Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease

Abraham, 2011, TRPV1 expression in acupuncture points: response to electroacupuncture stimulation, J. Chem. Neuroanat., 41, 129, 10.1016/j.jchemneu.2011.01.001 Ahn, 2019, Gami-Chunggan formula prevents motor dysfunction in MPTP/p-induced and A53T alpha-synuclein overexpressed parkinson's disease mouse model though DJ-1 and BDNF expression, Front. Aging Neurosci., 11, 230, 10.3389/fnagi.2019.00230 Avtandilov, 1991, The current statistical structure of the autopsy and biopsy material incoming per pathologist, Arkh. Patol., 53, 41 Baizabal-Carvallo, 2020, The link between gut dysbiosis and neuroinflammation in Parkinson's disease, Neuroscience, 432, 160, 10.1016/j.neuroscience.2020.02.030 Bonaz, 2018, The Vagus nerve at the interface of the microbiota-gut-brain axis, Front. Neurosci., 12, 49, 10.3389/fnins.2018.00049 Borovikova, 2000, Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin, Nature, 405, 458, 10.1038/35013070 Cai, 2018, Brain functional connectivity network studies of acupuncture: a systematic review on resting-state fMRI, J. Integr. Med., 16, 26, 10.1016/j.joim.2017.12.002 Chae, 2009, Parsing brain activity associated with acupuncture treatment in Parkinson's diseases, Mov. Disord., 24, 1794, 10.1002/mds.22673 Chey, 2011, Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome, Gut Liver, 5, 253, 10.5009/gnl.2011.5.3.253 Choi, 2016, Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice, Nat. Med., 22, 563, 10.1038/nm.4077 Chon, 2013, Acupuncture, Mayo Clin. Proc., 88, 1141, 10.1016/j.mayocp.2013.06.009 Chung, 2019, Exploration of microbiota targets for major depressive disorder and mood related traits, J. Psychiatr. Res., 111, 74, 10.1016/j.jpsychires.2019.01.016 Delahooke, 1995, Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysaccharide complex from Bacteroides species, Infect. Immun., 63, 840, 10.1128/IAI.63.3.840-846.1995 Dickson, 2012, Parkinson's disease and parkinsonism: neuropathology, Cold Spring Harb. Perspect. Med., 2, 10.1101/cshperspect.a009258 Dos Santos, 2008, Antidepressive-like effects of electroacupuncture in rats, Physiol. Behav., 93, 155, 10.1016/j.physbeh.2007.08.014 Du, 2013, Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism, World J. Gastroenterol., 19, 5988, 10.3748/wjg.v19.i36.5988 Edwards, 1991, Gastrointestinal symptoms in Parkinson's disease, Mov. Disord., 6, 151, 10.1002/mds.870060211 Erny, 2015, Host microbiota constantly control maturation and function of microglia in the CNS, Nat. Neurosci., 18, 965, 10.1038/nn.4030 Felice, 2016, Microbiota-gut-brain signalling in Parkinson's disease: implications for non-motor symptoms, Parkinsonism Relat. Disord., 27, 1, 10.1016/j.parkreldis.2016.03.012 Gao, 2011, Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease, Environ. Health Perspect., 119, 807, 10.1289/ehp.1003013 Ghaisas, 2016, Gut microbiome in health and disease: linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases, Pharmacol. Ther., 158, 52, 10.1016/j.pharmthera.2015.11.012 Goldman, 2010, Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture, Nat. Neurosci., 13, 883, 10.1038/nn.2562 Gorecki, 2019, Altered gut microbiome in Parkinson's disease and the influence of lipopolysaccharide in a human alpha-synuclein over-expressing mouse model, Front. Neurosci., 13, 839, 10.3389/fnins.2019.00839 Hartmann, 2004, Postmortem studies in Parkinson's disease, Dialogues Clin. Neurosci., 6, 281, 10.31887/DCNS.2004.6.3/ahartmann Hu, 2013, Electroacupuncture at Zusanli (ST36) prevents intestinal barrier and remote organ dysfunction following gut ischemia through activating the cholinergic anti-inflammatory-dependent mechanism, Evid. Based Complement Alternat. Med., 2013, 10.1155/2013/592127 Huang, 2018, Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia, Sci. Rep., 8, 6523, 10.1038/s41598-018-24654-y Huang, 2010, Complementary acupuncture in Parkinson's disease: a spect study, Int. J. Neurosci., 120, 150, 10.3109/00207450903316527 Hur, 1991, Dongeuibogam, Namsandang, 1 Jang, 2019, Acupuncture improves comorbid cognitive impairments induced by neuropathic pain in mice, Front. Neurosci., 13, 995, 10.3389/fnins.2019.00995 Jankovic, 2008, Parkinson's disease: clinical features and diagnosis, J. Neurol. Neurosurg. Psychiatry, 79, 368, 10.1136/jnnp.2007.131045 Jeon, 2008, Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model, Proteomics, 8, 4822, 10.1002/pmic.200700955 Keshavarzian, 2015, Colonic bacterial composition in Parkinson's disease, Mov. Disord., 30, 1351, 10.1002/mds.26307 Kim, 2019, Transneuronal propagation of pathologic alpha-synuclein from the gut to the brain models Parkinson's disease, Neuron, 103, 627, 10.1016/j.neuron.2019.05.035 Kim, 2011, Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease, PLoS One, 6, 10.1371/journal.pone.0027566 Kim, 2011, Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease, Int. J. Neurosci., 121, 562, 10.3109/00207454.2011.591515 Kung, 2006, The different immunomodulation of indirect moxibustion on normal subjects and patients with systemic lupus erythematosus, Am. J. Chin. Med., 34, 47, 10.1142/S0192415X0600362X Lai, 2018, Intestinal pathology and gut microbiota alterations in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease, Neurochem. Res., 43, 1986, 10.1007/s11064-018-2620-x Langille, 2013, Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences, Nat. Biotechnol., 31, 814, 10.1038/nbt.2676 Li, 2017, Fecal microbiota transplantation (FMT) could reverse the severity of experimental necrotizing enterocolitis (NEC) via oxidative stress modulation, Free Radic. Biol. Med., 108, 32, 10.1016/j.freeradbiomed.2017.03.011 Liu, 2011, Lipopolysaccharide animal models for Parkinson's disease, Parkinsons Dis., 2011 Mitchell, 2011, Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells, J. Neurochem., 117, 735 Mulak, 2015, Brain-gut-microbiota axis in Parkinson's disease, World J. Gastroenterol., 21, 10609, 10.3748/wjg.v21.i37.10609 Na, 2009, An fMRI study of neuronal specificity of an acupoint: electroacupuncture stimulation of Yanglingquan (GB34) and its sham point, Neurosci. Lett., 464, 1, 10.1016/j.neulet.2009.08.009 Park, 2003, Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model, Exp. Neurol., 180, 93, 10.1016/S0014-4886(02)00031-6 Park, 2015, p53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease, Biochem. Biophys. Res. Commun., 460, 772, 10.1016/j.bbrc.2015.03.105 Park, 2017, Novel neuroprotective effects of melanin-concentrating hormone in Parkinson's disease, Mol. Neurobiol., 54, 7706, 10.1007/s12035-016-0258-8 Park, 2018, Electroacupuncture therapy in inflammation regulation: current perspectives, J. Inflamm. Res., 11, 227, 10.2147/JIR.S141198 Park, 2014, From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia, J. Pain, 15, 535, 10.1016/j.jpain.2014.01.498 Qian, 2018, Alteration of the fecal microbiota in Chinese patients with Parkinson's disease, Brain Behav. Immun., 70, 194, 10.1016/j.bbi.2018.02.016 Rho, 2008, Molecular changes in remote tissues induced by electro-acupuncture stimulation at acupoint ST36, Mol. Cells, 25, 178 Sampson, 2016, Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease, Cell, 167, 1469, 10.1016/j.cell.2016.11.018 Scheperjans, 2015, Gut microbiota are related to Parkinson's disease and clinical phenotype, Mov. Disord., 30, 350, 10.1002/mds.26069 Sedelis, 2001, Behavioral phenotyping of the MPTP mouse model of Parkinson's disease, Behav. Brain Res., 125, 109, 10.1016/S0166-4328(01)00309-6 Shirai, 1988, Lactogenic immunity to transmissible gastroenteritis (TGE) of swine induced by the attenuated Nouzilly strain of TGE virus: neutralizing antibody classes and protection, Ann. Rech. Vet., 19, 267 Song, 2020, Electroacupuncture relieves irritable bowel syndrome by regulating IL-18 and gut microbial dysbiosis in a trinitrobenzene sulfonic acid-induced post-inflammatory animal model, Am. J. Chin. Med., 48, 77, 10.1142/S0192415X20500044 Sun, 2018, Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-alpha signaling pathway, Brain Behav. Immun., 70, 48, 10.1016/j.bbi.2018.02.005 Torres-Rosas, 2014, Dopamine mediates vagal modulation of the immune system by electroacupuncture, Nat. Med., 20, 291, 10.1038/nm.3479 Triantafyllou, 2014, Methanogens, methane and gastrointestinal motility, J. Neurogastroenterol. Motil., 20, 31, 10.5056/jnm.2014.20.1.31 Tysnes, 2017, Epidemiology of Parkinson's disease, J. Neural Transm. (Vienna), 124, 901, 10.1007/s00702-017-1686-y Villaran, 2010, Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson‘s disease, J. Neurochem., 114, 1687, 10.1111/j.1471-4159.2010.06879.x Wang, 2005, Acupuncture therapy for experimental stomach ulcer and c-Fos expression in rats, World J. Gastroenterol., 11, 5517, 10.3748/wjg.v11.i35.5517 Wang, 2015, Electroacupuncture at zusanli prevents severe scalds-induced gut ischemia and paralysis by activating the cholinergic pathway, Evid. Based Complement Alternat. Med., 2015, 10.1155/2015/787393 Wang, 2019, Acupuncture regulating gut microbiota in abdominal obese rats induced by high-fat diet, Evid. Based Complement Alternat. Med., 2019, 4958294, 10.1155/2019/4958294 Yeo, 2014, Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease, BMC Complement Altern. Med., 14, 336, 10.1186/1472-6882-14-336 Zhou, 2013, Vagus nerve stimulation attenuates intestinal epithelial tight junctions disruption in endotoxemic mice through alpha7 nicotinic acetylcholine receptors, Shock, 40, 144, 10.1097/SHK.0b013e318299e9c0