Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis
Wineke Bakker1,2, Monica Imbernon3, Casper Gravesen Salinas2,4,5, Daniela Herrera Moro Chao1, Rim Hassouna1, Chloe Morel1, Claire Martin1, Caroline Leger1, Raphael G.P. Denis1,6, Julien Castel1, Andreas Peter7,8,9, Martin Heni10,7,8, Walter Maetzler11,12,13, Heidi Solvang Nielsen2, Manon Duquenne3, Markus Schwaninger14, Sofia Lundh2, Wouter Frederic Johan Hogendorf2, Giuseppe Gangarossa1, Anna Secher2
1Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, 75013 Paris, France
2Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark
3University Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, EGID, UMR-S 1172, 59000 Lille, France
4Image Analysis & Computer Graphics, Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark
5Gubra ApS, Hørsholm Kongevej 11B, 2970 Hørsholm, Denmark
6Institut Cochin, Université Paris Cité, INSERM U1016, CNRS UMR 8104, 75014 Paris, France
7Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
8German Center for Diabetes Research (DZD), Tübingen, Germany
9Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tübingen, Germany
10Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University of Tübingen, Tübingen, Germany
11Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
12German Center for Neurodegenerative Diseases, Tübingen, Germany
13Department of Neurology, University of Kiel, Kiel, Germany
14Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany