Acute Hyperhomocysteinemia Induces Microvascular and Macrovascular Endothelial Dysfunction

Archives of Medical Research - Tập 38 - Trang 411-416 - 2007
Thomas N. Abahji1, Lars Nill1, Nagatoshi Ide2, Christiane Keller2, Ulrich Hoffmann1, Norbert Weiss1,2
1Department of Vascular Medicine, University of Munich Medical Center, Munich, Germany
2Section General Internal Medicine and Metabolic Diseases, Medical Policlinic–City Campus, University of Munich Medical Center, Munich, Germany

Tài liệu tham khảo

Weiss, 2002, Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia, Vasc Med, 7, 227, 10.1191/1358863x02vm428ra Weiss, 2005, Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function, Curr Drug Metab, 6, 27, 10.2174/1389200052997357 Guerra, 1989, Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF, Blood Vessels, 26, 300 Luscher, 1990, Endothelial control of vascular tone in large and small coronary arteries, J Am Coll Cardiol, 15, 519, 10.1016/0735-1097(90)90619-Z Woo, 1997, Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans, Circulation, 96, 2542, 10.1161/01.CIR.96.8.2542 Tawakol, 1997, Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans, Circulation, 95, 1119, 10.1161/01.CIR.95.5.1119 Holven, 2001, Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects, Am J Med, 110, 536, 10.1016/S0002-9343(01)00696-9 Hanratty, 1998, Homocysteine and endothelial vascular function, Lancet, 351, 1288, 10.1016/S0140-6736(05)79355-7 Chambers, 1999, Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy, Circulation, 99, 1156, 10.1161/01.CIR.99.9.1156 Kanani, 1999, Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans, Circulation, 100, 1161, 10.1161/01.CIR.100.11.1161 Lambert, 1999, Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries, Cardiovasc Res, 42, 743, 10.1016/S0008-6363(98)00338-1 Chao, 2000, Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults, Circulation, 101, 485, 10.1161/01.CIR.101.5.485 Bellamy, 1998, Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults, Circulation, 98, 1848, 10.1161/01.CIR.98.18.1848 Chambers, 2001, Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects, Circ Res, 89, 187, 10.1161/hh1401.093459 Bertsch, 2001, Homocysteine in cerebrovascular disease: an independent risk factor for subcortical vascular encephalopathy, Clin Chem Lab Med, 39, 721, 10.1515/CCLM.2001.120 Looker, 2003, Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes, Diabetologia, 46, 766, 10.1007/s00125-003-1104-x McCully, 1969, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis, Am J Pathol, 56, 111 Triggle, 2004, The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes, Mol Cell Biochem, 263, 21, 10.1023/B:MCBI.0000041845.62061.c9 De Vriese, 2004, Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia, Circulation, 109, 2331, 10.1161/01.CIR.0000129138.08493.4D World Medical Association Declaration of Helsiniki. Ethical Principles for Medical Research Involving Human Subjects. http://www.wma.net/e/policy/pdf/GGTSPU-11623-65270-DAT/17c.pdf. Accessed July 17, 2006. Celermajer, 1992, Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis, Lancet, 340, 1111, 10.1016/0140-6736(92)93147-F De Roos, 2003, Within-subject variability of flow-mediated vasodilation of the brachial artery in healthy men and women: implications for experimental studies, Ultrasound Med Biol, 29, 401, 10.1016/S0301-5629(02)00709-3 Farkas, 2004, Non-invasive assessment of microvascular endothelial function by laser Doppler flowmetry in patients with essential hypertension, Atherosclerosis, 173, 97, 10.1016/j.atherosclerosis.2003.11.015 Feussner, 1997, Determination of total homocysteine in human plasma by isocratic high-performance liquid chromatography, Eur J Clin Chem Clin Biochem, 35, 687 Wilcoxon, 1945, Individual comparisons by ranking methods, Biometrics, 1, 80, 10.2307/3001968 Bautista, 2002, Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies, J Clin Epidemiol, 55, 882, 10.1016/S0895-4356(02)00434-1 Weiss, 2001, Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction, Proc Natl Acad Sci USA, 98, 12503, 10.1073/pnas.231428998 Dayal, 2005, ADMA and hyperhomocysteinemia, Vasc Med, 10, S27, 10.1177/1358836X0501000105 Giannattasio, 2005, Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects, Arterioscler Thromb Vasc Biol, 25, 406, 10.1161/01.ATV.0000152231.93590.17 Gudmundsson, 2000, Resistance vessel endothelial function in healthy humans during transient postprandial hypertriglyceridemia, Am J Cardiol, 85, 381, 10.1016/S0002-9149(99)00751-1 Davis, 2001, Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function, Br J Clin Pharmacol, 52, 327, 10.1046/j.0306-5251.2001.01447.x ter Avest, 2005, Variation in non-invasive measurements of vascular function in healthy volunteers during daytime, Clin Sci (Lond), 108, 425, 10.1042/CS20040300