Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling

Cellular and Molecular Gastroenterology and Hepatology - Tập 15 - Trang 1000-1015 - 2023
Huimin Yu1, Zixin Zhang1, Gangping Li1, Yan Feng2, Lingling Xian3, Fatemeh Bakhsh4, Dongqing Xu5, Cheng Xu6, Tyrus Vong1, Bin Wu4, Florin M. Selaru1, Fengyi Wan5, Mark Donowitz1,6, G. William Wong6
1Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
2Department of Pathology and Laboratory Medicine, Pennsylvania Hospital, Penn Medicine, Philadelphia, Pennsylvania
3Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
4Department of Biophysics and Biophysics and Biochemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland
5Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

Tài liệu tham khảo

Kaplan, 2015, The global burden of IBD: from 2015 to 2025, Nat Rev Gastroenterol Hepatol, 12, 720, 10.1038/nrgastro.2015.150 Dahlhamer, 2016, Prevalence of inflammatory bowel disease among adults aged >/=18 years - United States, 2015, MMWR Morb Mortal Wkly Rep, 65, 1166, 10.15585/mmwr.mm6542a3 Ye, 2020, Prevalence of inflammatory bowel disease in pediatric and adult populations: recent estimates from large national databases in the United States, 2007-2016, Inflamm Bowel Dis, 26, 619 Chen, 2017, Smooth muscle hyperplasia/hypertrophy is the most prominent histological change in Crohn's fibrostenosing bowel strictures: a semiquantitative analysis by using a novel histological grading scheme, J Crohns Colitis, 11, 92, 10.1093/ecco-jcc/jjw126 Bettenworth, 2019, Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review, Gut, 68, 1115, 10.1136/gutjnl-2018-318081 Yoo, 2020, Fibrostenotic strictures in Crohn's disease, Intest Res, 18, 379, 10.5217/ir.2019.09148 Rimola, 2020, Differentiation of fibrotic and inflammatory component of Crohn's disease-associated strictures, Intest Res, 18, 144, 10.5217/ir.2020.00015 Otani, 1955, Pathology of regional enteritis and regional enterocolitis, J Mt Sinai Hosp N Y, 22, 147 Crohn, 2000, Regional ileitis: a pathologic and clinical entity. 1932, Mt Sinai J Med, 67, 263 Sheehan, 1992, Fat-wrapping in Crohn's disease: pathological basis and relevance to surgical practice, Br J Surg, 79, 955, 10.1002/bjs.1800790934 Desreumaux, 1999, Inflammatory alterations in mesenteric adipose tissue in Crohn's disease, Gastroenterology, 117, 73, 10.1016/S0016-5085(99)70552-4 Paul, 2006, Profiling adipocytokine secretion from creeping fat in Crohn's disease, Inflamm Bowel Dis, 12, 471, 10.1097/00054725-200606000-00005 Peyrin-Biroulet, 2007, Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander?, Gut, 56, 577, 10.1136/gut.2005.082925 Coffey, 2016, The mesentery: structure, function, and role in disease, Lancet Gastroenterol Hepatol, 1, 238, 10.1016/S2468-1253(16)30026-7 Zielinska, 2019, The role of adipose tissue in the pathogenesis of Crohn's disease, Pharmacol Rep, 71, 105, 10.1016/j.pharep.2018.09.011 Koon, 2009, Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis, Proc Natl Acad Sci U S A, 106, 8766, 10.1073/pnas.0903499106 Kredel, 2013, Adipokines from local fat cells shape the macrophage compartment of the creeping fat in Crohn's disease, Gut, 62, 852, 10.1136/gutjnl-2011-301424 Scheibe, 2019, Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation, Gastroenterology, 156, 1082, 10.1053/j.gastro.2018.11.029 Ha, 2020, Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans, Cell, 183, 666, 10.1016/j.cell.2020.09.009 Hofmann, 2011, C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts, Inflamm Bowel Dis, 17, 2462, 10.1002/ibd.21647 Li, 2017, C1q/TNF-related protein 3 (CTRP3) function and regulation, Compr Physiol, 7, 863, 10.1002/cphy.c160044 Schaffler, 2012, CTRP family: linking immunity to metabolism, Trends Endocrinol Metab, 23, 194, 10.1016/j.tem.2011.12.003 Schaffler, 2007, Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs, Trends Immunol, 28, 393, 10.1016/j.it.2007.07.003 Maeda, 2001, Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development, J Biol Chem, 276, 3628, 10.1074/jbc.M007898200 Wong, 2004, A family of Acrp30/adiponectin structural and functional paralogs, Proc Natl Acad Sci U S A, 101, 10302, 10.1073/pnas.0403760101 Wong, 2008, Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions, Biochem J, 416, 161, 10.1042/BJ20081240 Petersen, 2016, Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress, Physiol Rep, 4, 10.14814/phy2.12735 Peterson, 2013, CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism, Am J Physiol Gastrointest Liver Physiol, 305, G214, 10.1152/ajpgi.00102.2013 Peterson, 