Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease

Brain Research Reviews - Tập 48 - Trang 400-408 - 2005
Laura Gasparini1,2, Ennio Ongini1, Donna Wilcock3, David Morgan3
1Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
2Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
3Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33612, USA

Tài liệu tham khảo

Aisen, 2003, Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial, JAMA, 289, 2819, 10.1001/jama.289.21.2819 Ajmone-Cat, 2001, Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia, J. Neurosci. Res., 66, 715, 10.1002/jnr.10038 Akiyama, 2000, Inflammation and Alzheimer's disease, Neurobiol. Aging, 21, 383, 10.1016/S0197-4580(00)00124-X Bard, 2000, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat. Med., 6, 916, 10.1038/78682 Eikelenboom, 2002, Neuroinflammation in Alzheimer's disease and prion disease, Glia, 40, 232, 10.1002/glia.10146 Eriksen, 2003, NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ 42 in vivo, J Clin. Invest, 112, 440, 10.1172/JCI200318162 Eriksen, 2003, Chronic treatment of transgenic APP mice with R-flurbiprofen Etminan, 2003, Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies, BMJ, 327, 128, 10.1136/bmj.327.7407.128 Flower, 2003, The development of COX2 inhibitors, Nat. Rev., Drug Discov., 2, 179, 10.1038/nrd1034 Frolich, 1997, A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes, Trends Pharmacol. Sci., 18, 30, 10.1016/S0165-6147(96)01017-6 Gao, 2003, Novel anti-inflammatory therapy for Parkinson's disease, Trends Pharmacol. Sci., 24, 395, 10.1016/S0165-6147(03)00176-7 Gasparini, 2004, Modulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures, J. Neurochem., 88, 337, 10.1111/j.1471-4159.2004.02154.x Gasparini, 2004, Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action, J. Neurochem., 91, 521, 10.1111/j.1471-4159.2004.02743.x Greenfield, 2000, Cellular and molecular basis of β-amyloid precursor protein metabolism, Front. Biosci., 5, D72, 10.2741/Greenfield Hauss-Wegrzyniak, 1999, Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS, Brain Res., 815, 36, 10.1016/S0006-8993(98)01081-6 Hauss-Wegrzyniak, 1999, The effects of a novel NSAID on chronic neuroinflammation are age dependent, Neurobiol. Aging, 20, 305, 10.1016/S0197-4580(99)00028-7 in't Veld, 2001, Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease, N. Engl. J. Med., 345, 1515, 10.1056/NEJMoa010178 in 't Veld, 2002, Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence, Epidemiol. Rev., 24, 248, 10.1093/epirev/mxf001 Jantzen, 2002, Microglial activation and β-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice, J. Neurosci., 22, 2246, 10.1523/JNEUROSCI.22-06-02246.2002 Klegeris, 2004, S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity, J. Neuroimmunol., 152, 73, 10.1016/j.jneuroim.2004.04.001 Lanz, 2004, Lack of specific Aβ(1–42) suppression by NSAIDs in young, claque-free Tg2576 mice and in guinea pig neuronal cultures, J. Pharmacol. Exp. Ther., 312, 399, 10.1124/jpet.104.073965 Lim, 2000, Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease, J. Neurosci., 20, 5709, 10.1523/JNEUROSCI.20-15-05709.2000 Lim, 2001, The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse, J. Neurosci., 21, 8370, 10.1523/JNEUROSCI.21-21-08370.2001 Lim, 2001, Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice, Neurobiol. Aging, 22, 983, 10.1016/S0197-4580(01)00299-8 McGeer, 2003, Inflammatory processes in Alzheimer's disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 27, 741, 10.1016/S0278-5846(03)00124-6 Morgan, 2004, Evidence supporting a role for anti-Aβ antibodies in the treatment of Alzheimer's disease, Neurobiol. Aging, 25, 605, 10.1016/j.neurobiolaging.2004.02.005 Morihara, 2002, Selective inhibition of Aβ42 production by NSAID R-enantiomers, J. Neurochem., 83, 1009, 10.1046/j.1471-4159.2002.01195.x Netland, 1998, Indomethacin reverses the microglial response to amyloid β-protein, Neurobiol. Aging, 19, 201, 10.1016/S0197-4580(98)00047-5 Orgogozo, 2003, Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization, Neurology, 61, 46, 10.1212/01.WNL.0000073623.84147.A8 Prosperi, 2004, Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT1026 and NCX2216 on Abeta(1–42)-induced brain inflammation and neuronal damage in the rat, Int. J. Immunol. Pharmacol., 17, 317 Quinn, 2003, Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease, J. Neuroimmunol., 137, 32, 10.1016/S0165-5728(03)00037-7 Reines, 2004, Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study, Neurology, 62, 66, 10.1212/WNL.62.1.66 Rich, 1995, Nonsteroidal anti-inflammatory drugs in Alzheimer's disease, Neurology, 45, 51, 10.1212/WNL.45.1.51 Rogers, 1993, Clinical trial of indomethacin in Alzheimer's disease, Neurology, 43, 1609, 10.1212/WNL.43.8.1609 Rosi, 2003, The influence of brain inflammation upon neuronal adenosine A2B receptors, J. Neurochem., 86, 220, 10.1046/j.1471-4159.2003.01825.x Scharf, 1999, A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease, Neurology, 53, 197, 10.1212/WNL.53.1.197 Schenk, 1999, Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse, Nature, 400, 173, 10.1038/22124 Schwab, 2004, Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease, Exp. Neurol., 188, 52, 10.1016/j.expneurol.2004.03.016 Tegeder, 2001, Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen, FASEB J., 15, 2, 10.1096/fasebj.15.1.2 Van Groen, 2004, Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology, Brain Res. Rev. Wallace, 1995, Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester, Eur. J. Pharmacol., 280, 63, 10.1016/0014-2999(95)00184-M Wallace, 2004, Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester], J. Pharmacol. Exp. Ther., 309, 626, 10.1124/jpet.103.063453 Weggen, 2001, A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity, Nature, 414, 212, 10.1038/35102591 Wenk, 2004, Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid, J. Neurochem., 89, 484, 10.1111/j.1471-4159.2004.02359.x Wilcock, 2003, Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation, J. Neurosci., 23, 3745, 10.1523/JNEUROSCI.23-09-03745.2003 Wilcock, 2004, Microglial activation facilitates Aβ plaques removal following intracranial anti-Aβ antibody administration, Neurobiol. Dis., 15, 11, 10.1016/j.nbd.2003.09.015 Wilcock, 2004, Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition, J. Neurosci., 24, 6144, 10.1523/JNEUROSCI.1090-04.2004 Wyss-Coray, 2002, Inflammation in neurodegenerative disease—a double-edged sword, Neuron, 35, 419, 10.1016/S0896-6273(02)00794-8 Yan, 2001, Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid, Br. J. Pharmacol., 133, 89, 10.1038/sj.bjp.0704047 Yan, 2003, Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease, J. Neurosci., 23, 7504, 10.1523/JNEUROSCI.23-20-07504.2003