Adhesion-GPCRs: emerging roles for novel receptors

Trends in Biochemical Sciences - Tập 33 Số 10 - Trang 491-500 - 2008
Simon Yona1,2, Hsi‐Hsien Lin3, Willie O. Siu2, Siamon Gordon2, Martin Stacey4,2
1Present address: Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
2Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
3Department of Microbiology and Immunology, Chang Gung University, Tao-Yuan 333, Taiwan
4Present address: Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9J6, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Lagerstrom, 2008, Structural diversity of G protein-coupled receptors and significance for drug discovery, Nat. Rev. Drug Discov., 7, 339, 10.1038/nrd2518

Oldham, 2008, Heterotrimeric G protein activation by G-protein-coupled receptors, Nat. Rev. Mol. Cell Biol., 9, 60, 10.1038/nrm2299

Stacey, 2003, The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulphate glycosaminoglycans, Blood, 102, 2916, 10.1182/blood-2002-11-3540

Hamann, 1996, The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF), J. Exp. Med., 184, 1185, 10.1084/jem.184.3.1185

Xu, 2007, GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment, Cell Cycle, 6, 160, 10.4161/cc.6.2.3760

Park, 2007, BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module, Nature, 450, 430, 10.1038/nature06329

Iguchi, 2008, Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a Galpha 12/13 and Rho pathway, J. Biol. Chem., 283, 14469, 10.1074/jbc.M708919200

Lelianova, 1997, Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors, J. Biol. Chem., 272, 21504, 10.1074/jbc.272.34.21504

Little, 2004, Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association, Mol. Biol. Cell, 15, 2375, 10.1091/mbc.E03-12-0886

Yona, 2008, Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function, FASEB J., 22, 741, 10.1096/fj.07-9435com

Galle, 2006, Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion, Am. J. Pathol., 169, 1802, 10.2353/ajpath.2006.060006

Shiratsuchi, 1998, Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1, Biochem. Biophys. Res. Commun., 247, 597, 10.1006/bbrc.1998.8603

Lagerstrom, 2007, The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells, J. Neurochem., 100, 1129, 10.1111/j.1471-4159.2006.04281.x

Yamamoto, 2004, Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein, Oncogene, 23, 3889, 10.1038/sj.onc.1207495

Brzostowski, 2001, Signaling at zero G: G-protein-independent functions for 7-TM receptors, Trends Biochem. Sci., 26, 291, 10.1016/S0968-0004(01)01804-7

Marshall, 1999, GABA(B) receptors function as heterodimers, Biochem. Soc. Trans., 27, 530, 10.1042/bst0270530

Terrillon, 2004, Roles of G-protein-coupled receptor dimerization, EMBO Rep., 5, 30, 10.1038/sj.embor.7400052

Nechiporuk, 2001, ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily, J. Biol. Chem., 276, 4150, 10.1074/jbc.M004814200

Abe, 1999, Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs, J. Biol. Chem., 274, 19957, 10.1074/jbc.274.28.19957

Volynski, 2004, Latrophilin fragments behave as independent proteins that associate and signal on binding of LTX(N4C), EMBO J., 23, 4423, 10.1038/sj.emboj.7600443

Davies, 2007, The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptors, J. Biol. Chem., 282, 27343, 10.1074/jbc.M704096200

Krasnoperov, 1997, alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor, Neuron, 18, 925, 10.1016/S0896-6273(00)80332-3

Lin, 2004, Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site (GPS) motif, J. Biol. Chem., 279, 31823, 10.1074/jbc.M402974200

Chang, 2003, Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif, FEBS Lett., 547, 145, 10.1016/S0014-5793(03)00695-1

Ichtchenko, 1999, A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors, J. Biol. Chem., 274, 5491, 10.1074/jbc.274.9.5491

Qian, 2002, Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations, Proc. Natl. Acad. Sci. U. S. A., 99, 16981, 10.1073/pnas.252484899

Wei, 2007, Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene, J. Biol. Chem., 282, 21729, 10.1074/jbc.M703218200

Abe, 2002, Cleavage of Ig-Hepta at a ‘SEA’ module and at a conserved G protein-coupled receptor proteolytic site, J. Biol. Chem., 277, 23391, 10.1074/jbc.M110877200

Brannigan, 1995, A protein catalytic framework with an N-terminal nucleophile is capable of self-activation, Nature, 378, 416, 10.1038/378416a0

Krasnoperov, 2002, Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif, J. Biol. Chem., 277, 46518, 10.1074/jbc.M206415200

Jin, 2007, Disease-associated mutations affect GPR56 protein trafficking and cell surface expression, Hum. Mol. Genet., 16, 1972, 10.1093/hmg/ddm144

Piao, 2004, G protein-coupled receptor-dependent development of human frontal cortex, Science, 303, 2033, 10.1126/science.1092780

