation_id=CR125
citation_journal_title=Free Rad Biol Med; citation_title=Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy; citation_author=FL Muller, W Song, Y Liu, A Chaudhuri, S Pieke-Dahl, R Strong; citation_volume=40; citation_publication_date=2006; citation_pages=1993-2004; citation_id=CR126
citation_journal_title=Stem Cell Rep; citation_title=Transiently active Wnt/β-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration; citation_author=M Murphy Malea, C Keefe Alexandra, A Lawson Jennifer, D Flygare Steven, M Yandell, G Kardon; citation_volume=3; citation_publication_date=2014; citation_pages=475-488; citation_id=CR127
citation_journal_title=Exp Gerontol; citation_title=The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size; citation_author=R Nilwik, T Snijders, M Leenders, BB Groen, J Kranenburg, LB Verdijk; citation_volume=48; citation_publication_date=2013; citation_pages=492-498; citation_id=CR128
citation_journal_title=Eur J Clin Nutr; citation_title=Effect of inflammation on handgrip strength in the non-critically ill is independent from age, gender and body composition; citation_author=K Norman, N Stobaus, K Kulka, J Schulzke; citation_volume=68; citation_publication_date=2014; citation_pages=155-158; citation_id=CR129
citation_journal_title=J Nutr; citation_title=Protein supplementation at breakfast and lunch for 24 weeks beyond habitual intakes increases whole-body lean tissue mass in healthy older adults; citation_author=C Norton, C Toomey, WG McCormack, P Francis, J Saunders, E Kerin; citation_volume=146; citation_publication_date=2015; citation_pages=65-69; citation_id=CR130
citation_journal_title=Arch Histol Cytol; citation_title=The ultrastructure of skeletal and smooth muscle in experimental protein malnutrition in rats fed a low protein diet; citation_author=M Oumi, M Miyoshi, T Yamamoto; citation_volume=63; citation_publication_date=2000; citation_pages=451-457; citation_id=CR131
citation_journal_title=Am J Physiol; citation_title=Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions; citation_author=J Palomero, A Vasilaki, D Pye, A McArdle, MJ Jackson; citation_volume=305; citation_publication_date=2013; citation_pages=R351-R358; citation_id=CR132
citation_journal_title=Nutr Hosp; citation_title=Sarcopenia intervention with progressive resistance training and protein nutritional supplements; citation_author=M Palop, J Parraga, AE Lozana, C Arteaga; citation_volume=31; citation_publication_date=2015; citation_pages=1481-1490; citation_id=CR133
citation_journal_title=Mech Ageing Dev; citation_title=Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes; citation_author=M Pedersen, H Bruunsgaard, N Weis, H Hendel, B Andreassen, E Eldrup; citation_volume=124; citation_publication_date=2003; citation_pages=495-502; citation_id=CR134
citation_journal_title=Exp Gerontol; citation_title=Leucine supplementation improves regeneration of skeletal muscles from old rats; citation_author=MG Pereira, MT Silva, FM Cunha, AS Moriscot, MS Aoki, EH Miyabara; citation_volume=72; citation_publication_date=2015; citation_pages=269-277; citation_id=CR135
citation_journal_title=Am J Physiol; citation_title=Inhibition by insulin of cellular autophagy in proximal tubular cells of rat kidney; citation_author=U Pfeifer, M Warmuth-Metz; citation_volume=244; citation_publication_date=1983; citation_pages=E109-E114; citation_id=CR136
citation_journal_title=FASEB J; citation_title=Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction; citation_author=T Phillips, C Leeuwenburgh; citation_volume=19; citation_publication_date=2005; citation_pages=668-670; citation_id=CR137
citation_journal_title=J Physiol; citation_title=Age-related neuromuscular changes affecting human vastus lateralis; citation_author=M Piasecki, A Ireland, D Stashuk, A Hamilton-Wright, DA Jones, JS McPhee; citation_volume=594; citation_publication_date=2015; citation_pages=4525-4536; citation_id=CR138
citation_journal_title=BMC Geriatr; citation_title=High risk of malnutrition is associated with low muscle mass in older hospitalized patients - a prospective cohort study; citation_author=VD Pierik, CGM Meskers, JM Ancum, ST Numans, S Verlaan, K Scheerman; citation_volume=17; citation_publication_date=2017; citation_pages=118; citation_id=CR139
