Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Nature - Tập 534 Số 7606 - Trang 213-217 - 2016
Rachel J. Perry1, Liang Peng1, Natasha A. Barry2, Gary W. Cline1, Dongyan Zhang3, Rebecca Cardone1, Kitt Falk Petersen1, Richard G. Kibbey1, Andrew L. Goodman2, Gerald I. Shulman3
1Department of Internal Medicine, Yale University School of Medicine, New Haven, 06520, Connecticut, USA
2Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, 06510, Connecticut, USA
3Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, 06519, Connecticut, USA

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Tài liệu tham khảo

Rahat-Rozenbloom, S., Fernandes, J., Gloor, G. B. & Wolever, T. M. Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans. Int. J. Obes. 38, 1525–1531 (2014)

Shepherd, M. L., Ponder, M. A., Burk, A. O., Milton, S. C. & Swecker, W. S. Jr. Fibre digestibility, abundance of faecal bacteria and plasma acetate concentrations in overweight adult mares. J. Nutr. Sci. 3, e10 (2014)

Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006)

Fernandes, J., Su, W., Rahat-Rozenbloom, S., Wolever, T. M. & Comelli, E. M. Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans. Nutr. Diabetes 4, e121 (2014)

Li, M. et al. Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity. Benef. Microbes 5, 335–344 (2014)

Murugesan, S. et al. Study of the diversity and short-chain fatty acids production by the bacterial community in overweight and obese Mexican children. Eur. J. Clin. Microbiol. Inf. Dis. 34, 1337–1346 (2015)

Murphy, E. F. et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut 59, 1635–1642 (2010)

David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563 (2014)

La-ongkham, O., Nakphaichit, M., Leelavatcharamas, V., Keawsompong, S. & Nitisinprasert, S. Distinct gut microbiota of healthy children from two different geographic regions of Thailand. Arch. Microbiol. 197, 561–573 (2015)

Aguirre, M., Jonkers, D. M., Troost, F. J., Roeselers, G. & Venema, K. In vitro characterization of the impact of different substrates on metabolite production, energy extraction and composition of gut microbiota from lean and obese subjects. PLoS One 9, e113864 (2014)

Shen, W. et al. Protective effects of R-alpha-lipoic acid and acetyl-l-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J. Cell. Biochem. 104, 1232–1243 (2008)

Drucker, D. J. Minireview: the glucagon-like peptides. Endocrinology 142, 521–527 (2001)

MacDonald, P. E. et al. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes 51 (suppl. 3), S434–S442 (2002)

Ahrén, B. Autonomic regulation of islet hormone secretion—implications for health and disease. Diabetologia 43, 393–410 (2000)

Ronnebaum, S. M. et al. Chronic suppression of acetyl-CoA carboxylase 1 in β-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. J. Biol. Chem. 283, 14248–14256 (2008)

Ionescu, E., Rohner-Jeanrenaud, F., Berthoud, H. R. & Jeanrenaud, B. Increases in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve. Endocrinology 112, 904–910 (1983)

Sakaguchi, T. & Yamaguchi, K. Effects of electrical stimulation of the hepatic vagus nerve on the plasma insulin concentration in the rat. Brain Res. 164, 314–316 (1979)

Lee, K. C. & Miller, R. E. The hepatic vagus nerve and the neural regulation of insulin secretion. Endocrinology 117, 307–314 (1985)

Frohman, L. A., Ezdinli, E. Z. & Javid, R. Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes 16, 443–448 (1967)

Bergman, R. N. & Miller, R. E. Direct enhancement of insulin secretion by vagal stimulation of the isolated pancreas. Am. J. Physiol. 225, 481–486 (1973)

Ahrén, B. & Holst, J. J. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50, 1030–1038 (2001)

Yamazaki, H., Philbrick, W., Zawalich, K. C. & Zawalich, W. S. Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine. Am. J. Physiol. Endocrinol. Metab. 290, E26–E33 (2006)

D’Alessio, D. A., Kieffer, T. J., Taborsky, G. J., Jr & Havel, P. J. Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. J. Clin. Endocrinol. Metab. 86, 1253–1259 (2001)

Wichmann, A. et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe 14, 582–590 (2013)