Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (Callithrix jacchus)

Abbott, 2003, Aspects of common marmoset basic biology and life history important for biomedical research, Comp Med, 53, 339

10.1016/j.pbb.2014.10.009

10.1371/journal.pone.0046371

10.1074/jbc.M112.402123

10.1212/WNL.35.7.949

10.1016/j.coviro.2012.02.007

Cashman, 1986, Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations, Mol Pharmacol, 29, 163

10.1016/0014-2999(90)90592-T

Chiba, 1985, Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Drug Metab Dispos, 13, 342

Coleman, 1996, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4—implications for susceptibility to Parkinson’s disease, J Pharmacol Exp Ther, 277, 685

10.1038/nm0697-671

10.1016/j.brainresbull.2005.08.005

Herraiz, 2013, Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes, Biomed Res Int, 2013, 248608, 10.1155/2013/248608

10.1016/j.bcp.2004.03.018

Jenner, 2009, From the MPTP-treated primate to the treatment of motor complications in Parkinson’s disease, Parkinsonism Relat Disord, 15, S18, 10.1016/S1353-8020(09)70829-6

10.1093/toxsci/kfq374

Jones, 1986, Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates, J Biol Chem, 261, 2553, 10.1016/S0021-9258(17)35823-4

10.1007/s00228-010-0876-4

Langston, 1983, Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, N Engl J Med, 309, 310, 10.1056/NEJM198308043090511

Mansfield, 2003, Marmoset models commonly used in biomedical research, Comp Med, 53, 383

10.1016/j.siny.2012.07.002

10.1371/journal.pone.0100936

10.1538/expanim.61.389

10.1124/jpet.111.185009

10.3109/00498254.2010.501118

10.3109/03602532.2010.549492

10.1016/j.bcp.2013.04.012

10.1124/dmd.110.033274

10.1124/dmd.114.059220

10.1006/prep.2001.1578

10.1016/j.bcp.2013.03.020

10.1016/j.bcp.2014.04.019

Yoshihara, 2000, Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver: involvement of hepatic aldehyde oxidase as a detoxification enzyme, Drug Metab Dispos, 28, 538