citation_journal_title=Eur J Immunol; citation_title=Circulating mitochondrial DNA increases with age and is a familiar trait: implications for “inflamm-aging”; citation_author=M Pinti, E Cevenini, M Nasi, S Biasi, S Salvioli, D Monti; citation_volume=44; citation_publication_date=2014; citation_pages=1552-1562; citation_id=CR140
citation_journal_title=Stem Cells; citation_title=Hierarchization of myogenic and adipogenic progenitors within human skeletal muscle; citation_author=DF Pisani, N Clement, A Loubat, M Plaisant, S Sacconi, JY Kurzenne; citation_volume=28; citation_publication_date=2010; citation_pages=2182-2194; citation_id=CR141
citation_journal_title=Clin Nutr; citation_title=A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise; citation_author=CA Raguso, U Kyle, MP Kossovsky, C Roynette, A Paoloni-Giacobino, D Hans; citation_volume=25; citation_publication_date=2006; citation_pages=573-580; citation_id=CR142
citation_journal_title=J Physiol; citation_title=Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old rats; citation_author=KS Ramaswamy, ML Palmer, JH Meulen, A Renoux, TY Kostrominova, DE Michele; citation_volume=589; citation_publication_date=2011; citation_pages=1195-1208; citation_id=CR143
citation_journal_title=Ann Neurol; citation_title=Overexpression of copper/zinc superoxide dismutase: a novel cause of murine muscular dystrophy; citation_author=TA Rando, RS Crowley, EJ Carlson, CJ Epstein, PK Mohapatra; citation_volume=44; citation_publication_date=1998; citation_pages=381-386; citation_id=CR144
citation_journal_title=J Appl Physiol; citation_title=Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women; citation_author=U Raue, D Slivka, B Jemiolo, C Hollon, S Trappe; citation_volume=1985; citation_issue=101; citation_publication_date=2006; citation_pages=53-59; citation_id=CR145
citation_journal_title=Aging Clin Exp Res; citation_title=Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trial; citation_author=KF Reid, DM Callahan, RJ Carabello, EM Phillips, WR Frontera, RA Fielding; citation_volume=20; citation_publication_date=2008; citation_pages=337-343; citation_id=CR146
citation_journal_title=Sci Rep; citation_title=Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats; citation_author=MBT Ribeiro, V Guzzoni, JM Hord, GN Lopes, RC Marqueti, RV Andrade; citation_volume=7; citation_publication_date=2017; citation_pages=8593; citation_id=CR147
citation_journal_title=Am J Clin Nutr; citation_title=Summary comments: epidemiological and methodological problems in determining nutritional status of older persons; citation_author=I Rosenberg; citation_volume=50; citation_publication_date=1989; citation_pages=1231-1233; citation_id=CR148
citation_journal_title=Biogerontology; citation_title=“SR stress” in mixed hindlimb muscles of aging male rats; citation_author=DW Russ, J Krause, A Wills, R Arreguin; citation_volume=13; citation_publication_date=2012; citation_pages=547-555; citation_id=CR149
citation_journal_title=Biogerontology; citation_title=Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism; citation_author=DW Russ, IM Boyd, KM McCoy, KW McCorkle; citation_volume=16; citation_publication_date=2015; citation_pages=747-759; citation_id=CR150
citation_journal_title=Appl Physiol Nutr Metab; citation_title=Dietary HMB and beta-alanine co-supplementation does not improve in situ muscle function in sedentary, aged male rats; citation_author=DW Russ, C Acksel, IM Boyd, J Maynard, KW McCorkle, NK Edens; citation_volume=40; citation_publication_date=2015; citation_pages=1294-1301; citation_id=CR151
citation_journal_title=J Physiol; citation_title=Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training; citation_author=AP Russell, S Lamon, H Boon, S Wada, I Güller, EL Brown; citation_volume=591; citation_publication_date=2013; citation_pages=4637-4653; citation_id=CR152
citation_journal_title=J Gerontol Ser A; citation_title=Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles; citation_author=MJ Ryan, HJ Dudash, M Docherty, KB Geronilla, BA Baker, GG Haff; citation_volume=63; citation_publication_date=2008; citation_pages=1015-1026; citation_id=CR153
citation_journal_title=FASEB J; citation_title=Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases; citation_author=J Sacheck, J Philippe, K Hyatt, A Raffaello, R Thomas Jagoe, R Roy; citation_volume=21; citation_publication_date=2007; citation_pages=140-155; citation_id=CR154
