Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
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Alarcon, 2005, Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid, J. Biol. Chem., 280, 30406
Anzai, 2006, Protracted juvenile neuronal ceroid lipofuscinosis—an autopsy report and immunohistochemical analysis, Brain Dev., 28, 462, 10.1016/j.braindev.2005.12.004
Behl, 1994, Hydrogen peroxide mediates amyloid beta protein toxicity, Cell, 77, 817, 10.1016/0092-8674(94)90131-7
Berbaum, 2008, Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array, Cytokine, 41, 198, 10.1016/j.cyto.2007.11.012
Bierhaus, 2005, Understanding RAGE, the receptor for advanced glycation end products, J. Mol. Med., 83, 876, 10.1007/s00109-005-0688-7
Bigl, 2008, Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation, J. Neural Transm., 115, 1545, 10.1007/s00702-008-0126-4
Blatnik, 2008, Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress, Diabetes, 57, 41, 10.2337/db07-0838
Braak, 1988, Neuropil threads occur in dendrites of tangle-bearing nerve cells, Neuropathol. Appl. Neurobiol., 14, 39, 10.1111/j.1365-2990.1988.tb00864.x
Brett, 1993, Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues, Am. J. Pathol., 143, 1699
Brownlee, 1995, Advanced protein glycosylation in diabetes and aging, Annu. Rev. Med., 46, 223, 10.1146/annurev.med.46.1.223
Bucciarelli, 2002, RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease, Cell. Mol. Life Sci., 59, 1117, 10.1007/s00018-002-8491-x
Bucht, 1983, Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type, Acta Med. Scand., 213, 387, 10.1111/j.0954-6820.1983.tb03756.x
Carini, 2003, Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry, J. Mass Spectrom., 38, 996, 10.1002/jms.517
Carubelli, 1995, Cytotoxic effects of autoxidative glycation, Free Radic. Biol. Med., 18, 265, 10.1016/0891-5849(94)E0134-5
Casselmann, 2004, Age-dependent expression of advanced glycation end product receptor genes in the human heart, Gerontology, 50, 127, 10.1159/000076770
Chen, 2007, RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease, Curr. Mol. Med., 7, 735, 10.2174/156652407783220741
Cho, 2005, The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia, J. Neurosci., 25, 2504, 10.1523/JNEUROSCI.0035-05.2005
Chou, 2004, Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration, J. Neurochem., 90, 1389, 10.1111/j.1471-4159.2004.02609.x
Clynes, 2007, Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response, Curr. Mol. Med., 7, 743, 10.2174/156652407783220714
Cochrane, 1993, The role of bound lipid and transition metal in the formation of fluorescent advanced glycation endproducts by human serum albumin, Biochem. Soc. Trans., 21, 97S, 10.1042/bst021097s
de Arriba, 2003, Advanced glycation endproducts induce changes in glucose consumption, lactate production, and ATP levels in SH-SY5Y neuroblastoma cells by a redox-sensitive mechanism, J. Cereb. Blood Flow Metab., 23, 1307, 10.1097/01.WCB.0000090622.86921.0E
Deane, 2003, RAGE mediates amyloid-beta peptide transport across the blood–brain barrier and accumulation in brain, Nat. Med., 9, 907, 10.1038/nm890
Deuther-Conrad, 2001, Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism, Neurosci. Lett., 312, 29, 10.1016/S0304-3940(01)02174-7
Donahue, 2006, RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease, Acta Neuropathol. (Berl.), 112, 405, 10.1007/s00401-006-0115-3
Donato, 2001, S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles, Int. J. Biochem. Cell Biol., 33, 637, 10.1016/S1357-2725(01)00046-2
