Acute bacterial prostatitis after transrectal ultrasound‐guided prostate biopsy: Epidemiological, bacteria and treatment patterns from a 4‐year prospective study

International Journal of Urology - Tập 21 Số 2 - Trang 152-155 - 2014
A. Campeggi1, I. Ouzaïd1, Évanguelos Xylinas1, Alban Le Monnier2, András Hoznek1, Dimitri Vordos1, Claude‐Clément Abbou1, Laurent Salomon1, Alexandre de la Taille1
1Department of Urology Henri Mondor Hospital AP‐HP Paris‐Est University Créteil France
2Department of Infection Prevention Unit Henri Mondor Hospital AP‐HP Paris‐Est University Créteil France

Tóm tắt

ObjectivesTo evaluate the incidence, and clinical and bacterial features of iatrogenic prostatitis within 1 month after transrectal ultrasound‐guided biopsy for detection of prostate cancer.MethodsFrom January 2006 to December 2009, 3000 patients underwent a 21‐core transrectal ultrasound‐guided prostate biopsy at Henri Mondor Hospital (Créteil, France) and were prospectively followed. All patients had a fluoroquinolone antimicrobial prophylaxis for 7 days. The primary study end‐point was to evaluate the incidence of iatrogenic acute prostatitis within 1 month after the biopsy. The secondary end‐point was to analyze the clinical and the bacterial features of the prostatitis.ResultsOverall, 20 patients of the entire study population (0.67%) had an acute bacterial prostatitis within 2.90 ± 1.77 days (range 1–7 days) after the transrectal ultrasound‐guided biopsy. The groups of patients with (n = 20) and without (n = 2980) infection were similar in terms of age, prostate‐specific antigen level and prostate volume. Escherichia coli was the only isolated bacteria. The subsequent tests for antibiotic susceptibility showed a 95% resistance for fluroquinolone and amoxicillin. Resistance to amoxiclav, trimethoprim‐sulfamethoxazole, third generation cephalosporin and amikacin was 70%, 70%, 25% and 5% respectively. No resistance to imipenem was reported. They were all admitted for treatment without the need of intensive care unit referral. Complete recovery was achieved after 21.4 ± 7 days of antibiotic treatment.ConclusionsA fluroquinolone‐based regimen still represents an appropriate prophylaxis protocol to minimize the risk of acute prostatitis secondary to prostate biopsy. Patients should be provided the appropriate care soon after the onset of the symptoms. An intravenous third generation cephalosporin or imipenem‐based therapy seem to provide satisfying results.

Từ khóa


Tài liệu tham khảo

10.1016/j.eururo.2010.10.039

10.1097/01.ju.0000061280.23447.29

10.1111/j.1464-410X.2011.10561.x

10.1016/j.amjmed.2004.09.015

Drusano GL, 2000, Fluoroquinolone pharmacodynamics: prospective determination of relationships between exposure and outcome, J Chemother., 12, 21, 10.1080/1120009X.2000.11782309

10.1016/S0022-5347(05)64565-X

10.1046/j.1464-410x.2000.00576.x

Branco LM, 2008, Giant septal cavity due to coronary artery fistula and ventricular septal dissection after cardiac surgery, Eur. J. Echocardiogr., 9, 163

10.1016/S0090-4295(03)00108-0

10.1016/S0090-4295(98)00296-9

10.1016/j.juro.2007.10.071

10.1007/s10096-005-1278-x

10.1111/j.1464-410X.2010.09416.x

10.1023/A:1007115312039

10.1016/S0090-4295(98)00313-6

10.1016/j.juro.2009.11.043

10.1007/s10156-007-0570-3

10.1016/j.urology.2008.12.078

10.1111/j.1442-2042.2009.02386.x

Thông tin
Thông tin xuất bản

International Journal of Urology

Tập 21 Số 2

152-155

Thông tin tác giả