Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ Influx

Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring). 2012;20(2):306–12.

Després JP. Abdominal obesity and cardiovascular disease: is inflammation the missing link? Can J Cardiol. 2012;28(6):642–52.

de Souza RJ, Bray GA, Carey VJ, Hall KD, LeBoff MS, Loria CM, et al. Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr. 2012;95(3):614–25.

Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881–7.

Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116(1):39–48.

Mathieu P, Pibarot P, Larose E, Poirier P, Marette A, Despres JP. Visceral obesity and the heart. Int J Biochem Cell Biol. 2008;40(5):821–36.

Nilius B, Owsianik G. The transient receptor potential family of ion channels. Genome Biol. 2011;12(3):218.

Carmona Marinetto A, Lorenzo J. Intelligibility of language as a function of its consonant sounds. Study conducted in adult individuals with normal hearing. Acta Otorrinolaringol Esp. 1988;39(3):158–60.

Lorenzo R. Diffuse interstitial pulmonary fibrosis in tobacco-industry workers. Arch Monaldi Mal Torace. 1988;43(3):235–41.

Corsi M, Lorenzon G, Mesaglio S. Hepatic echography in acute viral hepatitis. Radiol Med. 1988;75(6):638–42.

Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, et al. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol. 1995;41(6):647–56.

Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr. 1998;80(6):503–10.

Marshall NJ, Liang L, Bodkin J, Dessapt-Baradez C, Nandi M, Collot-Teixeira S, et al. A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension. 2013;61(1):246–52.

Gram DX, Ahren B, Nagy I, Olsen UB, Brand CL, Sundler F, et al. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur J Neurosci. 2007;25(1):213–23.

Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab. 2010;7:65.

Lee TA, Li Z, Zerlin A, Heber D. Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial. Nutr Metab. 2010;7:78.

Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr. 2003;90(3):651–9.

Motter AL, Ahern GP. TRPV1-null mice are protected from diet-induced obesity. FEBS Lett. 2008;582(15):2257–62.

Baboota RK, Singh DP, Sarma SM, Kaur J, Sandhir R, Boparai RK, et al. Capsaicin induces “brite” phenotype in differentiating 3T3-L1 preadipocytes. PLoS One. 2014;9(7):e103093.

Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, et al. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res. 2007;100(7):1063–70.

Li Q, Li L, Wang F, Chen J, Zhao Y, Wang P, et al. Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor delta activation. Pflugers Arch. 2013;465(9):1303–16.

Lorenzo M, Roncero C, Fabregat I, Benito M. Hormonal regulation of rat foetal lipogenesis in brown-adipocyte primary cultures. Biochem J. 1988;251(2):617–20.

Yanagiya T, Tanabe A, Hotta K. Gap-Junctional Communication Is Required for Mitotic Clonal Expansion during Adipogenesis. Obesity. 2007;15(3):572–82.

Yeganeh A, Stelmack GL, Fandrich RR, Halayko AJ, Kardami E, Zahradka P. Connexin 43 phosphorylation and degradation are required for adipogenesis. Biochim Biophys Acta. 2012;1823(10):1731–44.

Song D, Liu X, Liu R, Yang L, Zuo J, Liu W. Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+]. Acta Biochim Biophys Sin (Shanghai). 2010;42(7):472–82.

Cappelluti G, Busilacchi P, Lorenzoni A. Surgical treatment of tumors of the extrahepatic bile ducts. Report on 5 years. Minerva Chir. 1988;43(11):929–33.

Szatkowski C, Vallet J, Dormishian M, Messaddeq N, Valet P, Boulberdaa M, et al. Prokineticin Receptor 1 as a Novel Suppressor of Preadipocyte Proliferation and Differentiation to Control Obesity. PLoS One. 2013;8(12):e81175.

Velasquez Almonacid L, Tafuri S, Dipineto L, Matteoli G, Fiorillo E, Morte RD, et al. Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica. Vet J. 2009;182(3):452–7.

Kamioka H, Ishihara Y, Ris H, Murshid SA, Sugawara Y, Takano-Yamamoto T, et al. Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts. Microsc Microanal. 2007;13(2):108–17.

Gomes P, Srinivas SP, Vereecke J, Himpens B. Gap junctional intercellular communication in bovine corneal endothelial cells. Exp Eye Res. 2006;83(5):1225.

Shen J, Wang L, Zheng L, Zhu J, Hu S. Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells. J Cardiovasc Pharmacol Ther. 2010;15(3):296–302.

