Advanced atrioventricular block induced by obstructive sleep apnea before oxygen desaturation

Ken-ichi Maeno1, Atsunobu Kasai1, Morimichi Setsuda1, Atsushi Nishiyama2, Shigetoshi Sakabe1, Takahiro Ohnishi1, Kimimasa Saito3, Hideo Nishikawa4
1Division of Cardiology, Yamada Red Cross Hospital, Mie, Japan
2Nishiyama Clinic, Mie, Japan
3Mie Sleep Clinic, Mie, Japan
4Department of Cardiology, Mie Heart Center, Mie, Japan

Tóm tắt

We report a patient with transient advanced atrioventricular (AV) block induced by obstructive sleep apnea (OSA). This 54-year-old man was diagnosed as having severe OSA and AV block with ventricular asystole for more than 6 s during overnight polysomnography, which occurred just from the onset of OSA before oxygen desaturation had occurred. An electrophysiological study revealed normal AV conduction system function and normal His-Purkinje system function. The resolution of OSA with continuous positive airway pressure therapy improved the advanced AV block. Therefore, the bradyarrhythmia was determined to be an OSA-induced AV block that occurred before oxygen desaturation.

Từ khóa


Tài liệu tham khảo

Tilkian AG, Guilleminault C, Schroeder JS, Lehrman KL, Simmons FB, Dement WC (1977) Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med 63:348–358

Guilleminault C, Connolly SJ, Winkle RA (1983) Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52:490–494

Miller WP (1982) Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 73:317–321

Flemons WW, Remmers JE, Gillis AM (1993) Sleep apnea and cardiac arrhythmias. Is there a relationship? Am Rev Respir Dis 148:618–621

Becker H, Brandenburg U, Peter JH, Von Wichert P (1995) Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continuous positive airway pressure. Am J Respir Crit Care Med 151:215–218

Grimm W, Hoffmann J, Menz V, Köhler U, Heitmann J, Peter JH, Maisch B (1996) Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea. Am J Cardiol 77:1310–1314

Becker HF, Koehler U, Stammnitz A, Peter JH (1998) Heart block in patients with sleep apnoea. Thorax 53:S29–S32

Koehler U, Fus E, Grimm W, Pankow W, Schäfer H, Stammnitz A, Peter JH (1998) Heart block in patients with obstructive sleep apnoea: pathogenetic factors and effects of treatment. Eur Respir J 11:434–439

Grimm W, Koehler U, Fus E, Hoffmann J, Menz V, Funck R, Peter JH, Maisch B (2000) Outcome of patients with sleep apnea-associated severe bradyarrhythmias after continuous positive airway pressure therapy. Am J Cardiol 86:688–692

Zwillich C, Devlin T, White D, Douglas N, Weil J, Martin R (1982) Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest 69:1286–1292

Hanly PJ, George CF, Millar TW, Kryger MH (1989) Heart rate response to breath-hold, Valsalva and Mueller maneuvers in obstructive sleep apnea. Chest 95:735–739

Andreas S, Hajak G, von Breska B, Rüther E, Kreuzer H (1992) Changes in heart rate during obstructive sleep apnoea. Eur Respir J 5: 853–857

Remmers JE, Richter DW, Ballantyne D, Bainton CR, Klein JP (1986) Reflex prolongation of stage I of expiration. Pfluegers Arch 407:190–198

Gilbey MP, Jordan D, Richter DW, Spyer KM (1984) Synaptic mechanisms involved in the inspiratory modulation of vagal cardio-inhibitory neurones in the cat. J Physiol 356:65–78

Grimm W, Hoffmann J, Köhler U, Heitmann J, Peter JH, Von Wichert P, Maisch B (1995) Invasive electrophysiological evaluation of patients with sleep apnoea-associated ventricular asystole-methods and preliminary results. J Sleep Res 4:160–165