Adequacy of Infant Formula With Protein Content of 1.6 g/100 kcal for Infants Between 3 and 12 Months

Journal of Pediatric Gastroenterology and Nutrition - Tập 61 Số 5 - Trang 596-603 - 2015
Ekhard E. Ziegler1, David A. Fields2, Steven D. Chernausek2, Philippe Steenhout3, Dominik Grathwohl3, Janice M. Jeter1, Steven E. Nelson1, Ferdinand Haschke4
1Department of Pediatrics, University of Iowa, Iowa City
2Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City
3Clinical Development Unit, Nestec Ltd, Vevey, Switzerland
4Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg, Austria

Tóm tắt

ABSTRACTObjectives:Infant formulas provide more protein than breast milk. High protein intakes may place infants at risk of later obesity. The present study tested whether a formula with protein content below the regulatory level supports normal growth from age 3 months.Methods:Randomized double‐blind trial enrolled healthy infants less than age 3 months. At 3 months, formula‐fed infants were assigned to experimental (EXPL, 1.61 g protein/100 kcal; modified bovine whey proteins with caseinoglycomacropeptide removed) or control (CTRL 2.15 g protein/100 kcal; unmodified bovine milk protein with a whey/casein ratio of 60/40) formula; breast‐fed (BF) infants were enrolled in a reference group. Complementary foods were allowed in small amounts from 4 to 6 months and unrestricted after 6 months.Results:Weight gain (g/day) from 3 to 6 months was similar in the EXPL and CTRL groups (EXPL‐CTRL −0.84 g/day; 95% confidence interval −2.25 to 0.57) and faster in the EXPL and CTRL groups than in the BF group. Weight analyzed longitudinally from 4 to 12 months was lower in the EXPL group than in the CTRL group (P = 0.031) but higher than in the BF group (P < 0.0001). Longitudinal analysis of odds ratios from 4 to 12 months indicated fewer infants with weight >85th percentile in the EXPL group than in the CTRL group (P = 0.015). Length z scores were lower than, and body mass index z scores were similar to, World Health Organization Standards in all of the groups. Serum biochemical parameters in the EXPL group reflected lower protein intake and were closer to parameters in the BF infants than in the CTRL group.Conclusions:A formula with 1.61 g of protein/100 kcal supports normal growth of infants after age 3 months. This protein content is adequate if provided from a high‐quality source.

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Journal of Pediatric Gastroenterology and Nutrition

Tập 61 Số 5

596-603

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