Drinda, 2004, Identification of the receptor for advanced glycation end products in synovial tissue of patients with rheumatoid arthritis, Rheumatol. Int., 25, 411, 10.1007/s00296-004-0456-y
Du, 2003, Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells, J. Clin. Invest., 112, 1049, 10.1172/JCI18127
Du Yan, 1997, Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A., 94, 5296, 10.1073/pnas.94.10.5296
Dukic-Stefanovic, 2003, Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs), J. Neurochem., 87, 2609, 10.1046/j.1471-4159.2003.01988.x
Dukic-Stefanovic, 2003, Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs), J. Neurochem., 87, 44, 10.1046/j.1471-4159.2003.01988.x
Emanuele, 2005, Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia, Arch. Neurol., 62, 1734, 10.1001/archneur.62.11.1734
Falcone, 2005, Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men, Arterioscler. Thromb. Vasc. Biol., 25, 1032, 10.1161/01.ATV.0000160342.20342.00
Fonteh, 2007, Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects, Amino Acids, 32, 213, 10.1007/s00726-006-0409-8
Franke, 2007, Advanced glycation endproducts influence the mRNA expression of RAGE RANKL and various osteoblastic genes in human osteoblasts, Arch. Physiol. Biochem., 113, 154, 10.1080/13813450701602523
Fujisawa, 1991, Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type, Biol. Psychiatry, 30, 1219, 10.1016/0006-3223(91)90158-I
Gasic-Milenkovic, 2001, Protein “AGEing”—cytotoxicity of a glycated protein increases with its degree of AGE-modification, Z. Gerontol. Geriatr., 34, 457, 10.1007/s003910170018
Gasic-Milenkovic, 2003, beta-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon-gamma and ‘advanced glycation endproducts’ in a murine microglia cell line, Eur. J. Neurosci., 17, 813, 10.1046/j.1460-9568.2003.02506.x
Gasser, 2008, Advanced glycation: implications in tissue damage and disease, Protein Pept. Lett., 15, 385, 10.2174/092986608784246515
Gerdemann, 2000, Low-molecular but not high-molecular advanced glycation end products (AGEs) are removed by high-flux dialysis, Clin. Nephrol., 54, 276
Geroldi, 2005, Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension, J. Hypertens., 23, 1725, 10.1097/01.hjh.0000177535.45785.64
Geroldi, 2006, Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target, Curr. Med. Chem., 13, 1971, 10.2174/092986706777585013
Ghidoni, 2008, Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment, J. Neural Transm., 115, 1047, 10.1007/s00702-008-0069-9
Girones, 2004, N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease, Free Radic. Biol. Med., 36, 1241, 10.1016/j.freeradbiomed.2004.02.006
Gohda, 2008, Increased serum endogenous secretory receptor for advanced glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function, Diabetes Res. Clin. Pract., 81, 196, 10.1016/j.diabres.2008.04.013
Gotz, 2001, Tau and transgenic animal models, Brain Res. Rev., 35, 266, 10.1016/S0165-0173(01)00055-8
Haass, 1994, Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor, J. Biol. Chem., 269, 17741, 10.1016/S0021-9258(17)32503-6
Heizmann, 2007, Pathologies involving the S100 proteins and RAGE, Subcell. Biochem., 45, 93, 10.1007/978-1-4020-6191-2_5
Hickman, 2008, Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice, J. Neurosci., 28, 8354, 10.1523/JNEUROSCI.0616-08.2008
Hipkiss, 2007, Could carnosine or related structures suppress Alzheimer's disease?, J. Alzheimers Dis., 11, 229, 10.3233/JAD-2007-11210
Horie, 1997, Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons, Biochem. Biophys. Res. Commun., 236, 327, 10.1006/bbrc.1997.6944
Hoyer, 1998, Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis, J. Neural Transm., 105, 415, 10.1007/s007020050067
