Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects
Tóm tắt
Từ khóa
Tài liệu tham khảo
Camu, 1994, Rapid purification of embryonic rat motoneurons : an in vitro model for studying MND / ALS pathogenesis, Neurol Sci, 26, 124
Vigh, 1997, Bimoclomol : a nontoxic , hydroxylamine derivative with stress protein - inducing activity and cytoprotective effects http dx org, Nat Med, 18, 1150, 10.1038/nm1097-1150
Batulan, 2003, High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF, Neurosci, 8, 1
Jin, 2002, Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF - kappaB activation and NO production http dx org, Nat Prod, 38, 89, 10.1021/np010428r
Evgrafov, 2004, Mutant small heat - shock protein causes axonal Charcot - Marie - Tooth disease and distal hereditary motor neuropathy http dx org, Nat Genet, 9, 602, 10.1038/ng1354
Sathasivam, 2005, Characterization of the caspase cascade in a cell culture model of SOD - related familial amyotrophic lateral sclerosis : expression , activation and therapeutic effects of inhibition http dx org, Neuropathol Appl Neurobiol, 33, 467, 10.1111/j.1365-2990.2005.00658.x
Nagase, 2003, Apoptosis induction in HL - cells and inhibition of topoisomerase II by triterpene celastrol http dx org, Biosci Biotechnol Biochem, 41, 1883, 10.1271/bbb.67.1883
Wang, 2003, Oxidative neurotoxicity in rat cerebral cortex neurons : synergistic effects of and NO on apoptosis involving activation of p mitogen - activated protein kinase and caspase - http dx org, Neurosci Res, 32, 508, 10.1002/jnr.10597
Veglianese, 2006, Activation of the p MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS http dx org, Mol Cell Neurosci, 35, 218, 10.1016/j.mcn.2005.09.009
Kalmar, 2002, The effect of neonatal nerve injury on the expression of heat shock proteins in developing rat motoneurones http dx org, Neurotrauma, 16, 667, 10.1089/089771502753754127
Gil, 2003, Cytosolic and mitochondrial ROS in staurosporine - induced retinal cell apoptosis Free Radic http dx org, Biol Med, 31, 1500, 10.1016/j.freeradbiomed.2003.08.022
Krohn, 1998, Staurosporine - induced apoptosis of cultured rat hippocampal neurons involves caspase - - like proteases as upstream initiators and increased production of superoxide as a main downstream effector, Neurosci, 30, 8186, 10.1523/JNEUROSCI.18-20-08186.1998
Gifondorwa, 2007, Exogenous delivery of heat shock protein increases lifespan in a mouse model of amyotrophic lateral sclerosis http dx org, Neurosci, 25, 13173, 10.1523/JNEUROSCI.4057-07.2007
Beere, 2001, Stress management - heat shock protein - and the regulation of apoptosis http dx org, Trends Cell Biol, 2, 6, 10.1016/S0962-8924(00)01874-2
Yang, 2006, Celastrol , a triterpene extracted from the Chinese Thunder of God Vine , is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice http dx org, Cancer Res, 42, 4758, 10.1158/0008-5472.CAN-05-4529
Bendotti, 2005, Inter - and intracellular signaling in amyotrophic lateral sclerosis : role of p mitogen - activated protein kinase http dx org, Neurodegener Dis, 34, 128, 10.1159/000089617
Krishnan, 2006, Role of heat shock response and Hsp in mutant SOD - dependent cell death http dx org, Exp Neurol, 37, 1, 10.1016/j.expneurol.2006.02.135
Yang, 2008, Calpain - mediated androgen receptor breakdown in apoptotic prostate cancer cells in press, Cell Physiol, 43
Maatkamp, 2004, Decrease of Hsp protein expression precedes degeneration of motoneurons in ALS - SOD mice http dx org, Eur J Neurosci, 6, 14, 10.1111/j.1460-9568.2004.03430.x
Watanabe, 2001, Histological evidence of protein aggregation in mutant SOD transgenic mice and in amyotrophic lateral sclerosis neural tissues http dx org, Neurobiol Dis, 14, 933, 10.1006/nbdi.2001.0443
