Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: role of l-carnitine

Beal, 2000, Mitochondria and pathogenesis of ALS, Brain, 123, 1291, 10.1093/brain/123.7.1291 Kwong, 2000, Age-related changes in activities of mitochondrial electron transport complexes in various tissues of mouse, Arch. Biochem. Biophys., 373, 16, 10.1006/abbi.1999.1495 Liu, 1996, Immobilization stress causes oxidative damage to lipid, protein and DNA in the brain of rats, FASEB J., 10, 1532, 10.1096/fasebj.10.13.8940299 Cortopassi, 1992, A pattern of accumulation of somatic deletion of mitochondrial DNA in aging tissue, Proc. Natl. Acad. Sci., 89, 7370, 10.1073/pnas.89.16.7370 Ozawa, 1997, Genetic and functional changes in mitochondria associated with aging, Physiol. Rev., 77, 425, 10.1152/physrev.1997.77.2.425 Wallace, 1992, Mitochondrial genetics: a paradigm for aging and degenerative diseases, Sciences, 61, 1175 Rebouche, 1992, Carnitine function and requirements during the life cycle, FASEB J., 6, 3379, 10.1096/fasebj.6.15.1464372 Iossa, 2002, Acetyl-l-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats, J. Nutr., 132, 636, 10.1093/jn/132.4.636 Taglialatela, 1994, Acetyl-l-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats, Exp. Gerontol., 29, 55, 10.1016/0531-5565(94)90062-0 Hagen, 2002, Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-l-carnitine and/or lipoic acid, Ann. N. Y. Acad. Sci., 959, 491, 10.1111/j.1749-6632.2002.tb02119.x Takasawa, 1993, Age associated damage in heart mitochondrial function in rat heart, Exp. Gerontol., 28, 269, 10.1016/0531-5565(93)90034-B Ernster, 1967, Skeletal muscle mitochondria, Methods Enzymol., 10, 86, 10.1016/0076-6879(67)10017-7 Slater, 1952, Effect of fluride on succinate oxidase system, Biochem. J., 52, 185, 10.1042/bj0520185 Lowry, 1951, Protein measurement with the folin phenol reagent, J. Biol. Chem., 1193, 265, 10.1016/S0021-9258(19)52451-6 M. Brich-Machin, S. Jacson, R.S. Kler, D.M. Turnbull, in: L.H. Lash, D.P Jones (Eds.), Mitochondrial Dysfunction, Academic Press, San Diego, CA, 1993, pp. 51–69. C.I. Ragan, M.T. Wilson, V.M. Darley-Usmar, P.N. Lowe, in: V.M. Darley-Usmar, D. Richwood, M.T. Wilson (Eds.), Mitochondria: a Practical Approach, IRC Press, Oxford, 1987, pp. 79–112. Wharton, 1967, Cytochrome oxidase from beef heart mitochondria, Methods Enzymol., 10, 245, 10.1016/0076-6879(67)10048-7 Lenaz, 1998, Role of mitochondria in oxidative stress and aging, Biochem. Biophys. Acta, 1336, 53 Filburn, 1996, Mitochondrial electron transport chain activities and DNA deletions in regions of rat brain, Mech. Aging Dev., 87, 35, 10.1016/0047-6374(96)01696-X Hsieh, 1994, Age dependent respiratory function and mitochondrial DNA deletion in human skeletal muscle mitochondria, Biochem. Mol. Biol. Int., 32, 1009 Melov, 1999, Mouse models of mitochondrial disease, oxidative stress and senescence, Mutat. Res., 434, 233, 10.1016/S0921-8777(99)00031-2 Schware, 1995, High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkey, Mech. Aging Dev., 83, 91, 10.1016/0047-6374(95)01611-3 S. Papa, N. Capitanio, G. Villani, in: S. Papa, F. Guerrieri, J. Tager (Eds.), Frontiers of Cellular Bioenergetics. Molecular Biology, Biochemistry and Physiopathology, Kluwer Academic/Plenum Press, New York, 2002. Singh, 2002, Glutathione: a marker and antioxidant for aging, J. Lab. Clin. Med., 140, 380, 10.1067/mlc.2002.129505 Vijg, 1999, Genetics of aging, Biochim. Biophys. Acta, 1423, R 1 Barja, 2000, The flux of free radical attack through mitochondrial DNA is related to aging, Aging, 12, 342 Sandhu, 2003, Mitochondrial electron transport chain complexes in aging rat brain and lymphocytes, Biogerontology, 4, 19, 10.1023/A:1022473219044 Drouet, 1999, Age associated changes in mitochondrial parameters on peripheral human lymphocytes, Exp. Gerontol., 34, 69, 10.1016/S0531-5565(99)00058-3 Wallace, 1999, Mitochondria diseases in man and mouse, Science, 283, 1482, 10.1126/science.283.5407.1482 Rani, 2001, Carnitine as a free radical scavenger in aging, Exp. Gerontol., 36, 1713, 10.1016/S0531-5565(01)00116-4 Benzi, 1992, The mitochondrial electron transfer alteration as a factor involved in the brain aging, Neurobiol. Aging, 13, 361, 10.1016/0197-4580(92)90109-B Sohal, 1993, Aging, cytochrome oxidase activity and hydrogen peroxide release by mitochondria, Free Radic. Biol. Med., 14, 583, 10.1016/0891-5849(93)90139-L Paradies, 1997, Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin, FEBS Lett., 406, 136, 10.1016/S0014-5793(97)00264-0