Activation of eosinophils by IL-12 family cytokine IL-27: Implications of the pleiotropic roles of IL-27 in allergic responses

Amadi-Obi, 2007, TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1, Nat. Med., 13, 711, 10.1038/nm1585 Artis, 2004, The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity, J. Immunol., 173, 5626, 10.4049/jimmunol.173.9.5626 Awasthi, 2007, A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells, Nat. Immunol., 8, 1380, 10.1038/ni1541 Baldwin, 1996, The NF-κB and IκB proteins: new discoveries and insights, Annu. Rev. Immunol., 14, 649, 10.1146/annurev.immunol.14.1.649 Batten, 2007, The biology and therapeutic potential of interleukin 27, J. Mol. Med., 85, 661, 10.1007/s00109-007-0164-7 Batten, 2006, Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells, Nat. Immunol., 7, 929, 10.1038/ni1375 Chae, 2007, Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population, J. Hum. Genet., 52, 355, 10.1007/s10038-007-0123-8 Chen, 2000, Development of Th1-type immune responses requires the type I cytokine receptor TCCR, Nature, 407, 916, 10.1038/35038103 Cheung, 2006, IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation, Allergy, 61, 878, 10.1111/j.1398-9995.2006.01102.x Cheung, 2008, Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation, J. Immunol., 180, 5625, 10.4049/jimmunol.180.8.5625 Fitzgerald, 2007, Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells, Nat. Immunol., 8, 1372, 10.1038/ni1540 Fujita, 2009, Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model, J. Immunol., 183, 254, 10.4049/jimmunol.0800520 Goriely, 2009, Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders, Allergy, 64, 702, 10.1111/j.1398-9995.2009.02039.x Hamano, 2003, WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production, Immunity, 19, 657, 10.1016/S1074-7613(03)00298-X Ho, 2008, Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways, Immunobiology, 213, 533, 10.1016/j.imbio.2008.01.003 Hogan, 2008, Eosinophils: biological properties and role in health and disease, Clin. Exp. Allergy, 38, 709, 10.1111/j.1365-2222.2008.02958.x Hölscher, 2005, The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis, J. Immunol., 174, 3534, 10.4049/jimmunol.174.6.3534 Ilarregui, 2009, Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10, Nat. Immunol., 10, 981, 10.1038/ni.1772 Kalliolias, 2008, IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38, J. Immunol., 180, 6325, 10.4049/jimmunol.180.9.6325 Kanda, 2008, IL-12, IL-23, and IL-27 enhance human β-defensin-2 production in human keratinocytes, Eur. J. Immunol., 38, 1287, 10.1002/eji.200738051 Kastelein, 2007, Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation, Annu. Rev. Immunol., 25, 221, 10.1146/annurev.immunol.22.012703.104758 Larousserie, 2006, Differential effects of IL-27 on human B cell subsets, J. Immunol., 176, 5890, 10.4049/jimmunol.176.10.5890 Miyazaki, 2005, Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice, J. Immunol., 175, 2401, 10.4049/jimmunol.175.4.2401 Murugaiyan, 2009, IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells, J. Immunol., 183, 2435, 10.4049/jimmunol.0900568 Nieuwenhuis, 2002, Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice, Proc. Natl. Acad. Sci. U.S.A., 99, 16951, 10.1073/pnas.252648899 Nutku, 2001, Functional expression of IL-12 receptor by human eosinophils: IL-12 promotes eosinophil apoptosis, J. Immunol., 167, 1039, 10.4049/jimmunol.167.2.1039 Owaki, 2006, IL-27 suppresses CD28-mediated IL-2 production through suppressor of cytokine signaling 3, J. Immunol., 176, 2773, 10.4049/jimmunol.176.5.2773 Owaki, 2005, A role for IL-27 in early regulation of Th1 differentiation, J. Immunol., 175, 2191, 10.4049/jimmunol.175.4.2191 Pflanz, 2004, WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27, J. Immunol., 172, 2225, 10.4049/jimmunol.172.4.2225 Pflanz, 2002, IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells, Immunity, 16, 779, 10.1016/S1074-7613(02)00324-2 Plötz, 2001, The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependent, Blood, 97, 235, 10.1182/blood.V97.1.235 Roebuck, 1999, Regulation of intercellular adhesion molecule-1 (CD54) gene expression, J. Leukoc. Biol., 66, 876, 10.1002/jlb.66.6.876 Shimizu, 2006, Antiangiogenic and antitumor activities of IL-27, J. Immunol., 176, 7317, 10.4049/jimmunol.176.12.7317 Simon, 2004, Eosinophils and atopic dermatitis, Allergy, 59, 561, 10.1111/j.1398-9995.2004.00476.x Spencer, 2009, Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially, J. Leukoc. Biol., 85, 117, 10.1189/jlb.0108058 Stumhofer, 2006, Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system, Nat. Immunol., 7, 937, 10.1038/ni1376 Stumhofer, 2007, Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10, Nat. Immunol., 8, 1363, 10.1038/ni1537 Takashi, 2001, Contribution of CD54 to human eosinophil and neutrophil superoxide production, J. Appl. Physiol., 91, 613, 10.1152/jappl.2001.91.2.613 Takeda, 2003, Cutting edge: role of IL-27/WSX-1 signaling for induction of T-Bet through activation of STAT1 during initial Th1 commitment, J. Immunol., 170, 4886, 10.4049/jimmunol.170.10.4886 Villarino, 2003, The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection, Immunity, 19, 645, 10.1016/S1074-7613(03)00300-5 Wong, 2007, Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation, Eur. J. Immunol., 37, 2337, 10.1002/eji.200636866 Wong, 2003, Interleukin-3,-5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-κB, Am. J. Respir. Cell Mol. Biol., 29, 133, 10.1165/rcmb.2002-0289OC Yamanaka, 2004, Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis, J. Immunol., 172, 3590, 10.4049/jimmunol.172.6.3590 Yang, 2008, Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t, Eur. J. Immunol., 38, 1204, 10.1002/eji.200838145 Yoshida, 2001, WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection, Immunity, 15, 569, 10.1016/S1074-7613(01)00206-0 Yoshimoto, 2007, IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation, J. Immunol., 179, 4415, 10.4049/jimmunol.179.7.4415