Age‐dependent changes in insulin‐like immunoreactivity in rat submandibular salivary glands

European Journal of Oral Sciences - Tập 104 Số 5-6 - Trang 630-633 - 1996
Dominique Deville de Périère1, M. Bombara2, Jean‐Christophe Égéa1, Michela Novelli2, Gérard Ribes3, Pellegrino Masiello1
1Faculté d'Odontologie, Laboratoire de Physiologie, 3 Bis Bd. Henri IV, 34028 Montpellier, France
2lstituto di Patologia Generale dell'UniversitAaG di Pisa, Via Roma, 55, 1-56100, Pisa, Italia
3Laboratoire de Pharmacologie, UMR CNRS -9921, Université Montpellier I, France

Tóm tắt

In recent years, a growing interest had arisen in hormonal factors in salivary glands. We have investigated the changes in the content of an insulin‐like immunoreactive (ILI) compound in the submandibular salivary glands of Sprague Dawley rats during physiological aging, in the range 15 days ‐27 months. The amount of ILI in the submandibular glands of young adult rats was found to be doubled in the post‐natal period until the age of puberty and was maintained in senescence. No significant correlation was found between age‐dependent variations in ILI levels of submandibular salivary glands and circulating insulin concentrations, further supporting previous indications that ILI is being synthesized in situ. It is possible that ILI could exert paracrine effects within the glands, as regards the development of other glandular structures during the first months of life, as well as the preservation of glandular function in senescent animals as well.

Từ khóa


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Thông tin
Thông tin xuất bản

European Journal of Oral Sciences

Tập 104 Số 5-6

630-633

Thông tin tác giả