citation_journal_title=Antioxid Redox Signal; citation_title=Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity; citation_author=GK Sakellariou, A Vasilaki, J Palomero, A Kayani, L Zibrik, A McArdle; citation_volume=18; citation_publication_date=2013; citation_pages=603-621; citation_id=CR155
citation_journal_title=Free Rad Res; citation_title=Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases; citation_author=GK Sakellariou, MJ Jackson, A Vasilaki; citation_volume=48; citation_publication_date=2014; citation_pages=12-29; citation_id=CR156
citation_journal_title=FASEB J; citation_title=Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice; citation_author=GK Sakellariou, CS Davis, Y Shi, MV Ivannikov, Y Zhang, A Vasilaki; citation_volume=28; citation_publication_date=2014; citation_pages=1666-1681; citation_id=CR157
citation_journal_title=Sci Rep; citation_title=Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy; citation_author=GK Sakellariou, T Pearson, AP Lightfoot, GA Nye, N Wells, II Giakoumaki; citation_volume=6; citation_publication_date=2016; citation_pages=33944; citation_id=CR158
citation_journal_title=Cell Commun Signal; citation_title=Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation; citation_author=SD Sandiford, KA Kennedy, X Xie, JG Pickering, SS Li; citation_volume=12; citation_publication_date=2014; citation_pages=5; citation_id=CR159
citation_journal_title=J Nutr Sci Vitaminol; citation_title=Regulation of skeletal muscle protein degradation and synthesis by oral administration of lysine in rats; citation_author=T Sato, Y Ito, T Nagasawa; citation_volume=59; citation_publication_date=2013; citation_pages=412-419; citation_id=CR160
citation_journal_title=Mol Cell Biochem; citation_title=Lysine suppresses protein degradation through autophagic-lysosomal system in C2C12 myotubes; citation_author=T Sato, Y Ito, T Nedachi, T Nagasawa; citation_volume=391; citation_publication_date=2014; citation_pages=37-46; citation_id=CR161
citation_journal_title=J Agric Food Chem; citation_title=Dietary l-lysine suppresses autophagic proteolysis and stimulates Akt/mTOR signaling in the skeletal muscle of rats fed a low-protein diet; citation_author=T Sato, Y Ito, T Nagasawa; citation_volume=63; citation_publication_date=2015; citation_pages=8192-8198; citation_id=CR162
citation_journal_title=Am J Med; citation_title=Inflammatory markers and loss of muscle mass (sarcopenia) and strength; citation_author=LA Schaap, SM Pluijm, DJ Deeg, M Visser; citation_volume=119; citation_publication_date=2006; citation_pages=526 e529-517; citation_id=CR163
citation_journal_title=J Gerontol Ser A; citation_title=Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength; citation_author=LA Schaap, SM Pluijm, DJ Deeg, TB Harris, SB Kritchevsky, AB Newman; citation_volume=64; citation_publication_date=2009; citation_pages=1183-1189; citation_id=CR164
citation_journal_title=EMBO J; citation_title=Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4; citation_author=R Scherz-Shouval, E Shvets, E Fass, H Shorer, L Gil, Z Elazar; citation_volume=26; citation_publication_date=2007; citation_pages=1749-1760; citation_id=CR165
citation_journal_title=Int J Sport Nutr Exerc Metab; citation_title=Effects of resistance training on the rate of muscle protein synthesis in frail elderly people; citation_author=JN Schulte, KE Yarasheski; citation_volume=11; citation_issue=Suppl; citation_publication_date=2001; citation_pages=S111-S118; citation_id=CR166
citation_journal_title=Metabolism; citation_title=The effect of intensive endurance exercise training on body fat distribution in young and older men; citation_author=RS Schwartz, WP Shuman, V Larson, KC Cain, GW Fellingham, JC Beard; citation_volume=40; citation_publication_date=1991; citation_pages=545-551; citation_id=CR167
citation_journal_title=Exp Cell Res; citation_title=Regulation and dysregulation of fibrosis in skeletal muscle; citation_author=AL Serrano, P Munoz-Canoves; citation_volume=316; citation_publication_date=2010; citation_pages=3050-3058; citation_id=CR168
citation_journal_title=J Pathol Bacteriol; citation_title=Regeneration in skeletal muscle of mouse: some electron-microscope observations; citation_author=SA Shafiq, MA Gorycki; citation_volume=90; citation_publication_date=1965; citation_pages=123-127; citation_id=CR169
citation_journal_title=Clin Interv Aging; citation_title=Effectiveness of exercise and protein supplementation intervention on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia; citation_author=S Shahar, NS Kamaruddin, M Badrasawi, NIM Sakian, ZA Manaf, Z Yassin; citation_volume=8; citation_publication_date=2013; citation_pages=1365-1375; citation_id=CR170
