Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

Cell Metabolism - Tập 8 - Trang 399-410 - 2008
Pazit Polak1, Nadine Cybulski1, Jerome N. Feige2, Johan Auwerx2, Markus A. Rüegg1, Michael N. Hall1
1Biozentrum, University of Basel, Basel, CH-4056, Switzerland
2Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut Clinique de la Souris, CNRS/INSERM, Université Louis Pasteur 67404, Illkirch, France

Tài liệu tham khảo

Aguilar, 2007, S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase, Cell Metab., 5, 476, 10.1016/j.cmet.2007.05.006 Bell, 2000, Rapamycin inhibits human adipocyte differentiation in primary culture, Obes. Res., 8, 249, 10.1038/oby.2000.29 Bentzinger, 2008, Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy, Cell Metabolism, 8, 411, 10.1016/j.cmet.2008.10.002 Beretta, 1996, Rapamycin blocks the phosphorylation of 4E–BP1 and inhibits cap-dependent initiation of translation, EMBO J., 15, 658, 10.1002/j.1460-2075.1996.tb00398.x Bishop, 2007, Genetic links between diet and lifespan: shared mechanisms from yeast to humans, Nat. Rev. Genet., 8, 835, 10.1038/nrg2188 Bonawitz, 2007, Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression, Cell Metab., 5, 265, 10.1016/j.cmet.2007.02.009 Brand, 2005, Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3, Cell Metab., 2, 85, 10.1016/j.cmet.2005.06.002 Brunn, 1997, Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin, Science, 277, 99, 10.1126/science.277.5322.99 Burnett, 1998, RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E–BP1, Proc. Natl. Acad. Sci. USA, 95, 1432, 10.1073/pnas.95.4.1432 Cederberg, 2001, FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance, Cell, 106, 563, 10.1016/S0092-8674(01)00474-3 Cho, 2004, Regulation of adipocyte differentiation and insulin action with rapamycin, Biochem. Biophys. Res. Commun., 321, 942, 10.1016/j.bbrc.2004.07.050 Christian, 2005, RIP140-targeted repression of gene expression in adipocytes, Mol. Cell. Biol., 25, 9383, 10.1128/MCB.25.21.9383-9391.2005 Considine, 1996, Serum immunoreactive-leptin concentrations in normal-weight and obese humans, N. Engl. J. Med., 334, 292, 10.1056/NEJM199602013340503 Corradetti, 2006, Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?, Oncogene, 25, 6347, 10.1038/sj.onc.1209885 Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1[agr] transcriptional complex, Nature, 450, 736, 10.1038/nature06322 Dowling, 2007, Metformin inhibits mammalian target of rapamycin dependent translation initiation in breast cancer cells, Cancer Res., 67, 10804, 10.1158/0008-5472.CAN-07-2310 El-Chaar, 2004, Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E–BP1, Int. J. Obes. Relat. Metab. Disord., 28, 191, 10.1038/sj.ijo.0802554 Frias, 2006, mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s, Curr. Biol., 16, 1865, 10.1016/j.cub.2006.08.001 Gagnon, 2001, Rapamycin-sensitive phase of 3T3–L1 preadipocyte differentiation after clonal expansion, J. Cell. Physiol., 189, 14, 10.1002/jcp.1132 Gimeno, 2005, Adipose tissue as an active endocrine organ: recent advances, Curr. Opin. Pharmacol., 5, 122, 10.1016/j.coph.2005.01.006 Guertin, 2007, Defining the role of mTOR in cancer, Cancer Cell, 12, 9, 10.1016/j.ccr.2007.05.008 Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007 Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol. Cell, 30, 214, 10.1016/j.molcel.2008.03.003 Hansen, 2004, Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation, Proc. Natl. Acad. Sci. USA., 101, 4112, 10.1073/pnas.0301964101 Hara, 2002, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action, Cell, 110, 177, 10.1016/S0092-8674(02)00833-4 Harrington, 2004, The TSC1–2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins, J. Cell Biol., 166, 213, 10.1083/jcb.200403069 Hay, 2004, Upstream and downstream of mTOR, Genes Dev., 18, 1926, 10.1101/gad.1212704 He, 2003, Adipose-specific peroxisome proliferator-activated receptor {gamma} knockout causes insulin resistance in fat and liver but not in muscle, Proc. Natl. Acad. Sci. USA, 100, 15712, 10.1073/pnas.2536828100 Jacinto, 2004, Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive, Nat. Cell Biol., 6, 1122, 10.1038/ncb1183 Jacinto, 2006, SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity, Cell, 127, 125, 10.1016/j.cell.2006.08.033 Kaeberlein, 2007, Sir2 and calorie restriction in yeast: A skeptical perspective, Ageing Res. Rev., 6, 128, 10.1016/j.arr.2007.04.001 Kaeberlein, 