Activation of the aryl hydrocarbon receptor by doxorubicin mediates cytoprotective effects in the heart

Cardiovascular Research - Tập 90 Số 2 - Trang 305-314 - 2011
Maria Volkova1, Monica Palmeri1, Kerry S. Russell1, Raymond R. Russell1
1Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, FMP 3, New Haven, CT 06520, USA.

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Von Hoff, 1979, Risk factors for doxorubicin-induced congestive heart failure, Ann Intern Med, 91, 710, 10.7326/0003-4819-91-5-710

Abu-Khalaf, 2007, Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer, Breast Cancer Res Treat, 104, 341, 10.1007/s10549-006-9413-7

Lipshultz, 1991, Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood, N Engl J Med, 324, 808, 10.1056/NEJM199103213241205

Dowd, 2001, Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo, J Clin Invest, 108, 585, 10.1172/JCI200111334

Kotamraju, 2004, Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis, Methods Enzymol, 378, 362, 10.1016/S0076-6879(04)78026-X

Kotamraju, 2000, Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species, J Biol Chem, 275, 33585, 10.1074/jbc.M003890200

Shizukuda, 2005, Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice, Mol Cell Biochem, 273, 25, 10.1007/s11010-005-5905-8

Yeh, 2004, Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death, Oncogene, 23, 3580, 10.1038/sj.onc.1207426

Chua, 2006, Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells, Am J Physiol Heart Circ Physiol, 290, H2606, 10.1152/ajpheart.01138.2005

Wu, 2000, Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells, J Biol Chem, 275, 40113, 10.1074/jbc.M004108200

Childs, 2002, Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio, Cancer Res, 62, 4592

Wang, 2001, Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes, J Pharmacol Exp Ther, 298, 461

Sardao, 2009, Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts, Cancer Chemother Pharmacol, 64, 811, 10.1007/s00280-009-0932-x

Ikuta, 1998, Nuclear localization and export signals of the human aryl hydrocarbon receptor, J Biol Chem, 273, 2895, 10.1074/jbc.273.5.2895

Nebert, 2000, Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis, Biochem Pharmacol, 59, 65, 10.1016/S0006-2952(99)00310-X

Fernandez-Salguero, 1996, Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity, Toxicol Appl Pharmacol, 140, 173, 10.1006/taap.1996.0210

Tomita, 2003, T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution, J Immunol, 171, 4113, 10.4049/jimmunol.171.8.4113

Fujii-Kuriyama, 1992, Regulation of CYP1A1 expression, Faseb J, 6, 706, 10.1096/fasebj.6.2.1537460

Gewirtz, 1999, A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin, Biochem Pharmacol, 57, 727, 10.1016/S0006-2952(98)00307-4

Gramatzki, 2009, Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells, Oncogene, 28, 2593, 10.1038/onc.2009.104

Zhao, 2010, CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor, Toxicol Sci, 117, 393, 10.1093/toxsci/kfq217

Jacoby, 2003, Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age, Proc Natl Acad Sci USA, 100, 12929, 10.1073/pnas.2134694100

Liu, 2004, Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice, Am J Physiol Heart Circ Physiol, 286, H933, 10.1152/ajpheart.00759.2003

Liu, 2008, ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes, Am J Physiol Heart Circ Physiol, 295, H1956, 10.1152/ajpheart.00407.2008

Davies, 1986, Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase, J Biol Chem, 261, 3060, 10.1016/S0021-9258(17)35746-0

Doroshow, 1986, Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical, J Biol Chem, 261, 3068, 10.1016/S0021-9258(17)35747-2

Kotamraju, 2002, Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis, J Biol Chem, 277, 17179, 10.1074/jbc.M111604200

Minotti, 2004, Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms, Methods Enzymol, 378, 340, 10.1016/S0076-6879(04)78025-8

Armstrong, 2004, Anti-oxidants and apoptosis: attenuation of doxorubicin induced cardiomyopathy by carvedilol, J Mol Cell Cardiol, 37, 817, 10.1016/j.yjmcc.2004.07.001

