Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
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Aguilar, 2007, S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase, Cell Metab., 5, 476, 10.1016/j.cmet.2007.05.006
Bell, 2000, Rapamycin inhibits human adipocyte differentiation in primary culture, Obes. Res., 8, 249, 10.1038/oby.2000.29
Bentzinger, 2008, Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy, Cell Metabolism, 8, 411, 10.1016/j.cmet.2008.10.002
Beretta, 1996, Rapamycin blocks the phosphorylation of 4E–BP1 and inhibits cap-dependent initiation of translation, EMBO J., 15, 658, 10.1002/j.1460-2075.1996.tb00398.x
Bishop, 2007, Genetic links between diet and lifespan: shared mechanisms from yeast to humans, Nat. Rev. Genet., 8, 835, 10.1038/nrg2188
Bonawitz, 2007, Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression, Cell Metab., 5, 265, 10.1016/j.cmet.2007.02.009
Brand, 2005, Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3, Cell Metab., 2, 85, 10.1016/j.cmet.2005.06.002
Brunn, 1997, Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin, Science, 277, 99, 10.1126/science.277.5322.99
Burnett, 1998, RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E–BP1, Proc. Natl. Acad. Sci. USA, 95, 1432, 10.1073/pnas.95.4.1432
Cederberg, 2001, FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance, Cell, 106, 563, 10.1016/S0092-8674(01)00474-3
Cho, 2004, Regulation of adipocyte differentiation and insulin action with rapamycin, Biochem. Biophys. Res. Commun., 321, 942, 10.1016/j.bbrc.2004.07.050
Christian, 2005, RIP140-targeted repression of gene expression in adipocytes, Mol. Cell. Biol., 25, 9383, 10.1128/MCB.25.21.9383-9391.2005
Considine, 1996, Serum immunoreactive-leptin concentrations in normal-weight and obese humans, N. Engl. J. Med., 334, 292, 10.1056/NEJM199602013340503
Corradetti, 2006, Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?, Oncogene, 25, 6347, 10.1038/sj.onc.1209885
Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1[agr] transcriptional complex, Nature, 450, 736, 10.1038/nature06322
Dowling, 2007, Metformin inhibits mammalian target of rapamycin dependent translation initiation in breast cancer cells, Cancer Res., 67, 10804, 10.1158/0008-5472.CAN-07-2310
El-Chaar, 2004, Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E–BP1, Int. J. Obes. Relat. Metab. Disord., 28, 191, 10.1038/sj.ijo.0802554
Frias, 2006, mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s, Curr. Biol., 16, 1865, 10.1016/j.cub.2006.08.001
Gagnon, 2001, Rapamycin-sensitive phase of 3T3–L1 preadipocyte differentiation after clonal expansion, J. Cell. Physiol., 189, 14, 10.1002/jcp.1132
Gimeno, 2005, Adipose tissue as an active endocrine organ: recent advances, Curr. Opin. Pharmacol., 5, 122, 10.1016/j.coph.2005.01.006
Guertin, 2007, Defining the role of mTOR in cancer, Cancer Cell, 12, 9, 10.1016/j.ccr.2007.05.008
Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007
Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol. Cell, 30, 214, 10.1016/j.molcel.2008.03.003
Hansen, 2004, Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation, Proc. Natl. Acad. Sci. USA., 101, 4112, 10.1073/pnas.0301964101
Hara, 2002, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action, Cell, 110, 177, 10.1016/S0092-8674(02)00833-4
Harrington, 2004, The TSC1–2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins, J. Cell Biol., 166, 213, 10.1083/jcb.200403069
Hay, 2004, Upstream and downstream of mTOR, Genes Dev., 18, 1926, 10.1101/gad.1212704
He, 2003, Adipose-specific peroxisome proliferator-activated receptor {gamma} knockout causes insulin resistance in fat and liver but not in muscle, Proc. Natl. Acad. Sci. USA, 100, 15712, 10.1073/pnas.2536828100
Jacinto, 2004, Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive, Nat. Cell Biol., 6, 1122, 10.1038/ncb1183
Jacinto, 2006, SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity, Cell, 127, 125, 10.1016/j.cell.2006.08.033
Kaeberlein, 2007, Sir2 and calorie restriction in yeast: A skeptical perspective, Ageing Res. Rev., 6, 128, 10.1016/j.arr.2007.04.001
Kaeberlein, 2005, Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients, Science, 310, 1193, 10.1126/science.1115535
Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Curr. Biol., 14, 885, 10.1016/j.cub.2004.03.059
