Advances in research on Cordyceps militaris degeneration
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Chen YS, Liu BL, Chang YN (2011) Effects of light and heavy metals on Cordyceps militaris fruit body growth in rice grain-based cultivation. Korean J Chem Eng 28(3):875–879
Chen A, Wang Y, Shao Y, Huang B (2017) A novel technique for rejuvenation of degenerated caterpillar medicinal mushroom, Cordyceps militaris (Ascomycetes), a valued traditional Chinese medicine. Int J Med Mushrooms 19(1):87–91
Chen BX, Wei T, Ye ZW, Yun F, Kang LZ, Tang HB, Guo LQ, Lin JF (2018) Efficient CRISPR-Cas9 gene disruption system in edible-medicinal mushroom Cordyceps militaris. Front Microbiol 9:1157
Cui JD (2015) Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine. Crit Rev Biotechnol 35(4):475–484
Dang HN, Wang CL, Lay HL (2018) Effect of nutrition, vitamin, grains, and temperature on the mycelium growth and antioxidant capacity of Cordyceps militaris (strains AG-1 and PSJ-1). J Radiat Res Appl Sci 11(2):130–138
Das SK, Masuda M, Sakurai A, Sakakibara M (2010) Medicinal uses of the mushroom Cordyceps militaris: current state and prospects. Fitoterapia 81(8):961–968
Dong JZ, Wang SH, Ai XR, Yao L, Sun ZW, Lei C, Wang Y, Wang Q (2013) Composition and characterization of cordyxanthins from Cordyceps militaris fruit bodies. J Funct Foods 5(3):1450–1455
Gao X (2008) Study on the mating type of Cordyceps militaris. Acta Edulis Fungi 15(1):1–5 (in Chinese)
Guo M, Bian Y, Wang J, Wang G, Ma X, Xu Z (2017) Biological and molecular characteristics of a novel partitivirus infecting the edible fungus Lentinula edodes. Plant Dis 101(5):726–733
He L, Han C, Li P, Chen Y, Liu D, Geng L (2009) Effect of mineral elements on colony types of Cordyceps militaris in subculturing. J Shenyang Agric Univ 40(6):672–677 (in Chinese)
Jiang K, Han R (2015) Rhf1 gene is involved in the fruiting body production of Cordyceps militaris fungus. J Ind Microbiol Biotechnol 42(8):1183–1196
Kim SY, Kim KH, Im CH, Ali A, Lee CY, Kong WS, Ryu JS (2014) Identification of degenerate nuclei and development of a SCAR marker for Flammulina velutipes. PLoS One 9(9):e107207
Kunhorm P, Chaicharoenaudomrung N, Noisa P (2019) Enrichment of cordycepin for cosmeceutical applications: culture systems and strategies. Appl Microbiol Biotechnol 103(4):1681–1691
Lee HJ, Kim SW, Ryu JS, Lee CY, Ro HS (2014) Isolation of a variant strain of Pleurotus eryngii and the development of specific DNA markers to identify the variant strain. Mycobiology 42(1):46–51
Lee HH, Kang N, Park I, Park J, Kim I, Kim J, Kim N, Lee JY, Seo YS (2017) Characterization of newly bred Cordyceps militaris strains for higher production of cordycepin through HPLC and URP-PCR analysis. J Microbiol Biotechnol 27(7):1223–1232
Li MN, Wu XJ, Li CY, Feng BS, Li QW (2003) Molecular analysis of degeneration of artificial planted Cordyceps militaris. Mycosystema 22(2):277–282 (in Chinese)
Li X, Liu Q, Li W, Li Q, Qian Z, Liu X, Dong C (2018) A breakthrough in the artificial cultivation of Chinese cordyceps on a large-scale and its impact on science, the economy, and industry. Crit Rev Biotechnol 39(2):381–391
Lin QQ, Qiu XH, Zheng ZL, Xie CH, Xu ZF, Han RC (2010) Characteristics of the degenerate strains of Cordyceps militaris. Mycosystema 29(5):670–677 (in Chinese)
Lin S, Liu ZQ, Xue YP, Baker PJ, Wu H, Xu F, Teng Y, Brathwaite ME, Zheng YG (2016) Biosynthetic pathway analysis for improving the cordycepin and cordycepic acid production in Hirsutella sinensis. Appl Biochem Biotechnol 179(4):633–649
Lou HW, Ye ZW, Yun F, Lin JF, Guo LQ, Chen BX, Mu ZX (2018) Targeted gene deletion in Cordyceps militaris using the split-marker approach. Mol Biotechnol 60(5):380–385
Lou HW, Ye ZW, Yu YH, Lin JF, Guo LQ, Chen BX, Tang HB, Wei T, Chen LT, Yun F (2019) The efficient genetic transformation of Cordyceps militaris by using mononuclear protoplasts. Sci Hortic 243:307–313
Magae Y, Akahane K, Nakamura K, Tsunoda S (2005) Simple colorimetric method for detecting degenerate strains of the cultivated basidiomycete Flammulina velutipes (Enokitake). Appl Environ Microbiol 71(10):6388–6389
Masuda M, Das SK, Fujihara S, Hatashita M, Sakurai A (2011) Production of cordycepin by a repeated batch culture of a Cordyceps militaris mutant obtained by proton beam irradiation. J Biosci Bioeng 111(1):55–60