Yu, 2007, Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure, Proc. Natl. Acad. Sci. U. S. A., 104, 18688, 10.1073/pnas.0708217104

Kwakkenbos, 2006, An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2, FASEB J., 20, 2582, 10.1096/fj.06-6500fje

Whittaker, 2006, The echinoderm adhesome, Dev. Biol., 300, 252, 10.1016/j.ydbio.2006.07.044

Nordstrom, 2008, The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors, BMC Evol. Biol., 8, 9, 10.1186/1471-2148-8-9

Usui, 1999, Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled, Cell, 98, 585, 10.1016/S0092-8674(00)80046-X

McGee, 2006, The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles, J. Neurosci., 26, 6543, 10.1523/JNEUROSCI.0693-06.2006

Hamann, 2003, Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence, Eur. J. Immunol., 33, 1365, 10.1002/eji.200323881

Shiratsuchi, 1997, Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1), Cytogenet. Cell Genet., 79, 103, 10.1159/000134693

McMillan, 2002, Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system, J. Biol. Chem., 277, 785, 10.1074/jbc.M108929200

Kwakkenbos, 2005, Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells, J. Leukoc. Biol., 77, 112, 10.1189/jlb.0704402

Wang, 2005, CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells, Blood, 105, 2836, 10.1182/blood-2004-07-2878

Vallon, 2006, Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans, J. Biol. Chem., 281, 34179, 10.1074/jbc.M605291200

Fukuzawa, 2006, Multiple processing of Ig-Hepta/GPR116, a G protein-coupled receptor with immunoglobulin (Ig)-like repeats, and generation of EGF2-like fragment, J. Biochem., 140, 445, 10.1093/jb/mvj170

Kaur, 2005, Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor, Oncogene, 24, 3632, 10.1038/sj.onc.1208317

Gray, 1996, CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation, J. Immunol., 157, 5438, 10.4049/jimmunol.157.12.5438

Osterhoff, 1997, Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily, DNA Cell Biol., 16, 379, 10.1089/dna.1997.16.379

LopezJimenez, 2005, Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells, Genomics, 85, 472, 10.1016/j.ygeno.2004.12.005

Taylor, 2005, Macrophage receptors and immune recognition, Annu. Rev. Immunol., 23, 901, 10.1146/annurev.immunol.23.021704.115816

Chang, 2007, CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells, Biochem. Biophys. Res. Commun., 353, 133, 10.1016/j.bbrc.2006.11.148

Hamann, 1999, Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue, Arthritis Rheum., 42, 650, 10.1002/1529-0131(199904)42:4<650::AID-ANR7>3.0.CO;2-S

Leemans, 2004, The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense, J. Immunol., 172, 1125, 10.4049/jimmunol.172.2.1125

Matmati, 2007, The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes, J. Leukoc. Biol., 81, 440, 10.1189/jlb.0406276

van Pel, 2008, Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization, Haematologica, 93, 601, 10.3324/haematol.11606

Austyn, 1981, F4/80, a monoclonal antibody directed specifically against the mouse macrophage, Eur. J. Immunol., 11, 805, 10.1002/eji.1830111013

Lin, 2005, The macrophage receptor F4/80 is involved in the induction of CD8+ regulatory T cells in peripheral tolerance, J. Exp. Med., 201, 1615, 10.1084/jem.20042307

Hamann, 2007, EMR1, the human homolog of F4/80, is an eosinophil-specific receptor, Eur. J. Immunol., 37, 2797, 10.1002/eji.200737553

Stacey, 2002, EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20, J. Biol. Chem., 277, 29283, 10.1074/jbc.M204306200

Visser, 2002, Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis, J. Neuroimmunol., 132, 156, 10.1016/S0165-5728(02)00306-5

Kop, 2006, CD97 neutralisation increases resistance to collagen-induced arthritis in mice, Arthritis Res. Ther., 8, R155, 10.1186/ar2049

Capasso, 2006, Costimulation via CD55 on human CD4+ T cells mediated by CD97, J. Immunol., 177, 1070, 10.4049/jimmunol.177.2.1070

Wang, 2007, Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97, Infect. Immun., 75, 1144, 10.1128/IAI.00869-06

Fung, 2008, Expression profile of the cadherin family in the developing Drosophila brain, J. Comp. Neurol., 506, 469, 10.1002/cne.21539

Hadjantonakis, 1997, Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter, Genomics, 45, 97, 10.1006/geno.1997.4892

Lu, 1999, Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila, Curr. Biol., 9, 1247, 10.1016/S0960-9822(99)80505-3

Bao, 2007, The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila, Mol. Cell. Neurosci., 34, 662, 10.1016/j.mcn.2007.01.007