citation_journal_title=Ageing Cell; citation_title=Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle; citation_author=G Shefer, D Mark, J Richardson, Z Yablonka-Reuveni; citation_volume=294; citation_publication_date=2006; citation_pages=50-66; citation_id=CR171
citation_journal_title=Neurobiol Aging; citation_title=Muscle strength and size are associated with motor unit connectivity in aged mice; citation_author=KA Sheth, CC Iyer, CG Wier, AE Crum, A Bratasz, SJ Kolb; citation_volume=67; citation_publication_date=2018; citation_pages=128-136; citation_id=CR172
citation_journal_title=Diabetes; citation_title=Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity; citation_author=K Short, J Vittone, M Bigelow, D Proctor, R Rizza, J Coenen-Shimke; citation_volume=52; citation_publication_date=2003; citation_pages=1888-1896; citation_id=CR173
citation_journal_title=PNAS; citation_title=Decline in skeletal muscle mitochondrial function with aging in humans; citation_author=K Short, M Bigelow, J Kahl, R Singh, J Coenen-Schimke; citation_volume=102; citation_publication_date=2005; citation_pages=5618-5623; citation_id=CR174
citation_journal_title=J Clin Endocrinol and Metab; citation_title=Age-related anabolic resistance of myofibrillar protein synthesis is exacerbated in obese inactive individuals; citation_author=B Smeuninx, J McKendry, D Wilson, U Martin, L Breen; citation_volume=102; citation_publication_date=2017; citation_pages=3535-3545; citation_id=CR175
citation_journal_title=Am J Clin Nutr; citation_title=Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women; citation_author=MY Song, E Ruts, J Kim, I Janumala, S Heymsfield, D Gallagher; citation_volume=79; citation_publication_date=2004; citation_pages=874-880; citation_id=CR176
citation_journal_title=Aging Cell; citation_title=Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration; citation_author=A Soriano-Arroquia, R McCormick, AP Molloy, A McArdle, K Goljanek-Whysall; citation_volume=15; citation_publication_date=2016; citation_pages=361-369; citation_id=CR177
citation_journal_title=Biogerontology; citation_title=The functional consequences of age-related changes in microRNA expression in skeletal muscle; citation_author=A Soriano-Arroquia, L House, L Tregilgas, E Canty-Laird, K Goljanek-Whysall; citation_volume=17; citation_publication_date=2016; citation_pages=641-654; citation_id=CR178
citation_journal_title=Nature; citation_title=Geriatric muscle stem cells switch reversible quiescence into senescence; citation_author=P Sousa-Victor, S Gutarra, L Garcia-Prat, J Rodriguez-Ubreva, L Ortet, V Ruiz-Bonilla; citation_volume=506; citation_publication_date=2014; citation_pages=316-321; citation_id=CR179
citation_journal_title=Vnitr Lekarstvi; citation_title=Testosteron treatment in sarcopenia; citation_author=L Stárka; citation_volume=52; citation_publication_date=2006; citation_pages=909-911; citation_id=CR180
citation_journal_title=J Oesteoporosis; citation_title=Whole-body electromyostimulation to fight osteopenia in elderly females: the randomized controlled training and electrostimulation trial (TEST-III); citation_author=S Stengel, M Bebenek, K Engelke, W Kemmler; citation_publication_date=2015; citation_doi=10.1155/2015/643520; citation_id=CR181
citation_journal_title=BMC Geriatr; citation_title=Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia; citation_author=M Sullivan-Gunn, P Lewandowski; citation_volume=13; citation_publication_date=2013; citation_pages=104; citation_id=CR182
citation_journal_title=Am J Clin Nutr; citation_title=Aging does not impair the anabolic response to a protein-rich meal; citation_author=TB Symons, SE Schutzler, TL Cocke, DL Chinkes, RR Wolfe, D Paddon-Jones; citation_volume=86; citation_publication_date=2007; citation_pages=451-456; citation_id=CR183
citation_journal_title=J Am Geriatr Soc; citation_title=Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults; citation_author=DR Taaffe, C Duret, S Wheeler, R Marcus; citation_volume=47; citation_publication_date=1999; citation_pages=1208-1214; citation_id=CR184
citation_journal_title=Dis Model Mech; citation_title=Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats; citation_author=JL Tarry-Adkins, DS Fernandez-Twinn, JH Chen, IP Hargreaves, V Neergheen, CE Aiken; citation_volume=9; citation_publication_date=2016; citation_pages=1221-1229; citation_id=CR185
