Những thay đổi liên quan đến tuổi tác của các phân nhóm bạch cầu đơn nhân và các con đường hóa học liên quan đến bạch cầu đơn nhân ở người trưởng thành khỏe mạnh

BMC Immunology - Tập 11 Số 1 - 2010
Sebastian Seidler1, Henning W. Zimmermann1, Matthias Bartneck2, Christian Trautwein1, Frank Tacke1
1Department of Medicine III, University Hospital, RWTH-Aachen, Pauwelsstr 30, 52074, Aachen, Germany
2Interdisciplinary Centre for Clinical Research, University Hospital, RWTH-Aachen, Pauwelsstr 30, 52074, Aachen, Germany

Tóm tắt

Tóm tắt Bối cảnh

Các phương pháp thí nghiệm gần đây đã phát hiện ra những khác biệt về di động và chức năng thiết yếu của các phân nhóm bạch cầu đơn nhân ở chuột. Để có thể chuyển giao những phát hiện này vào sinh lý học và bệnh lý học của con người, các phân nhóm bạch cầu đơn nhân ở người cần được xem xét cẩn thận trong cả sức khỏe và bệnh tật. Giống như trong các nghiên cứu trên chuột, chúng tôi giả định rằng các phân nhóm bạch cầu đơn nhân ở người thay đổi một cách năng động trong suốt quá trình lão hóa, có khả năng ảnh hưởng đến chức năng của chúng và góp phần vào tình trạng suy giảm miễn dịch do tuổi tác.

Từ khóa

#bạch cầu đơn nhân #tuổi tác #chức năng miễn dịch #hóa học bạch cầu đơn nhân #lão hóa #chức năng bạch cầu đơn nhân

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