Acute bone changes after lower limb amputation resulting from traumatic injury

Debra A. Bemben1, Vanessa D. Sherk2, William Ertl3
1University of Oklahoma,
2Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
3Department of Orthopedic Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Rittweger J, Simunic B, Bilancio G et al (2009) Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment. Bone 44:612–618

Morgan JLL, Heer M, Hargens AR et al (2014) Sex-specific responses of bone metabolism and renal stone risk during bed rest. Physiol Rep 2:e12119. doi: 10.14814/phy2.12119

Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19:1006–1012

Esquenazi A, DiGiacomo R (2001) Rehabilitation after amputation. J Am Podiatr Med Assoc 91:13–22

Davies B, Datta D (2003) Mobility outcome following unilateral lower limb amputation. Prosthetics Orthot Int 27:186–190

Perry J (2004) Amputee gait. In: Smith DG, Michael JW, Bowker JH (eds) Atlas of amputations and limb deficiencies: surgical, prosthetic, and rehabilitation principles. American Academy of Orthopaedic Surgeons, Rosemont, IL, pp 367–384

Robling AG, Turner C (2009) Mechanical signaling for bone modeling and remodeling. Crit Rev Eukaryot Gene Expr 19:219–338

Kulkarni J, Adams J, Thomas E, Silman A (1998) Association between amputation, arthritis and osteopenia in British male war veterans with major lower limb amputations. Clin Rehabil 12:348–353

Leclerq MM, Bonidan O, Haaby E, Pierrejean C, Sengler J (2003) Study of bone mass with dual energy x-ray absorptiometry in a population of 99 lower limb amputees. Annales de Readaptation et de Medicine Physique 46:24–30

Rush PJ, Wong JSW, Kirsh J, Devlin M (1994) Osteopenia in patients with above knee amputation. Arch Phys Med Rehabil 75:112–115

Meerkin J, Parker T (2002) Bone mineral apparent density of transfemoral amputees. Proceedings of the Australian Conference of Science and Medicine in Sport: Sports Medicine and Science at the Extremes

Royer T, Koenig M (2005) Joint loading and bone mineral density in persons with unilateral, trans-tibial amputation. Clin Biomech 20:1119–1125

Yazicioglu K, Tugcu I, Yilmaz B, Goktepe AS, Mohur H (2008) Osteoporosis: a factor on residual limb pain in traumatic trans-tibial amputations. Prosthetics Orthot Int 32:172–178

Tugcu I, Safaz I, Yilmaz B, Goktepe AH, Taskaynatan MA, Yazicioglu K (2009) Muscle strength and bone mineral density in mine victims with transtibial amputation. Prosthetics Orthot Int 33:299–306

Flint JH, Wade AM, Stocker DJ, Pasquina PF, Howard RS, Potter BK (2014) Bone mineral density loss after combat-related lower extremity amputation. J Orthop Trauma 28:238–244

Smith E, Comiskey C, Carroll A, Ryall N (2011) A study of bone mineral density in lower limb amputees at a National Prosthetics Center. J Prosthet Orthot 23:14–20

Gonzalez EG, Matthews MM (1980) Femoral fractures in patients with lower extremity amputations. Arch Phys Med Rehabil 61:276–280

Sherk VD, Bemben MG, Bemben DA (2008) Bone density and bone geometry in transtibial and transfemoral amputees. J Bone Miner Res 23:1449–1457

Sherk VD, Bemben MG, Bemben DA (2010) Interlimb muscle and fat comparisons in persons with lower limb amputations. Arch Phys Med Rehabil 91:1077–1081

Miller WC, Speechley M, Deathe B (2001) The prevalence and risk factors of falling and fear of falling among lower extremity amputees. Arch Phys Med Rehabil 82:1031–1037

Pauley T, Devlin M, Heslin K (2006) Falls sustained during inpatient rehabilitation after lower limb amputation: prevalence and predictors. Am J Phys Med Rehabil 85(6):521–532 quiz, 533-5

Robling AG, Niziolek PJ, Baldridge LA et al (2008) Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 283:5866–5875

Lin C, Jiang X, Dai Z et al (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24:1651–1661

Frings-Meuthen P, Boehme G, Liphardt AM, Baecker N, Heer M, Rittweger J (2013) Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men. J Musculoskelet Neuronal Interact 13:45–52

Belavy DL, Baecker N, Armbrecht G et al (2016) Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest. J Bone Miner Metab 34:354–365

Gaudio A, Pennisi P, Bratengeier C et al (2010) Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab 95:2248–2253

Sarahrudi K, Thomas A, Albrecht C, Aharinejad S (2012) Strongly enhanced levels of sclerostin during human fracture healing. J Orthop Res 30:1549–1555

Cox G, Einhorn TA, Tzioupis C, Giannoudis PV (2010) Bone-turnover markers in fracture healing. J Bone Joint Surg 92-B:329–334

Krusenstjerna-Hafstrom T, Rasmussen MH, Raschke M, Govender S, Madsen J, Christiansen JS (2011) Biochemical markers of bone turnover in tibia fracture patients randomly assigned to growth hormone (GH) or placebo injections. Growth Hormon IGF Res 21:331–335

Moghaddam A, Müller U, Roth HJ, Wentzensen A, Grützner PA, Zimmermann G (2011) TRACP 5b and CTX as osteological markers of delayed fracture healing. Injury 42:758–764

Szulc P, Bauer DC, Eastell R (2013) Biochemical markers of bone turnover in osteoporosis. In: Rosen CJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 8th edn. Wiley-Blackwell, Ames Iowa, pp 297–306

Seeman E (2013) Age- and menopause-related bone loss compromise cortical and trabecular microstructure. J Gerontol A Biol Sci Med 68:1218–1225

Rissanen JP, Suominen MI, Peng Z, Halleen JM (2008) Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 82:108–115

Holick MF (2009) Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 19:73–78

Schousboe JT, Shepherd JA, Bilezikian JP, Baim S (2013) Executive summary of the 2013 International Society for Clinical Densitometry position development conference on bone densitometry. J Clin Densitom 16:455–466

IOM (Institute of Medicine) (2011) Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington, DC

Ramirez JF, Isaza JA, Mariaka I, Velez JA (2011) Analysis of bone demineralization due to the use of exoprosthesis by comparing Young’s modulus of the femur in unilateral amputees. Prosthetics Orthot Int 35:459–466

Lam FMH, Bui M, Yang FZH, Pang MYC (2016) Chronic effects of stroke on hip bone density and tibial morphology: a longitudinal study. Osteoporosis Int 27:591–603

Kostovski E, Hjeltnes N, Eriksen EF, Kolset SO, Iversen PO (2015) Differences in bone mineral density, markers of bone turnover and extracellular matrix and daily life muscular activity among patients with recent motor-incomplete versus motor-complete spinal cord injury. Calcif Tissue Int 96:145–154

Coupaud S, McLean AN, Purcell M, Fraser MH, Allan DB (2015) Decreases in bone mineral density at cortical and trabecular sites in the tibia and femur during the first year of spinal cord injury. Bone 74:69–75

Melton LJ III, Khosla S, Atkinson EJ, O’Connor MK, O’Fallon WM, Riggs BL (2000) Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporosis Int 11:592–599