Accidental Overdose of Oral Cyclosporine in Haematopoietic Stem Cell Transplantation: A Case Report and Literature Review

Ali Tafazoli1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, PO Box 14155/6153, Tehran, Iran

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Tafazoli A. Cyclosporine use in hematopoietic stem cell transplantation: pharmacokinetic approach. Immunotherapy. 2015;7(7):811–36.

Dijkmans B, van Rijthoven A, Goei Thè H, Boers M, Cats A. Cyclosporine in rheumatoid arthritis. Semin Arthritis Rheum. 1992;22(1):30–6.

Baumhefner RW, Myers LW, Ellison GW, Tourtellote WW, Belendiuk GW, Wilkinson A, et al. Huge cyclosporin overdose with favourable outcome. Lancet. 1987;2(8554):332.

Eagle D, Gian V, Lauwers G, Manivel J, Moreb J, Mastin S, et al. Gastroparesis following bone marrow transplantation. Bone Marrow Transplant. 2001;28(1):59–62.

Piñana J, Valcárcel D, Martino R, Barba P, Moreno E, Sureda A, et al. Study of kidney function impairment after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation: a single-center experience. Biol Blood Marrow Transplant. 2009;15(1):21–9.

Dussol B, Reynaud-Gaubert M, Saingra Y, Daniel L, Berland Y. Acute tubular necrosis induced by high level of cyclosporine A in a lung transplant. Transplantation. 2000;70(8):1234–6.

Banner N, Yacoub M. Cyclosporine in thoracic organ transplantation. Transplant Proc. 2004;36(2 Suppl):302S–8S.

Zager R, O’Quigley J, Zager B, Alpers C, Shulman H, Gamelin L, et al. Acute renal failure following bone marrow transplantation: a retrospective study of 272 patients. Am J Kidney Dis. 1989;13(3):210–6.

Trull A, Hue K, Tan K, Gore S, Whitewood S, Smyth R, et al. Cross-correlation of cyclosporine concentrations and biochemical measures of kidney and liver function in heart and heart–lung transplant recipients. Clin Chem. 1990;36(8 Pt 1):1474–8.

Nghiem DD. Role of pharmacologic enhancement of p-450 in cyclosporine overdose. Transplantation. 2002;74(9):1355–6.

de Perrot M, Spiliopoulos A, Cottini S, Nicod L, Ricou B. Massive cerebral edema after IV cyclosporin overdose. Transplantation. 2000;70(8):1259–60.

Shbarou R, Chao N, Morgenlander J. Cyclosporin A-related cerebral vasculopathy. Bone Marrow Transplant. 2000;26(7):801–4.

Torelli G, Natalino F, Barberi W, Iori A, Andreoli C, Valle V, et al. Early onset of posterior reversible encephalopathy syndrome (PRES) during cyclosporine A infusion. Leuk Res. 2011;35(10):1423–4.

Eisenberg S. The case of the toxic transplant tremors. ONS Connect. 2013;28(3):41.

Barbui T, Rambaldi A, Parenzan L, Zucchelli M, Perico N, Remuzzi G. Neurological symptoms and coma associated with doxorubicin administration during chronic cyclosporin therapy. Lancet. 1992;339(8806):1421.

Taler S, Textor S, Canzanello V, Schwartz L. Cyclosporin-induced hypertension: incidence, pathogenesis and management. Drug Saf. 1999;20(5):437–49.

Fujisaki G, Kami M, Murashige N, Kishi Y, Inokuchi C, Tanosaki R, et al. Sinus bradycardia associated with cyclosporine following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005;35(2):211–2.

Kingma I, Harmsen E, ter Keurs H, Benediktsson H, Paul L. Cyclosporine-associated reduction in systolic myocardial function in the rat. Int J Cardiol. 1991;31(1):15–22.

LoVecchio FA, Goltz HR. Atrial fibrillation following acute overdose with oral cyclosporine. Ann Pharmacother. 2000;34(3):405.

van Hooff J, Bessems P, Beuman G, Leunissen K. The absence of an allergic reaction to cyclosporine capsules in a patient allergic to standard oral and intravenous solutions of cyclosporine. Transplant Proc. 1988;20(2 Suppl 2):640.

Honcharik N, Anthone S. Activated charcoal in acute cyclosporin overdose. Lancet. 1985;1(8436):1051.

Anderson AB, Primack W. Treatment of a child with acute cyclosporine overdose. Pediatr Nephrol (Berlin, Germany). 1992;6(2):222.

Lucey MR, Kolars JC, Merion RM, Campbell DA, Aldrich M, Watkins PB. Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA. Lancet. 1990;335(8680):11–5.

Leitner GC, Hiesmayr M, Hoecker P, Jilma B. Therapeutic approaches in the management of oral cyclosporine A intoxication. Transplantation. 2003;75(10):1764–5.

Kwon SU, Lim SH, Rhee I, Kim SW, Kim JK, Kim DW, et al. Successful whole blood exchange by apheresis in a patient with acute cyclosporine intoxication without long-term sequelae. J Heart Lung Transplant. 2006;25(4):483–5.

Moorman M, Epstein R, Smith J, O’Neal C, Holter J. Management of cyclosporine overdose in a hematopoietic stem cell transplant patient with sequential plasma exchange and red blood cell exchange. J Clin Apher. 2011;26(3):156–8.

Arellano F, Monka C, Krupp PF. Acute cyclosporin overdose: a review of present clinical experience. Drug Saf. 1991;6(4):266–76.

Ceschi A, Rauber-Luthy C, Kupferschmidt H, Banner NR, Ansari M, Krahenbuhl S, et al. Acute calcineurin inhibitor overdose: analysis of cases reported to a national poison center between 1995 and 2011. Am J Transplant. 2013;13(3):786–95.

Fahimi F, Baniasadi S, Najafi Zadeh K. Dose switch to another dosage form of Neoral increase the risk of medication error? Ann Transplant. 2009;14(4):58–60.

von Bahr C, Steiner E, Koike Y, Gabrielsson J. Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism. Clin Pharmacol Ther. 1998;64(1):18–26.