Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer

Lu, 2009, Breast cancer metastasis: challenges and opportunities, Cancer Res, 69, 4951, 10.1158/0008-5472.CAN-09-0099

Muller, 2001, Involvement of chemokine receptors in breast cancer metastasis, Nature, 410, 50, 10.1038/35065016

Mukherjee, 2013, The role of chemokine receptor CXCR4 in breast cancer metastasis, Am J Cancer Res, 3, 46

Gil, 2013, Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases, Proc Natl Acad Sci USA, 110, E1291, 10.1073/pnas.1220580110

Luker, 2006, Functions of CXCL12 and CXCR4 in breast cancer, Cancer Lett, 238, 30, 10.1016/j.canlet.2005.06.021

Fernandis, 2004, Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells, Oncogene, 23, 157, 10.1038/sj.onc.1206910

Rhodes, 2011, Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer, Cancer Res, 71, 603, 10.1158/0008-5472.CAN-10-3185

Prasad, 2004, Slit protein- mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells, J Biol Chem, 279, 9115, 10.1074/jbc.M308083200

Liang, 2007, CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway, Biochem Biophys Res Commun, 359, 716, 10.1016/j.bbrc.2007.05.182

Vila-Coro, 1999, The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway, FASEB J, 13, 1699, 10.1096/fasebj.13.13.1699

Ahr, 2005, Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation, J Biol Chem, 280, 6692, 10.1074/jbc.M408481200

Ling, 2007, The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling, Cancer Res, 67, 4210, 10.1158/0008-5472.CAN-06-3629

Alvarez, 2005, Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors, Cancer Res, 65, 5054, 10.1158/0008-5472.CAN-04-4281

Germain, 2007, Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy, Clin Cancer Res, 13, 5665, 10.1158/1078-0432.CCR-06-2491

Al Zaid Siddiquee, 2008, STAT3 as a target for inducing apoptosis in solid and hematological tumors, Cell Res, 18, 254, 10.1038/cr.2008.18

Bromberg, 1999, Stat3 as an oncogene, Cell, 98, 295, 10.1016/S0092-8674(00)81959-5

Turkson, 2004, STAT proteins as novel targets for cancer drug discovery, Expert Opin Ther Targets, 8, 409, 10.1517/14728222.8.5.409

Wang, 2012, STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (Review), Int J Oncol, 14, 1181, 10.3892/ijo.2012.1568

Groner, 2008, The function of Stat3 in tumor cells and their microenvironment, Semin Cell Dev Biol, 19, 341, 10.1016/j.semcdb.2008.06.005

Soriano, 2003, Chemokines integrate JAK/STAT and G-protein pathways during chemotaxis and calcium flux responses, Eur J Immunol, 33, 1328, 10.1002/eji.200323897

Moriguchi, 2005, CXCL12 signaling is independent of Jak2 and Jak3, J Biol Chem, 280, 17408, 10.1074/jbc.M414219200

Majka, 2006, SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells, Folia Histochem Cytobiol, 44, 155

Pfeiffer, 2009, Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer, Br J Cancer, 100, 1949, 10.1038/sj.bjc.6605068

Shen, 2013, CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancer cells, Asian Pac J Cancer Prev, 14, 5403, 10.7314/APJCP.2013.14.9.5403

Lee, 2009, Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer, Int J Oncol, 34, 473

Diaz, 2006, Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression, Clin Cancer Res, 12, 20, 10.1158/1078-0432.CCR-04-1749

Ling, 2005, Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice, Cancer Res, 65, 2532, 10.1158/0008-5472.CAN-04-2425

Selander, 2004, Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy, Cancer Res, 64, 6924, 10.1158/0008-5472.CAN-03-2516

Zhao, 2009, Silencing of estrogen receptor alpha (ERalpha) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer, Breast Cancer Res Treat, 117, 253, 10.1007/s10549-008-0192-1

Bai, 2012, Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients, Med Oncol, 29, 1543, 10.1007/s12032-011-0086-7

Pellegrini, 1997, The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs), Eur J Biochem, 248, 615, 10.1111/j.1432-1033.1997.00615.x

Teicher, 2010, CXCL12 (SDF-1)/CXCR4 pathway in cancer, Clin Cancer Res, 16, 2927, 10.1158/1078-0432.CCR-09-2329

Xu, 2013, The impact of chemokine receptor CXCR4 on breast cancer prognosis: A meta-analysis, Cancer Epidemiol, 37, 725, 10.1016/j.canep.2013.04.017

Jin, 2012, New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation, Mol Cancer Res, 10, 1021, 10.1158/1541-7786.MCR-11-0498

Zhang, 2012, The differences in CXCR4 protein expression are significant for the five molecular subtypes of breast cancer, Ultrastruct Pathol, 36, 381, 10.3109/01913123.2012.728687

Ling, 2013, The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo, PLoS One, 8, e58426, 10.1371/journal.pone.0058426

Hao, 2007, Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer, Cancer Lett, 253, 34, 10.1016/j.canlet.2007.01.005

Andre, 2009, CXCR4 expression in early breast cancer and risk of distant recurrence, Oncologist, 14, 1182, 10.1634/theoncologist.2009-0161

Cabioglu, 2004, Expression of CXCR4 predicts lymph node metastasis in early breast cancer, J Clin Oncol, 22, 841s, 10.1200/jco.2004.22.14_suppl.9525

Schioppa, 2003, Regulation of the chemokine receptor CXCR4 by hypoxia, J Exp Med, 198, 1391, 10.1084/jem.20030267

Li, 2004, Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis, Cancer Cell, 6, 459, 10.1016/j.ccr.2004.09.027

Rahimi, 2010, EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms, Int J Cancer, 126, 1850, 10.1002/ijc.24964

Zhao, 2010, Transforming growth factor-beta1 upregulates the expression of CXC chemokine receptor 4 (CXCR4) in human breast cancer MCF-7 cells, Acta Pharmacol Sin, 31, 347, 10.1038/aps.2009.204

Dechow, 2004, Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C, Proc Natl Acad Sci USA, 101, 10602, 10.1073/pnas.0404100101

Berishaj, 2007, Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer, Breast Cancer Res, 9, R32, 10.1186/bcr1680

Marotta, 2011, The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24− stem cell-like breast cancer cells in human tumors, J Clin Invest, 121, 2723, 10.1172/JCI44745

Behera, 2010, Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells, Carcinogenesis, 31, 192, 10.1093/carcin/bgp289