Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Structure - Tập 21 - Trang 1942-1953 - 2013
Rachelle R. Landgraf1, Devrishi Goswami1, Francis Rajamohan2, Melissa S. Harris2, Matthew F. Calabrese2, Lise R. Hoth2, Rachelle Magyar2, Bruce D. Pascal1, Michael J. Chalmers1, Scott A. Busby1, Ravi G. Kurumbail2, Patrick R. Griffin1,3
1Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
2Pfizer Worldwide Research and Development, Groton, CT 06340, USA
3The Scripps Research Molecular Screening Center (SRMSC), The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA

Tài liệu tham khảo

Amodeo, 2007, Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1, Nature, 449, 492, 10.1038/nature06127 Bieri, 2012, AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding, Biophys. J., 102, 305, 10.1016/j.bpj.2011.12.012 Bruning, 2007, Partial agonists activate PPARgamma using a helix 12 independent mechanism, Structure, 15, 1258, 10.1016/j.str.2007.07.014 Cacicedo, 2011, Acute exercise activates AMPK and eNOS in the mouse aorta, Am. J. Physiol. Heart Circ. Physiol., 301, H1255, 10.1152/ajpheart.01279.2010 Carling, 2012, AMP-activated protein kinase: new regulation, new roles?, Biochem. J., 445, 11, 10.1042/BJ20120546 Celenza, 1984, Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae, Mol. Cell. Biol., 4, 49 Chalmers, 2006, Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry, Anal. Chem., 78, 1005, 10.1021/ac051294f Chen, 2011, Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms, J. Biol. Chem., 286, 21993, 10.1074/jbc.M111.225805 Chen, 2012, AMP-activated protein kinase undergoes nucleotide-dependent conformational changes, Nat. Struct. Mol. Biol., 19, 716, 10.1038/nsmb.2319 Chen, 2013, Conserved regulatory elements in AMPK, Nature, 498, E8, 10.1038/nature12189 Choi, 2010, Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5, Nature, 466, 451, 10.1038/nature09291 Choi, 2011, Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation, Nature, 477, 477, 10.1038/nature10383 Cool, 2006, Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome, Cell Metab., 3, 403, 10.1016/j.cmet.2006.05.005 Dai, 2008, Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method, Proc. Natl. Acad. Sci. USA, 105, 7171, 10.1073/pnas.0710802105 Fryer, 2002, The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways, J. Biol. Chem., 277, 25226, 10.1074/jbc.M202489200 Giordanetto, 2012, Direct AMP-activated protein kinase activators: a review of evidence from the patent literature, Expert Opin Ther Pat, 22, 1467, 10.1517/13543776.2012.743994 Hardie, 2007, AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy, Nat. Rev. Mol. Cell Biol., 8, 774, 10.1038/nrm2249 Hardie, 2011, AMP-activated protein kinase: also regulated by ADP?, Trends Biochem. Sci., 36, 470, 10.1016/j.tibs.2011.06.004 Hardie, 2012, AMPK: a nutrient and energy sensor that maintains energy homeostasis, Nat. Rev. Mol. Cell Biol., 13, 251, 10.1038/nrm3311 Hawley, 2003, Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, J. Biol., 2, 28 Hawley, 2005, Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase, Cell Metab., 2, 9, 10.1016/j.cmet.2005.05.009 Hawley, 2012, The ancient drug salicylate directly activates AMP-activated protein kinase, Science, 336, 918, 10.1126/science.1215327 Hurley, 2005, The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases, J. Biol. Chem., 280, 29060, 10.1074/jbc.M503824200 Hwang, 2009, AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols, New Biotechnol., 26, 17, 10.1016/j.nbt.2009.03.005 Itani, 2003, Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase, Diabetes, 52, 1635, 10.2337/diabetes.52.7.1635 Johnson, 2010, Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila, PLoS ONE, 5, 5, 10.1371/journal.pone.0012799 Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab., 1, 15, 10.1016/j.cmet.2004.12.003 Kemp, 2007, AMPK structure and regulation from three angles, Structure, 15, 1161, 10.1016/j.str.2007.09.006 Koay, 2010, AMPK beta subunits display isoform specific affinities for carbohydrates, FEBS Lett., 584, 3499, 10.1016/j.febslet.2010.07.015 Maniatis, 1982 Marx, 2010, Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases, FASEB J., 24, 1637, 10.1096/fj.09-148064 McBride, 2009, The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor, Cell Metab., 9, 23, 10.1016/j.cmet.2008.11.008 Mihaylova, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism, Nat. Cell Biol., 13, 1016, 10.1038/ncb2329 Momcilovic, 2006, Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro, J. Biol. Chem., 281, 25336, 10.1074/jbc.M604399200 Neumann, 2003, Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli, Protein Expr. Purif., 30, 230, 10.1016/S1046-5928(03)00126-8 Oakhill, 2010, β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK), Proc. Natl. Acad. Sci. USA, 107, 19237, 10.1073/pnas.1009705107 Oakhill, 2012, AMPK functions as an adenylate charge-regulated protein kinase, Trends Endocrinol. Metab., 23, 125, 10.1016/j.tem.2011.12.006 Pang, 2008, Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells, J. Biol. Chem., 283, 16051, 10.1074/jbc.M710114200 Polekhina, 2003, AMPK beta subunit targets metabolic stress sensing to glycogen, Curr. Biol., 13, 867, 10.1016/S0960-9822(03)00292-6 Polekhina, 2005, Structural basis for glycogen recognition by AMP-activated protein kinase, Structure, 13, 1453, 10.1016/j.str.2005.07.008 Rajamohan, 2010, Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase, Protein Expr. Purif., 73, 189, 10.1016/j.pep.2010.04.022 Riek, 2008, Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding, J. Biol. Chem., 283, 18331, 10.1074/jbc.M708379200 Rudolph, 2010, An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 66, 999, 10.1107/S1744309110028265 Sanders, 2007, Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family, J. Biol. Chem., 282, 32539, 10.1074/jbc.M706543200 Schimmack, 2006, AMP-activated protein kinase: Role in metabolism and therapeutic implications, Diabetes Obes. Metab., 8, 591, 10.1111/j.1463-1326.2005.00561.x Scott, 2008, Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes, Chem. Biol., 15, 1220, 10.1016/j.chembiol.2008.10.005 Shang, 2011, AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation, Autophagy, 7, 924, 10.4161/auto.7.8.15860 Steinberg, 2009, AMPK in Health and Disease, Physiol. Rev., 89, 1025, 10.1152/physrev.00011.2008 Vingtdeux, 2011, Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis, Mol. Med., 17, 1022, 10.2119/molmed.2011.00163 Xiao, 2007, Structural basis for AMP binding to mammalian AMP-activated protein kinase, Nature, 449, 496, 10.1038/nature06161 Xiao, 2011, Structure of mammalian AMPK and its regulation by ADP, Nature, 472, 230, 10.1038/nature09932 Zhang, 2011, DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex, Nat. Struct. Mol. Biol., 18, 556, 10.1038/nsmb.2046 Zhu, 2011, Structural insights into the architecture and allostery of full-length AMP-activated protein kinase, Structure, 19, 515, 10.1016/j.str.2011.01.018