2010, C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output, J Biol Chem, 285, 39691, 10.1074/jbc.M110.180695 Wolf, 2016, CTRP3 deficiency reduces liver size and alters IL-6 and TGFbeta levels in obese mice, Am J Physiol Endocrinol Metab, 310, E332, 10.1152/ajpendo.00248.2015 Ban, 2014, Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose, PLoS One, 9, 10.1371/journal.pone.0112931 Choi, 2012, C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome, Diabetes, 61, 2932, 10.2337/db12-0217 Deng, 2015, Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance, Diabetol Metab Syndr, 7, 33, 10.1186/s13098-015-0029-0 Park, 2005, Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6, Diabetes Res Clin Pract, 69, 29, 10.1016/j.diabres.2004.11.007 Yoo, 2013, Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome, PLoS One, 8, 10.1371/journal.pone.0055744 Wolf, 2015, Lower circulating C1q/TNF-related protein-3 (CTRP3) levels are associated with obesity: a cross-sectional study, PLoS One, 10, 10.1371/journal.pone.0133955 Wagner, 2016, Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study, PeerJ, 4, e2573, 10.7717/peerj.2573 Flehmig, 2014, Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation, PLoS One, 9, 10.1371/journal.pone.0099785 Mohamadinarab, 2020, Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance, IUBMB Life, 72, 1698, 10.1002/iub.2293 Li, 2016, Identification of putative receptors for the novel adipokine CTRP3 using ligand-receptor capture technology, PLoS One, 11 Lv, 2020, CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-kappaB/p53 axis, Biosci Rep, 40, 10.1042/BSR20200092 Murayama, 2014, CTRP3 plays an important role in the development of collagen-induced arthritis in mice, Biochem Biophys Res Commun, 443, 42, 10.1016/j.bbrc.2013.11.040 Wu, 2015, CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation, J Mol Med (Berl), 93, 1311, 10.1007/s00109-015-1309-8 Yuan, 2018, CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1, J Mol Cell Cardiol, 114, 38, 10.1016/j.yjmcc.2017.10.008 Lawrence, 2009, The nuclear factor NF-kappaB pathway in inflammation, Cold Spring Harb Perspect Biol, 1, a001651, 10.1101/cshperspect.a001651 Rogler, 1998, Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa, Gastroenterology, 115, 357, 10.1016/S0016-5085(98)70202-1 Schreiber, 1998, Activation of nuclear factor kappa B inflammatory bowel disease, Gut, 42, 477, 10.1136/gut.42.4.477 Wellman, 2017, Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota, Gastroenterology, 153, 772, 10.1053/j.gastro.2017.05.022 Lo Sasso, 2014, Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer, PLoS One, 9, 10.1371/journal.pone.0102495 Caruso, 2014, Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut, Mucosal Immunol, 7, 1467, 10.1038/mi.2014.35 Cooper, 1993, Clinicopathologic study of dextran sulfate sodium experimental murine colitis, Lab Invest, 69, 238 Eder, 2019, The role of adipose tissue in the pathogenesis and therapeutic outcomes of inflammatory bowel disease, Cells, 8, 628, 10.3390/cells8060628 Gettler, 2019, Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets, Genes Immun, 20, 577, 10.1038/s41435-019-0059-y Fiocchi, 2008, What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation?, Inflamm Bowel Dis, 14, S77, 10.1097/00054725-200810001-00040 Cho, 2008, The genetics and immunopathogenesis of inflammatory bowel disease, Nat Rev Immunol, 8, 458, 10.1038/nri2340 Geremia, 2014, Innate and adaptive immunity in inflammatory bowel disease, Autoimmun Rev, 13, 3, 10.1016/j.autrev.2013.06.004 Mitsialis, 2020, Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn's disease, Gastroenterology, 159, 591, 10.1053/j.gastro.2020.04.074 Corridoni, 2018, Emerging mechanisms of innate immunity and their translational potential in inflammatory bowel disease, Front Med (Lausanne), 5, 32, 10.3389/fmed.2018.00032 Tsai, 2020, Adipokine-modulated immunological homeostasis shapes the pathophysiology of inflammatory bowel disease, Int J Mol Sci, 21, 9564, 10.3390/ijms21249564 Koelink, 2018, Development of reliable, valid and responsive scoring systems for endoscopy and histology in animal models for inflammatory bowel disease, J Crohns Colitis, 12, 794, 10.1093/ecco-jcc/jjy035 Lyubimova, 2013, Single-molecule mRNA detection and counting in mammalian tissue, Nat Protoc, 8, 1743, 10.1038/nprot.2013.109 Sato, 2011, Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium, Gastroenterology, 141, 1762, 10.1053/j.gastro.2011.07.050 Johnson, 2020, Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways, Am J Physiol Cell Physiol, 319, C321, 10.1152/ajpcell.00179.2020