Cole, 2006, The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity, Cardiovasc Res, 69, 186, 10.1016/j.cardiores.2005.07.012

Neilan, 2007, Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin, Circulation, 116, 506, 10.1161/CIRCULATIONAHA.106.652339

Dolwick, 1993, In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition, Proc Natl Acad Sci USA, 90, 8566, 10.1073/pnas.90.18.8566

Casado, 2006, Activation of the aryl hydrocarbon receptor by carbaryl: Computational evidence of the ability of carbaryl to assume a planar conformation, Environ Toxicol Chem, 25, 3141, 10.1897/06-131R.1

Denison, 2003, Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, Annu Rev Pharmacol Toxicol, 43, 309, 10.1146/annurev.pharmtox.43.100901.135828

Kanzawa, 2004, Biochemical and molecular biological analysis of different responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo heart and liver, Arch Biochem Biophys, 427, 58, 10.1016/j.abb.2004.04.021

Kim, 2006, Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor, Mol Pharmacol, 69, 1871, 10.1124/mol.105.021832

Brunnberg, 2006, The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for dioxin exposure–effects in vital organs, Toxicology, 224, 191, 10.1016/j.tox.2006.04.045

Nerurkar, 1996, Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction, Mol Pharmacol, 49, 874

Venkatesan, 1998, Curcumin attenuation of acute adriamycin myocardial toxicity in rats, Br J Pharmacol, 124, 425, 10.1038/sj.bjp.0701877

Jokinen, 2003, Increase in cardiovascular pathology in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl, Cardiovasc Toxicol, 3, 299, 10.1385/CT:3:4:299

Brewster, 1987, Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on guinea pig heart muscle, Toxicol Appl Pharmacol, 89, 408, 10.1016/0041-008X(87)90160-8

Mehrabi, 2002, The arylhydrocarbon receptor (AhR), but not the AhR-nuclear translocator (ARNT), is increased in hearts of patients with cardiomyopathy, Virchows Arch, 441, 481, 10.1007/s00428-002-0659-0

Dabir, 2008, Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells, Circ Res, 102, 1558, 10.1161/CIRCRESAHA.108.176990

Conway, 2009, Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress, Cardiovasc Res, 81, 669, 10.1093/cvr/cvn360

Roman, 2009, Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma, J Biol Chem, 284, 25135, 10.1074/jbc.M109.013292

Korashy, 2006, The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases, Drug Metab Rev, 38, 411, 10.1080/03602530600632063

Zordoky, 2010, Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats, Toxicol Appl Pharmacol, 242, 38, 10.1016/j.taap.2009.09.012

Paranka, 1994, Effect of doxorubicin on glutathione and glutathione-dependent enzymes in cultured rat heart cells, Anticancer Res, 14, 2047

L'Ecuyer, 2004, Glutathione S-transferase overexpression protects against anthracycline-induced H9C2 cell death, Am J Physiol Heart Circ Physiol, 286, H2057, 10.1152/ajpheart.00778.2003

Zhu, 2009, Cruciferous dithiolethione-mediated coordinated induction of total cellular and mitochondrial antioxidants and phase 2 enzymes in human primary cardiomyocytes: cytoprotection against oxidative/electrophilic stress and doxorubicin toxicity, Exp Biol Med (Maywood), 234, 418, 10.3181/0811-RM-340

Zaher, 1998, Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse, Biochem Pharmacol, 55, 235, 10.1016/S0006-2952(97)00476-0

Galvan, 2003, Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver, Toxicol Appl Pharmacol, 193, 84, 10.1016/S0041-008X(03)00338-7

Nobori, 2002, ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3, J Mol Cell Cardiol, 34, 1387, 10.1006/jmcc.2002.2091

Kobayashi, 2010, Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death, J Biol Chem, 285, 793, 10.1074/jbc.M109.070037

Tsuchiya, 2005, Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity, Fertil Steril, 84, 454, 10.1016/j.fertnstert.2005.01.130

Kim, 2007, Aryl hydrocarbon receptor gene polymorphisms affect lung cancer risk, Lung Cancer, 56, 9, 10.1016/j.lungcan.2006.11.010