Hoyer, 2004, Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications, Adv. Exp. Med. Biol., 541, 135, 10.1007/978-1-4419-8969-7_8
Hudson, 2003, Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders, Arch. Biochem. Biophys., 419, 80, 10.1016/j.abb.2003.08.030
Hudson, 2008, Identification, classification, and expression of RAGE gene splice variants, FASEB J., 22, 1572, 10.1096/fj.07-9909com
Humpert, 2007, Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes, Cardiovasc. Diabetol., 6, 9, 10.1186/1475-2840-6-9
Iwata, 2004, Effect of carbonyl compounds on red blood cells deformability, Biochem. Biophys. Res. Commun., 321, 700, 10.1016/j.bbrc.2004.07.026
Jerums, 2003, Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease, Arch. Biochem. Biophys., 419, 55, 10.1016/j.abb.2003.08.017
Jeynes, 2008, Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis, Curr. Alzheimer Res., 5, 432, 10.2174/156720508785908937
Kimura, 1995, Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease?, Neuroreport, 6, 866, 10.1097/00001756-199504190-00010
Ko, 1999, An immunochemical study on tau glycation in paired helical filaments, Brain Res., 830, 301, 10.1016/S0006-8993(99)01415-8
Kodl, 2008, Cognitive dysfunction and diabetes mellitus, Endocr. Rev., 29, 494, 10.1210/er.2007-0034
Kuhla, 2004, Differential effects of “Advanced glycation endproducts” and beta-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y, J. Neural Transm., 111, 427, 10.1007/s00702-003-0038-2
Ledesma, 1994, Analysis of microtubule-associated protein tau glycation in paired helical filaments, J. Biol. Chem., 269, 21614, 10.1016/S0021-9258(17)31849-5
Lichtenthaler, 1997, Mutations in the transmembrane domain of APP altering gamma-secretase specificity, Biochemistry, 36, 15396, 10.1021/bi971071m
Loske, 1998, Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress, J. Neural Transm., 105, 1005, 10.1007/s007020050108
Loske, 2000, Transition metal-mediated glycoxidation accelerates cross-linking of beta-amyloid peptide, Eur. J. Biochem., 267, 4171, 10.1046/j.1432-1327.2000.01452.x
Lotze, 2005, High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal, Nat. Rev. Immunol., 5, 331, 10.1038/nri1594
Lovell, 1998, Copper, iron and zinc in Alzheimer's disease senile plaques, J. Neurol. Sci., 158, 47, 10.1016/S0022-510X(98)00092-6
Lue, 2001, Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism, Exp. Neurol., 171, 29, 10.1006/exnr.2001.7732
Lüth, 2005, Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains, Cereb. Cortex, 15, 211, 10.1093/cercor/bhh123
Mackic, 2002, Circulating amyloid-beta peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions, Vascul. Pharmacol., 38, 303, 10.1016/S1537-1891(02)00198-2
Martel, 1996, Blood–brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs, Neurosci. Lett., 206, 157, 10.1016/S0304-3940(96)12462-9
Miyata, 1997, Accumulation of pyrraline-modified albumin in phagocytes due to reduced degradation by lysosomal enzymes, J. Biol. Chem., 272, 4037, 10.1074/jbc.272.7.4037
Monnier, 1981, Nonenzymatic browning in vivo: possible process for aging of long-lived proteins, Science, 211, 491, 10.1126/science.6779377
Muhlemann, 2008, Recognition and elimination of nonsense mRNA, Biochim. Biophys. Acta, 1779, 538, 10.1016/j.bbagrm.2008.06.012
Mullarkey, 1990, Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes, Biochem. Biophys. Res. Commun., 173, 932, 10.1016/S0006-291X(05)80875-7
Münch, 1997, Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide, Biochim. Biophys. Acta, 1360, 17, 10.1016/S0925-4439(96)00062-2
Münch, 1997, Advanced glycation endproducts in ageing and Alzheimer's disease, Brain Res. Rev., 23, 134, 10.1016/S0165-0173(96)00016-1
