Acute Experimental Barrier Injury Triggers Ulcerative Colitis–Specific Innate Hyperresponsiveness and Ulcerative Colitis–Type Microbiome Changes in Humans

Cellular and Molecular Gastroenterology and Hepatology - Tập 12 - Trang 1281-1296 - 2021
Jakob Benedict Seidelin1,2, Martin Iain Bahl3, Tine Rask Licht3, Benjamin E. Mead4,5,6,7,8,9,10, Jeffrey M. Karp4,6,7,11,12, Jens Vilstrup Johansen13, Lene Buhl Riis14, Marina Ramírez Galera15,16, Anders Woetmann15,16, Jacob Tveiten Bjerrum1
1Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
2Department of Clinical Medicine University of Copenhagen, Copenhagen, Denmark
3National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
4Harvard-MIT Division of Health Sciences and Technology, Institute for Medical and Engineering Science and Harvard Medical School, Cambridge, Massachusetts
5Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts
6Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts
7Broad Institute of MIT and Harvard, Cambridge, Massachusetts
8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts
9Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts
10Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts
11Harvard Medical School, Boston, Massachusetts
12Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Cambridge, Massachusetts
13Bioinformatics Core Facility, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
14Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
15Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
16LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark

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