Nurmamat E, Xiao H, Zhang Y, Jiao Z (2018) Effects of different temperatures on the chemical structure and antitumor activities of polysaccharides from Cordyceps militaris. Polymers 10(4):430
Shrestha B, Kim HK, Sung GH, Spatafora JW, Sung JM (2004) Bipolar heterothallism, a principal mating system of Cordyceps militaris in vitro. Biotechnol Bioprocess Eng 9(6):440–446
Shrestha B, Han SK, Sung JM, Sung GH (2012) Fruiting body formation of Cordyceps militaris from multi-ascospore isolates and their single ascospore progeny strains. Mycobiology 40(2):100–106
Sun SJ, Deng CH, Zhang LY, Hu KH (2017) Molecular analysis and biochemical characteristics of degenerated strains of Cordyceps militaris. Arch Microbiol 199(6):939–944
Sun H, Hu T, Guo Y, Liang Y (2018) Preservation affects the vegetative growth and fruiting body production of Cordyceps militaris. World J Microbiol Biotechnol 34(11):166
Wang L, Zhang WM, Hu B, Chen YQ, Qu LH (2008) Genetic variation of Cordyceps militaris and its allies based on phylogenetic analysis of rDNA ITS sequence data. Fungal Divers 31:147–155
Wang H, Wei J, Lin N, Feng A, Chen M, Bao D (2010) Distribution of mating-type genes in fruiting and non-fruiting forms of Cordyceps militaris. Acta Edulis Fungi 17(4):1–4 (in Chinese)
Wang YL, Wang ZX, Liu C, Wang SB, Huang B (2015) Genome-wide analysis of DNA methylation in the sexual stage of the insect pathogenic fungus Cordyceps militaris. Fungal Biol 119(12):1246–1254
Wang D, He X, Zhao R, Ren G, Liu Y (2016) Comparison of Cordyceps militaris spawn rejuvenation method. North Hortic 40(17):137–139 (in Chinese)
Wang F, Song X, Dong X, Zhang J, Dong C (2017) DASH-type cryptochromes regulate fruiting body development and secondary metabolism differently than CmWC-1 in the fungus Cordyceps militaris. Appl Microbiol Biotechnol 101(11):4645–4657
Wang CC, Wu JY, Chang CY, Yu ST, Liu YC (2019) Enhanced exopolysaccharide production by Cordyceps militaris using repeated batch cultivation. J Biosci Bioeng 127(4):499–505
Wen TC, Li MF, Kang JC, He J (2012) A molecular genetic study on fruiting-body formation of Cordyceps militaris. Afr J Microbiol Res 6(24):5215–5221
Wen ZX, Meng N, Li XJ, Du XF, Ma SH, Mi R, Sun YX, Li SY, Li YJ (2017) Research on Cordyceps militaris spawn rejuvenation with silkworm. Edible Fungi China 37(1):19–21 (in Chinese)
Xia Y, Luo F, Shang Y, Chen P, Lu Y, Wang C (2017) Fungal cordycepin biosynthesis is coupled with the production of the safeguard molecule pentostatin. Cell Chem Biol 24(12):1479–1489
Xiang X, Wang X, Bian Y, Xu Z (2016) Development of crossbreeding high-yield-potential strains for commercial cultivation in the medicinal mushroom Wolfiporia cocos (Higher Basidiomycetes). J Nat Med 70(3):645–652
Xin X, Yin J, Zhang B, Li Z, Zhao S, Gui Z (2019) Genome-wide analysis of DNA methylation in subcultured Cordyceps militaris. Arch Microbiol 201(3):369–375
Xiong C, Xia Y, Zheng P, Wang C (2013) Increasing oxidative stress tolerance and subculturing stability of Cordyceps militaris by overexpression of a glutathione peroxidase gene. Appl Microbiol Biotechnol 97(5):2009–2015
Yang T, Dong C (2014) Photo morphogenesis and photo response of the blue-light receptor gene Cmwc-1 in different strains of Cordyceps militaris. FEMS Microbiol Lett 352(2):190–197
Yin J, Xin X, Weng Y, Gui Z (2017) Transcriptome-wide analysis reveals the progress of Cordyceps militaris subculture degeneration. PLoS One 12(10):e0186279
Yin J, Xin XD, Weng YJ, Li SH, Jia JQ, Gui ZZ (2018) Genotypic analysis of degenerative Cordyceps militaris cultured in the pupa of Bombyx mori. Entomol Res 48(3):137–144
Zhang G, Liang Y (2013) Improvement of fruiting body production in Cordyceps militaris by molecular assessment. Arch Microbiol 195(8):579–585
Zhang X, Dong X, Song X, Wang F, Dong C (2017) Photoperiodic responses and characterization of the Cmvvd gene encoding a blue light photoreceptor from the medicinal caterpillar fungus Cordyceps militaris (Ascomycetes). Int J Med Mushrooms 19(2):163–172
Zhang J, Wang F, Liu K, Liu Q, Yang Y, Dong C (2018) Heat and light stresses affect metabolite production in the fruit body of Cordyceps militaris. Appl Microbiol Biotechnol 102(10):4523–4533
Zheng P, Xia Y, Xiao G, Xiong C, Hu X, Zhang S, Zheng H, Huang Y, Zhou Y, Wang S, Zhao GP, Liu X, St Leger RJ, Wang C (2011a) Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine. Genome Biol 12(11):R116