Achalasia: unusual cause of chronic cough in children

Naima Mehdi1, Miles Weinberger2, Mutasim Abu-Hasan2
1Pediatrics Pulmonary Section, University of Oklahoma, 940 NE 13th Street, Room 3B 3314, Oklahoma City, OK, 73104, USA
2Pediatric Allergy and Pulmonary Division, 2544 JCP, University of Iowa, 200 Hawkins Dr, Iowa City, IA, 52242, USA

Tóm tắt

Abstract Achalasia is a rare motility disorder of the esophagus which results from lack of enervation of the lower esophageal sphincter muscles and leads to dilatation of proximal esophagus. Patients with achalasia presents typically with dysphagia, vomiting of undigested food and failure to thrive. Cough can be present in achalasia patients due to aspiration of food or due to airway compression by the dilated esophagus. We report two cases of achalasia presenting primarily with prolonged cough. Diagnosis of achalasia in both cases was delayed due to this atypical presentation. This highlights the importance of recognizing achalasia as a potential cause of chronic cough in order to avoid delayed diagnosis and mismanagement.

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Tài liệu tham khảo

Wong RK, Maydonovitch CL: Achalasia. The esophagus. Edited by: Castell DO. 1992, Boston. Little Brown and Company, 233-260.

Colombo JL, Hallberg TK: Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation. Pediatr Pulmonol. 1987, 3 (2): 86-89. 10.1002/ppul.1950030209.

Farr CM: Achalasia: new thoughts on an old disease. J Clin Gastroenterol. 1992, 15 (1): 2-4. 10.1097/00004836-199207000-00002.

Cash BD, Wong RK: Historical perspective of achalasia. Gastrointest Endosc Clin N Am. 2001, 11 (2): 221-234.

Zarate N, Mearin F, Hidalgo A, Malagelada JR: Prospective evaluation of esophageal motor dysfunction in Down's syndrome. Am J Gastroenterol. 2001, 96 (6): 1718-1724.

Nihoul-Fekete C, Bawab F, Lortat-Jacob S, Arhan P: Achalasia of the esophagus in childhood. Surgical treatment in 35 cases, with special reference to familial cases and glucocorticoid deficiency association. Hepatogastroenterology. 1991, 38 (6): 510-513.

Myers NA, Jolley SG, Taylor R: Achalasia of the cardia in children: a worldwide survey. J Pediatr Surg. 1994, 29 (10): 1375-1379. 10.1016/0022-3468(94)90119-8.

Starinsky R, Berlovitz I, Mares AJ, Versano D, Pajewsky M, Modai D: Infantile achalasia. Pediatr Radiol. 1984, 14 (2): 113-115. 10.1007/BF01625820.

Akritidis N, Gousis C, Dimos G, Paparounas K: Fever, cough, and bilateral lung infiltrates. Achalasia associated with aspiration pneumonia. Chest. 2003, 123 (2): 608-612. 10.1378/chest.123.2.608.

Kugelman A, Berkowitz D, Best LA, Bentur L: Upper airway obstruction as a presenting sign of achalasia in childhood. Acta Paediatr. 2000, 89 (3): 356-358. 10.1080/080352500750028528.

Chapman S, Weller PH, Campbell CA, Buick RG: Tracheal compression caused by achalasia. Pediatr Pulmonol. 1989, 7 (1): 49-51. 10.1002/ppul.1950070111.

Givan DC, Scott PH, Eigen H, Grosfeld JL, Clark JH: Achalasia and tracheal obstruction in a child. Eur J Respir Dis. 1985, 66 (1): 70-73.

Akhter J, Newcomb RW: Tracheal obstruction secondary to esophageal achalasia. J Pediatr Gastroenterol Nutr. 1988, 7 (5): 769-772.

El-Takli I, O'Brien P, Paterson WG: Clinical diagnosis of achalasia: how reliable is the barium x-ray?. Can J Gastroenterol. 2006, 20 (5): 335-337.

Rabushka LS, Fishman EK, Kuhlman JE: CT evaluation of achalasia. J Comput Assist Tomogr. 1991, 15 (3): 434-439. 10.1097/00004728-199105000-00016.

Carter M, Deckmann RC, Smith RC, Burrell MI, Traube M: Differentiation of achalasia from pseudoachalasia by computed tomography. Am J Gastroenterol. 1997, 92 (4): 624-628.

Smith Hammond C: "Cough and aspiration of food and liquids due to oral pharyngeal Dysphagia". Lung. 2008, 186 (Suppl 1): S35-40. 10.1007/s00408-007-9064-4.

Robinson GV, Kanji H, Davies RJ, Gleeson FV: Selective pulmonary fat aspiration complicating oesophageal achalasia. Thorax. 59 (2): 180-10.1136/thx.2003.017814.

Akritidis N, Gousis C, Dimos G, Paparounas K: Fever, cough, and bilateral lung infiltrates. Achalasia associated with aspiration pneumonia. Chest. 2003, 123 (2): 608-12. 10.1378/chest.123.2.608.