Münch, 1999, Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library, Nat. Biotechnol., 17, 1006, 10.1038/13704
Muscat, 2007, Coffee and Maillard products activate NF-kappaB in macrophages via H(2)O(2) production, Mol. Nutr. Food Res., 51, 525, 10.1002/mnfr.200600254
Nakamura, 2007, Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes, Mol. Med., 13, 185, 10.2119/2006-00090.Nakamura
Neeper, 1992, Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins, J. Biol. Chem., 267, 14998, 10.1016/S0021-9258(18)42138-2
Nitti, 2007, PKC delta and NADPH oxidase in AGE-induced neuronal death, Neurosci. Lett., 416, 261, 10.1016/j.neulet.2007.02.013
Ortwerth, 1998, The generation of superoxide anions in glycation reactions with sugars, osones, and 3-deoxyosones, Biochem. Biophys. Res. Commun., 245, 161, 10.1006/bbrc.1998.8401
Ott, 1999, Diabetes mellitus and the risk of dementia: the Rotterdam Study, Neurology, 53, 1937, 10.1212/WNL.53.9.1937
Pepeu, 1989, Nootropic drugs and brain cholinergic mechanisms, Prog. Neuropsychopharmacol. Biol. Psychiatry, S77, 10.1016/0278-5846(89)90112-7
Price, 2001, Chelating activity of advanced glycation end-product inhibitors, J. Biol. Chem., 276, 48967, 10.1074/jbc.M108196200
Rahbar, 2000, Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation, Clin. Chim. Acta, 301, 65, 10.1016/S0009-8981(00)00327-2
Rahbar, 2000, Novel inhibitors of advanced glycation endproducts (part II), Mol. Cell Biol. Res. Commun., 3, 360, 10.1006/mcbr.2000.0239
Raucci, 2008, A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10), FASEB J., 22, 3716, 10.1096/fj.08-109033
Rauvala, 2007, RAGE as a receptor of HMGB1 (Amphoterin): roles in health and disease, Curr. Mol. Med., 7, 725, 10.2174/156652407783220750
Reddy, 2005, Carnosine: a versatile antioxidant and antiglycating agent, Sci. Aging Knowledge Environ., pe12
Rogers, 2007, Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?, Int. Rev. Neurobiol., 82, 235, 10.1016/S0074-7742(07)82012-5
Saletu, 1989, Psychophysiological research in psychiatry and neuropsychopharmacology II. The investigation of antihypoxidotic/nootropic drugs (tenilsetam and co-dergocrine-mesylate) in elderlies with the Viennese Psychophysiological Test-System (VPTS), Methods Find. Exp. Clin. Pharmacol., 11, 43
Salkovic-Petrisic, 2007, Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach, J. Neural Transm. Suppl., 217
Sasaki, 1998, Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases, Am. J. Pathol., 153, 1149, 10.1016/S0002-9440(10)65659-3
Schmidt, 1994, Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins, Proc. Natl. Acad. Sci. U.S.A., 91, 8807, 10.1073/pnas.91.19.8807
Schmidt, 2005, Drug development and PET-diagnostics for Alzheimer's disease, Curr. Med. Chem., 12, 1677, 10.2174/0929867054367130
Schubert, 2005, Glucose metabolism and Alzheimer's disease, Ageing Res. Rev., 4, 240, 10.1016/j.arr.2005.02.003
Sebekova, 1998, Advanced glycated albumin impairs protein degradation in the kidney proximal tubules cell line LLC-PK1, Cell. Mol. Biol. (Noisy-le-grand), 44, 1051
Shoda, 1997, Inhibitory effects of tenilsetam on the Maillard reaction, Endocrinology, 138, 1886, 10.1210/endo.138.5.5151
Simard, 2006, Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, Neuron, 49, 489, 10.1016/j.neuron.2006.01.022
Smith, 1994, Alzheimer disease: an imbalance of proteolytic regulation?, Med. Hypotheses, 42, 277, 10.1016/0306-9877(94)90132-5
Smith, 1995, Amyloidosis, advanced glycation end products and Alzheimer disease, Neuroreport, 6, 1595, 10.1097/00001756-199508000-00001