Kershaw, 2004, Adipose tissue as an endocrine organ, J. Clin. Endocrinol. Metab., 89, 2548, 10.1210/jc.2004-0395
Kim, 2004, Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis, Diabetes, 53, 2748, 10.2337/diabetes.53.11.2748
Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5
Kim, 2003, GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR, Mol. Cell, 11, 895, 10.1016/S1097-2765(03)00114-X
Kiskinis, 2007, RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes, EMBO J., 26, 4831, 10.1038/sj.emboj.7601908
Krebs, 2007, The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man, Diabetes, 56, 1600, 10.2337/db06-1016
Kubota, 1999, PPAR[gamma] mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance, Mol. Cell, 4, 597, 10.1016/S1097-2765(00)80210-5
Le Bacquer, 2007, Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E–BP1 and 4E–BP2, J. Clin. Invest., 117, 387, 10.1172/JCI29528
Lemonnier, 1972, Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet, J. Clin. Invest., 51, 2907, 10.1172/JCI107115
Leonardsson, 2004, Nuclear receptor corepressor RIP140 regulates fat accumulation, Proc. Natl. Acad. Sci. USA, 101, 8437, 10.1073/pnas.0401013101
Loewith, 2002, Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control, Mol. Cell, 10, 457, 10.1016/S1097-2765(02)00636-6
Nicholls, 2001, A history of UCP1, Biochem. Soc. Trans., 29, 751, 10.1042/bst0290751
Pende, 2000, Hypoinsulinaemia, glucose intolerance and diminished [beta]-cell size in S6K1-deficient mice, Nature, 408, 994, 10.1038/35050135
Powers, 2006, Extension of chronological life span in yeast by decreased TOR pathway signaling, Genes Dev., 20, 174, 10.1101/gad.1381406
Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5
Rovira, 2008, Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients, Transpl. Int., 21, 992, 10.1111/j.1432-2277.2008.00710.x
Sarbassov, 2004, Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton, Curr. Biol., 14, 1296, 10.1016/j.cub.2004.06.054
Sarbassov, 2006, Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB, Mol. Cell, 22, 159, 10.1016/j.molcel.2006.03.029
Schieke, 2006, The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity, J. Biol. Chem., 281, 27643, 10.1074/jbc.M603536200
Scime, 2005, Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1, Cell Metab., 2, 283, 10.1016/j.cmet.2005.10.002
Seale, 2007, Transcriptional control of brown fat determination by PRDM16, Cell Metab., 6, 38, 10.1016/j.cmet.2007.06.001
Shah, 2004, Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies, Curr. Biol., 14, 1650, 10.1016/j.cub.2004.08.026
Shaw, 2004, The LKB1 tumor suppressor negatively regulates mTOR signaling, Cancer Cell, 6, 91, 10.1016/j.ccr.2004.06.007
Shaw, 2005, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin, Science, 310, 1642, 10.1126/science.1120781
Shi, 2004, Lipid metabolic enzymes: emerging drug targets for the treatment of obesity, Nat. Rev. Drug Discov., 3, 695, 10.1038/nrd1469
Tontonoz, 1994, Stimulation of adipogenesis in fibroblasts by PPAR[gamma]2, a lipid-activated transcription factor, Cell, 79, 1147, 10.1016/0092-8674(94)90006-X
Tzatsos, 2006, Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation, Mol. Cell. Biol., 26, 63, 10.1128/MCB.26.1.63-76.2006
Ueno, 2005, Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway, Diabetologia, 48, 506, 10.1007/s00125-004-1662-6
Um, 2004, Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity, Nature, 431, 200, 10.1038/nature02866
Vander Haar, 2007, Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40, Nat. Cell Biol., 9, 316, 10.1038/ncb1547
Vellai, 2003, Genetics: Influence of TOR kinase on lifespan in C. elegans, Nature, 426, 620, 10.1038/426620a
Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest., 112, 1796, 10.1172/JCI200319246
Weisberg, 2006, CCR2 modulates inflammatory and metabolic effects of high-fat feeding, J. Clin. Invest., 116, 115, 10.1172/JCI24335
Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016
Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, J. Clin. Invest., 112, 1821, 10.1172/JCI200319451
Yang, 2006, Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity, Genes Dev., 20, 2820, 10.1101/gad.1461206
Yeh, 1995, Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3–L1 cells, Proc. Natl. Acad. Sci. USA, 92, 11086, 10.1073/pnas.92.24.11086