Urushitani, 2004, CHIP promotes proteasomal degradation of familial ALS - linked mutant SOD by ubiquitinating Hsp http dx org, Neurochem, 7, 231, 10.1111/j.1471-4159.2004.02486.x
Williamson, 1999, Slowing of axonal transport is a very early event in the toxicity of ALS - linked SOD mutants to motor neurons http dx org, Nat Neurosci, 11, 50, 10.1038/4553
Vleminckx, 2002, Upregulation of HSP in a transgenic model of ALS, Exp Neurol, 5, 968
Kieran, 2004, Treatment with arimoclomol , a coinducer of heat shock proteins , delays disease progression in ALS mice http dx org, Nat Med, 17, 402, 10.1038/nm1021
Kiaei, 2005, Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis http dx org, Neurodegener Dis, 21, 246, 10.1159/000090364
Greig, 2000, Characterization of the AMPA - activated receptors present on motoneurons http dx org, Neurochem, 27, 179, 10.1046/j.1471-4159.2000.0740179.x
Trott, 2008, Activation of heat shock and antioxidant responses by the natural product celastrol : transcriptional signatures of a thiol - targeted molecule http dx org, Mol Biol Cell, 45, 1104, 10.1091/mbc.E07-10-1004
Breuer, 1987, Fast axonal transport in amyotrophic lateral sclerosis : an intra - axonal organelle traffic analysis, Neurology, 10, 738, 10.1212/WNL.37.5.738
Chow, 2007, Induction of heat shock proteins in differentiated human and rodent neurons by celastrol http dx org, Cell Stress Chaperones, 39, 237, 10.1379/CSC-269.1
Samali, 1996, Heat shock proteins increase resistance to apoptosis http dx org, Exp Cell Res, 1, 223, 10.1006/excr.1996.0070
Hargitai, 2003, Bimoclomol , a heat shock protein co - inducer , acts by the prolonged activation of heat shock factor - http dx org, Biochem Biophys Res Commun, 19, 307, 10.1016/S0006-291X(03)01254-3
Liu, 2005, Elevation of the Hsp chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis http dx org, Neurochem, 24, 875, 10.1111/j.1471-4159.2005.03054.x
Kalmar, 2002, Upregulation of heat shock proteins rescues motoneurones from axotomy - induced cell death in neonatal rats http dx org, Exp Neurol, 4, 176, 10.1006/exnr.2002.7945
Munch, 2004, Point mutations of the p subunit of dynactin DCTN gene in ALS, Neurology, 13, 150
Guzhova, 1997, Major stress protein Hsp interacts with NF - kB regulatory complex in human T - lymphoma cells http dx org, Cell Stress Chaperones, 29, 132, 10.1379/1466-1268(1997)002<0132:MSPHIW>2.3.CO;2
Westerheide, 2004, Celastrols as inducers of the heat shock response and cytoprotection http dx org, Biol Chem, 22, 279, 10.1074/jbc.M409267200
Wang, 2005, Reversal of a full - length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine - mediated aggregation http dx org, BMC Neurosci, 28, 1, 10.1186/1471-2202-6-1
Cleren, 2005, Celastrol protects against http dx org, Neurochem, 20, 995, 10.1111/j.1471-4159.2005.03253.x
Garofalo, 1991, Ubiquitin and heat shock protein expression in amyotrophic lateral sclerosis http dx org, Neuropathol Appl Neurobiol, 3, 39, 10.1111/j.1365-2990.1991.tb00692.x
Zhang, 2007, Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response http dx org, Mol Med, 40, 1421, 10.1007/s00109-007-0251-9
Patel, 2005, and Hsp administered in combination have a potent protective effect against FALS - associated SOD - mutant - induced cell death in mammalian neuronal cells http dx org, Brain Res Mol Brain Res, 23, 256, 10.1016/j.molbrainres.2004.10.028
Lee, 2006, Inhibition of NF - kappa B activation through targeting I kappa B kinase by celastrol , a quinone methide triterpenoid http dx org, Biochem Pharmacol, 44, 1311, 10.1016/j.bcp.2006.08.014
Strey, 2004, Dysregulation of stathmin , a microtubule - destabilizing protein , and up - regulation of Hsp and the antioxidant peroxiredoxin in a mouse model of familial amyotrophic lateral sclerosis, Am J Pathol, 36, 27
Okado, 2002, Amyotrophic lateral sclerosis : a proposed mechanism, Proc Natl Acad Sci, 15, 99