Activation of cardiac G-proteins by muscarinic acetylcholine receptors: regulation by Mg2+ and Na+ ions

Aktories, 1982, Stimulation of a low Km GTPase by inhibitors of adipocyte adenylate cyclase, Mol. Pharmacol., 21, 336 Asano, 1984, Reconstitution of catecholamine-stimulated binding of guanosine 5′-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase, Biochemistry, 23, 5460, 10.1021/bi00318a013 Bartfai, 1979, Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes, Adv. Cycl. Nucl. Res., 10, 219 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Brandt, 1986, Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by β-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles, J. Biol. Chem., 261, 1656, 10.1016/S0021-9258(17)35991-4 Breitwieser, 1985, Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue, Nature, 317, 538, 10.1038/317538a0 Brown, 1983, Muscarinic stimulation of phosphatidylinositol metabolism in atria, Mol. Pharmacol., 24, 351 Brown, 1984, Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism, J. Biol. Chem., 259, 3777, 10.1016/S0021-9258(17)43162-0 Cassel, 1976, Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes, Biochim. Biophys. Acta, 452, 538, 10.1016/0005-2744(76)90206-0 Cerione, 1984, The mammalian β2-adrenergic receptor: Reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system, Biochemistry, 23, 4519, 10.1021/bi00315a003 Fields, 1978, Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization, J. Biol. Chem., 253, 3251, 10.1016/S0021-9258(17)40829-5 Fleming, 1988, Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma, Circ. Res., 64, 340, 10.1161/01.RES.63.2.340 Gierschik, 1988, Regulation of G-protein-mediated signal transfer by ions, J. Cardiovasc. Pharmacol., 12, S20, 10.1097/00005344-198806125-00004 Gilman, 1987, G proteins: Transducers of receptor-generated signals, Ann. Rev. Biochem., 56, 615, 10.1146/annurev.bi.56.070187.003151 Hazeki, 1981, Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells, J. Biol. Chem., 256, 2856, 10.1016/S0021-9258(19)69693-6 Higashijima, 1987, Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride, J. Biol. Chem., 262, 3597, 10.1016/S0021-9258(18)61394-8 Jakobs, 1979, GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists, Naunyn-Schmiedeb. Arch. Pharmacol., 310, 113, 10.1007/BF00500275 Jakobs, 1984, Sodium regulation of hormone-sensitive adenylate cyclase, J. Rec. Res., 4, 443, 10.3109/10799898409042566 Koski, 1982, Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase, J. Biol. Chem., 257, 14035, 10.1016/S0021-9258(19)45339-8 Masters, 1985, Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization, Biochem. J., 227, 933, 10.1042/bj2270933 Nunnari, 1987, Regulation of porcine brain α2-adrenergic receptors by Na+, H+ and inhibitors of Na+/H+ exchange, J. Biol. Chem., 262, 12387, 10.1016/S0021-9258(18)45365-3 Ott, 1988, Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis, J. Biol. Chem., 263, 10524, 10.1016/S0021-9258(19)81547-8 Petersen, 1984, Large scale preparation and characterization of membrane-bound and detergent-solubilized muscarinic acetylcholine receptor from pig atria, Prep. Biochem., 14, 33, 10.1080/10826068408070612 Pfaffinger, 1985, GTP-binding proteins couple cardiac muscarinic receptors to a K channel, Nature, 317, 536, 10.1038/317536a0 Rosenberger, 1980, Cardiac muscarinic cholinergic receptor binding is regulated by Na+ and guanyl nucleotides, J. Biol. Chem., 255, 820, 10.1016/S0021-9258(19)86101-X Sekura, 1983, Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase, J. Biol. Chem., 258, 14647, 10.1016/S0021-9258(17)43911-1 Walseth, 1979, The enzymatic preparation of [α32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP, Biochim. Biophys. Acta, 562, 11, 10.1016/0005-2787(79)90122-9 Watanabe, 1978, Muscarinic cholinergic receptor modulation of β-adrenergic receptor affinity for catecholamines, J. Biol. Chem., 253, 4833, 10.1016/S0021-9258(17)34620-3 Yatani, 1987, Direct activation of atrial muscarinic potassium channels by GTP regulatory protein Gk, Science, 235, 207, 10.1126/science.2432660