Oviedo-Orta E, Howard Evans W. Gap junctions and connexin-mediated communication in the immune system. Biochim Biophys Acta. 2004;1662(1–2):102–12.

Sung B, Prasad S, Ravindran J, Yadav VR, Aggarwal BB. Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic Biol Med. 2012;53(10):1977–87.

Haq N, Grose D, Ward E, Chiu O, Tigue N, Dowell SJ, et al. A high-throughput assay for connexin 43 (Cx43, GJA1) gap junctions using codon-optimized aequorin. Assay Drug Dev Technol. 2013;11(2):93–100.

Mohapatra DP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem. 2003;278(50):50080–90.

Ma W, Quirion R. Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain. Expert Opin Ther Targets. 2007;11(3):307–20.

Marín J, Encabo A, Briones A, García-Cohen E-C, Alonso MJ. Mechanisms involved in the cellular calcium homeostasis in vascular smooth muscle: Calcium pumps. Life Sci. 1998;64(5):279–303.

Sun J, Pu Y, Wang P, Chen S, Zhao Y, Liu C, et al. TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction. Cardiovasc Diabetol. 2013;12:69.

Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr. 2002;21(2):146S–51.

Argilés JM, López-Soriano FJ, Busquets S. Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity. Drug Discov Today. 2009;14(3):208–13.

Zhang SW, Liu Y, Huang GZ, Liu L. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Toxicol In Vitro. 2007;21(8):1476–85.

Peracchia C, Sotkis A, Wang XG, Peracchia LL, Persechini A. Calmodulin directly gates gap junction channels. J Biol Chem. 2000;275(34):26220–4.

Xu Q, Kopp RF, Chen Y, Yang JJ, Roe MW, Veenstra RD. Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain. Am J Physiol Cell Physiol. 2012;302(10):C1548–56.

Huang RY, Laing JG, Kanter EM, Berthoud VM, Bao M, Rohrs HW, et al. Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res. 2011;10(3):1098–109.

Yamanouchi K, Yada E, Ishiguro N, Nishihara M. 18 alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Cell Physiol Biochem. 2007;20(6):781–90.

Schiller PC, D’Ippolito G, Brambilla R, Roos BA, Howard GA. Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro. J Biol Chem. 2001;276(17):14133–8.

Boitano S, Dirksen ER, Evans WH. Sequence-specific antibodies to connexins block intercellular calcium signaling through gap junctions. Cell Calcium. 1998;23(1):1–9.

Cotrina ML, Lin JH-C, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, et al. Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A. 1998;95(26):15735–40.

Nakagami T, Tanaka H, Dai P, Lin SF, Tanabe T, Mani H, et al. Generation of reentrant arrhythmias by dominant-negative inhibition of connexin43 in rat cultured myocyte monolayers. Cardiovasc Res. 2008;79(1):70–9.

Schalper KA, Sánchez HA, Lee SC, Altenberg GA, Nathanson MH, Sáez JC. Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol. 2010;299(6):C1504–15.

Kurebayashi N, Nishizawa H, Nakazato Y, Kurihara H, Matsushita S, Daida H, et al. Aberrant cell-to-cell coupling in Ca2+-overloaded guinea pig ventricular muscles. Am J Physiol Cell Physiol. 2008;294(6):C1419–29.

Ahmed W, Ziouzenkova O, Brown J, Devchand P, Francis S, Kadakia M, et al. PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? J Intern Med. 2007;262(2):184–98.

Tesauro B, Negro G, Percopo V, Lorenzo M. Thymectomy and myasthenia gravis. Critical remarks on our experience. Minerva Chir. 1988;43(17):1319–22.

Desjardins JG, Bass J, Leboeuf G, Di Lorenzo M, Letarte J, Khan AH, et al. A twenty-year experience with thyroid carcinoma in children. J Pediatr Surg. 1988;23(8):709–13.

Di Lorenzo M, Collin PP. Pulmonary metastases in children: results of surgical treatment. J Pediatr Surg. 1988;23(8):762–5.

de Lorenzo V, Herrero M, Neilands JB. IS1-mediated mobility of the aerobactin system of pColV-K30 in Escherichia coli. Mol Gen Genet. 1988;213(2–3):487–90.

Jensen-Urstad AP, Semenkovich CF. Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger? Biochim Biophys Acta. 2012;1821(5):747–53.

He H, Yang D, Ma L, Luo Z, Ma S, Feng X, et al. Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways. Hypertension. 2010;55(4):869–79.

Yang D, Luo Z, Ma S, Wong WT, Ma L, Zhong J, et al. Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab. 2010;12(2):130–41.