citation_journal_title=Physiol Genom; citation_title=Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading; citation_author=AE Thalacker-Mercer, LJ Dell’Italia, X Cui, JM Cross, MM Bamman; citation_volume=40; citation_publication_date=2010; citation_pages=141-149; citation_id=CR186
citation_journal_title=Lung Cell Mol Physiol; citation_title=Reactive oxygen species in cell signaling; citation_author=VJ Thannickal, BL Fanburg; citation_volume=279; citation_publication_date=2000; citation_pages=L1005-L1028; citation_id=CR187
citation_journal_title=J Gerontol Ser A; citation_title=Inflammatory markers and physical performance among nonagenarians; citation_author=K Tiainen, M Hurme, A Hervonen, T Luukkaala, M Jylha; citation_volume=65; citation_publication_date=2010; citation_pages=658-663; citation_id=CR188
citation_journal_title=J Am Med Dir Assoc; citation_title=Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial; citation_author=M Tieland, ML Dirks, N Zwaluw, LB Verdijk, O Rest, LC Groot; citation_volume=13; citation_publication_date=2012; citation_pages=713-719; citation_id=CR189
citation_journal_title=J Neurol Sci; citation_title=The numbers of limb motor neurons in the human lumbosacral cord throughout life; citation_author=BE Tomlinson, D Irving; citation_volume=34; citation_publication_date=1977; citation_pages=213-219; citation_id=CR190
citation_journal_title=Scand J Med Sci Sports; citation_title=Slow movement resistance training using body weight improves muscle mass in the elderly: a randomized controlled trial; citation_author=S Tsuzuku, T Kajioka, H Sakakibara, K Shimaoka; citation_volume=28; citation_publication_date=2018; citation_pages=1339-1344; citation_id=CR191
citation_journal_title=Ageing Res Rev; citation_title=Physical strategies to prevent disuse-induced functional decline in the elderly; citation_author=PL Valenzuela, JS Morales, H Pareja-Galeano, M Izquierdo, E Emanuele, P Villa; citation_volume=47; citation_publication_date=2018; citation_pages=80-88; citation_id=CR192
citation_journal_title=Aging Cell; citation_title=Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity; citation_author=A Vasilaki, A Mansouri, H Remmen, JH Meulen, L Larkin, AG Richardson; citation_volume=5; citation_publication_date=2006; citation_pages=109-117; citation_id=CR193
citation_journal_title=Aging Cell; citation_title=The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu, Zn superoxide dismutase; citation_author=A Vasilaki, JH Meulen, L Larkin, DC Harrison, T Pearson, H Remmen; citation_volume=9; citation_publication_date=2010; citation_pages=979-990; citation_id=CR194
citation_journal_title=Age; citation_title=The effect of lengthening contractions on neuromuscular junction structure in adult and old mice; citation_author=A Vasilaki, N Pollock, I Giakoumaki, K Goljanek-Whysall, GK Sakellariou, T Pearson; citation_volume=38; citation_publication_date=2016; citation_pages=259-272; citation_id=CR195
citation_journal_title=J Biogerontol; citation_title=Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men; citation_author=LB Verdijk, B Gleeson, R Jonkers, K Meijer, H Savelberg, P Dendale; citation_volume=64A; citation_publication_date=2009; citation_pages=332-339; citation_id=CR196
citation_journal_title=Am J Clin Nutr; citation_title=Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men; citation_author=LB Verdijk, RA Jonkers, BG Gleeson, M Beelen, K Meijer, HH Savelberg; citation_volume=89; citation_publication_date=2009; citation_pages=608-616; citation_id=CR197
citation_journal_title=Age; citation_title=Satellite cells in human skeletal muscle; from birth to old age; citation_author=LB Verdijk, T Snijders, M Drost, T Delhaas, F Kadi, LJC Loon; citation_volume=36; citation_publication_date=2014; citation_pages=545-557; citation_id=CR198
citation_journal_title=Am J Clin Nutr; citation_title=A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial; citation_author=AM Verreijen, S Verlaan, MF Engberink, S Swinkels, J Vogel-van den Bosch, PJ Weijs; citation_volume=101; citation_publication_date=2015; citation_pages=279-286; citation_id=CR199
citation_journal_title=Mol Biol Cell; citation_title=Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts; citation_author=AM Vertino, JM Taylor-Jones, KA Longo, ED Bearden, TF Lane, RE McGehee; citation_volume=16; citation_publication_date=2005; citation_pages=2039-2048; citation_id=CR200
