1Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Basel 4070, Switzerland
2Pharmaceutical Development, Technical Development Europe Biologics, F. Hoffmann-La Roche Ltd. Basel 4070, Switzerland
3Macromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Zurich 8092, Switzerland
4Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, United States
5Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, United States