Addressing Unmet Clinical Needs with 3D Printing Technologies
Tóm tắt
Recent advances in 3D printing have enabled the creation of novel 3D constructs and devices with an unprecedented level of complexity, properties, and functionalities. In contrast to manufacturing techniques developed for mass production, 3D printing encompasses a broad class of fabrication technologies that can enable 1) the creation of highly customized and optimized 3D physical architectures from digital designs; 2) the synergistic integration of properties and functionalities of distinct classes of materials to create novel hybrid devices; and 3) a biocompatible fabrication approach that facilitates the creation and cointegration of biological constructs and systems. This progress report describes how these capabilities can potentially address a myriad of unmet clinical needs. First, the creation of 3D‐printed prosthetics to regain lost functionalities by providing structural support for skeletal and tubular organs is highlighted. Second, novel drug delivery strategies aided by 3D‐printed devices are described. Third, the advancement of medical research heralded by 3D‐printed tissue/organ‐on‐chips systems is discussed. Fourth, the developments of 3D‐printed tissue and organ regeneration are explored. Finally, the potential for seamless integration of engineered organs with active devices by leveraging the versatility of multimaterial 3D printing is envisioned.
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Tài liệu tham khảo
U. S. FDA Hip Implants May2018 https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/MetalonMetalHipImplants/ucm241594.htm.
Ford S. L., 2014, J. Int. Commer. Econ., 6, 40
E. M.Sachs J. S.Haggerty M. J.Cima P. A.Williams US Patent 5204055A 1993.
C. W.Hull US Patent 4575330A 1986.
J. J.Beaman C. R.Deckard US Patent 4938816A 1990.
ASTM International, 2012, Standard Terminology for Additive Manufacturing Technologies
Voelker R., 2015, JAMA, J. Am. Med. Assoc., 314, 1108
S. S.Crump US Patent 5121329A 1992.
Novakova‐Marcincinova L., 2012, Manuf. and Ind. Eng., 11, 24
Comotti C., 2015, Proc. of the 3rd 2015 Workshop on ICTs for Improving Patients Rehabilitation Research Techniques
Liu W., 2017, Adv. Mater., 29
Childress D. S., 1985, Clin. Prosthet. Orthot., 9, 2
Slade P., 2015, 2015 IEEE Int. Conf. on Robotics and Automation (ICRA)
MacBarb R. F., 2017, Int. J. Spine Surg., 11, 116
Jehring A., 2018, The SUN
Mikołajewska E., 2014, J. Health Sci., 4, 78
Schmidt R., 2015, SIGGRAPH 2015: Studio
E.Alt T.Fliedner R.Alter A.Stemberger US Patent 5843117A 1998.
Ventola C. L., 2014, Pharmacol. Ther., 39, 704
Biswas S., 2010, Appl. Phys. Lett., 96, 125
Sabaté E., 2003, Adherence to Long‐Term Therapies: Evidence for Action
BioArchitects World's First 3D‐Printed Titanium Cranial Implant Cleared By FDA May2018 https://bioarchitects.com/en/worlds‐first‐3d‐printed‐titanium‐cranial‐implant‐cleared‐by‐fda/.
A. B.Varotsis Introduction to Binder Jetting 3D Printing https://www.3dhubs.com/knowledge‐base/introduction‐binder‐jetting‐3d‐printing(accessed: 23 May2018).
J.Jacob N.Coyle D. C.Monkhouse H. L.Surprenant N. B.Jain US Patent 9669009B2 2017.