citation_journal_title=Am J Physiol Endocrinol Metab; citation_title=The origin of intermuscular adipose tissue and its pathophysiological implications; citation_author=R Vettor, G Milan, C Franzin, M Sanna, P Coppi, R Rizzuto; citation_volume=297; citation_publication_date=2009; citation_pages=E987-E998; citation_id=CR201
citation_journal_title=JAMA; citation_title=Basal muscle amino acid kinetics and protein synthesis in healthy young and older men; citation_author=E Volpi, M Sheffield-Moore, BB Rasmussen, RR Wolfe; citation_volume=286; citation_publication_date=2001; citation_pages=1206-1212; citation_id=CR202
citation_journal_title=Am J Clin Nutr; citation_title=Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults; citation_author=E Volpi, H Kobayashi, M Sheffield-Moore, B Mittendorfer, RR Wolfe; citation_volume=78; citation_publication_date=2003; citation_pages=250-258; citation_id=CR203
citation_journal_title=PLoS ONE; citation_title=Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion; citation_author=BT Wall, SH Gorissen, B Pennings, R Koopman, BB Groen, LB Verdijk; citation_volume=10; citation_publication_date=2015; citation_pages=e0140903; citation_id=CR204
citation_journal_title=Am J Physiol Endocrinol Metab; citation_title=Functional impact of high protein intake on healthy elderly people; citation_author=S Walrand, KR Short, ML Bigelow, AJ Sweatt, SM Hutson, KS Nair; citation_volume=295; citation_publication_date=2008; citation_pages=E921-E928; citation_id=CR205
citation_journal_title=FASEB J; citation_title=Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia; citation_author=J Wanagat, Z Cao, P Pathare, JM Aiken; citation_volume=15; citation_publication_date=2001; citation_pages=322-332; citation_id=CR206
citation_journal_title=Aging Cell; citation_title=Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide; citation_author=Y Wang, M Wehling-Henricks, G Samengo, JG Tidball; citation_volume=14; citation_publication_date=2015; citation_pages=678-688; citation_id=CR207
citation_journal_title=J Nutr; citation_title=The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake; citation_author=R Weindruch, R Walford, S Fligiel, A Guthrie; citation_volume=116; citation_publication_date=1986; citation_pages=614-654; citation_id=CR208
citation_journal_title=Am J Clin Nutr; citation_title=Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial; citation_author=EP Weiss, SB Racette, DT Villareal, L Fontana, K Steger-May, KB Schechtman; citation_volume=84; citation_publication_date=2006; citation_pages=1033-1042; citation_id=CR209
citation_journal_title=Am J Physiol; citation_title=Myofibrillar protein synthesis in young and old men; citation_author=S Welle, C Thornton, R Jozefowicz, M Statt; citation_volume=264; citation_publication_date=1993; citation_pages=693-698; citation_id=CR210
citation_journal_title=Phys Sportsmed; citation_title=Chronic exercise preserves lean muscle mass in masters athletes; citation_author=AP Wroblewski, F Amati, MA Smiley, B Goodpaster, V Wright; citation_volume=39; citation_publication_date=2011; citation_pages=172-178; citation_id=CR212
citation_journal_title=PLoS ONE; citation_title=Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis; citation_author=Z Xu, Z Tan, Q Zhang, Q Gui, T Yang; citation_volume=9; citation_publication_date=2014; citation_pages=e109141; citation_id=CR213
citation_journal_title=J Cell Physiol; citation_title=Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1; citation_author=YS Yoon, DS Yoon, IK Lim, SH Yoon, HY Chung, M Rojo; citation_volume=209; citation_publication_date=2006; citation_pages=468-480; citation_id=CR214
citation_journal_title=J Cell Biol; citation_title=Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?; citation_author=PS Zammit, JP Golding, Y Nagata, V Hudon, TA Partridge, JR Beauchamp; citation_volume=166; citation_publication_date=2004; citation_pages=347-357; citation_id=CR215
citation_journal_title=J Nutr; citation_title=Two-year whey protein supplementation did not enhance muscle mass and physical function in well-nourished healthy older postmenopausal women; citation_author=K Zhu, DA Kerr, X Meng, A Devine, V Solah, CW Binns; citation_volume=145; citation_publication_date=2015; citation_pages=2520-2526; citation_id=CR216