Smith, 1996, Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link, Diabetologia, 39, 247, 10.1007/BF00403972
Smith, 1996, Early contribution of oxidative glycation in Alzheimer disease, Neurosci. Lett., 217, 210, 10.1016/0304-3940(96)13100-1
Steele, 2007, The molecular basis of the prevention of Alzheimer's disease through healthy nutrition, Exp. Gerontol., 42, 28, 10.1016/j.exger.2006.06.002
Sternberg, 2008, Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity, Mult. Scler., 14, 759, 10.1177/1352458507088105
Stolzing, 2006, Degradation of glycated bovine serum albumin in microglial cells, Free Radic. Biol. Med., 40, 1017, 10.1016/j.freeradbiomed.2005.10.061
Sugaya, 1994, Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3, Genomics, 23, 408, 10.1006/geno.1994.1517
Takedo, 1996, Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain, Neurosci. Lett., 221, 17, 10.1016/S0304-3940(96)13275-4
Takeuchi, 2008, Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease, Curr. Pharm. Des., 14, 973, 10.2174/138161208784139693
Tan, 1998, Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus, Biochim. Biophys. Acta, 1407, 69, 10.1016/S0925-4439(98)00031-3
Tanaka, 2000, The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells, J. Biol. Chem., 275, 25781, 10.1074/jbc.M001235200
Thomas, 2005, The role of AGEs and AGE inhibitors in diabetic cardiovascular disease, Curr. Drug Targets, 6, 453, 10.2174/1389450054021873
Thornalley, 2003, Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts, Arch. Biochem. Biophys., 419, 31, 10.1016/j.abb.2003.08.013
Thorpe, 1996, Role of the Maillard reaction in diabetes mellitus and diseases of aging, Drugs Aging, 9, 69, 10.2165/00002512-199609020-00001
Toth, 2007, RAGE, diabetes, and the nervous system, Curr. Mol. Med., 7, 766, 10.2174/156652407783220705
Ueda, 1994, Amyloid beta protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid beta protein, Brain Res., 639, 240, 10.1016/0006-8993(94)91736-1
Vitek, 1994, Advanced glycation end products contribute to amyloidosis in Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A., 91, 4766, 10.1073/pnas.91.11.4766
Wolf, 2002, Oxidative DNA damage as a marker of aging in WI-38 human fibroblasts, Exp. Gerontol., 37, 647, 10.1016/S0531-5565(02)00005-0
Wong, 2001, Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia, Eur. J. Neurosci., 14, 1961, 10.1046/j.0953-816x.2001.01820.x
Xia, 1997, Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins, J. Biol. Chem., 272, 7977, 10.1074/jbc.272.12.7977
Yan, 1994, Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress, Proc. Natl. Acad. Sci. U.S.A., 91, 7787, 10.1073/pnas.91.16.7787
Yan, 1996, RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease, Nature, 382, 685, 10.1038/382685a0
Yan, 1996, RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease, Nature, 382, 685, 10.1038/382685a0
Yesavage, 2002, Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment, J. Psychiatr. Res., 36, 281, 10.1016/S0022-3956(02)00020-1
Yonekura, 2003, Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury, Biochem. J., 370, 1097, 10.1042/bj20021371
Zeng, 2004, Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice, Hepatology, 39, 422, 10.1002/hep.20045
Zhang, 2008, Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases, J. Biol. Chem., 283, 35507, 10.1074/jbc.M806948200
Zlokovic, 2008, New therapeutic targets in the neurovascular pathway in Alzheimer's disease, Neurotherapeutics, 5, 409, 10.1016/j.nurt.2008.05.011
Zlokovic, 1985, Blood–brain barrier permeability to leucine-enkephalin d-alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine), Brain Res., 336, 125, 10.1016/0006-8993(85)90423-8