Tissir, 2002, Developmental expression profiles of Celsr (Flamingo) genes in the mouse, Mech. Dev., 112, 157, 10.1016/S0925-4773(01)00623-2

Formstone, 2001, The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development, Mech. Dev., 109, 91, 10.1016/S0925-4773(01)00515-9

Shima, 2004, Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin, Dev. Cell, 7, 205, 10.1016/j.devcel.2004.07.007

Curtin, 2003, Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse, Curr. Biol., 13, 1129, 10.1016/S0960-9822(03)00374-9

Weston, 2004, Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II, Am. J. Hum. Genet., 74, 357, 10.1086/381685

Takeichi, 2000, Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily, Philos. Trans. R. Soc. Lond. B Biol. Sci., 355, 885, 10.1098/rstb.2000.0624

Tissir, 2005, Protocadherin Celsr3 is crucial in axonal tract development, Nat. Neurosci., 8, 451, 10.1038/nn1428

Wada, 2006, Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain, Development, 133, 4749, 10.1242/dev.02665

Beall, 2005, Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity, J. Androl., 26, 529, 10.2164/jandrol.05003

Davies, 2004, Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility, Mol. Cell. Biol., 24, 8642, 10.1128/MCB.24.19.8642-8648.2004

Nishimori, 1997, A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis, Oncogene, 15, 2145, 10.1038/sj.onc.1201542

Carson-Walter, 2001, Cell surface tumor endothelial markers are conserved in mice and humans, Cancer Res., 61, 6649

Aust, 2002, CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas, Am. J. Clin. Pathol., 118, 699, 10.1309/A6AB-VF3F-7M88-C0EJ

Steinert, 2002, Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues, Am. J. Pathol., 161, 1657, 10.1016/S0002-9440(10)64443-4

Koh, 2004, Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin, Exp. Cell Res., 294, 172, 10.1016/j.yexcr.2003.11.008

Shashidhar, 2005, GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion, Oncogene, 24, 1673, 10.1038/sj.onc.1208395

Lajus, 2006, Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells, J. Biol. Chem., 281, 5522, 10.1074/jbc.M510528200

Matsushita, 1999, The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution, FEBS Lett., 443, 348, 10.1016/S0014-5793(99)00005-8

Sugita, 1998, alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis, J. Biol. Chem., 273, 32715, 10.1074/jbc.273.49.32715

Caminschi, 2001, Molecular cloning of F4/80-like-receptor, a seven-span membrane protein expressed differentially by dendritic cell and monocyte-macrophage subpopulations, J. Immunol., 167, 3570, 10.4049/jimmunol.167.7.3570

Koh, 2001, Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein, Brain Res. Mol. Brain Res., 87, 223, 10.1016/S0169-328X(01)00004-3

Hume, 1983, The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs, J. Exp. Med., 158, 1522, 10.1084/jem.158.5.1522

Aust, 2006, Diversity of CD97 in smooth muscle cells, Cell Tissue Res., 324, 139, 10.1007/s00441-005-0103-2

Kee, 2002, Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis, J. Cereb. Blood Flow Metab., 22, 1054, 10.1097/00004647-200209000-00003

Jeong, 2006, Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor, FEBS Lett., 580, 669, 10.1016/j.febslet.2005.12.086

Kee, 2004, Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma, FEBS Lett., 569, 307, 10.1016/j.febslet.2004.06.011

Formstone, 2000, Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9, Mamm. Genome, 11, 392, 10.1007/s003350010073

Seandel, 2008, Niche players: spermatogonial progenitors marked by GPR125, Cell Cycle, 7, 135, 10.4161/cc.7.2.5248

Seandel, 2007, Generation of functional multipotent adult stem cells from GPR125+ germline progenitors, Nature, 449, 346, 10.1038/nature06129

Doyle, 2006, Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart, Dev. Dyn., 235, 3213, 10.1002/dvdy.20973

Moriguchi, 2004, DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites, Genes Cells, 9, 549, 10.1111/j.1356-9597.2004.00743.x

Stehlik, 2004, VIGR–a novel inducible adhesion family G-protein coupled receptor in endothelial cells, FEBS Lett., 569, 149, 10.1016/j.febslet.2004.05.038

McMillan, 2004, Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice, Mol. Cell. Neurosci., 26, 322, 10.1016/j.mcn.2004.02.005

Fredriksson, 2002, Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions, FEBS Lett., 531, 407, 10.1016/S0014-5793(02)03574-3

Vanti, 2003, Novel human G-protein-coupled receptors, Biochem. Biophys. Res. Commun., 305, 67, 10.1016/S0006-291X(03)00709-5

Bjarnadottir, 2004, The human and mouse repertoire of the adhesion family of G-protein-coupled receptors, Genomics, 84, 23, 10.1016/j.ygeno.2003.12.004