2005, Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients, Science, 310, 1193, 10.1126/science.1115535 Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Curr. Biol., 14, 885, 10.1016/j.cub.2004.03.059 Kershaw, 2004, Adipose tissue as an endocrine organ, J. Clin. Endocrinol. Metab., 89, 2548, 10.1210/jc.2004-0395 Kim, 2004, Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis, Diabetes, 53, 2748, 10.2337/diabetes.53.11.2748 Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5 Kim, 2003, GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR, Mol. Cell, 11, 895, 10.1016/S1097-2765(03)00114-X Kiskinis, 2007, RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes, EMBO J., 26, 4831, 10.1038/sj.emboj.7601908 Krebs, 2007, The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man, Diabetes, 56, 1600, 10.2337/db06-1016 Kubota, 1999, PPAR[gamma] mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance, Mol. Cell, 4, 597, 10.1016/S1097-2765(00)80210-5 Le Bacquer, 2007, Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E–BP1 and 4E–BP2, J. Clin. Invest., 117, 387, 10.1172/JCI29528 Lemonnier, 1972, Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet, J. Clin. Invest., 51, 2907, 10.1172/JCI107115 Leonardsson, 2004, Nuclear receptor corepressor RIP140 regulates fat accumulation, Proc. Natl. Acad. Sci. USA, 101, 8437, 10.1073/pnas.0401013101 Loewith, 2002, Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control, Mol. Cell, 10, 457, 10.1016/S1097-2765(02)00636-6 Nicholls, 2001, A history of UCP1, Biochem. Soc. Trans., 29, 751, 10.1042/bst0290751 Pende, 2000, Hypoinsulinaemia, glucose intolerance and diminished [beta]-cell size in S6K1-deficient mice, Nature, 408, 994, 10.1038/35050135 Powers, 2006, Extension of chronological life span in yeast by decreased TOR pathway signaling, Genes Dev., 20, 174, 10.1101/gad.1381406 Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5 Rovira, 2008, Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients, Transpl. Int., 21, 992, 10.1111/j.1432-2277.2008.00710.x Sarbassov, 2004, Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton, Curr. Biol., 14, 1296, 10.1016/j.cub.2004.06.054 Sarbassov, 2006, Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB, Mol. Cell, 22, 159, 10.1016/j.molcel.2006.03.029 Schieke, 2006, The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity, J. Biol. Chem., 281, 27643, 10.1074/jbc.M603536200 Scime, 2005, Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1, Cell Metab., 2, 283, 10.1016/j.cmet.2005.10.002 Seale, 2007, Transcriptional control of brown fat determination by PRDM16, Cell Metab., 6, 38, 10.1016/j.cmet.2007.06.001 Shah, 2004, Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies, Curr. Biol., 14, 1650, 10.1016/j.cub.2004.08.026 Shaw, 2004, The LKB1 tumor suppressor negatively regulates mTOR signaling, Cancer Cell, 6, 91, 10.1016/j.ccr.2004.06.007 Shaw, 2005, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin, Science, 310, 1642, 10.1126/science.1120781 Shi, 2004, Lipid metabolic enzymes: emerging drug targets for the treatment of obesity, Nat. Rev. Drug Discov., 3, 695, 10.1038/nrd1469 Tontonoz, 1994, Stimulation of adipogenesis in fibroblasts by PPAR[gamma]2, a lipid-activated transcription factor, Cell, 79, 1147, 10.1016/0092-8674(94)90006-X Tzatsos, 2006, Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation, Mol. Cell. Biol., 26, 63, 10.1128/MCB.26.1.63-76.2006 Ueno, 2005, Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway, Diabetologia, 48, 506, 10.1007/s00125-004-1662-6 Um, 2004, Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity, Nature, 431, 200, 10.1038/nature02866 Vander Haar, 2007, Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40, Nat. Cell Biol., 9, 316, 10.1038/ncb1547 Vellai, 2003, Genetics: Influence of TOR kinase on lifespan in C. elegans, Nature, 426, 620, 10.1038/426620a Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest., 112, 1796, 10.1172/JCI200319246 Weisberg, 2006, CCR2 modulates inflammatory and metabolic effects of high-fat feeding, J. Clin. Invest., 116, 115, 10.1172/JCI24335 Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, J. Clin. Invest., 112, 1821, 10.1172/JCI200319451 Yang, 2006, Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity, Genes Dev., 20, 2820, 10.1101/gad.1461206 Yeh, 1995, Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3–L1 cells, Proc. Natl. Acad. Sci. USA, 92, 11086, 10.1073/pnas.92.24.11086